papaverine has been researched along with Disease Models, Animal in 83 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of the present study was to investigate whether papaverine, a novel RAGE inhibitor, could suppress inflammatory pain in mice after several time points, which was induced by the injection of complete Freund's adjuvant (CFA)." | 8.02 | Antinociceptive activity of the novel RAGE inhibitor, papaverine, in a mouse model of chronic inflammatory pain. ( Nakamura, T; Sato, A; Takahashi, Y; Takasawa, R; Takeuchi, K; Tanuma, SI; Ukai, S; Yoshizawa, K, 2021) |
| "The mechanism of the papaverine (PV) for the treatment of cerebral ischemia remains unclear." | 7.96 | Pluripotent anti-inflammatory immunomodulatory effects of papaverine against cerebral ischemic-reperfusion injury. ( Gu, H; Guan, S; Liu, J; Liu, Q; Qi, YF; Wang, Z; Wei, PL; Zhang, YY, 2020) |
| " In the present study we examined the effects of a vasoconstrictor (pseudoephedrine) and a vasodilator (papaverine) on the outcome of DSS-induced colitis." | 7.74 | Contrasting effects of pseudoephedrine and papaverine in dextran sodium sulfate-induced colitis. ( Carter, PR; Harris, NR; Morgan, GA; Specian, RD, 2008) |
| " In the present study, the effects of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) on neurological signs, such as ischemic seizures, lactate and ATP contents of the cerebral cortex, and local cerebral blood flow, were assessed in stroke-prone spontaneously hypertensive rats (SHRSP) with experimentally induced cerebral ischemia." | 7.67 | Effects of idebenone on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia. ( Kakihana, M; Nagaoka, A; Shibota, M; Suno, M, 1989) |
| "The effects of microwave induced hyperthermia, papaverine, and chemotherapy were evaluated in transplanted CI300 murine neuroblastoma." | 7.66 | Synergistic effect of hyperthermia, papaverine, and chemotherapy in murine neuroblastoma. ( Grosfeld, JL; Weber, TR; West, KW, 1980) |
| "Papaverine has potential for producing CBO by multiple routes." | 5.32 | Bronchiolitis obliterans induced by intratracheal papaverine: a novel animal model. ( Herndon, B; Molteni, A; Svetlecic, J, 2004) |
| "r-CBF was reduced by 40% during cerebral ischemia." | 5.26 | [Effects of dilazep on cerebral blood flow under normal conditions and recirculation impairment after cerebral ischemia (author's transl)]. ( Kawada, M; Kondo, S; Sano, N, 1981) |
| " The aim of the present study was to investigate whether papaverine, a novel RAGE inhibitor, could suppress inflammatory pain in mice after several time points, which was induced by the injection of complete Freund's adjuvant (CFA)." | 4.02 | Antinociceptive activity of the novel RAGE inhibitor, papaverine, in a mouse model of chronic inflammatory pain. ( Nakamura, T; Sato, A; Takahashi, Y; Takasawa, R; Takeuchi, K; Tanuma, SI; Ukai, S; Yoshizawa, K, 2021) |
| "The mechanism of the papaverine (PV) for the treatment of cerebral ischemia remains unclear." | 3.96 | Pluripotent anti-inflammatory immunomodulatory effects of papaverine against cerebral ischemic-reperfusion injury. ( Gu, H; Guan, S; Liu, J; Liu, Q; Qi, YF; Wang, Z; Wei, PL; Zhang, YY, 2020) |
| " The IL-6 antagonist LMT-28 prevented impairment of cerebral autoregulation and hippocampal CA1 and CA3 neuronal necrosis after FPI." | 3.91 | Inhaled Nitric Oxide Protects Cerebral Autoregulation and Reduces Hippocampal Necrosis After Traumatic Brain Injury Through Inhibition of ET-1, ERK MAPK and IL-6 Upregulation in Pigs. ( Armstead, WM; Curvello, V; Hekierski, H; Pastor, P, 2019) |
| "The primary aim of this study was to validate the assessment of IMR in a large animal model, and the secondary aim was to compare two doses of intracoronary papaverine, 5 and 10 mg, for induction of maximal hyperemia and its evolution over time." | 3.80 | Invasive assessment of the coronary microcirculation using the index of microcirculatory resistance: description and validation of an animal model. ( Cacela, D; Cardim, N; Carrapiço, B; Cavaco-Gonçalves, S; Cruz Ferreira, R; Fiarresga, A; Oliveira, E; Selas, M, 2014) |
