papaverine has been researched along with Depressive Disorder in 2 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Priapism occurred in ten patients undergoing treatment of depression with trazodone or impotence with papaverine." | 7.68 | Pharmacological priapism: comparison of trazodone- and papaverine-associated cases. ( Bardin, ED; Krieger, JN, 1990) |
| "Priapism occurred in ten patients undergoing treatment of depression with trazodone or impotence with papaverine." | 3.68 | Pharmacological priapism: comparison of trazodone- and papaverine-associated cases. ( Bardin, ED; Krieger, JN, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Malison, RT | 1 |
| Price, LH | 1 |
| Nestler, EJ | 1 |
| Heninger, GR | 1 |
| Duman, RS | 1 |
| Bardin, ED | 1 |
| Krieger, JN | 1 |
2 other studies available for papaverine and Depressive Disorder
| Article | Year |
|---|---|
Efficacy of papaverine addition for treatment-refractory major depression.
Topics: Buspirone; Cyclohexanols; Depressive Disorder; Drug Resistance; Drug Therapy, Combination; Female; H | 1997 |
Pharmacological priapism: comparison of trazodone- and papaverine-associated cases.
Topics: Depressive Disorder; Erectile Dysfunction; Humans; Male; Papaverine; Priapism; Trazodone | 1990 |