papaverine has been researched along with Depression in 6 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This is the first double-blind study in outpatients to evaluate the effectiveness of dihydrogenated ergot alkaloids (DEA) (Hydergine) versus papaverine in the treatment of selected symptoms associated with mental aging." | 5.04 | Mental decline in the elderly: pharmacotherapy (ergot alkaloids versus papaverine). ( Rosen, HJ, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jägestedt, M | 1 |
| von Bahr, C | 1 |
| Reisberg, B | 1 |
| Ferris, SH | 1 |
| Gershon, S | 1 |
| Rosen, HJ | 1 |
| Einspruch, BC | 1 |
| Cole, JO | 1 |
| Stotsky, BA | 1 |
| Stern, FH | 1 |
1 review available for papaverine and Depression
| Article | Year |
|---|---|
Pharmacotherapy of senile dementia.
Topics: Adult; Age Factors; Aged; Alzheimer Disease; Amphetamine; Antidepressive Agents, Tricyclic; Dementia | 1980 |
3 trials available for papaverine and Depression
| Article | Year |
|---|---|
Mental decline in the elderly: pharmacotherapy (ergot alkaloids versus papaverine).
Topics: Aged; Aging; Clinical Trials as Topic; Confusion; Dementia; Depression; Dihydroergotoxine; Ergoloid | 1975 |
Helping to make the final years meaningful for the elderly residents of nursing homes.
Topics: Activities of Daily Living; Aged; Anxiety; Clinical Trials as Topic; Confusion; Depression; Dihydroe | 1976 |
Management of chronic brain syndrome secondary to cerebral arteriosclerosis, with special reference to papaverine hydrochloride.
Topics: Aged; Anxiety; Clinical Trials as Topic; Dementia; Depression; Humans; Intracranial Arteriosclerosis | 1970 |
2 other studies available for papaverine and Depression
| Article | Year |
|---|---|
[Combination of serotonergic agents resulted in severe adverse effects].
Topics: Antidepressive Agents, Second-Generation; Buspirone; Cytochrome P-450 CYP2D6; Depression; Drug Inter | 2004 |
Improving psychiatric drug therapy. A matter of dosage and choice.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anticoagulants; Antidepressive Agents; Antiparkinson Agents; B | 1974 |