| " In the present study we examined the effects of a vasoconstrictor (pseudoephedrine) and a vasodilator (papaverine) on the outcome of DSS-induced colitis." | 3.74 | Contrasting effects of pseudoephedrine and papaverine in dextran sodium sulfate-induced colitis. ( Carter, PR; Harris, NR; Morgan, GA; Specian, RD, 2008) |
| "After laminectomy was performed and contusive spinal cord injuries were induced in adult female Macaca rhesus, three received intrathecal papaverine, and three received saline 0." | 3.74 | Effect of intrathecal papaverine on blood flow and secondary injury in injured cord. ( Huang, L; Huiyong, S; Jie, L; Li, J; Lin, H; Ma, YC; Peng, W; Rui, Y; Shen, HY; Tang, Y; Wang, P; Wei, Y; Wu, YF; Yanfeng, W; Yang, R; Yang, W; Yong, T; Yuanchen, M, 2008) |
| " Intracoronary papaverine (20 mg) was used to induce hyperemia." | 3.72 | Comparison of coronary thermodilution and Doppler velocity for assessing coronary flow reserve. ( Balsam, LB; Caffarelli, AD; Cooke, DT; Farouque, HM; Fearon, WF; Fitzgerald, PJ; Robbins, RC; Yeung, AC; Yock, PG, 2003) |
| "A case of loss of spontaneous and evoked facial muscle activity, and transient postoperative facial paralysis, after topical application of papaverine in the CPA during surgery for an acoustic neuroma using intraoperative cranial nerve monitoring is reported." | 3.70 | Topical papaverine and facial nerve dysfunction in cerebellopontine angle surgery. ( Digoy, GP; Eisenman, DJ; Selesnick, SH; Victor, JD, 1999) |
| " In the present study, the effects of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) on neurological signs, such as ischemic seizures, lactate and ATP contents of the cerebral cortex, and local cerebral blood flow, were assessed in stroke-prone spontaneously hypertensive rats (SHRSP) with experimentally induced cerebral ischemia." | 3.67 | Effects of idebenone on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia. ( Kakihana, M; Nagaoka, A; Shibota, M; Suno, M, 1989) |
| "The effects of microwave induced hyperthermia, papaverine, and chemotherapy were evaluated in transplanted CI300 murine neuroblastoma." | 3.66 | Synergistic effect of hyperthermia, papaverine, and chemotherapy in murine neuroblastoma. ( Grosfeld, JL; Weber, TR; West, KW, 1980) |
| "Roflumilast treatment (1nM delivered 6h post-injury) significantly increased total AMPA glutamate receptor 1 (GluR1) subunit expression, phosphorylation of the GluR1 subunit at the serine-831 site, and phosphorylation of stargazin at the serine-239/240 site upon LTP induction, measured 24h following injury." | 1.46 | Phosphodiesterase-4 inhibition restored hippocampal long term potentiation after primary blast. ( Bass, CR; Meaney, DF; Morales, FN; Morrison, B; Vogel, EW, 2017) |
| "Papaverine and zolpidem were recently shown to be protective of bioenergetic loss in cell models of optic neuropathy." | 1.46 | Rescue of cell death and inflammation of a mouse model of complex 1-mediated vision loss by repurposed drug molecules. ( Cortopassi, GA; Datta, S; McMackin, MZ; Yu, AK, 2017) |
| "Papaverine treatment improved spatial and object recognition memories in R6/1 mice, and significantly increased pGluA1 and pCREB levels in R6/1 mice hippocampus." | 1.39 | PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model. ( Alberch, J; Arumí, H; Carretón, O; Giralt, A; Pérez-Navarro, E; Saavedra, A; Tyebji, S, 2013) |
| "Clinical studies of gene therapy for hemophilia B revealed the limitations of the intramuscular route, compelling an aggressive approach to the study of scale-independent circulatory means of vector delivery." | 1.37 | Gene transfer to muscle from the isolated regional circulation. ( Bridges, CR; Malik, A; Mead, A; Petrov, M; Stedman, HH, 2011) |
| "10% glycerol solution was able to prevent microvascular alterations due to BCCAO protecting cerebral tissue." | 1.35 | Pial microvascular responses to transient bilateral common carotid artery occlusion: effects of hypertonic glycerol. ( Colantuoni, A; Lapi, D; Marchiafava, PL, 2008) |
