papaverine has been researched along with Cell Transformation, Neoplastic in 3 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, however, changes in intracellular cyclic AMP level in several lines of cultured cells (normal 3T3 and SV40 and polyomavirus-transformed 3T3 cells; 3T6, C6 GLIOMA, MOUSE L, and Novikoff rat hepatoma cells) by treatment with papaverine, prostaglandine E1 or isoproterenol did not correlate with the inhibition of the uridine, hypoxanthine or deoxyglucose transport rates by these chemicals." | 3.65 | Cyclic AMP, membrane transport and cell division. I. Effects of various chemicals on cyclic AMP levels and rate of transport of neucleosides, hypoxanthine and deoxyglucose in several lines of cultured cells. ( Plagemann, PG; Sheppard, JR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alpers, DH | 1 |
| Philpott, G | 1 |
| Grimme, NL | 1 |
| Margolis, DM | 1 |
| Sheppard, JR | 1 |
| Plagemann, PG | 1 |
| Mott, DM | 1 |
| Fabisch, PH | 1 |
| Sorof, S | 1 |
3 other studies available for papaverine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Control of thymidine incorporation in mucosal explants from patients with chronic ulcerative colitis.
Topics: Cell Transformation, Neoplastic; Colitis, Ulcerative; Colon; Colonic Neoplasms; Cyclic AMP; DNA; Hum | 1980 |
Cyclic AMP, membrane transport and cell division. I. Effects of various chemicals on cyclic AMP levels and rate of transport of neucleosides, hypoxanthine and deoxyglucose in several lines of cultured cells.
Topics: Animals; Biological Transport, Active; Bucladesine; Carcinoma, Hepatocellular; Cell Division; Cell L | 1975 |
Cyclic AMP phosphodiesterase inhibitors depress production of plasminogen activator by Chinese hamster ovary cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cell Line; Cell Transformation, Neoplastic; Ethanol; Papaverine | 1976 |