papaverine has been researched along with Cognition Disorders in 4 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To test whether the loss of PDE10A activity in the striatum was detrimental to normal brain function, we treated wild-type (WT) mice with chronic administration of papaverine, which is a specific inhibitor of PDE10A." | 1.35 | Phosphodiesterase 10A inhibition is associated with locomotor and cognitive deficits and increased anxiety in mice. ( Denovan-Wright, EM; Hebb, AL; Robertson, HA, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hebb, AL | 1 |
| Robertson, HA | 1 |
| Denovan-Wright, EM | 1 |
| Agnoli, A | 1 |
| Bazo, AJ | 1 |
| Perfilov, PA | 1 |
| Lushin, IuK | 1 |
| Muravskaia, LV | 1 |
1 trial available for papaverine and Cognition Disorders
| Article | Year |
|---|---|
An ergot alkaloid preparation (Hydergine) versus papaverine in treating common complaints of the aged: double-blind study.
Topics: Aged; Behavior; Cerebrovascular Disorders; Clinical Trials as Topic; Cognition Disorders; Emotions; | 1973 |
3 other studies available for papaverine and Cognition Disorders
| Article | Year |
|---|---|
Phosphodiesterase 10A inhibition is associated with locomotor and cognitive deficits and increased anxiety in mice.
Topics: Analysis of Variance; Animals; Anxiety; Avoidance Learning; Behavior, Animal; Cognition Disorders; C | 2008 |
[Problems in the long-term medical treatment of sequelae of acute cerebrovascular diseases. Double-blind studies].
Topics: Cerebrovascular Disorders; Cognition Disorders; Emotions; Headache; Humans; Mental Processes; Motor | 1976 |
[Certain characteristics of clinical manifestations and treatment of transitory disorders of cerebral circulation].
Topics: Adult; Aged; Benzimidazoles; Brain; Cardiac Glycosides; Cerebrovascular Circulation; Cognition Disor | 1974 |