| "It is now well established that hydrocephalus is associated with impaired bladder function." | 1.35 | Alterations in the mechanical properties of bladder smooth muscle in hydrocephalus rat model. ( Etuş, V; Tugay, M; Tugay, S; Utkan, T; Yazir, Y, 2008) |
| "Rotenone is a mitochondrial toxin which can produce Parkinson syndrome (PS) in rats." | 1.33 | Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism. ( Pasha, MK; Rajput, AH; Sharma, RK, 2005) |
| "Hypothyroidism has been reported to occur in 6% of impotent men." | 1.33 | Effect of hypothyroidism on the nitrergic relaxant responses of corpus cavernosal smooth muscle in rabbits. ( Bagcivan, I; Kaya, K; Kilicarslan, H; Sarac, B; Yildirim, MK; Yildirim, S, 2006) |
| "Hypothyroidism has been reported to occur in 6% of impotent men." | 1.33 | Effect of hypothyroidism on the NO/cGMP pathway of corpus cavernosum in rabbits. ( Bagcivan, I; Kaya, T; Kilicarslan, H; Sarac, B; Yildirim, MK, 2006) |
| "Papaverine has potential for producing CBO by multiple routes." | 1.32 | Bronchiolitis obliterans induced by intratracheal papaverine: a novel animal model. ( Herndon, B; Molteni, A; Svetlecic, J, 2004) |
| " The dose-response curve for NE (0." | 1.31 | Lead-cadmium interaction effect on the responsiveness of rat mesenteric vessels to norepinephrine and angiotensin II. ( Andrzejak, R; Skoczyńska, A; Wróbel, J, 2001) |
| "In the Han:SPRD rat model of autosomal dominant polycystic kidney disease (ADPKD), gene transfer occurred into the vasculature, some epithelial cysts and interstitial cells." | 1.29 | In vivo adenovirus-mediated gene transfer into normal and cystic rat kidneys. ( Cowley, BD; Nicolson, AG; Rosen, S; Sukhatme, VP; Zhu, G, 1996) |
| "In the acute study, arteriogenic impotence was induced in 6 dogs by bilateral ligation of the penile arteries just proximal to the crus of the penis." | 1.28 | Cavernous vein arterialization for vasculogenic impotence. An animal model. ( Aboseif, SR; Breza, J; Lue, TF; Tanagho, EA, 1990) |
| "r-CBF was reduced by 40% during cerebral ischemia." | 1.26 | [Effects of dilazep on cerebral blood flow under normal conditions and recirculation impairment after cerebral ischemia (author's transl)]. ( Kawada, M; Kondo, S; Sano, N, 1981) |
| " In response to intra-arterial injections of norepinephrine, hypertensive pigs (n = 8) demonstrated shifts in the dose-response curves to the left and lower vasoconstrictor thresholds than controls (n = 10)." | 1.26 | Structural and functional changes in vascular resistance and reactivity in the deoxycorticosterone acetate (DOCA)-hypertensive pig. ( Berecek, KH; Bohr, DF, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (33.73) | 18.7374 |
| 1990's | 12 (14.46) | 18.2507 |
| 2000's | 25 (30.12) | 29.6817 |
| 2010's | 12 (14.46) | 24.3611 |
| 2020's | 6 (7.23) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Ručilová, V | 1 |
| Świerczek, A | 1 |
| Vanda, D | 1 |
| Funk, P | 1 |
| Lemrová, B | 1 |
| Gawalska, A | 1 |
| Bucki, A | 1 |
| Nowak, B | 1 |
| Zadrożna, M | 1 |
| Pociecha, K | 1 |
| Soural, M | 1 |
| Wyska, E | 1 |
| Pawłowski, M | 1 |
| Chłoń-Rzepa, G | 1 |
| Zajdel, P | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Ma, S | 1 |
| Zhang, K | 1 |
| Zhu, Y | 1 |
| Cao, X | 1 |
| Wang, L | 1 |
| Guan, S | 1 |
| Liu, Q | 1 |
| Gu, H | 1 |
| Zhang, YY | 1 |
| Wei, PL | 1 |
| Qi, YF | 1 |
| Liu, J | 1 |
| Wang, Z | 1 |
| Leem, YH | 1 |
| Park, JS | 1 |
| Park, JE | 1 |
| Kim, DY | 1 |
| Kang, JL | 1 |
| Kim, HS | 1 |
| Yoshizawa, K | 1 |
| Takeuchi, K | 1 |
| Nakamura, T | 1 |
| Ukai, S | 1 |
| Takahashi, Y | 1 |
| Sato, A | 1 |
| Takasawa, R | 1 |
| Tanuma, SI | 1 |
| Vogel, EW | 1 |
| Morales, FN | 1 |
| Meaney, DF | 1 |
| Bass, CR | 1 |
| Morrison, B | 1 |
| Yu, AK | 1 |
| Datta, S | 1 |
| McMackin, MZ | 1 |
| Cortopassi, GA | 1 |
| Curvello, V | 1 |
| Pastor, P | 1 |
| Hekierski, H | 1 |
| Armstead, WM | 1 |
| Giralt, A | 1 |
| Saavedra, A | 1 |
| Carretón, O | 1 |
| Arumí, H | 1 |
| Tyebji, S | 1 |
| Alberch, J | 1 |
| Pérez-Navarro, E | 1 |
| Fiarresga, A | 1 |
| Selas, M | 1 |
| Oliveira, E | 1 |
| Cavaco-Gonçalves, S | 1 |
| Cacela, D | 1 |
| Carrapiço, B | 1 |
| Cardim, N | 1 |
