Page last updated: 2024-11-02

papaverine and Cardiomegaly

papaverine has been researched along with Cardiomegaly in 9 studies

Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.

Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Research Excerpts

ExcerptRelevanceReference
"To examine the role played by angiotensin II (AII) in the development of prehypertensive vascular hypertrophy in the spontaneously hypertensive rat (SHR) and to determine whether normalization of prehypertensive vascular hypertrophy attenuates the development of hypertension."3.69Role of angiotensin II in early cardiovascular growth and vascular amplifier development in spontaneously hypertensive rats. ( Black, MJ; Bobik, A; Kanellakis, P, 1997)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19907 (77.78)18.7374
1990's2 (22.22)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
HEIMANN, W1
WILBRANDT, W1
HANNA, C1
ESPLUGUES, J1
BRUGGER, A1
HUESO, E1
SOTO, L1
Black, MJ1
Kanellakis, P1
Bobik, A1
McNamara, RF1
Schmid, PG2
Schmidt, JA1
Lund, DD1
Bhatnagar, RK1
Mayer, HE1
Mark, AL1
Heistad, DD1
Abboud, FM1
Antony, I1
Nitenberg, A1
Foult, JM1
Severin, SE1
Zoli, I1
Baroncini, S1
Cornia, GL1
Donato, S1
Minore, G1
Pigini, G1
Pretolani, E1

Other Studies

9 other studies available for papaverine and Cardiomegaly

ArticleYear
[Studies on coronary-dilatating effects on Langendorff's preparation and its interpretation on the basis of competitive antagonism].
    Helvetica physiologica et pharmacologica acta, 1954, Volume: 12, Issue:3

    Topics: Caffeine; Cardiomegaly; Heart; Humans; Khellin; Papaverine; Theophylline

1954
Papaverine analogs. VII. Studies on the time of onset of coronary dilator action.
    Archives internationales de pharmacodynamie et de therapie, 1959, Mar-01, Volume: 119, Issue:1-2

    Topics: Cardiomegaly; Coronary Vessels; Heart; Humans; Papaverine

1959
[INVERSION OF THE CORONARY DILATOR EFFECT OF SOME DRUGS BY ERGOTAMINE TARTRATE].
    Revista espanola de fisiologia, 1963, Volume: 19

    Topics: Animals; Blood Circulation; Cardiomegaly; Coronary Vessels; Dipyridamole; Dogs; Ergotamine; Papaveri

1963
Role of angiotensin II in early cardiovascular growth and vascular amplifier development in spontaneously hypertensive rats.
    Journal of hypertension, 1997, Volume: 15, Issue:9

    Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Antihypertensiv

1997
Humoral regulation of vascular resistance after 30 days of pulmonary artery constriction.
    The American journal of physiology, 1979, Volume: 236, Issue:6

    Topics: Angiotensin II; Animals; Cardiomegaly; Catecholamines; Dopamine; Epinephrine; Guinea Pigs; Heart Fai

1979
Differences in the regulation of vascular resistance in guinea pigs with right and left heart failure.
    Circulation research, 1977, Volume: 41, Issue:1

    Topics: Angiotensin II; Animals; Aorta; Arterial Occlusive Diseases; Blood Gas Analysis; Cardiomegaly; Elect

1977
[Coronary reserve in treated hypertension with persistent left ventricular hypertrophy].
    Archives des maladies du coeur et des vaisseaux, 1991, Volume: 84, Issue:8

    Topics: Cardiomegaly; Coronary Circulation; Coronary Disease; Hemodynamics; Humans; Hypertension; Middle Age

1991
[Basic directions in the study of the biochemistry of the myocardium].
    Kardiologiia, 1967, Volume: 7, Issue:11

    Topics: Adaptation, Physiological; Animals; Camphor; Cardiac Glycosides; Cardiomegaly; Cardiovascular Diseas

1967
[Therapeutic possibilities in coronary disease].
    Minerva medica, 1973, Nov-24, Volume: 64, Issue:84

    Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Arteriosclerosis; Cardiomegaly; Coronary Disease

1973
chemdatabank.com