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papaverine and Cirrhosis

papaverine has been researched along with Cirrhosis in 17 studies

Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.

Research Excerpts

ExcerptRelevanceReference
"Intracorporeal papaverine self-injection is a new therapy for erectile dysfunction."7.67Papaverine-induced fibrosis of the corpus cavernosum. ( Brawer, MK; Fuchs, ME, 1989)
"Intracavernous administration of papaverine and phentolamine has become an essential and indispensible element in the diagnosis and treatment of erectile dysfunction."4.77How safe is the treatment of impotence with intracavernous autoinjection? ( Ludwig, G; Zentgraf, M; Ziegler, M, 1989)
"Using papaverine, papaverine/phentolamine, or prostaglandin E1 (PGE1), intracavernosal pharmacotherapy has been successful in treating erectile dysfunction."3.69Experience with intracavernosal tri-mixture for the management of neurogenic erectile dysfunction. ( Chao, R; Clowers, DE, 1994)
"We report 3 cases of penile curvature deformity and fibrosis of the tunica albuginea after long-term self-injection with papaverine hydrochloride and phentolamine mesylate."3.67Fibrosis of tunica albuginea: complication of long-term intracavernous pharmacological self-injection. ( Burks, C; Christy, WC; Hu, KN, 1987)
"Intracorporeal papaverine self-injection is a new therapy for erectile dysfunction."3.67Papaverine-induced fibrosis of the corpus cavernosum. ( Brawer, MK; Fuchs, ME, 1989)
" Dose-dependent response with reversed drug sensitivity was found in the papaverine group, but only elongation to tumescence was found in the PGE1 group, even with double dosage (probably because of scarce PGE1 receptors in monkey's penile tissue)."1.28Histopathological change of corpora cavernosa after long-term intracavernous injection. ( Chu, HW; Ho, WL; Hwang, TI; Yang, CR, 1991)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19906 (35.29)18.7374
1990's8 (47.06)18.2507
2000's3 (17.65)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Asuar Aydillo, S1
Moemen, MN1
Hamed, HA1
Kamel, II1
Shamloul, RM1
Ghanem, HM1
Meinhardt, W1
Lycklama à Nijeholt, AA1
Kropman, RF1
Vermeij, P1
Zwartendijk, J1
Chao, R1
Clowers, DE1
De Rose, AF1
Oppezzi, GF1
Scotto, S1
Casabé, A1
Bechara, A1
Cheliz, G1
Romano, S1
Rey, H1
Fredotovich, N1
Sahin, M1
Başar, MM1
Bozdoğan, O1
Atan, A1
Hwang, TI1
Yang, CR1
Ho, WL1
Chu, HW1
Stief, CG2
Wetterauer, U1
Kulvelis, F1
Popken, G1
Staubesand, J1
Sommerkamp, H1
Lakin, MM1
Montague, DK1
VanderBrug Medendorp, S1
Tesar, L1
Schover, LR1
Gall, H1
Scherb, W1
Bähren, W1
Hu, KN1
Burks, C1
Christy, WC1
Zentgraf, M1
Ludwig, G1
Ziegler, M1
Fuchs, ME1
Brawer, MK1
Corriere, JN1
Fishman, IJ1
Benson, GS1
Carlton, CE1
Abozeid, M1
Juenemann, KP1
Luo, JA1
Lue, TF1
Yen, TS1
Tanagho, EA1
Larsen, EH1
Gasser, TC1
Bruskewitz, RC1

Reviews

1 review available for papaverine and Cirrhosis

ArticleYear
How safe is the treatment of impotence with intracavernous autoinjection?
    European urology, 1989, Volume: 16, Issue:3

    Topics: Drug Combinations; Erectile Dysfunction; Fibrosis; Humans; Male; Papaverine; Penile Erection; Penis;

1989

Trials

2 trials available for papaverine and Cirrhosis

ArticleYear
Clinical and sonographic assessment of the side effects of intracavernous injection of vasoactive substances.
    International journal of impotence research, 2004, Volume: 16, Issue:2

    Topics: Adult; Alprostadil; Drug Combinations; Erectile Dysfunction; Fibrosis; Humans; Injections, Intralesi

2004
Comparison of a mixture of papaverine, phentolamine and prostaglandin E1 with other intracavernous injections.
    European urology, 1994, Volume: 26, Issue:4

    Topics: Alprostadil; Drug Combinations; Erectile Dysfunction; Fibrosis; Follow-Up Studies; Humans; Injection

