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papaverine and Glioma

papaverine has been researched along with Glioma in 16 studies

Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"The concentration of methotrexate (MTX) in tumor was measured in 18 patients with cerebral glioma, and 155 patients with malignant glioma were treated by intracarotid infusion of papaverine and Bis-chloronitrosourea (BCNU)."9.08Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma. ( Kong, L; Wang, H; Xue, H; Zhou, H, 1998)
"The concentration of methotrexate (MTX) in tumor was measured in 18 patients with cerebral glioma, and 155 patients with malignant glioma were treated by intracarotid infusion of papaverine and Bis-chloronitrosourea (BCNU)."5.08Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma. ( Kong, L; Wang, H; Xue, H; Zhou, H, 1998)
" In the present study, however, changes in intracellular cyclic AMP level in several lines of cultured cells (normal 3T3 and SV40 and polyomavirus-transformed 3T3 cells; 3T6, C6 GLIOMA, MOUSE L, and Novikoff rat hepatoma cells) by treatment with papaverine, prostaglandine E1 or isoproterenol did not correlate with the inhibition of the uridine, hypoxanthine or deoxyglucose transport rates by these chemicals."3.65Cyclic AMP, membrane transport and cell division. I. Effects of various chemicals on cyclic AMP levels and rate of transport of neucleosides, hypoxanthine and deoxyglucose in several lines of cultured cells. ( Plagemann, PG; Sheppard, JR, 1975)
"Rat C 6 glioma is known to possess a beta-adrenergic receptor with which intracellular cyclic adenosine monophosphate (cAMP) levels are altered to control cell growth in vitro."1.27[Treatment of rat glioma with a beta-adrenergic agonist and a phosphodiesterase inhibitor in vivo]. ( Egawa, T; Hayakawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1987)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199012 (75.00)18.7374
1990's1 (6.25)18.2507
2000's0 (0.00)29.6817
2010's3 (18.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yang, ZH1
Liu, LB2
Zhao, LN1
Liu, YH3
Xue, YX3
Wang, JE1
Xia, CY1
Zhang, Z1
Wang, ZH1
Chelmicka-Schorr, E2
Arnason, BG2
Holshouser, SJ1
Reynolds, CP1
Perez-Polo, JR1
Sportiello, MG1
Atweh, SF1
Yoshikawa, Y1
Yamanouchi, K1
Xue, H1
Wang, H1
Kong, L1
Zhou, H1
Sheppard, JR1
Plagemann, PG1
Doore, BJ1
Bashor, MM1
Spitzer, N1
Mawe, RC1
Saier, MH1
Edström, A1
Kanje, M1
Löfgren, P1
Walum, E1
Yoshida, T1
Shimizu, K1
Ushio, Y1
Hayakawa, T1
Mogami, H1
Sakamoto, Y1
Egawa, T1
Ogura, H1
Sato, H1
Hatano, M1
Wüllenweber, R1
Hamprecht, B1
Schultz, J1
Vidovszky, T1

Trials

1 trial available for papaverine and Glioma

ArticleYear
Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma.
    Chinese medical journal, 1998, Volume: 111, Issue:8

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Blood-Brain Barrier; Brain Neoplasms; Caro

1998

Other Studies

15 other studies available for papaverine and Glioma

ArticleYear
Permeability of the blood-tumor barrier is enhanced by combining vascular endothelial growth factor with papaverine.
    Journal of neuroscience research, 2014, Volume: 92, Issue:6

    Topics: Animals; Blotting, Western; Brain Neoplasms; Capillary Permeability; Cell Line, Tumor; Enzyme-Linked

2014
Effects of combining low frequency ultrasound irradiation with papaverine on the permeability of the blood-tumor barrier.
    Journal of neuro-oncology, 2011, Volume: 102, Issue:2

    Topics: Animals; Blood-Brain Barrier; Blotting, Western; Brain Neoplasms; Capillary Permeability; Claudin-5;

2011
The modulation of protein kinase A and heat shock protein 70 is involved in the reversible increase of blood-brain tumor barrier permeability induced by papaverine.
    Brain research bulletin, 2010, Nov-20, Volume: 83, Issue:6