| Cruz Ferreira, R | 1 |
| Sun, Z | 1 |
| Tong, G | 1 |
| Kim, TH | 1 |
| Ma, N | 1 |
| Niu, G | 1 |
| Cao, F | 1 |
| Chen, X | 1 |
| Zhang, DY | 2 |
| Kong, QQ | 1 |
| Zhang, CB | 1 |
| Zhu, JH | 2 |
| Chen, MD | 1 |
| Wang, P | 2 |
| Hill, JV | 1 |
| Findon, G | 1 |
| Appelhoff, RJ | 1 |
| Endre, ZH | 1 |
| Wang, JE | 1 |
| Liu, YH | 2 |
| Liu, LB | 1 |
| Xia, CY | 1 |
| Zhang, Z | 1 |
| Xue, YX | 2 |
| Wang, ZH | 1 |
| Petrov, M | 1 |
| Malik, A | 1 |
| Mead, A | 1 |
| Bridges, CR | 1 |
| Stedman, HH | 1 |
| Lacroix, P | 1 |
| Tang, Y | 2 |
| Zhou, C | 1 |
| Luan, J | 1 |
| Hu, J | 1 |
| Coulson, RJ | 1 |
| Chesler, NC | 1 |
| Vitullo, L | 1 |
| Cipolla, MJ | 1 |
| Zhang, F | 1 |
| Sprague, SM | 1 |
| Farrokhi, F | 1 |
| Henry, MN | 1 |
| Son, MG | 1 |
| Vollmer, DG | 1 |
| Fearon, WF | 1 |
| Farouque, HM | 1 |
| Balsam, LB | 1 |
| Caffarelli, AD | 1 |
| Cooke, DT | 1 |
| Robbins, RC | 1 |
| Fitzgerald, PJ | 1 |
| Yeung, AC | 1 |
| Yock, PG | 1 |
| Morawski, K | 1 |
| Telischi, FF | 1 |
| Merchant, F | 1 |
| Namyslowski, G | 1 |
| Lisowska, G | 1 |
| Lonsbury-Martin, BL | 1 |
| Svetlecic, J | 2 |
| Molteni, A | 2 |
| Herndon, B | 2 |
| Davila, HH | 1 |
| Rajfer, J | 1 |
| Gonzalez-Cadavid, NF | 1 |
| Rodefer, JS | 1 |
| Murphy, ER | 1 |
| Baxter, MG | 1 |
| Pasha, MK | 1 |
| Sharma, RK | 1 |
| Rajput, AH | 1 |
| Chen, Y | 1 |
| Al-Hamed, M | 1 |
| Quinn, T | 1 |
| Svensson, LG | 1 |
| Sarac, B | 2 |
| Yildirim, MK | 2 |
| Bagcivan, I | 2 |
| Kaya, K | 1 |
| Kilicarslan, H | 2 |
| Yildirim, S | 1 |
| Kaya, T | 1 |
| Zhao, WZ | 1 |
| Wu, MW | 1 |
| Hu, YL | 1 |
| Cheng, LB | 1 |
| Li, YH | 1 |
| Lapi, D | 1 |
| Marchiafava, PL | 1 |
| Colantuoni, A | 1 |
| Harris, NR | 1 |
| Specian, RD | 1 |
| Carter, PR | 1 |
| Morgan, GA | 1 |
| Trejo, HE | 1 |
| Urich, D | 1 |
| Pezzulo, AA | 1 |
| Caraballo, JC | 1 |
| Gutiérrez, J | 1 |
| Castro, IJ | 1 |
| Centeno, GR | 1 |
| Sánchez de León, R | 1 |
| Tugay, M | 1 |
| Tugay, S | 1 |
| Etuş, V | 1 |
| Yazir, Y | 1 |
| Utkan, T | 1 |
| Yong, T | 1 |
| Shen, HY | 1 |
| Huiyong, S | 1 |
| Huang, L | 1 |
| Lin, H | 1 |
| Wu, YF | 1 |
| Yanfeng, W | 1 |
| Yang, W | 1 |
| Wei, Y | 1 |
| Ma, YC | 1 |
| Yuanchen, M | 1 |
| Yang, R | 1 |
| Rui, Y | 1 |
| Li, J | 1 |
| Jie, L | 1 |
| Peng, W | 1 |
| Varsos, VG | 1 |
| Liszczak, TM | 1 |
| Han, DH | 1 |
| Kistler, JP | 1 |
| Vielma, J | 1 |
| Black, PM | 1 |
| Heros, RC | 1 |
| Zervas, NT | 1 |
| Kondo, S | 1 |
| Kawada, M | 1 |
| Sano, N | 1 |
| West, KW | 1 |
| Weber, TR | 1 |
| Grosfeld, JL | 1 |
| Durick, JE | 1 |
| Winter, TC | 1 |
| Schmiedl, UP | 1 |
| Cyr, DR | 1 |
| Starr, FL | 1 |
| Mack, LA | 1 |
| Zhu, G | 1 |
| Nicolson, AG | 1 |
| Cowley, BD | 1 |
| Rosen, S | 1 |
| Sukhatme, VP | 1 |
| Gherardini, G | 1 |
| Gürlek, A | 1 |
| Cromeens, D | 1 |
| Joly, GA | 1 |
| Wang, BG | 1 |
| Evans, GR | 1 |
| Eisenman, DJ | 1 |
| Digoy, GP | 1 |
| Victor, JD | 1 |
| Selesnick, SH | 1 |
| Sun, J | 1 |
| Hirsch, D | 1 |
| Svensson, G | 1 |
| Başar, MM | 2 |
| Yildiz, M | 1 |
| Başar, H | 1 |
| Ak, F | 1 |
| Akan, H | 1 |
| Atan, A | 2 |
| Martinez-Lemus, LA | 1 |
| Hester, RK | 1 |
| Becker, EJ | 1 |
| Jeffrey, JS | 1 |
| Odom, TW | 1 |
| Nath, KA | 1 |
| Shah, V | 1 |
| Haggard, JJ | 1 |
| Croatt, AJ | 1 |
| Smith, LA | 1 |
| Hebbel, RP | 1 |
| Katusic, ZS | 1 |
| Didion, SP | 1 |
| Heistad, DD | 1 |
| Faraci, FM | 1 |
| Skoczyńska, A | 1 |
| Wróbel, J | 1 |
| Andrzejak, R | 1 |
| Sahin, M | 1 |
| Bozdoğan, O | 1 |
| Major, O | 1 |
| Szeifert, GT | 1 |
| Radatz, MW | 1 |
| Walton, L | 1 |
| Kemeny, AA | 1 |
| Krell, RD | 1 |
| Chakrin, LW | 1 |
| Peterson, EW | 1 |
| Leblanc, R | 1 |
| Searle, R | 1 |
| Mandy, F | 1 |
| Myers, RD | 1 |
| Bookstein, JJ | 1 |
| Goldberger, L | 1 |
| Niwayama, G | 1 |
| Naderi, MJ | 1 |
| Brahme, FJ | 1 |
| Jones, TA | 1 |
| Parker, PE | 1 |
| Bashour, FA | 1 |
| Downey, HF | 1 |
| Boutros, IS | 1 |
| Berecek, KH | 1 |
| Bohr, DF | 1 |
| Nagai, H | 1 |
| Noda, S | 1 |
| Mabe, H | 1 |
| Baky, SH | 1 |
| Lee, RJ | 1 |
| Ten Cate, FJ | 1 |
| Silverman, PR | 1 |
| Sassen, LM | 1 |
| Verdouw, PD | 1 |
| Bouchot, O | 1 |
| Bondil, P | 1 |
