papaverine has been researched along with Chemical and Drug Induced Liver Injury in 17 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (58.82) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Tong, W | 1 |
| Pathy, MS | 1 |
| Reynolds, AJ | 1 |
| Niklasson, PM | 1 |
| Runehagen, A | 1 |
| Deséchalliers, JP | 1 |
| Lerebours, E | 1 |
| Tilly, H | 1 |
| Colin, R | 1 |
| Chousterman, M | 1 |
| Pulik, M | 1 |
| Perie, G | 1 |
| Brown, SL | 1 |
| Haas, CA | 1 |
| Koehler, M | 1 |
| Bodner, DR | 1 |
| Seftel, AD | 1 |
| Sahin, M | 1 |
| Başar, MM | 1 |
| Bozdoğan, O | 1 |
| Atan, A | 1 |
| Poupon, R | 1 |
| Longchal, C | 1 |
| Darnis, F | 1 |
| Snider, GB | 1 |
| Gogate, SA | 1 |
| Jobard, JM | 1 |
| Cleau, D | 1 |
| Vuitton, D | 1 |
| Wagschal, G | 1 |
| Daoudal, P | 1 |
| Prenat, T | 1 |
| Kiaer, HW | 1 |
| Olsen, S | 1 |
| Ronnov-Jessen, V | 2 |
| Driemen, PM | 1 |
| Tjernlund, A | 1 |
| Zimmerman, HJ | 1 |
1 review available for papaverine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
1 trial available for papaverine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Papaverine and hepatotoxicity.
Topics: Aged; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Delayed-Action Preparations; | 1980 |
15 other studies available for papaverine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
[Acute liver damage after papaverine].
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Papaverine | 1982 |
[Chronic hepatitis as complication of cirrhosis, due to papaverine].
Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Cirrhosis; Papaverine | 1981 |
[Papaverine hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Papaverine | 1980 |
Hepatotoxicity related to intracavernous pharmacotherapy with papaverine.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Erectile Dysfunction; Follow-Up Studies; Humans | 1998 |
Short-term histopathologic effects of different intracavernosal agents on corpus cavernosum and antifibrotic activity of intracavernosal verapamil: an experimental study.
Topics: Alprostadil; Animals; Calcium Channel Blockers; Chemical and Drug Induced Liver Injury; Disease Mode | 2001 |
[Chronic hepatitis after long-term administration of papaverine (author's transl)].
Topics: Chemical and Drug Induced Liver Injury; Drug Evaluation; Female; Humans; Hypertension; Middle Aged; | 1978 |
Clinical observations following papaverine therapy.
Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Male; Papaverin | 1978 |
[Hepatitis with rapid evolution to cirrhosis: role of papaverine].
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Humans; Li | 1990 |
Hepatotoxicity of papaverine.
Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Biopsy; Chemical and | 1974 |
Papaverine--hepatotoxic or not?
Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Brain Dama | 1973 |
Hepatotoxicity due to treatment with papaverine. Report of four cases.
Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Biopsy; Bo | 1969 |
Papaverine revisited as a hepatotoxin.
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Eosinophils; Humans; Jaundice; Liver; | 1969 |