    Topics: Actins; Analysis of Variance; Animals; Blood-Brain Barrier; Brain Neoplasms; Claudin-5; Cyclic AMP-D

2010
C-6 glioma growth in rats: suppression with a beta-adrenergic agonist and a phosphodiesterase inhibitor.
    Annals of neurology, 1980, Volume: 8, Issue:4

    Topics: Animals; Brain Neoplasms; Cell Line; Cyclic AMP; Drug Therapy, Combination; Glioma; Humans; Isoprote

1980
Induction of neurite outgrowth in the IMR-32 human neuroblastoma cell line by nerve growth factor.
    Journal of neuroscience research, 1981, Volume: 6, Issue:3

    Topics: Animals; Axons; Bucladesine; Cell Differentiation; Cell Line; Culture Media; Glioma; Humans; Male; M

1981
Response of C-6 glioma to isoproterenol and papaverine in vivo depends on beta-adrenergic receptor density.
    Annals of neurology, 1984, Volume: 15, Issue:1

    Topics: Animals; Cells, Cultured; Glioma; In Vitro Techniques; Isoproterenol; Neoplasm Transplantation; Neop

1984
Effect of papaverine treatment on replication of measles virus in human neural and nonneural cells.
    Journal of virology, 1984, Volume: 50, Issue:2

    Topics: Animals; Carcinoma; Cell Line; DNA Replication; Glioma; Humans; Kinetics; Measles virus; Mouth Neopl

1984
Cyclic AMP, membrane transport and cell division. I. Effects of various chemicals on cyclic AMP levels and rate of transport of neucleosides, hypoxanthine and deoxyglucose in several lines of cultured cells.
    Journal of cellular physiology, 1975, Volume: 85, Issue:2 Pt 1

    Topics: Animals; Biological Transport, Active; Bucladesine; Carcinoma, Hepatocellular; Cell Division; Cell L

1975
Regulation of adenosine 3' :5'-monophosphate efflux from rat glioma cells in culture*.
    The Journal of biological chemistry, 1975, Jun-10, Volume: 250, Issue:11

    Topics: Animals; Biological Transport; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Membrane; Ce

1975
Drug-induced alterations in morphology and level of cAMP in cultured human glioma cells.
    Experimental cell research, 1975, Oct-15, Volume: 95, Issue:2

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Catecholamines; Cell Line; Cyclic AMP; Cycl

1975
[Treatment of rat glioma with a beta-adrenergic agonist and a phosphodiesterase inhibitor in vivo].
    No to shinkei = Brain and nerve, 1987, Volume: 39, Issue:8

    Topics: Animals; Brain Neoplasms; Cyclic AMP; Glioma; Injections, Spinal; Isoproterenol; Meningeal Neoplasms

1987
Inhibitory effect of papaverine on HVJ (Sendai virus) replication in rat glioma C6 cells.
    The Journal of general virology, 1987, Volume: 68 ( Pt 4)

    Topics: Animals; Antigens, Surface; Antigens, Viral; Cell Line; Cell Membrane; Cyclic AMP; Cyclic GMP; Gliom

1987
"Intracerebral steal" in man recorded by a heat clearance technique.
    Scandinavian journal of clinical and laboratory investigation. Supplementum, 1968, Volume: 102

    Topics: Aminophylline; Animals; Astrocytoma; Blood Pressure; Brain Edema; Brain Injuries; Brain Neoplasms; C

1968
Influence of noradrenalin, prostaglandin E1 and inhibitors of phosphodiesterase activity on levels of the cyclic adenosine 3':5'-monophosphate in somatic cell hybrids.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1973, Volume: 354, Issue:12

    Topics: Animals; Bromodeoxyuridine; Carbon Radioisotopes; Clone Cells; Cyclic AMP; Drug Resistance; Glioma;

1973
[Comparative study on the vasodilatory activities of bencyclane and papaverine by cerebral angiography].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:10

    Topics: Adult; Aged; Brain Neoplasms; Cerebral Angiography; Cycloheptanes; Diagnosis, Differential; Female;

1970