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papaverine and Depression

papaverine has been researched along with Depression in 6 studies

Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"This is the first double-blind study in outpatients to evaluate the effectiveness of dihydrogenated ergot alkaloids (DEA) (Hydergine) versus papaverine in the treatment of selected symptoms associated with mental aging."5.04Mental decline in the elderly: pharmacotherapy (ergot alkaloids versus papaverine). ( Rosen, HJ, 1975)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19905 (83.33)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jägestedt, M1
von Bahr, C1
Reisberg, B1
Ferris, SH1
Gershon, S1
Rosen, HJ1
Einspruch, BC1
Cole, JO1
Stotsky, BA1
Stern, FH1

Reviews

1 review available for papaverine and Depression

ArticleYear
Pharmacotherapy of senile dementia.
    Proceedings of the annual meeting of the American Psychopathological Association, 1980, Volume: 69

    Topics: Adult; Age Factors; Aged; Alzheimer Disease; Amphetamine; Antidepressive Agents, Tricyclic; Dementia

1980

Trials

3 trials available for papaverine and Depression

ArticleYear
Mental decline in the elderly: pharmacotherapy (ergot alkaloids versus papaverine).
    Journal of the American Geriatrics Society, 1975, Volume: 23, Issue:4

    Topics: Aged; Aging; Clinical Trials as Topic; Confusion; Dementia; Depression; Dihydroergotoxine; Ergoloid

1975
Helping to make the final years meaningful for the elderly residents of nursing homes.
    Diseases of the nervous system, 1976, Volume: 37, Issue:8

    Topics: Activities of Daily Living; Aged; Anxiety; Clinical Trials as Topic; Confusion; Depression; Dihydroe

1976
Management of chronic brain syndrome secondary to cerebral arteriosclerosis, with special reference to papaverine hydrochloride.
    Journal of the American Geriatrics Society, 1970, Volume: 18, Issue:6

    Topics: Aged; Anxiety; Clinical Trials as Topic; Dementia; Depression; Humans; Intracranial Arteriosclerosis

1970

Other Studies

2 other studies available for papaverine and Depression

ArticleYear
[Combination of serotonergic agents resulted in severe adverse effects].
    Lakartidningen, 2004, Apr-29, Volume: 101, Issue:18

    Topics: Antidepressive Agents, Second-Generation; Buspirone; Cytochrome P-450 CYP2D6; Depression; Drug Inter

2004
Improving psychiatric drug therapy. A matter of dosage and choice.
    Geriatrics, 1974, Volume: 29, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Aged; Anticoagulants; Antidepressive Agents; Antiparkinson Agents; B

1974