papaverine has been researched along with Coronary Stenosis in 23 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Coronary Stenosis: Narrowing or constriction of a coronary artery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effect of the papaverine dose increment method to confirm maximal hyperemia for fractional flow reserve (FFR) measurements." | 7.96 | Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine. ( Iwasaki, K; Nakayama, M; Tanaka, N; Yamashita, J, 2020) |
| "We examined whether caffeine attenuated intravenous adenosine-induced hyperemia in the measurement of fractional flow reserve (FFR) and whether an increased dose of adenosine overcame the caffeine antagonism." | 7.80 | Effect of caffeine on intravenous adenosine-induced hyperemia in fractional flow reserve measurement. ( Matsuda, T; Matsumoto, H; Mikuri, M; Nakatsuma, K; Shimada, T; Ushimaru, S; Yamazaki, T, 2014) |
| "Nicorandil 2 mg is a safe and practical alternative for patients who consume caffeine-containing products before the test or have contraindications for adenosine/ATP." | 5.56 | Feasibility of intracoronary nicorandil for inducing hyperemia on fractional flow reserve measurement: Comparison with intracoronary papaverine. ( Arai, T; Masaki, R; Matsumoto, H; Mikuri, M; Ogura, K; Oishi, Y; Okada, N; Sakai, R; Shinke, T; Tanaka, H, 2020) |
| " FFR was performed in patients with more than intermediate coronary stenosis using the intravenous infusion of ATP at 140 μg/kg/min (normal dose) and 170 μg/kg/min (high dose), and the intracoronary infusion of papaverine." | 5.27 | Effects of caffeine on fractional flow reserve values measured using intravenous adenosine triphosphate. ( Chikamori, T; Hijikata, N; Ito, R; Kimura, Y; Kobori, Y; Nakayama, M; Sato, H; Uchiyama, T; Yamashina, A; Yuhara, M, 2018) |
| " Intracoronary papaverine (PAP) is the most potent vasodilator used for the achievement of maximal hyperemia." | 4.02 | Clinical Efficacy of Intracoronary Papaverine After Nicorandil Administration for Safe and Optimal Fractional Flow Reserve Measurement. ( Anai, R; Araki, M; Inoue, K; Kataoka, M; Miura, T; Naka, Y; Okabe, H; Setoyama, K; Sonoda, S, 2021) |
| "We investigated the effect of the papaverine dose increment method to confirm maximal hyperemia for fractional flow reserve (FFR) measurements." | 3.96 | Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine. ( Iwasaki, K; Nakayama, M; Tanaka, N; Yamashita, J, 2020) |
| " We clarified the optimal measuring procedure for FFR for SFA lesions and investigated the necessary dose of papaverine for inducing maximal hyperemia in SFA lesions." | 3.83 | Measuring Procedure and Maximal Hyperemia in the Assessment of Fractional Flow Reserve for Superficial Femoral Artery Disease. ( Araki, M; Hirano, K; Ishimori, H; Ito, Y; Kobayashi, N; Muramatsu, T; Nakano, M; Sakai, T; Tsukahara, R; Yamawaki, M, 2016) |
| "We examined whether caffeine attenuated intravenous adenosine-induced hyperemia in the measurement of fractional flow reserve (FFR) and whether an increased dose of adenosine overcame the caffeine antagonism." | 3.80 | Effect of caffeine on intravenous adenosine-induced hyperemia in fractional flow reserve measurement. ( Matsuda, T; Matsumoto, H; Mikuri, M; Nakatsuma, K; Shimada, T; Ushimaru, S; Yamazaki, T, 2014) |
| "In 21 patients with an isolated coronary stenosis, coronary vasodilation was induced successively by papaverine (20 mg intracoronary), adenosine (20 and 40 microg intracoronary), ATP (20 and 40 microg intracoronary), iohexol (6 mL intracoronary), adenosine or ATP through an antecubital vein (140 and 180 microg x kg(-1) x min(-1)), or adenosine or ATP through a femoral vein (140 and 180 microg x kg(-1) x min(-1))." | 3.72 | Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans. ( Barbato, E; Bartunek, J; Bech, JW; De Bruyne, B; Heyndrickx, GR; Pijls, NH; Wijns, W, 2003) |
