papaverine has been researched along with Edema in 12 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Papaverine salicylate (MR-800) has been tested as a topical antiinflammatory agent in several models of skin inflammation in rodents, such as mouse ear dermatitis induced by croton oil, cantharidin or zymosan, and rat paw oedema induced by PAF." | 7.69 | Protective effects of papaverine salicylate in mouse ear dermatitis and PAF-induced rat paw oedema. ( Amico-Roxas, M; Caruso, A; Cutuli, VM; de Bernardis, E; Leonardi, G, 1994) |
| "Papaverine salicylate (MR-800) has been tested as a topical antiinflammatory agent in several models of skin inflammation in rodents, such as mouse ear dermatitis induced by croton oil, cantharidin or zymosan, and rat paw oedema induced by PAF." | 3.69 | Protective effects of papaverine salicylate in mouse ear dermatitis and PAF-induced rat paw oedema. ( Amico-Roxas, M; Caruso, A; Cutuli, VM; de Bernardis, E; Leonardi, G, 1994) |
| "An in vitro constant-flow, alternatively constant-pressure, perfusion method for studying microvascular myogenic responsiveness in otherwise intact rat hindquarters was used to explore how three types of influences affect the pressure-flow induced enhancements of myogenic tone: (1) Changes of potassium concentration over the range 2-50 mmol; (2) Whether myogenic responsiveness, which is fairly weak during these conditions of high shear rates, is enhanced by blockade of endothelial prostacyclin and nitrous oxide formation; (3) Whether some of the drawbacks of the constant-flow technique, like rapid edema formation, is offset by a constant-pressure variant." | 3.68 | Myogenic responsiveness in rat hindquarter vessels during constant-flow and constant-pressure perfusion in vitro; effects of various potassium concentrations and of endothelial nitrous oxide blockade. ( Folkow, B; Johnsson, E; Karlström, G, 1991) |
| "In rats pretreated with indomethacin, injection of PGE1 (prostaglandin E1) with carrageenan potentiated the carrageenan paw oedema." | 3.66 | Characteristics of prostaglandin E1 potentiation of inflammatory activity of some agents. ( Thomas, G, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thomas, G | 1 |
| Alekseenko, AV | 1 |
| Iftodiĭ, AG | 1 |
| Fedoriak, SS | 1 |
| Reva, VB | 1 |
| Luste, AO | 1 |
| Goriachev, VV | 1 |
| de Bernardis, E | 1 |
| Leonardi, G | 1 |
| Caruso, A | 1 |
| Cutuli, VM | 1 |
| Amico-Roxas, M | 1 |
| Koch, T | 1 |
| Neuhof, H | 1 |
| Kohler, P | 1 |
| Duncker, HP | 1 |
| Buse, A | 1 |
| van Ackern, K | 1 |
| Henriksen, O | 1 |
| Kristensen, JK | 1 |
| Johnsson, E | 1 |
| Folkow, B | 1 |
| Karlström, G | 1 |
| LeDouarec, JC | 1 |
| Duhault, J | 1 |
| Laubie, M | 1 |
| Eichler, O | 1 |
| Koch, C | 1 |
| Bartsch, R | 1 |
| Nowak, R | 1 |
| Femmer, K | 1 |
| Stade, K | 1 |
| Myhre, HO | 1 |
| Dedichen, H | 1 |
| Aberg, B | 1 |
| Lindahl, SO | 1 |
| Nakanishi, M | 1 |
| Imamura, H | 1 |
| Maruyama, Y | 1 |
1 trial available for papaverine and Edema
| Article | Year |
|---|---|
[Use of intra-tissue electrophoresis and electrophonophoresis in the multimodal treatment of edematous forms of pancreatitis].
Topics: Adolescent; Adult; Aged; Aminophylline; Anti-Ulcer Agents; Aprotinin; Combined Modality Therapy; Ede | 1994 |
11 other studies available for papaverine and Edema
| Article | Year |
|---|---|
Characteristics of prostaglandin E1 potentiation of inflammatory activity of some agents.
Topics: Adenosine; Animals; Bradykinin; Carrageenan; Drug Synergism; Edema; Histamine; Indomethacin; Inflamm | 1980 |
Protective effects of papaverine salicylate in mouse ear dermatitis and PAF-induced rat paw oedema.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cantharidin; Croton Oil; Dermatitis; Dose-Response | 1994 |
Effect of hypertonic NaCl-starch-solution on oedema of different pathogenesis.
Topics: Animals; Blood Vessels; Body Water; Bradykinin; Capillary Permeability; Edema; Extracellular Space; | 1994 |
'Distensibility' of the papaverine-relaxed vascular bed in human subcutaneous tissue.
Topics: Blood Pressure; Blood Vessels; Connective Tissue; Edema; Hand; Humans; Leg; Muscle, Smooth, Vascular | 1979 |
Myogenic responsiveness in rat hindquarter vessels during constant-flow and constant-pressure perfusion in vitro; effects of various potassium concentrations and of endothelial nitrous oxide blockade.
Topics: Animals; Blood Vessels; Edema; Endothelium, Vascular; Epoprostenol; Hindlimb; In Vitro Techniques; M | 1991 |
[Pharmacological study of phenethyl-8-oxa-1-diaza-3,8-spiro(4,5)decanone-2 hydrochloride or fenspiride (JP 428)].
Topics: Anaphylaxis; Anesthesia; Animals; Anti-Inflammatory Agents; Atropine; Autonomic Nervous System; Bron | 1969 |
[Antiphlogistic, analgesic and spasmolytic effect of harpagoside, a glycoside from the root of Harpagophytum procumbens DC].
Topics: Acetylcholine; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Atropine; Croton Oil; Depre | 1970 |
[Pharmacology of the new antihistaminic 9,9-dioxopromethazine (Prothanon)].
Topics: Abnormalities, Drug-Induced; Anesthetics, Local; Animals; Behavior, Animal; Blood Pressure; Bronchia | 1970 |
Haemodynamic factors in the oedema of arterial reconstructions.
Topics: Arteriosclerosis; Blood Flow Velocity; Blood Pressure; Edema; Foot; Hemodynamics; Humans; Hyperemia; | 1972 |
An in-vitro method of investigating the rates of transcapillary exchange and net filtration by single-injection technique.
Topics: Albumins; Animals; Blood Flow Velocity; Blood Glucose; Blood Vessels; Capillary Permeability; Capill | 1973 |
[Studies on anti-inflammatory agents. II. Analgesic and anti-edematous activities of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6, 7-tetrahydrothieno (2,3-c)pyridine (Y-3642)].
Topics: Aminopyrine; Amphetamine; Analgesics; Animals; Anti-Inflammatory Agents; Edema; Imipramine; Male; Mi | 1970 |