papaverine has been researched along with Glioblastoma in 5 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The concentration of methotrexate (MTX) in tumor was measured in 18 patients with cerebral glioma, and 155 patients with malignant glioma were treated by intracarotid infusion of papaverine and Bis-chloronitrosourea (BCNU)." | 9.08 | Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma. ( Kong, L; Wang, H; Xue, H; Zhou, H, 1998) |
| " In the present study, we examined the anticancer effects of papaverine in human glioblastoma (GBM) temozolomide (TMZ; as a first-line anticancer medicine)-sensitive U87MG and TMZ-resistant T98G cells." | 7.91 | Anticancer effects of a non-narcotic opium alkaloid medicine, papaverine, in human glioblastoma cells. ( Akasaki, Y; Ichimura, K; Inada, M; Kobayashi, K; Sato, A; Shindo, M; Tanuma, SI; Yamamoto, Y, 2019) |
| "Papaverine is a potential anticancer drug in GBM treatment." | 5.51 | Anticancer Non-narcotic Opium Alkaloid Papaverine Suppresses Human Glioblastoma Cell Growth. ( Akasaki, Y; Ichimura, K; Inada, M; Sato, A; Shindo, M; Tanuma, SI; Yamamoto, Y, 2019) |
| "The concentration of methotrexate (MTX) in tumor was measured in 18 patients with cerebral glioma, and 155 patients with malignant glioma were treated by intracarotid infusion of papaverine and Bis-chloronitrosourea (BCNU)." | 5.08 | Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma. ( Kong, L; Wang, H; Xue, H; Zhou, H, 1998) |
| " In the present study, we examined the anticancer effects of papaverine in human glioblastoma (GBM) temozolomide (TMZ; as a first-line anticancer medicine)-sensitive U87MG and TMZ-resistant T98G cells." | 3.91 | Anticancer effects of a non-narcotic opium alkaloid medicine, papaverine, in human glioblastoma cells. ( Akasaki, Y; Ichimura, K; Inada, M; Kobayashi, K; Sato, A; Shindo, M; Tanuma, SI; Yamamoto, Y, 2019) |
| "Papaverine is a potential anticancer drug in GBM treatment." | 1.51 | Anticancer Non-narcotic Opium Alkaloid Papaverine Suppresses Human Glioblastoma Cell Growth. ( Akasaki, Y; Ichimura, K; Inada, M; Sato, A; Shindo, M; Tanuma, SI; Yamamoto, Y, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Inada, M | 2 |
| Sato, A | 2 |
| Shindo, M | 2 |
| Yamamoto, Y | 2 |
| Akasaki, Y | 2 |
| Ichimura, K | 2 |
| Tanuma, SI | 2 |
| Kobayashi, K | 1 |
| Xue, H | 1 |
| Wang, H | 1 |
| Kong, L | 1 |
| Zhou, H | 1 |
| Wüllenweber, R | 1 |
| Rösler, H | 1 |
| Huber, P | 1 |
| Kinser, J | 1 |
| Stalder, A | 1 |
1 trial available for papaverine and Glioblastoma
| Article | Year |
|---|---|
Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Blood-Brain Barrier; Brain Neoplasms; Caro | 1998 |
4 other studies available for papaverine and Glioblastoma
| Article | Year |
|---|---|
Anticancer Non-narcotic Opium Alkaloid Papaverine Suppresses Human Glioblastoma Cell Growth.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cel | 2019 |
Anticancer effects of a non-narcotic opium alkaloid medicine, papaverine, in human glioblastoma cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Glioblastoma; Heterografts; HM | 2019 |
"Intracerebral steal" in man recorded by a heat clearance technique.
Topics: Aminophylline; Animals; Astrocytoma; Blood Pressure; Brain Edema; Brain Injuries; Brain Neoplasms; C | 1968 |
Functional radioangiographic studies of cerebral vascular haemodynamics (preliminary report).
Topics: Blood Pressure; Brain Neoplasms; Cerebral Arteries; Cerebrovascular Circulation; Glioblastoma; Heman | 1972 |