papaverine has been researched along with Diarrhea in 10 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This retrospective study investigated the effectiveness and safety of neuromuscular electrical stimulation (NMES) as an adjunctive therapy to drotaverine hydrochloride (DHC) in patients with diarrhea-predominant irritable bowel syndrome (BP-IBS)." | 7.88 | Neuromuscular electrical stimulation as an adjunctive therapy to drotaverine hydrochloride for treating patients with diarrhea-predominant irritable bowel syndrome: A retrospective study. ( Liu, J; Wang, JK, 2018) |
| " In the IBS subjects, pain severity, as well as the sensory response to rectal balloon distention and rectal and sigmoid motility, were studied at baseline and after two weeks therapy with either oral buscopan (20 mg three times a day, n=37), a buscopan suppository (30 mg once daily, n=21), oral drotaverine (80 mg three times a day, n=30), calcium gluconate tablets (one three times a day, n=16) as a control for oral agents, or calendula suppository (once daily, n=14) as a control for those who received a suppository." | 5.14 | Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics). ( Dzhanayev, YA; Golovenko, OV; Khalif, IL; Makarchuk, PA; Podmarenkova, LF; Quigley, EM, 2009) |
| "This retrospective study investigated the effectiveness and safety of neuromuscular electrical stimulation (NMES) as an adjunctive therapy to drotaverine hydrochloride (DHC) in patients with diarrhea-predominant irritable bowel syndrome (BP-IBS)." | 3.88 | Neuromuscular electrical stimulation as an adjunctive therapy to drotaverine hydrochloride for treating patients with diarrhea-predominant irritable bowel syndrome: A retrospective study. ( Liu, J; Wang, JK, 2018) |
| "We attempted to characterize the antidiarrheal action of Hange-shashin-to (TJ-14), a kampo medicine, by comparing its action with that of loperamide." | 3.69 | Pharmacological studies on antidiarrheal effects of Hange-shashin-to. ( Aburada, M; Hayakawa, T; Ishige, A; Kase, Y; Okada, M; Takeda, S, 1996) |
| " Thus, the present investigation revealed the phytochemical constituents and explored the detailed pharmacodynamic basis for the curative use of G." | 1.72 | The Detailed Pharmacodynamics of the Gut Relaxant Effect and GC-MS Analysis of the ( Ahmad, W; Amir, M; Ansari, MN; Rehman, NU, 2022) |
| " Hence, the drug suffers from brief residence in the highly moving intestine during diarrhoea which leads to poor bioavailability and frequent dosing." | 1.40 | Design of innovated lipid-based floating beads loaded with an antispasmodic drug: in-vitro and in-vivo evaluation. ( Adel, S; ElKasabgy, NA, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rehman, NU | 3 |
| Ansari, MN | 3 |
| Ahmad, W | 2 |
| Amir, M | 2 |
| Samad, A | 1 |
| Wang, JK | 1 |
| Liu, J | 1 |
| Adel, S | 1 |
| ElKasabgy, NA | 1 |
| Khalif, IL | 1 |
| Quigley, EM | 1 |
| Makarchuk, PA | 1 |
| Golovenko, OV | 1 |
| Podmarenkova, LF | 1 |
| Dzhanayev, YA | 1 |
| Khan, M | 1 |
| Khan, AU | 1 |
| Gilani, AH | 1 |
| Kase, Y | 1 |
| Hayakawa, T | 1 |
| Takeda, S | 1 |
| Ishige, A | 1 |
| Aburada, M | 1 |
| Okada, M | 1 |
| Kocián, J | 1 |
| Kociánová, J | 1 |
| Caprilli, R | 1 |
| Paoluzi, P | 1 |
2 trials available for papaverine and Diarrhea
| Article | Year |
|---|---|
Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics).
Topics: Administration, Oral; Administration, Rectal; Adult; Butylscopolammonium Bromide; Calcium Gluconate; | 2009 |
[Clinical experiences with preparation Hylakombun in gastroenterology].
Topics: Adult; Aged; Clinical Trials as Topic; Constipation; Diarrhea; Drug Combinations; Drug Evaluation; D | 1975 |
8 other studies available for papaverine and Diarrhea
| Article | Year |
|---|---|
GC-MS Analysis and In Vivo and Ex Vivo Antidiarrheal and Antispasmodic Effects of the Methanolic Extract of
Topics: Acacia; Animals; Antidiarrheals; Diarrhea; Gas Chromatography-Mass Spectrometry; Gastrointestinal Ag | 2022 |
The Detailed Pharmacodynamics of the Gut Relaxant Effect and GC-MS Analysis of the
Topics: Animals; Antidiarrheals; Diarrhea; Fruit; Gas Chromatography-Mass Spectrometry; Grewia; Jejunum; Mic | 2022 |
In Silico, Ex Vivo and In Vivo Studies of Roflumilast as a Potential Antidiarrheal and Antispasmodic agent: Inhibition of the PDE-4 Enzyme and Voltage-gated Ca++ ion Channels.
Topics: Aminopyridines; Animals; Antidiarrheals; Benzamides; Binding Sites; Calcium Channel Blockers; Carbac | 2020 |
Neuromuscular electrical stimulation as an adjunctive therapy to drotaverine hydrochloride for treating patients with diarrhea-predominant irritable bowel syndrome: A retrospective study.
Topics: Adult; Combined Modality Therapy; Diarrhea; Electric Stimulation Therapy; Female; Humans; Irritable | 2018 |
Design of innovated lipid-based floating beads loaded with an antispasmodic drug: in-vitro and in-vivo evaluation.
Topics: Adult; Alginates; Animals; Diarrhea; Dogs; Drug Delivery Systems; Emulsions; Glucuronic Acid; Hexuro | 2014 |
Pharmacological explanation for the medicinal use of Juniperus excelsa in hyperactive gastrointestinal and respiratory disorders.
Topics: Animals; Bronchodilator Agents; Calcium Channel Blockers; Diarrhea; Gastrointestinal Diseases; Guine | 2012 |
Pharmacological studies on antidiarrheal effects of Hange-shashin-to.
Topics: Animals; Atropine; Barium Compounds; Castor Oil; Chlorides; Diarrhea; Drugs, Chinese Herbal; Gastroi | 1996 |
[The "irritable colon" syndromes].
Topics: Atropa belladonna; Colonic Diseases, Functional; Diarrhea; Diet Therapy; Humans; Intestinal Mucosa; | 1967 |