papaverine has been researched along with Graft Occlusion, Vascular in 12 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Graft Occlusion, Vascular: Obstruction of flow in biological or prosthetic vascular grafts.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study is planned bringing about a new choice for the prophylaxis of RA spasm which is topical iloprost and compares its efficacy with papaverine and diltiazem." | 9.12 | An alternative agent for radial arterial graft spasm: application of topical iloprost. ( Besogul, Y; Ikizler, M; Karakaya, A; Ozdemir, C; Sirmagul, B, 2007) |
| "This study is planned bringing about a new choice for the prophylaxis of RA spasm which is topical iloprost and compares its efficacy with papaverine and diltiazem." | 5.12 | An alternative agent for radial arterial graft spasm: application of topical iloprost. ( Besogul, Y; Ikizler, M; Karakaya, A; Ozdemir, C; Sirmagul, B, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 7 (58.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yoshizaki, T | 1 |
| Tabuchi, N | 1 |
| Toyama, M | 1 |
| Ozdemir, C | 1 |
| Ikizler, M | 1 |
| Besogul, Y | 1 |
| Karakaya, A | 1 |
| Sirmagul, B | 1 |
| Song, C | 1 |
| Por, YC | 1 |
| Wong, CH | 1 |
| Woo, EK | 1 |
| Sayers, RD | 1 |
| Watt, PA | 1 |
| Bell, PR | 1 |
| Thurston, H | 1 |
| Karacagil, S | 1 |
| Granbo, A | 1 |
| Almgren, B | 1 |
| Ljungman, C | 1 |
| Bergqvist, D | 1 |
| Mügge, A | 1 |
| Heublein, B | 1 |
| Kuhn, M | 1 |
| Nolte, C | 1 |
| Haverich, A | 1 |
| Warnecke, J | 1 |
| Forssmann, WG | 1 |
| Lichtlen, PR | 1 |
| Dregelid, E | 1 |
| Heldal, K | 1 |
| Andersen, KS | 1 |
| Stangeland, L | 1 |
| Svendsen, E | 1 |
| Frierson, JH | 1 |
| Bigelow, JC | 1 |
| Duke, DJ | 1 |
| Mahoney, TM | 1 |
| Dimas, AP | 1 |
| Schwartz, LB | 1 |
| Purut, CM | 1 |
| Craig, DM | 1 |
| Smith, PK | 1 |
| Moawad, J | 1 |
| McCann, RL | 1 |
| Davies, AH | 1 |
| Horrocks, M | 1 |
| Rapoport, S | 1 |
| Glickman, MG | 1 |
| Salomon, JC | 1 |
| Cuono, CB | 1 |
| Meyer, B | 1 |
| Pfisterer, M | 1 |
| Grädel, E | 1 |
| Hasse, J | 1 |
| Stulz, P | 1 |
| Wolff, G | 1 |
| Skarvan, K | 1 |
| Schmitt, HE | 1 |
| Burkart, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Topical Nitroglycerine Treatment for Radial Artery Spasm Prevention[NCT02832115] | Phase 4 | 100 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in Radial artery cross sectional area in mm^2 - Before application of topical nitroglycerine / placebo (Pre dilation) vs Prior to arterial puncture after application of topical nitroglycerine / placebo (Post-dilation) (NCT02832115)
Timeframe: Application of nitroglycerine / placebo until prior to arterial puncture. Approximate 60 to 120 minutes
| Intervention | mm^2 (Mean) |
|---|---|
| Study | 2.5 |
| Control | -0.2 |
Need to abort procedure or convert to transfemoral access (NCT02832115)
Timeframe: Intraprocedural: From procedure start to application of radial band. Approximate time 30 to 90 minutes.
| Intervention | Participants (Count of Participants) |
|---|---|
| Study | 0 |
| Control | 4 |
Patient discomfort or pain during procedure measured using Visual analog scale 0-10, 0 being no discomfort or pain (best) and 10 being worst discomfort or pain (worst) (NCT02832115)
Timeframe: Intraprocedural: From procedure start to application of radial band. Approximate time 30 to 90 minutes.
