Page last updated: 2024-11-02

papaverine and Headache

papaverine has been researched along with Headache in 9 studies

Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.

Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"As far as the head pain was concerned, the feeling of giddiness, congestion in the head, rapid exhaustion, above all, tinnitus, responded best to the medication (the improvement amounting to approximately 40%), whereas of the mental complaints, a feeling of being "lost" or "abandoned" and a morose mood were most amenable to improvement (degree of improvement approximately 30%)."1.26[Eutergin in the treatment of chronic cerebrovascular disturbance patterns (author's transl)]. ( Prosenz, P, 1980)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19908 (88.89)18.7374
1990's0 (0.00)18.2507
2000's1 (11.11)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kruuse, C1
Thomsen, LL1
Jacobsen, TB1
Olesen, J1
Prosenz, P1
Feine-Haake, G1
Neiss, A1
Weinert, W1
Agnoli, A2
Duvoisin, RC1
Vogel, G1
Krusch, G1
Piccinelli, A1
Neri, G1
Aring, CD1
von Albert, HH1
Marguth, F1

Trials

3 trials available for papaverine and Headache

ArticleYear
The phosphodiesterase 5 inhibitor sildenafil has no effect on cerebral blood flow or blood velocity, but nevertheless induces headache in healthy subjects.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2002, Volume: 22, Issue:9

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adult; Brain; Cerebral Arteries; Cerebrovascular Circulation; C

2002
[The treatment of cerebrovascular insufficiency. Their evaluation in a double-blind study].
    MMW, Munchener medizinische Wochenschrift, 1975, Jun-27, Volume: 117, Issue:26

    Topics: Aged; Aging; Cerebrovascular Disorders; Clinical Trials as Topic; Confusion; Drug Combinations; Drug

1975
[Long-term medical treatment of acute cerebrovascular disease sequelae (comparison papaverine-piribedil].
    Minerva medica, 1974, Nov-10, Volume: 65, Issue:80

    Topics: Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as Topic; Dioxoles; Drug Eva

1974

Other Studies

6 other studies available for papaverine and Headache

ArticleYear
[Eutergin in the treatment of chronic cerebrovascular disturbance patterns (author's transl)].
    Aktuelle Gerontologie, 1980, Volume: 10, Issue:6

    Topics: Aged; Antidepressive Agents; Cerebrovascular Disorders; Chronic Disease; Dementia; Dihydroergotoxine

1980
[Problems in the long-term medical treatment of sequelae of acute cerebrovascular diseases. Double-blind studies].
    Minerva medica, 1976, May-26, Volume: 67, Issue:26

    Topics: Cerebrovascular Disorders; Cognition Disorders; Emotions; Headache; Humans; Mental Processes; Motor

1976
Antagonism of levodopa by papaverine.
    JAMA, 1975, Feb-24, Volume: 231, Issue:8

    Topics: Aged; Corpus Striatum; Fatigue; Female; Headache; Humans; Hyperhidrosis; Intracranial Arterioscleros

1975
[The effect of various drugs in clinical use on thrombocyte functions].
    Folia haematologica (Leipzig, Germany : 1928), 1969, Volume: 92, Issue:4

    Topics: Adolescent; Adult; Aged; Aminobenzoates; Aminocaproates; Arthritis, Rheumatoid; Aspirin; Blood Coagu

1969
Emotion-induced headache.
    Postgraduate medicine, 1974, Volume: 56, Issue:3

    Topics: Ergotamine; Fluphenazine; Headache; Humans; Methysergide; Migraine Disorders; Muscle Contraction; Pa

1974
[Therapy of headaches, including migraine].
    Bibliotheca psychiatrica et neurologica, 1969, Volume: 139

    Topics: Analgesics; Brain Injuries; Brain Neoplasms; Drug Synergism; Ergoloid Mesylates; Eye Diseases; Heada

1969