| Navratil, H | 1 |
| Sasaki, S | 1 |
| Ueda, M | 1 |
| Kaneda, T | 1 |
| Saga, S | 1 |
| Matsuyama, M | 1 |
| Mooney, MP | 1 |
| Siegel, MI | 1 |
| Hurwitz, DJ | 1 |
| Edington, H | 1 |
| Breza, J | 1 |
| Aboseif, SR | 1 |
| Lue, TF | 1 |
| Tanagho, EA | 1 |
| Nagaoka, A | 1 |
| Suno, M | 1 |
| Shibota, M | 1 |
| Kakihana, M | 1 |
| Akopov, SE | 1 |
| Sarkisian, SB | 1 |
| Gabrielian, ES | 1 |
| Lamm, WJ | 1 |
| Luchtel, D | 1 |
| Albert, RK | 1 |
| Baker, AR | 1 |
| Prytherch, DR | 1 |
| Evans, DH | 1 |
| Bell, PR | 1 |
| Maitai, CK | 1 |
| Njoroge, DK | 1 |
| Munenge, RW | 1 |
| Welch, KM | 1 |
| Spira, PJ | 1 |
| Knowles, L | 1 |
| Lance, JW | 1 |
| Witty, RT | 1 |
| Davis, JO | 1 |
| Shade, RE | 1 |
| Johnson, JA | 1 |
| Prewitt, RL | 1 |
| Besznyák, I | 1 |
| Sebestény, M | 1 |
| Nemes, A | 1 |
| Rényi-Vámos, F | 1 |
| Ogata, M | 1 |
| Marshall, BM | 1 |
| Lougheed, WM | 1 |
| Jaenike, JR | 2 |
| Borzeix, MG | 1 |
| Labos, M | 1 |
| Cahn, J | 1 |
| Mac Gowan, WA | 1 |
| Holland, PD | 1 |
| Browne, HI | 1 |
| Byrnes, DP | 1 |
| Monroe, RG | 1 |
| LaFarge, CG | 1 |
| Gamble, WJ | 1 |
| Kumar, AE | 1 |
| Manasek, FJ | 1 |
| Echlin, FA | 1 |
| Appelgren, KL | 1 |
| Lewis, DH | 1 |
| Dutta, D | 1 |
| Bhargava, KC | 1 |
| Chakravarti, RN | 1 |
| Dhall, SR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Multi-center Clinical Trial for Evaluating the Effectiveness and Safety of Coronary Angiography-Derived Index of Microcirculatory Resistance Measured Online by a Coronary Functional Measurement System[NCT05009667] | 116 participants (Actual) | Observational | 2021-10-14 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for papaverine and Disease Models, Animal
| Article | Year |
|---|---|
Paralysis after aortic surgery: in search of lost cord function.
Topics: Animals; Aorta; Aortic Aneurysm; Aortic Rupture; Cerebrospinal Fluid; Disease Models, Animal; Draina | 2005 |
[A year in male impotence].
Topics: Age Factors; Alprostadil; Animals; Castration; Clinical Trials as Topic; Disease Models, Animal; Dog | 1991 |
Current concepts in the etiology and treatment of vasospasm.
Topics: Animals; Brain Edema; Cerebral Angiography; Cerebral Arteries; Cerebrovascular Circulation; Disease | 1968 |
80 other studies available for papaverine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases.
Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Cyclic Nucleotide Phosphodiesterases, Type 7 | 2021 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Effect of papaverine on axonal outgrowth of primary retinal ganglion cells of Sprague Dawley rats.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Glaucoma; Nerve Regeneration; Neuronal Outgrowth; | 2021 |
Pluripotent anti-inflammatory immunomodulatory effects of papaverine against cerebral ischemic-reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cytokines; Disease Models, Animal; Gene Expressio | 2020 |
Papaverine inhibits α-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP/P mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Astrocytes; Disease Models, | 2020 |
Antinociceptive activity of the novel RAGE inhibitor, papaverine, in a mouse model of chronic inflammatory pain.
Topics: Analgesics; Animals; Disease Models, Animal; Mice; Pain; Papaverine; Receptor for Advanced Glycation | 2021 |
Phosphodiesterase-4 inhibition restored hippocampal long term potentiation after primary blast.
Topics: Aminopyridines; Animals; Animals, Newborn; Benzamides; Blast Injuries; Cell Death; Cyclic Nucleotide | 2017 |
Rescue of cell death and inflammation of a mouse model of complex 1-mediated vision loss by repurposed drug molecules.
Topics: Animals; Disease Models, Animal; DNA, Mitochondrial; Electron Transport Complex I; Glaucoma, Open-An | 2017 |
Inhaled Nitric Oxide Protects Cerebral Autoregulation and Reduces Hippocampal Necrosis After Traumatic Brain Injury Through Inhibition of ET-1, ERK MAPK and IL-6 Upregulation in Pigs.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Brain Injuries, Traumatic; Disease Models, An | 2019 |
PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model.
