papaverine has been researched along with Headache in 9 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As far as the head pain was concerned, the feeling of giddiness, congestion in the head, rapid exhaustion, above all, tinnitus, responded best to the medication (the improvement amounting to approximately 40%), whereas of the mental complaints, a feeling of being "lost" or "abandoned" and a morose mood were most amenable to improvement (degree of improvement approximately 30%)." | 1.26 | [Eutergin in the treatment of chronic cerebrovascular disturbance patterns (author's transl)]. ( Prosenz, P, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kruuse, C | 1 |
| Thomsen, LL | 1 |
| Jacobsen, TB | 1 |
| Olesen, J | 1 |
| Prosenz, P | 1 |
| Feine-Haake, G | 1 |
| Neiss, A | 1 |
| Weinert, W | 1 |
| Agnoli, A | 2 |
| Duvoisin, RC | 1 |
| Vogel, G | 1 |
| Krusch, G | 1 |
| Piccinelli, A | 1 |
| Neri, G | 1 |
| Aring, CD | 1 |
| von Albert, HH | 1 |
| Marguth, F | 1 |
3 trials available for papaverine and Headache
| Article | Year |
|---|---|
The phosphodiesterase 5 inhibitor sildenafil has no effect on cerebral blood flow or blood velocity, but nevertheless induces headache in healthy subjects.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adult; Brain; Cerebral Arteries; Cerebrovascular Circulation; C | 2002 |
[The treatment of cerebrovascular insufficiency. Their evaluation in a double-blind study].
Topics: Aged; Aging; Cerebrovascular Disorders; Clinical Trials as Topic; Confusion; Drug Combinations; Drug | 1975 |
[Long-term medical treatment of acute cerebrovascular disease sequelae (comparison papaverine-piribedil].
Topics: Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as Topic; Dioxoles; Drug Eva | 1974 |
6 other studies available for papaverine and Headache
| Article | Year |
|---|---|
[Eutergin in the treatment of chronic cerebrovascular disturbance patterns (author's transl)].
Topics: Aged; Antidepressive Agents; Cerebrovascular Disorders; Chronic Disease; Dementia; Dihydroergotoxine | 1980 |
[Problems in the long-term medical treatment of sequelae of acute cerebrovascular diseases. Double-blind studies].
Topics: Cerebrovascular Disorders; Cognition Disorders; Emotions; Headache; Humans; Mental Processes; Motor | 1976 |
Antagonism of levodopa by papaverine.
Topics: Aged; Corpus Striatum; Fatigue; Female; Headache; Humans; Hyperhidrosis; Intracranial Arterioscleros | 1975 |
[The effect of various drugs in clinical use on thrombocyte functions].
Topics: Adolescent; Adult; Aged; Aminobenzoates; Aminocaproates; Arthritis, Rheumatoid; Aspirin; Blood Coagu | 1969 |
Emotion-induced headache.
Topics: Ergotamine; Fluphenazine; Headache; Humans; Methysergide; Migraine Disorders; Muscle Contraction; Pa | 1974 |
[Therapy of headaches, including migraine].
Topics: Analgesics; Brain Injuries; Brain Neoplasms; Drug Synergism; Ergoloid Mesylates; Eye Diseases; Heada | 1969 |