papaverine has been researched along with HbS Disease in 3 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Herein we describe the use of intracavernous methylene blue (MB), a guanylate cyclase inhibitor, or internal pudendal artery embolization for the treatment of priapism." | 3.70 | Alternative approaches to the management of priapism. ( Angle, JF; deHoll, JD; Shin, PA; Steers, WD, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DIGGS, LW | 1 |
| WILLIAMS, DL | 1 |
| deHoll, JD | 1 |
| Shin, PA | 1 |
| Angle, JF | 1 |
| Steers, WD | 1 |
| Nath, KA | 1 |
| Shah, V | 1 |
| Haggard, JJ | 1 |
| Croatt, AJ | 1 |
| Smith, LA | 1 |
| Hebbel, RP | 1 |
| Katusic, ZS | 1 |
3 other studies available for papaverine and HbS Disease
| Article | Year |
|---|---|
Treatment of painful sickle cell crises with papaverine: preliminary report.
Topics: Anemia; Anemia, Sickle Cell; Erythrocytes, Abnormal; Humans; Pain; Papaverine | 1963 |
Alternative approaches to the management of priapism.
Topics: Adult; Alprostadil; Anemia, Sickle Cell; Embolization, Therapeutic; Enzyme Inhibitors; Guanylate Cyc | 1998 |
Mechanisms of vascular instability in a transgenic mouse model of sickle cell disease.
Topics: Anemia, Sickle Cell; Animals; Aorta; Autoantibodies; Blood Pressure; Calcimycin; Cyclic GMP; Disease | 2000 |