papaverine has been researched along with Dementia in 17 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind, placebo-controlled study was conducted in 20 elderly patients with dementia associated with diffuse cerebrovascular disease to determine the effects of papaverine on the electrical activity of the brain." | 5.04 | Effect of papaverine on cerebral electrogenesis. ( Culebras, A, 1976) |
| "This is the first double-blind study in outpatients to evaluate the effectiveness of dihydrogenated ergot alkaloids (DEA) (Hydergine) versus papaverine in the treatment of selected symptoms associated with mental aging." | 5.04 | Mental decline in the elderly: pharmacotherapy (ergot alkaloids versus papaverine). ( Rosen, HJ, 1975) |
| "As far as the head pain was concerned, the feeling of giddiness, congestion in the head, rapid exhaustion, above all, tinnitus, responded best to the medication (the improvement amounting to approximately 40%), whereas of the mental complaints, a feeling of being "lost" or "abandoned" and a morose mood were most amenable to improvement (degree of improvement approximately 30%)." | 1.26 | [Eutergin in the treatment of chronic cerebrovascular disturbance patterns (author's transl)]. ( Prosenz, P, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prosenz, P | 1 |
| Reisberg, B | 1 |
| Ferris, SH | 1 |
| Gershon, S | 1 |
| Cook, P | 1 |
| James, I | 1 |
| Branconnier, RJ | 1 |
| Cole, JO | 2 |
| Ghazvinian, S | 1 |
| Venn, RD | 1 |
| Petrie, WM | 1 |
| Ban, TA | 1 |
| Yesavage, JA | 1 |
| Tinklenberg, JR | 1 |
| Hollister, LE | 2 |
| Berger, PA | 1 |
| Culebras, A | 1 |
| Nelson, JJ | 1 |
| Rosen, HJ | 1 |
| Stotsky, BA | 1 |
| Stern, FH | 1 |
| Simard, D | 1 |
| Olesen, J | 1 |
| Paulson, OB | 1 |
| Lassen, NA | 1 |
| Skinhoj, E | 1 |
| Lambert, PA | 1 |
| Bouchardy, M | 1 |
3 reviews available for papaverine and Dementia
| Article | Year |
|---|---|
Pharmacotherapy of senile dementia.
Topics: Adult; Age Factors; Aged; Alzheimer Disease; Amphetamine; Antidepressive Agents, Tricyclic; Dementia | 1980 |
Drug therapy: cerebral vasodilators (first of two parts).
Topics: Aged; Aging; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as Topic; Cycla | 1981 |
Drugs in geropsychiatry.
Topics: Aged; Anticoagulants; Central Nervous System Agents; Dementia; Dihydroergotoxine; Humans; Hypnotics | 1978 |
6 trials available for papaverine and Dementia
| Article | Year |
|---|---|
Drug therapy: cerebral vasodilators (first of two parts).
Topics: Aged; Aging; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as Topic; Cycla | 1981 |
Deapril-ST for senile dementia.
Topics: Aged; Clinical Trials as Topic; Dementia; Dihydroergotoxine; Double-Blind Method; Humans; Papaverine | 1977 |
Effect of papaverine on cerebral electrogenesis.
Topics: Aged; Alpha Rhythm; Brain; Clinical Trials as Topic; Delta Rhythm; Dementia; Drug Evaluation; Electr | 1976 |
Relieving select symptoms of the elderly.
Topics: Age Factors; Aged; Anxiety Disorders; Attitude; Brain; Clinical Trials as Topic; Dementia; Dihydroer | 1975 |
Mental decline in the elderly: pharmacotherapy (ergot alkaloids versus papaverine).
Topics: Aged; Aging; Clinical Trials as Topic; Confusion; Dementia; Depression; Dihydroergotoxine; Ergoloid | 1975 |
Management of chronic brain syndrome secondary to cerebral arteriosclerosis, with special reference to papaverine hydrochloride.
Topics: Aged; Anxiety; Clinical Trials as Topic; Dementia; Depression; Humans; Intracranial Arteriosclerosis | 1970 |
9 other studies available for papaverine and Dementia
| Article | Year |
|---|---|
[Eutergin in the treatment of chronic cerebrovascular disturbance patterns (author's transl)].
Topics: Aged; Antidepressive Agents; Cerebrovascular Disorders; Chronic Disease; Dementia; Dihydroergotoxine | 1980 |
Does papaverine affect brain dopamine?
Topics: Brain; Dementia; Dopamine; Double-Blind Method; Humans; Middle Aged; Papaverine; Prolactin | 1982 |
Review of clinical studies with ergots in gerontology.
Topics: Aged; Cerebrovascular Circulation; Dementia; Dihydroergotoxine; Double-Blind Method; Ergot Alkaloids | 1980 |
Vasodilators in senile dementias: a review of the literature.
Topics: Aged; Cinnarizine; Cyclandelate; Dementia; Dihydroergotoxine; Drug Evaluation; Humans; Isoxsuprine; | 1979 |
Drugs for improvement of cerebral function in the elderly.
Topics: Aged; Cyclandelate; Dementia; Dihydroergotoxine; Drug Evaluation; Humans; Mental Processes; Papaveri | 1976 |
Alzheimer's disease. Is it worth treating?
Topics: Aged; Alzheimer Disease; Dementia; Dihydroergotoxine; Humans; Nafronyl; Papaverine; Pentoxifylline; | 1985 |
Improving psychiatric drug therapy. A matter of dosage and choice.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anticoagulants; Antidepressive Agents; Antiparkinson Agents; B | 1974 |
Regional cerebral blood flow and its regulation in dementia.
Topics: Adult; Aged; Alcohol Amnestic Disorder; Biopsy; Blood Flow Velocity; Brain; Carbon Dioxide; Cerebral | 1971 |
[Can psychiatric disorders on the aged be influenced by affecting the cerebral circulation?].
Topics: Aged; Cerebrovascular Disorders; Dementia; Ergot Alkaloids; Female; Humans; Male; Middle Aged; Neuro | 1968 |