| " Intracoronary papaverine (20 mg) was used to induce hyperemia." | 3.72 | Comparison of coronary thermodilution and Doppler velocity for assessing coronary flow reserve. ( Balsam, LB; Caffarelli, AD; Cooke, DT; Farouque, HM; Fearon, WF; Fitzgerald, PJ; Robbins, RC; Yeung, AC; Yock, PG, 2003) |
| "Caffeine was ingested at <12 hours in 85 patients, at 12-24 hours in 35 patients, and at >24 hours in 89 patients." | 1.62 | Linear concentration-response relationship of serum caffeine with adenosine-induced fractional flow reserve overestimation: a comparison with papaverine. ( Hosonuma, M; Inoue, K; Kondo, S; Masaki, R; Matsumoto, H; Ogura, K; Oishi, Y; Okada, N; Sakai, K; Sato, S; Sekimoto, T; Shinke, T; Sumida, A; Takahashi, H; Tanaka, H; Tsujita, H; Tsukamoto, S, 2021) |
| "Nicorandil 2 mg is a safe and practical alternative for patients who consume caffeine-containing products before the test or have contraindications for adenosine/ATP." | 1.56 | Feasibility of intracoronary nicorandil for inducing hyperemia on fractional flow reserve measurement: Comparison with intracoronary papaverine. ( Arai, T; Masaki, R; Matsumoto, H; Mikuri, M; Ogura, K; Oishi, Y; Okada, N; Sakai, R; Shinke, T; Tanaka, H, 2020) |
| "Papaverine has been reported to increase the risk of ventricular arrhythmia (VA)." | 1.48 | Evaluation of the risk factors for ventricular arrhythmias secondary to QT prolongation induced by papaverine injection during coronary flow reserve studies using a 4 Fr angio-catheter. ( Kaneko, S; Mitamura, Y; Murai, H; Okabe, Y; Otowa, K; Takamura, M; Usui, S, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 10 (43.48) | 24.3611 |
| 2020's | 6 (26.09) | 2.80 |
| Authors | Studies |
|---|---|
| Inoue, K | 2 |
| Sonoda, S | 1 |
| Naka, Y | 1 |
| Okabe, H | 1 |
| Setoyama, K | 1 |
| Miura, T | 1 |
| Anai, R | 1 |
| Araki, M | 2 |
| Kataoka, M | 1 |
| Tanaka, H | 2 |
| Matsumoto, H | 3 |
| Takahashi, H | 1 |
| Hosonuma, M | 1 |
| Sato, S | 1 |
| Ogura, K | 2 |
| Oishi, Y | 2 |
| Masaki, R | 2 |
| Sakai, K | 1 |
| Sekimoto, T | 1 |
| Kondo, S | 1 |
| Tsujita, H | 1 |
| Tsukamoto, S | 1 |
| Sumida, A | 1 |
| Okada, N | 2 |
| Shinke, T | 3 |
| Nakayama, M | 4 |
| Tanaka, N | 3 |
| Yamashita, J | 1 |
| Iwasaki, K | 2 |
| Uchiyama, T | 2 |
| Hijikata, N | 2 |
| Kobori, Y | 2 |
| Mikuri, M | 2 |
| Arai, T | 1 |
| Sakai, R | 1 |
| Mizukami, T | 1 |
| Sonck, J | 1 |
| Gallinoro, E | 1 |
| Kodeboina, M | 1 |
| Canvedra, A | 1 |
| Nagumo, S | 1 |
| Bartunek, J | 2 |
| Wyffels, E | 1 |
| Vanderheyden, M | 1 |
| De Bruyne, B | 4 |
| Collet, C | 1 |
| Shiode, N | 1 |
| Okimoto, T | 1 |
| Tamekiyo, H | 1 |
| Kawase, T | 1 |
| Yamane, K | 1 |
| Kagawa, Y | 1 |
| Fujii, Y | 1 |
| Ueda, Y | 1 |
| Hironobe, N | 1 |
| Kato, Y | 1 |
| Hayashi, Y | 1 |
| Okabe, Y | 1 |
| Otowa, K | 1 |
| Mitamura, Y | 1 |
| Murai, H | 1 |
| Usui, S | 1 |
| Kaneko, S | 1 |
| Takamura, M | 1 |
| Goto, M | 1 |
| Sato, M | 2 |
| Kitazawa, H | 2 |
| Takahashi, M | 2 |
| Fuse, K | 2 |
| Saito, A | 2 |
| Okabe, M | 2 |
| Aizawa, Y | 2 |
| Nakatsuma, K | 1 |
| Shimada, T | 1 |
| Ushimaru, S | 1 |
| Yamazaki, T | 1 |
| Matsuda, T | 1 |
| Bedogni, F | 1 |
| Indolfi, C | 1 |
| Ribichini, F | 1 |
| Verna, E | 1 |
| Leone, AM | 1 |
| Polimeni, A | 1 |
| Bollati, M | 1 |
| Biondi-Zoccai, G | 1 |
| Testa, L | 1 |
| Berti, S | 1 |
| Kobayashi, N | 1 |
