papaverine has been researched along with Glioma in 16 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The concentration of methotrexate (MTX) in tumor was measured in 18 patients with cerebral glioma, and 155 patients with malignant glioma were treated by intracarotid infusion of papaverine and Bis-chloronitrosourea (BCNU)." | 9.08 | Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma. ( Kong, L; Wang, H; Xue, H; Zhou, H, 1998) |
| "The concentration of methotrexate (MTX) in tumor was measured in 18 patients with cerebral glioma, and 155 patients with malignant glioma were treated by intracarotid infusion of papaverine and Bis-chloronitrosourea (BCNU)." | 5.08 | Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma. ( Kong, L; Wang, H; Xue, H; Zhou, H, 1998) |
| " In the present study, however, changes in intracellular cyclic AMP level in several lines of cultured cells (normal 3T3 and SV40 and polyomavirus-transformed 3T3 cells; 3T6, C6 GLIOMA, MOUSE L, and Novikoff rat hepatoma cells) by treatment with papaverine, prostaglandine E1 or isoproterenol did not correlate with the inhibition of the uridine, hypoxanthine or deoxyglucose transport rates by these chemicals." | 3.65 | Cyclic AMP, membrane transport and cell division. I. Effects of various chemicals on cyclic AMP levels and rate of transport of neucleosides, hypoxanthine and deoxyglucose in several lines of cultured cells. ( Plagemann, PG; Sheppard, JR, 1975) |
| "Rat C 6 glioma is known to possess a beta-adrenergic receptor with which intracellular cyclic adenosine monophosphate (cAMP) levels are altered to control cell growth in vitro." | 1.27 | [Treatment of rat glioma with a beta-adrenergic agonist and a phosphodiesterase inhibitor in vivo]. ( Egawa, T; Hayakawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (75.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, ZH | 1 |
| Liu, LB | 2 |
| Zhao, LN | 1 |
| Liu, YH | 3 |
| Xue, YX | 3 |
| Wang, JE | 1 |
| Xia, CY | 1 |
| Zhang, Z | 1 |
| Wang, ZH | 1 |
| Chelmicka-Schorr, E | 2 |
| Arnason, BG | 2 |
| Holshouser, SJ | 1 |
| Reynolds, CP | 1 |
| Perez-Polo, JR | 1 |
| Sportiello, MG | 1 |
| Atweh, SF | 1 |
| Yoshikawa, Y | 1 |
| Yamanouchi, K | 1 |
| Xue, H | 1 |
| Wang, H | 1 |
| Kong, L | 1 |
| Zhou, H | 1 |
| Sheppard, JR | 1 |
| Plagemann, PG | 1 |
| Doore, BJ | 1 |
| Bashor, MM | 1 |
| Spitzer, N | 1 |
| Mawe, RC | 1 |
| Saier, MH | 1 |
| Edström, A | 1 |
| Kanje, M | 1 |
| Löfgren, P | 1 |
| Walum, E | 1 |
| Yoshida, T | 1 |
| Shimizu, K | 1 |
| Ushio, Y | 1 |
| Hayakawa, T | 1 |
| Mogami, H | 1 |
| Sakamoto, Y | 1 |
| Egawa, T | 1 |
| Ogura, H | 1 |
| Sato, H | 1 |
| Hatano, M | 1 |
| Wüllenweber, R | 1 |
| Hamprecht, B | 1 |
| Schultz, J | 1 |
| Vidovszky, T | 1 |
1 trial available for papaverine and Glioma
| Article | Year |
|---|---|
Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Blood-Brain Barrier; Brain Neoplasms; Caro | 1998 |
15 other studies available for papaverine and Glioma
| Article | Year |
|---|---|
Permeability of the blood-tumor barrier is enhanced by combining vascular endothelial growth factor with papaverine.
Topics: Animals; Blotting, Western; Brain Neoplasms; Capillary Permeability; Cell Line, Tumor; Enzyme-Linked | 2014 |
Effects of combining low frequency ultrasound irradiation with papaverine on the permeability of the blood-tumor barrier.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Brain Neoplasms; Capillary Permeability; Claudin-5; | 2011 |
The modulation of protein kinase A and heat shock protein 70 is involved in the reversible increase of blood-brain tumor barrier permeability induced by papaverine.
Topics: Actins; Analysis of Variance; Animals; Blood-Brain Barrier; Brain Neoplasms; Claudin-5; Cyclic AMP-D | 2010 |
C-6 glioma growth in rats: suppression with a beta-adrenergic agonist and a phosphodiesterase inhibitor.
Topics: Animals; Brain Neoplasms; Cell Line; Cyclic AMP; Drug Therapy, Combination; Glioma; Humans; Isoprote | 1980 |
Induction of neurite outgrowth in the IMR-32 human neuroblastoma cell line by nerve growth factor.
Topics: Animals; Axons; Bucladesine; Cell Differentiation; Cell Line; Culture Media; Glioma; Humans; Male; M | 1981 |
Response of C-6 glioma to isoproterenol and papaverine in vivo depends on beta-adrenergic receptor density.
Topics: Animals; Cells, Cultured; Glioma; In Vitro Techniques; Isoproterenol; Neoplasm Transplantation; Neop | 1984 |
Effect of papaverine treatment on replication of measles virus in human neural and nonneural cells.
Topics: Animals; Carcinoma; Cell Line; DNA Replication; Glioma; Humans; Kinetics; Measles virus; Mouth Neopl | 1984 |
Cyclic AMP, membrane transport and cell division. I. Effects of various chemicals on cyclic AMP levels and rate of transport of neucleosides, hypoxanthine and deoxyglucose in several lines of cultured cells.
Topics: Animals; Biological Transport, Active; Bucladesine; Carcinoma, Hepatocellular; Cell Division; Cell L | 1975 |
Regulation of adenosine 3' :5'-monophosphate efflux from rat glioma cells in culture*.
Topics: Animals; Biological Transport; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Membrane; Ce | 1975 |
Drug-induced alterations in morphology and level of cAMP in cultured human glioma cells.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Catecholamines; Cell Line; Cyclic AMP; Cycl | 1975 |
[Treatment of rat glioma with a beta-adrenergic agonist and a phosphodiesterase inhibitor in vivo].
Topics: Animals; Brain Neoplasms; Cyclic AMP; Glioma; Injections, Spinal; Isoproterenol; Meningeal Neoplasms | 1987 |
Inhibitory effect of papaverine on HVJ (Sendai virus) replication in rat glioma C6 cells.
Topics: Animals; Antigens, Surface; Antigens, Viral; Cell Line; Cell Membrane; Cyclic AMP; Cyclic GMP; Gliom | 1987 |
"Intracerebral steal" in man recorded by a heat clearance technique.
Topics: Aminophylline; Animals; Astrocytoma; Blood Pressure; Brain Edema; Brain Injuries; Brain Neoplasms; C | 1968 |
Influence of noradrenalin, prostaglandin E1 and inhibitors of phosphodiesterase activity on levels of the cyclic adenosine 3':5'-monophosphate in somatic cell hybrids.
Topics: Animals; Bromodeoxyuridine; Carbon Radioisotopes; Clone Cells; Cyclic AMP; Drug Resistance; Glioma; | 1973 |
[Comparative study on the vasodilatory activities of bencyclane and papaverine by cerebral angiography].
Topics: Adult; Aged; Brain Neoplasms; Cerebral Angiography; Cycloheptanes; Diagnosis, Differential; Female; | 1970 |