| Intervention | score on a scale (Mean) |
|---|---|
| Study | 0.792 |
| Control | 0.875 |
"Incidence of radial artery spasm indicated by a Radial artery spasm score of 1 or more. Radial artery spasm score is sum of:~Intraprocedural pain in the forearm aggravated by movement of the catheter/sheath - Absent :0; Present:1~Difficulty in manipulating the catheter- Absence :0; Present:1~Difficulty with sheath removal: Absent: 0; Present:1~Additional use of intraarterial nitroglycerine or verapamil after the initial vasodilator cocktail- No:0; Yes:1" (NCT02832115)
Timeframe: Intraprocedural: From procedure start to application of radial band. Approximate time 30 to 90 minutes.
| Intervention | Participants (Count of Participants) |
|---|---|
| Study | 8 |
| Control | 15 |
Radial pulse at end of procedure 0- 4+, 0 indicating no palpable pulse (worst); 1 + indicating a faint, but detectable pulse; 2 + suggesting a slightly more diminished pulse than normal; 3 + is a normal pulse; and 4 + indicating a bounding pulse (best). (NCT02832115)
Timeframe: At the end of transradial cardiac catheterization after sheath removal
| Intervention | score on a scale (Mean) |
|---|---|
| Study | 2.208333333 |
| Control | 2.166666667 |
2 trials available for papaverine and Graft Occlusion, Vascular
| Article | Year |
|---|---|
An alternative agent for radial arterial graft spasm: application of topical iloprost.
Topics: Administration, Topical; Aged; Arterial Occlusive Diseases; Coronary Artery Bypass; Diltiazem; Dose- | 2007 |
Dilation of the internal mammary artery by external papaverine application to the pedicle--an improved method.
Topics: Adult; Aged; Analysis of Variance; Blood Flow Velocity; Coronary Artery Bypass; Dilatation; Female; | 1993 |
10 other studies available for papaverine and Graft Occlusion, Vascular
| Article | Year |
|---|---|
Verapamil and nitroglycerin improves the patency rate of radial artery grafts.
Topics: Administration, Topical; Aged; Coronary Artery Bypass; Drug Combinations; Female; Graft Occlusion, V | 2008 |
Novel use of continuous topical papaverine infusion delivered via a balloon pump to help maintain vascular patency in a case of intractable arterial spasm in a smoker.
Topics: Arterial Occlusive Diseases; Graft Occlusion, Vascular; Humans; Infusion Pumps; Male; Middle Aged; P | 2008 |
The effects of intraoperative vasodilators and angiographic contrast medium on the endothelium and smooth muscle cells of vein grafts.
Topics: Aged; Blood Vessel Prosthesis; Dose-Response Relationship, Drug; Endothelium, Vascular; Graft Occlus | 1993 |
The effect of postocclusion reactive hyperaemia, papaverine and nifedipine on duplex derived haemodynamic parameters of infrainguinal bypass grafts.
Topics: Aged; Arteriovenous Shunt, Surgical; Blood Flow Velocity; Blood Vessel Prosthesis; Female; Graft Occ | 1995 |
Impaired coronary dilator responses to substance P and impaired flow-dependent dilator responses in heart transplant patients with graft vasculopathy.
Topics: Adult; Analysis of Variance; Blood Flow Velocity; Blood Platelets; Cardiac Catheterization; Coronary | 1993 |
Treatment of perioperative mammary artery graft spasm with nifedipine.
Topics: Aged; Female; Graft Occlusion, Vascular; Heart Arrest; Humans; Internal Mammary-Coronary Artery Anas | 1993 |
Measurement of vascular input impedance in infrainguinal vein grafts.
Topics: Aged; Angiography; Arteriovenous Shunt, Surgical; Female; Follow-Up Studies; Graft Occlusion, Vascul | 1997 |
Outflow resistance measurements.
Topics: Angiography; Blood Flow Velocity; Graft Occlusion, Vascular; Humans; Ischemia; Leg; Papaverine; Ultr | 1992 |
Aggressive postoperative pharmacotherapy for vascular compromise of replanted digits.
Topics: Angiography; Drug Therapy, Combination; Fingers; Follow-Up Studies; Graft Occlusion, Vascular; Hepar | 1985 |
[Relation between intraoperative blood flow measurements and graft patency afer aortocoronary bypass surgery].
Topics: Coronary Artery Bypass; Coronary Circulation; Female; Graft Occlusion, Vascular; Humans; Intraoperat | 1985 |