| Hirano, K | 1 |
| Nakano, M | 1 |
| Ito, Y | 1 |
| Sakai, T | 1 |
| Ishimori, H | 1 |
| Yamawaki, M | 1 |
| Tsukahara, R | 1 |
| Muramatsu, T | 1 |
| Nishi, T | 1 |
| Kitahara, H | 1 |
| Iwata, Y | 1 |
| Fujimoto, Y | 1 |
| Nakayama, T | 1 |
| Takahara, M | 1 |
| Sugimoto, K | 1 |
| Kobayashi, Y | 1 |
| Chikamori, T | 1 |
| Kimura, Y | 1 |
| Ito, R | 1 |
| Yuhara, M | 1 |
| Sato, H | 1 |
| Yamashina, A | 2 |
| Kern, MJ | 1 |
| Hoshino, K | 1 |
| Pijls, NH | 3 |
| Barbato, E | 2 |
| Bech, JW | 1 |
| Wijns, W | 1 |
| Heyndrickx, GR | 1 |
| Ishida, S | 1 |
| Hamasaki, S | 1 |
| Kamekou, M | 1 |
| Yoshitama, T | 1 |
| Nakano, F | 1 |
| Yoshikawa, A | 1 |
| Kataoka, T | 1 |
| Saihara, K | 1 |
| Minagoe, S | 1 |
| Tei, C | 1 |
| Fearon, WF | 2 |
| Farouque, HM | 1 |
| Balsam, LB | 2 |
| Caffarelli, AD | 1 |
| Cooke, DT | 2 |
| Robbins, RC | 2 |
| Fitzgerald, PJ | 2 |
| Yeung, AC | 2 |
| Yock, PG | 2 |
| Aarnoudse, W | 2 |
| Geven, M | 1 |
| Botman, KJ | 1 |
| Battaloglu, B | 1 |
| Nisanoglu, V | 1 |
| Erdil, N | 1 |
| Ozgur, B | 1 |
| Eroglu, T | 1 |
| Aydin, N | 1 |
| Kaynak, M | 1 |
| Secici, S | 1 |
| McGeoch, RJ | 1 |
| Oldroyd, KG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| CONTRAST (Can cONTrast Injection Better Approximate FFR compAred to Pure reSTing Physiology?)[NCT02184117] | 763 participants (Actual) | Observational | 2014-07-31 | Completed | |||
| Evaluation of Diagnostic Accuracy, Safety, and Cost-Effectiveness of the Non-Invasive Cardiolens FFR-CT Pro Method to Measure the Fractional Flow Reserve in Diagnostics of Chronic Coronary Syndromes Versus the Standard Diagnostic Modalities. A Multicentre[NCT04777513] | 450 participants (Anticipated) | Observational [Patient Registry] | 2020-08-06 | Recruiting | |||
| A Prospective, Multi-center Clinical Trial for Evaluating the Effectiveness and Safety of Coronary Angiography-Derived Index of Microcirculatory Resistance Measured Online by a Coronary Functional Measurement System[NCT05009667] | 116 participants (Actual) | Observational | 2021-10-14 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for papaverine and Coronary Stenosis
| Article | Year |
|---|---|
Pharmacological options for inducing maximal hyperaemia during studies of coronary physiology.
Topics: Adenosine; Adenosine Triphosphate; Animals; Caffeine; Coronary Stenosis; Dobutamine; Fractional Flow | 2008 |
2 trials available for papaverine and Coronary Stenosis
| Article | Year |
|---|---|
Effects of caffeine on fractional flow reserve values measured using intravenous adenosine triphosphate.
Topics: Adenosine Triphosphate; Aged; Angina Pectoris; Caffeine; Cardiac Catheterization; Coffee; Coronary A | 2018 |
Effects of pretreatment with different topical vasodilators on blood flow in the internal mammary artery: a prospective randomized study.
Topics: Adenosine; Administration, Topical; Adult; Aged; Coronary Angiography; Coronary Artery Bypass; Coron | 2007 |
20 other studies available for papaverine and Coronary Stenosis
| Article | Year |
|---|---|
Clinical Efficacy of Intracoronary Papaverine After Nicorandil Administration for Safe and Optimal Fractional Flow Reserve Measurement.
Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Case-Control Studies; Coronary Angiography; Coronary | 2021 |
Linear concentration-response relationship of serum caffeine with adenosine-induced fractional flow reserve overestimation: a comparison with papaverine.
Topics: Adenosine; Caffeine; Coronary Angiography; Coronary Stenosis; Fractional Flow Reserve, Myocardial; H | 2021 |
Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine.