1994

Other Studies

14 other studies available for papaverine and Cirrhosis

ArticleYear
[Current role of intracavernous therapy in the treatment of erectile dysfunction].
    Archivos espanoles de urologia, 2002, Volume: 55, Issue:5

    Topics: Adrenergic alpha-Antagonists; Alprostadil; Clinical Trials as Topic; Drug Combinations; Erectile Dys

2002
Experience with intracavernosal tri-mixture for the management of neurogenic erectile dysfunction.
    Archives of physical medicine and rehabilitation, 1994, Volume: 75, Issue:3

    Topics: Adult; Alprostadil; Cost-Benefit Analysis; Drug Combinations; Drug Costs; Drug Monitoring; Drug Syne

1994
[Local complications of papaverine-induced erection: follow-up at 7 years].
    Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 1993, Volume: 65, Issue:3

    Topics: Adult; Aged; Erectile Dysfunction; Fibrosis; Follow-Up Studies; Humans; Hypertrophy; Male; Middle Ag

1993
Drop-out reasons and complications in self-injection therapy with a triple vasoactive drug mixture in sexual erectile dysfunction.
    International journal of impotence research, 1998, Volume: 10, Issue:1

    Topics: Adult; Aged; Alprostadil; Erectile Dysfunction; Fibrosis; Humans; Male; Middle Aged; Papaverine; Pen

1998
Short-term histopathologic effects of different intracavernosal agents on corpus cavernosum and antifibrotic activity of intracavernosal verapamil: an experimental study.
    Urology, 2001, Volume: 58, Issue:3

    Topics: Alprostadil; Animals; Calcium Channel Blockers; Chemical and Drug Induced Liver Injury; Disease Mode

2001
Histopathological change of corpora cavernosa after long-term intracavernous injection.
    European urology, 1991, Volume: 20, Issue:4

    Topics: Alprostadil; Animals; Dose-Response Relationship, Drug; Erectile Dysfunction; Fibrosis; Injections;

1991
Intracavernous drug delivery system: an alternative to intracavernous injection in the treatment of impotence?
    Urologia internationalis, 1990, Volume: 45, Issue:6

    Topics: Animals; Drug Combinations; Erectile Dysfunction; Fibrosis; Infusion Pumps, Implantable; Macaca fasc

1990
Intracavernous injection therapy: analysis of results and complications.
    The Journal of urology, 1990, Volume: 143, Issue:6

    Topics: Drug Therapy, Combination; Erectile Dysfunction; Fibrosis; Hematoma; Humans; Male; Middle Aged; Papa

1990
Erectile response to intracavernous injection of vasoactive drugs after penile prosthesis removal.
    Urology, 1990, Volume: 36, Issue:2

    Topics: Aged; Fibrosis; Humans; Injections; Male; Middle Aged; Papaverine; Penile Erection; Penile Prosthesi

1990
Fibrosis of tunica albuginea: complication of long-term intracavernous pharmacological self-injection.
    The Journal of urology, 1987, Volume: 138, Issue:2

    Topics: Aged; Drug Combinations; Erectile Dysfunction; Fibrosis; Humans; Male; Middle Aged; Papaverine; Peni

1987
Papaverine-induced fibrosis of the corpus cavernosum.
    The Journal of urology, 1989, Volume: 141, Issue:1

    Topics: Erectile Dysfunction; Fibrosis; Humans; Male; Middle Aged; Papaverine; Penile Erection; Penis; Self

1989
Development of fibrotic penile lesions secondary to the intracorporeal injection of vasoactive agents.
    The Journal of urology, 1988, Volume: 140, Issue:3

    Topics: Adult; Erectile Dysfunction; Fibrosis; Humans; Male; Middle Aged; Papaverine; Penile Erection; Penis

1988
Chronic papaverine treatment: the effect of repeated injections on the simian erectile response and penile tissue.
    The Journal of urology, 1987, Volume: 138, Issue:5

    Topics: Animals; Dose-Response Relationship, Drug; Fibrosis; Hypertrophy; Injections; Liver; Macaca fascicul

1987
Fibrosis of corpus cavernosum after intracavernous injection of phentolamine/papaverine.
    The Journal of urology, 1987, Volume: 137, Issue:2

    Topics: Adult; Drug Combinations; Erectile Dysfunction; Fibrosis; Humans; Injections; Male; Papaverine; Peni

1987