Topics: Analysis of Variance; Animals; CREB-Binding Protein; Disease Models, Animal; Gene Expression Regulat | 2013 |
Invasive assessment of the coronary microcirculation using the index of microcirculatory resistance: description and validation of an animal model.
Topics: Animals; Coronary Circulation; Diagnostic Techniques, Cardiovascular; Disease Models, Animal; Hypere | 2014 |
PEGylated exendin-4, a modified GLP-1 analog exhibits more potent cardioprotection than its unmodified parent molecule on a dose to dose basis in a murine model of myocardial infarction.
Topics: Aminophylline; Animals; Atropine; Blotting, Western; Cardiovascular Agents; Disease Models, Animal; | 2015 |
[Expression of Bcl-2 and Bax proteins in myocardial cells after Macleaya cordata alkaloids poisoning in rats].
Topics: Animals; bcl-2-Associated X Protein; Disease Models, Animal; Female; Immunohistochemistry; Male; Myo | 2009 |
Renal autoregulation and passive pressure-flow relationships in diabetes and hypertension.
Topics: Angiotensin II; Animals; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Di | 2010 |
Effects of combining low frequency ultrasound irradiation with papaverine on the permeability of the blood-tumor barrier.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Brain Neoplasms; Capillary Permeability; Claudin-5; | 2011 |
The modulation of protein kinase A and heat shock protein 70 is involved in the reversible increase of blood-brain tumor barrier permeability induced by papaverine.
Topics: Actins; Analysis of Variance; Animals; Blood-Brain Barrier; Brain Neoplasms; Claudin-5; Cyclic AMP-D | 2010 |
Gene transfer to muscle from the isolated regional circulation.
Topics: Animals; Blood Pressure; Capillaries; Capillary Permeability; Dependovirus; Disease Models, Animal; | 2011 |
Electrocardiographic toxicity in the guinea pig.
Topics: Amitriptyline; Anesthesia; Animals; Disease Models, Animal; Drug-Related Side Effects and Adverse Re | 2002 |
Improvement of length of survival of expanded flap by application of topical papaverine cream.
Topics: Administration, Topical; Animals; Disease Models, Animal; Graft Survival; Papaverine; Plastic Surger | 2012 |
Effects of ischemia and myogenic activity on active and passive mechanical properties of rat cerebral arteries.
Topics: Animals; Biomechanical Phenomena; Blood Pressure; Disease Models, Animal; Elasticity; In Vitro Techn | 2002 |
Reversal of attenuation of cerebrovascular reactivity to hypercapnia by a nitric oxide donor after controlled cortical impact in a rat model of traumatic brain injury.
Topics: Animals; Blood Pressure; Brain Injuries; Carbon Dioxide; Cerebrovascular Circulation; Cortical Sprea | 2002 |
Comparison of coronary thermodilution and Doppler velocity for assessing coronary flow reserve.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Coronary Circulation; Coronary Stenosis; Disease Model | 2003 |
Preventing internal auditory artery vasospasm using topical papaverine: an animal study.
Topics: Administration, Topical; Animals; Cerebellopontine Angle; Cochlea; Disease Models, Animal; Laser-Dop | 2003 |
Bronchiolitis obliterans induced by intratracheal papaverine: a novel animal model.
Topics: Animals; Bronchi; Bronchiolitis Obliterans; Bronchoalveolar Lavage; Disease Models, Animal; Male; Pa | 2004 |
Corporal veno-occlusive dysfunction in aging rats: evaluation by cavernosometry and cavernosography.
Topics: Absorptiometry, Photon; Aging; Animals; Castration; Disease Models, Animal; Erectile Dysfunction; Ma | 2004 |
PDE10A inhibition reverses subchronic PCP-induced deficits in attentional set-shifting in rats.
Topics: Analysis of Variance; Animals; Attention; Attention Deficit Disorder with Hyperactivity; Behavior, A | 2005 |
Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism.
Topics: Acyl Coenzyme A; Aminophylline; Animals; Atropine; Disease Models, Animal; Drug Combinations; Humans | 2005 |
Transplant-related bronchiolitis obliterans (BOS) demonstrates unique cytokine profiles compared to toxicant-induced BOS.
Topics: Animals; Antibodies, Antinuclear; Bronchiolitis Obliterans; Cell Nucleus; Cytokines; Disease Models, | 2005 |
Effect of hypothyroidism on the nitrergic relaxant responses of corpus cavernosal smooth muscle in rabbits.
Topics: Animals; Carbachol; Cholinergic Agonists; Disease Models, Animal; Electric Stimulation; Hypothyroidi | 2006 |
Effect of hypothyroidism on the NO/cGMP pathway of corpus cavernosum in rabbits.
Topics: Animals; Carbachol; Cyclic GMP; Disease Models, Animal; Electric Stimulation; Hypothyroidism; Impote | 2006 |
[Apoptosis in myocardial cells after macleaya cordata total alkaloids poisoning in rats].
Topics: Acute Disease; Animals; Apoptosis; Cell Count; Disease Models, Animal; Female; Immunohistochemistry; | 2006 |
Pial microvascular responses to transient bilateral common carotid artery occlusion: effects of hypertonic glycerol.