Topics: Aged; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Dose-Response Relationship, Drug; E | 2020 |
Effect of QTU prolongation on hyperemic instantaneous wave-free ratio value: a prospective single-center study.
Topics: Adenosine Triphosphate; Aged; Aged, 80 and over; Blood Flow Velocity; Cardiac Catheterization; Coron | 2020 |
Feasibility of intracoronary nicorandil for inducing hyperemia on fractional flow reserve measurement: Comparison with intracoronary papaverine.
Topics: Coronary Angiography; Coronary Circulation; Coronary Stenosis; Feasibility Studies; Fractional Flow | 2020 |
Duration of Hyperemia With Intracoronary Administration of Papaverine.
Topics: Aged; Coronary Stenosis; Coronary Vessels; Female; Fractional Flow Reserve, Myocardial; Humans; Hype | 2021 |
A Comparison between the Instantaneous Wave-free Ratio and Resting Distal Coronary Artery Pressure/Aortic Pressure and the Fractional Flow Reserve: The Diagnostic Accuracy Can Be Improved by the Use of both Indices.
Topics: Aged; Aorta; Arterial Pressure; Coronary Angiography; Coronary Artery Disease; Coronary Stenosis; Fe | 2017 |
Evaluation of the risk factors for ventricular arrhythmias secondary to QT prolongation induced by papaverine injection during coronary flow reserve studies using a 4 Fr angio-catheter.
Topics: Aged; Cardiac Catheters; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Electrocardiogra | 2018 |
Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation.
Topics: Coronary Stenosis; Coronary Vessels; Electrocardiography; Female; Fractional Flow Reserve, Myocardia | 2014 |
Effect of caffeine on intravenous adenosine-induced hyperemia in fractional flow reserve measurement.
Topics: Adenosine; Administration, Oral; Aged; Blood Pressure; Caffeine; Coronary Angiography; Coronary Sten | 2014 |
[Position paper on the theoretical basis, practical application and health economic evaluation of the functional assessment of coronary lesions endorsed by the Italian Society of Invasive Cardiology (SICI-GISE)].
Topics: Adenosine Triphosphate; Cardiac Catheterization; Clinical Trials as Topic; Collateral Circulation; C | 2015 |
Measuring Procedure and Maximal Hyperemia in the Assessment of Fractional Flow Reserve for Superficial Femoral Artery Disease.
Topics: Aged; Cardiology; Coronary Stenosis; Endovascular Procedures; Female; Femoral Artery; Heart Failure; | 2016 |
Efficacy of combined administration of intracoronary papaverine plus intravenous adenosine 5'-triphosphate in assessment of fractional flow reserve.
Topics: Adenosine Triphosphate; Aged; Coronary Angiography; Coronary Stenosis; Female; Fractional Flow Reser | 2016 |
Can we apply coronary physiologic methods to renal artery stenosis assessment?
Topics: Biomarkers; Blood Pressure; Blood Pressure Determination; Coronary Circulation; Coronary Stenosis; H | 2010 |
Papaverine-induced polymorphic ventricular tachycardia in relation to QTU and giant T-U waves in four cases.
Topics: Aged; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Electrocardiography; Female; Fracti | 2012 |
Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans.
Topics: Adenosine; Adenosine Triphosphate; Contrast Media; Coronary Angiography; Coronary Circulation; Coron | 2003 |
Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans.
Topics: Adenosine; Adenosine Triphosphate; Contrast Media; Coronary Angiography; Coronary Circulation; Coron | 2003 |
Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans.
Topics: Adenosine; Adenosine Triphosphate; Contrast Media; Coronary Angiography; Coronary Circulation; Coron | 2003 |
Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans.
Topics: Adenosine; Adenosine Triphosphate; Contrast Media; Coronary Angiography; Coronary Circulation; Coron | 2003 |
Advancing age is associated with diminished vascular remodeling and impaired vasodilation in resistance coronary arteries.
Topics: Acetylcholine; Age Factors; Arteries; Coronary Angiography; Coronary Circulation; Coronary Stenosis; | 2003 |
Comparison of coronary thermodilution and Doppler velocity for assessing coronary flow reserve.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Coronary Circulation; Coronary Stenosis; Disease Model | 2003 |
Microvascular resistance is not influenced by epicardial coronary artery stenosis severity: experimental validation.
Topics: Animals; Arterial Occlusive Diseases; Collateral Circulation; Coronary Circulation; Coronary Stenosi | 2004 |
Effect of phentolamine on the hyperemic response to adenosine in patients with microvascular disease.
Topics: Adenosine; Adrenergic alpha-Antagonists; Blood Flow Velocity; Coronary Angiography; Coronary Stenosi | 2005 |