papaverine has been researched along with Heart Disease, Ischemic in 10 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effect of the papaverine dose increment method to confirm maximal hyperemia for fractional flow reserve (FFR) measurements." | 7.96 | Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine. ( Iwasaki, K; Nakayama, M; Tanaka, N; Yamashita, J, 2020) |
| "Fifty-six patients with atypical chest pain were randomly assigned to two groups: 25 patients were treated with the ACE inhibitor enalapril (ACE inhibitor group), and 31 were not treated with ACE inhibitors (non-ACE inhibitor group)." | 5.09 | Bradykinin stimulates the release of tissue plasminogen activator in human coronary circulation: effects of angiotensin-converting enzyme inhibitors. ( Horie, H; Kinoshita, M; Matsumoto, T; Minai, K; Ohira, N; Takashima, H; Yokohama, H, 2001) |
| "We investigated the effect of the papaverine dose increment method to confirm maximal hyperemia for fractional flow reserve (FFR) measurements." | 3.96 | Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine. ( Iwasaki, K; Nakayama, M; Tanaka, N; Yamashita, J, 2020) |
| "Myocardial ischemia is associated with impaired endothelium-independent vasodilation of resistance coronary arteries and increased minimal coronary resistance." | 1.32 | Contribution of increased minimal coronary resistance and attenuated vascular adaptive remodeling to myocardial ischemia in patients with systemic hypertension and ventricular hypertrophy. ( Fukudome, T; Hamasaki, S; Ishida, S; Kataoka, T; Minagoe, S; Mizoguchi, E; Ninomiya, Y; Okui, H; Otsuji, Y; Saihara, K; Shinsato, T; Tei, C, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakayama, M | 1 |
| Tanaka, N | 1 |
| Yamashita, J | 1 |
| Iwasaki, K | 1 |
| Krüger, D | 1 |
| ElMokhtari, NE | 1 |
| Wieckhorst, A | 1 |
| Simon-Herrmann, G | 1 |
| Simon, R | 1 |
| Gori, T | 1 |
| Fineschi, M | 1 |
| Shamloul, R | 1 |
| Ghanem, HM | 1 |
| Salem, A | 1 |
| Elnashaar, A | 1 |
| Elnaggar, W | 1 |
| Darwish, H | 1 |
| Mousa, AA | 1 |
| Kataoka, T | 1 |
| Hamasaki, S | 1 |
| Ishida, S | 1 |
| Saihara, K | 1 |
| Okui, H | 1 |
| Fukudome, T | 1 |
| Shinsato, T | 1 |
| Mizoguchi, E | 1 |
| Ninomiya, Y | 1 |
| Otsuji, Y | 1 |
| Minagoe, S | 1 |
| Tei, C | 1 |
| Morioka, T | 1 |
| Kitakaze, M | 1 |
| Minamino, T | 1 |
| Takashima, S | 1 |
| Node, K | 1 |
| Okazaki, Y | 1 |
| Sato, H | 1 |
| Shinozaki, Y | 1 |
| Chujo, M | 1 |
| Mori, H | 1 |
| Zeiher, AM | 1 |
| Krause, T | 1 |
| Schächinger, V | 1 |
| Minners, J | 1 |
| Moser, E | 1 |
| Schlack, W | 1 |
| Uebing, A | 1 |
| Schäfer, M | 1 |
| Bier, F | 1 |
| Grunert, S | 1 |
| Ebel, D | 1 |
| Piper, HM | 1 |
| Thämer, V | 1 |
| Rossen, JD | 1 |
| Nahser, PJ | 1 |
| Oskarsson, H | 1 |
| Brown, RE | 1 |
| Winniford, MD | 1 |
| Minai, K | 1 |
| Matsumoto, T | 1 |
| Horie, H | 1 |
| Ohira, N | 1 |
| Takashima, H | 1 |
| Yokohama, H | 1 |
| Kinoshita, M | 1 |
1 review available for papaverine and Heart Disease, Ischemic
| Article | Year |
|---|---|
Two coronary "orphan" diseases in search of clinical consideration: coronary syndromes x and y.
Topics: Acute Coronary Syndrome; Adult; Aged; Angina Pectoris; Chest Pain; Coronary Angiography; Electrocard | 2012 |
1 trial available for papaverine and Heart Disease, Ischemic
| Article | Year |
|---|---|
Bradykinin stimulates the release of tissue plasminogen activator in human coronary circulation: effects of angiotensin-converting enzyme inhibitors.
Topics: Acetylcholine; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Blood Flow Velocity; | 2001 |
8 other studies available for papaverine and Heart Disease, Ischemic
| Article | Year |
|---|---|
Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine.
Topics: Aged; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Dose-Response Relationship, Drug; E | 2020 |
Intravascular ultrasound study and evidence of pathological coronary flow reserve in patients with isolated coronary artery aneurysms.
Topics: Aged; Blood Flow Velocity; Case-Control Studies; Coronary Aneurysm; Coronary Angiography; Coronary C | 2010 |
Correlation between penile duplex findings and stress electrocardiography in men with erectile dysfunction.
Topics: Adrenergic alpha-Antagonists; Adult; Coronary Disease; Echocardiography, Stress; Humans; Impotence, | 2004 |
Contribution of increased minimal coronary resistance and attenuated vascular adaptive remodeling to myocardial ischemia in patients with systemic hypertension and ventricular hypertrophy.
Topics: Acetylcholine; Aged; Blood Flow Velocity; Cardiac Volume; Coronary Angiography; Coronary Artery Dise | 2004 |
Downward shift of coronary pressure-flow relationship following a brief period of ischemia in dogs.
Topics: Adenosine; Animals; Blood Pressure; Coronary Circulation; Dogs; Myocardial Contraction; Myocardial I | 1995 |
Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia.
Topics: Acetylcholine; Aged; Coronary Angiography; Coronary Circulation; Coronary Vessels; Exercise; Exercis | 1995 |
Intracoronary SIN-1C during reperfusion reduces infarct size in dog.
Topics: Acetonitriles; Animals; Coronary Circulation; Dogs; Electrocardiography; Female; Infusions, Intraven | 1995 |
Does pharmacologic coronary flow reserve reflect vasodilator responsiveness to increased myocardial demand in humans?
Topics: Adenosine; Adrenergic beta-Agonists; Blood Flow Velocity; Blood Pressure; Cardiac Catheterization; C | 1996 |