Topics: Animals; Blood Flow Velocity; Capillary Permeability; Carotid Artery, Common; Carotid Stenosis; Cell | 2008 |
Contrasting effects of pseudoephedrine and papaverine in dextran sodium sulfate-induced colitis.
Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Drug Administration Routes; Male; | 2008 |
Beneficial effects of hydrocortisone and papaverine on a model of pulmonary embolism induced by autologous blood clots in isolated and perfused rabbit lungs.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Hemodynamics; Hydrocortisone; In Vitro Te | 2007 |
Alterations in the mechanical properties of bladder smooth muscle in hydrocephalus rat model.
Topics: Adrenergic beta-Agonists; Animals; Biomechanical Phenomena; Disease Models, Animal; Dose-Response Re | 2008 |
Effect of intrathecal papaverine on blood flow and secondary injury in injured cord.
Topics: Animals; Blood Flow Velocity; Disease Models, Animal; Female; Injections, Spinal; Laminectomy; Laser | 2008 |
Delayed cerebral vasospasm is not reversible by aminophylline, nifedipine, or papaverine in a "two-hemorrhage" canine model.
Topics: Aminophylline; Animals; Disease Models, Animal; Dog Diseases; Dogs; Ischemic Attack, Transient; Papa | 1983 |
[Effects of dilazep on cerebral blood flow under normal conditions and recirculation impairment after cerebral ischemia (author's transl)].
Topics: Animals; Azepines; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Cerebrovascular Dis | 1981 |
Synergistic effect of hyperthermia, papaverine, and chemotherapy in murine neuroblastoma.
Topics: Animals; Cyclophosphamide; Disease Models, Animal; Hyperthermia, Induced; Male; Mice; Microwaves; Ne | 1980 |
Renal perfusion: pharmacologic changes depicted with power Doppler US in an animal model.
Topics: Animals; Blood Pressure; Disease Models, Animal; Epinephrine; Female; Heart Rate; Image Enhancement; | 1995 |
In vivo adenovirus-mediated gene transfer into normal and cystic rat kidneys.
Topics: Adenoviridae; Animals; beta-Galactosidase; Cold Temperature; Disease Models, Animal; Dopamine; Gene | 1996 |
Drug-induced vasodilation: in vitro and in vivo study on the effects of lidocaine and papaverine on rabbit carotid artery.
Topics: Animals; Carotid Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; In Vitro Techni | 1998 |
Topical papaverine and facial nerve dysfunction in cerebellopontine angle surgery.
Topics: Action Potentials; Administration, Topical; Adult; Animals; Arteries; Cerebellopontine Angle; Cerebe | 1999 |
Spinal cord protection by papaverine and intrathecal cooling during aortic crossclamping.
Topics: Administration, Topical; Animals; Aorta, Thoracic; Cold Temperature; Disease Models, Animal; Intubat | 1998 |
Electrical activity of the corpus cavernosum in denervated rats.
Topics: Animals; Autonomic Nervous System; Denervation; Disease Models, Animal; Electromyography; Erectile D | 1999 |
Pulmonary artery endothelium-dependent vasodilation is impaired in a chicken model of pulmonary hypertension.
Topics: Acetylcholine; Animals; Arginine; Calcimycin; Chickens; Disease Models, Animal; Endothelium, Vascula | 1999 |
Mechanisms of vascular instability in a transgenic mouse model of sickle cell disease.
Topics: Anemia, Sickle Cell; Animals; Aorta; Autoantibodies; Blood Pressure; Calcimycin; Cyclic GMP; Disease | 2000 |
Mechanisms that produce nitric oxide-mediated relaxation of cerebral arteries during atherosclerosis.
Topics: Animals; Basilar Artery; Cerebral Arteries; Cholesterol; Diet, Atherogenic; Dinoprost; Disease Model | 2001 |
Lead-cadmium interaction effect on the responsiveness of rat mesenteric vessels to norepinephrine and angiotensin II.
Topics: Analysis of Variance; Angiotensin II; Animals; Cadmium Poisoning; Calcium; Dinoprostone; Disease Mod | 2001 |
Short-term histopathologic effects of different intracavernosal agents on corpus cavernosum and antifibrotic activity of intracavernosal verapamil: an experimental study.
Topics: Alprostadil; Animals; Calcium Channel Blockers; Chemical and Drug Induced Liver Injury; Disease Mode | 2001 |
Experimental stereotactic gamma knife radiosurgery. Vascular contractility studies of the rat middle cerebral artery after chronic survival.
Topics: Animals; Arginine; Dinoprost; Disease Models, Animal; Dose-Response Relationship, Drug; Histamine; I | 2002 |
An in vitro model of canine immediate-type hypersensitivity reactions.
Topics: Animals; Antigens; Ascaris; Carbachol; Cromolyn Sodium; Disease Models, Animal; Dogs; Guanidines; Hi | 1976 |
Some considerations on cerebral vasospasm.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Animals; Cats; Cerebral Arteries; Cerebral He | 1975 |
Tetrahydroisoquinolines in the brain: the basis of an animal model of alcoholism.
Topics: Alcohol Drinking; Alcoholism; Alkaloids; Animals; Brain; Carbolines; Disease Models, Animal; Humans; | 1978 |
Angiographic aspects of experimental nonocclusive intestinal ischemic injury.
Topics: Angiography; Animals; Disease Models, Animal; Dogs; Humans; Infusions, Parenteral; Intestines; Ische | 1977 |
Coronary reperfusion: effects of vasodilators (papaverine and adenosine).
Topics: Adenosine; Animals; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Injections | 1977 |
Structural and functional changes in vascular resistance and reactivity in the deoxycorticosterone acetate (DOCA)-hypertensive pig.
Topics: Animals; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Implan | 1977 |
Experimental cerebral vasospasm. Part 2: effects of vasoactive drugs and sympathectomy on early and late spasm.
Topics: Animals; Circle of Willis; Disease Models, Animal; Dogs; Ischemic Attack, Transient; Isoxsuprine; Me | 1975 |
Effects of several antianginal agents on pacing-induced S-T Segment depression in the atherosclerotic rabbit.
Topics: Angina Pectoris; Animals; Arteriosclerosis; Autonomic Agents; Cardiac Catheterization; Chromonar; De | 1975 |
Can myocardial contrast echo determine coronary flow reserve?
Topics: Animals; Blood Pressure; Contrast Media; Coronary Artery Disease; Coronary Circulation; Disease Mode | 1992 |
Inhibition of wound contraction by papaverine: in vitro analysis with a submucosal tissue model.
Topics: Actins; Administration, Topical; Animals; Bandages; Collagen; Contracture; Disease Models, Animal; D | 1991 |
Pharmacologic manipulation of postoperative labial wound contraction and midfacial growth in rabbits.
Topics: Analysis of Variance; Animals; Cleft Lip; Contracture; Disease Models, Animal; Electromyography; Fac | 1991 |
Cavernous vein arterialization for vasculogenic impotence. An animal model.
Topics: Animals; Arteriovenous Shunt, Surgical; Disease Models, Animal; Dogs; Electric Stimulation; Erectile | 1990 |
Effects of idebenone on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia.
Topics: Animals; Benzoquinones; Brain; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; | 1989 |
[Approaches to the creation of a model of cerebral thrombocytic microembolism and to research on the effects of drugs].
Topics: Acid-Base Equilibrium; Animals; Blood Pressure; Cats; Collagen; Disease Models, Animal; Drug Evaluat | 1987 |
Sites of leakage in three models of acute lung injury.
Topics: Animals; Arteries; Arterioles; Blood Pressure; Capillary Permeability; Disease Models, Animal; Embol | 1988 |
Characterisation of aorto-iliac arterial stenoses in terms of pressure and flow.
Topics: Animals; Aorta; Arterial Occlusive Diseases; Blood Flow Velocity; Blood Pressure; Disease Models, An | 1985 |
A comparative study of two antispasmodic products: Buscopan and NO-Spa.
Topics: Animals; Butylscopolammonium Bromide; Disease Models, Animal; Guinea Pigs; Ileal Diseases; Papaverin | 1985 |
Simultaneous measurement of internal and external carotid blood flow in the monkey. An approach to the study of migraine mechanisms.
Topics: Animals; Blood Pressure; Carbon Dioxide; Carotid Arteries; Carotid Artery, External; Carotid Artery, | 1974 |
Mechanisms regulating renin release in dogs with thoracic caval constriction.
Topics: Angiotensin II; Animals; Ascites; Blood Pressure; Constriction; Creatinine; Disease Models, Animal; | 1972 |
Hyperbaric oxygenation as a therapeutic method in experimental subacute and chronic peripheral circulatory disturbances.
Topics: Animals; Disease Models, Animal; Ergotamine; Ethanolamines; Gangrene; Hyperbaric Oxygenation; Ischem | 1969 |
Observations on the effects of intrathecal papaverine in experimental vasospasm.
Topics: Animals; Basilar Artery; Cerebral Angiography; Disease Models, Animal; Haplorhini; Injections, Spina | 1973 |
The renal functional defect of postobstructive nephyropathy. The effects of bilateral ureteral obstruction in the rat.
Topics: Animals; Biological Transport; Blood Pressure; Disease Models, Animal; Diuresis; Female; Glomerular | 1972 |
[Experimental model of brain edema for the study of drugs acting on blood flow and-or brain metabolism].
Topics: Animals; Arachnoid; Biological Assay; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Cere | 1972 |
The local effects of intra-arterial injections of sodium tetradecyl sulphate (S.T.D) 3 per cent. An experimental study.
Topics: Angiography; Animals; Arterial Occlusive Diseases; Blood; Contrast Media; Disease Models, Animal; Do | 1972 |
Left ventricular performance and coronary flow after coronary embolization with plastic microspheres.
Topics: Animals; Atropine; Blood Pressure; Cardiac Output; Coronary Circulation; Disease Models, Animal; Dog | 1971 |
Capillary flow and capillary transport in dog skeletal muscle in hemorrhagic shock.
Topics: Animals; Autoradiography; Biological Transport; Blood Pressure; Capillary Permeability; Capillary Re | 1972 |
Therapeutic studies in experimental amniotic fluid embolism in rabbits.
Topics: Anaphylaxis; Animals; Atropine; Bronchial Spasm; Disease Models, Animal; Electrocardiography; Emboli | 1970 |
The renal response to ureteral obstruction: a model for the study of factors which influence glomerular filtration pressure.
Topics: Acetylcholine; Acute Kidney Injury; Animals; Aorta, Abdominal; Disease Models, Animal; Female; Glome | 1970 |