papaverine has been researched along with Cardiac Failure in 18 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We clarified the optimal measuring procedure for FFR for SFA lesions and investigated the necessary dose of papaverine for inducing maximal hyperemia in SFA lesions." | 3.83 | Measuring Procedure and Maximal Hyperemia in the Assessment of Fractional Flow Reserve for Superficial Femoral Artery Disease. ( Araki, M; Hirano, K; Ishimori, H; Ito, Y; Kobayashi, N; Muramatsu, T; Nakano, M; Sakai, T; Tsukahara, R; Yamawaki, M, 2016) |
| "The authors realized a retrospective clinical-statistical study about 121 cases of acute myocardial infarction (AMI), treated in the Department of general medicine with a pharmacological association of Lysine acetylsalicylate--Erythrityl tetranitrate--Papaverine hydrochloride, with the purpose of obtaining a vasodilatation on coronary arteries and a platelet antiaggregation, in the light of the new etiopathogenetic views about the prolonged coronary spasm and the platelet aggregation, in some cases of myocardial infarction with or without thrombosis." | 3.66 | [Clinical and statistical study of 121 cases of acute myocardial infarct from 1976 to 1981 (month of April). Critical review]. ( Carile, L; Di Falco, C; Laquaglia, GA; Marchionni, F; Martone, P, 1982) |
| "Milrinone (Win 47203) is a dipyridine related to amrinone, which is about 20-50 times as effective as amrinone when assayed on cardiac contractility." | 1.27 | The search for a digitalis substitute II milrinone (Win 47203). Its action on the heart-lung preparation of the dog. ( Farah, A; Kabela, E; Mendez, R; Pastelin, G, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (77.78) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kobayashi, N | 1 |
| Hirano, K | 1 |
| Nakano, M | 1 |
| Ito, Y | 1 |
| Sakai, T | 1 |
| Ishimori, H | 1 |
| Yamawaki, M | 1 |
| Araki, M | 1 |
| Tsukahara, R | 1 |
| Muramatsu, T | 1 |
| MAZZONE, O | 1 |
| BLASI, A | 1 |
| STRANO, A | 1 |
| KOBAYASHI, T | 1 |
| TAKEUCHI, M | 1 |
| Wimmer, H | 1 |
| Spesshardt, K | 1 |
| Chekman, IS | 1 |
| Kazak, LI | 1 |
| Denisiuk, VI | 1 |
| Pastelin, G | 1 |
| Mendez, R | 1 |
| Kabela, E | 1 |
| Farah, A | 1 |
| Carile, L | 1 |
| Laquaglia, GA | 1 |
| Martone, P | 1 |
| Marchionni, F | 1 |
| Di Falco, C | 1 |
| Leshchinskiĭ, LA | 1 |
| Pimenov, LT | 1 |
| Trusov, VV | 1 |
| Grassi, G | 1 |
| Giannattasio, C | 1 |
| Failla, M | 1 |
| Pesenti, A | 1 |
| Peretti, G | 1 |
| Marinoni, E | 1 |
| Fraschini, N | 1 |
| Vailati, S | 1 |
| Mancia, G | 1 |
| Lindsay, DC | 1 |
| Holdright, DR | 1 |
| Clarke, D | 1 |
| Anand, IS | 1 |
| Poole-Wilson, PA | 1 |
| Collins, P | 1 |
| Suehiro, K | 1 |
| Shimizu, J | 1 |
| Yi, GH | 1 |
| Gu, A | 1 |
| Wang, J | 1 |
| Keren, G | 1 |
| Burkhoff, D | 1 |
| McNamara, RF | 1 |
| Schmid, PG | 2 |
| Schmidt, JA | 1 |
| Lund, DD | 1 |
| Bhatnagar, RK | 1 |
| Mayer, HE | 1 |
| Mark, AL | 1 |
| Heistad, DD | 1 |
| Abboud, FM | 1 |
| Witty, RT | 1 |
| Davis, JO | 1 |
| Shade, RE | 1 |
| Johnson, JA | 1 |
| Prewitt, RL | 1 |
| Giertz, H | 1 |
| Hahn, F | 1 |
| Rowe, GG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System[NCT03109795] | Phase 4 | 30 participants (Actual) | Interventional | 2017-04-10 | Terminated (stopped due to Funding ended) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for papaverine and Cardiac Failure
| Article | Year |
|---|---|
[Mechanisms of the therapeutic action of vasodilator agents in cardiac insufficiency (review of the literature)].
Topics: Adrenergic alpha-Antagonists; Animals; Coronary Disease; Dogs; Heart Failure; Humans; Muscle Relaxan | 1981 |
Responses of the coronary circulation to physiologic changes and pharmacologic agents.
Topics: Angina Pectoris; Animals; Atropine; Blood Pressure; Cardiac Output; Coronary Circulation; Dogs; Epin | 1974 |
16 other studies available for papaverine and Cardiac Failure
| Article | Year |
|---|---|
Measuring Procedure and Maximal Hyperemia in the Assessment of Fractional Flow Reserve for Superficial Femoral Artery Disease.
Topics: Aged; Cardiology; Coronary Stenosis; Endovascular Procedures; Female; Femoral Artery; Heart Failure; | 2016 |
[Research on the capillaroscopic picture in subjects with manifestations of cardio-respiratory insufficiency. Action of papaverine].
Topics: Capillaries; Cardiovascular System; Heart Failure; Humans; Microscopic Angioscopy; Papaverine; Respi | 1963 |
[THE THERAPEUTIC PRESCRIPTION IN CIRCULATORY INSUFFICIENCY].
Topics: Cardiac Glycosides; Central Nervous System Stimulants; Diet; Diet Therapy; Diuretics; Heart Failure; | 1963 |
[REHABILITATION IN HEART DISEASE].
Topics: Acenocoumarol; Dipyridamole; Electrocardiography; Geriatrics; Heart Defects, Congenital; Heart Disea | 1963 |
[The treatment of heart diseases from various causes with the combination preparation Spasmo-Guttacor].
Topics: Coronary Disease; Heart Failure; Humans; Papaverine; Phenobarbital; Plants, Medicinal; Quinidine | 1966 |
[Effect of antibradykinin preparations and nicotinic acid on the microcirculation and blood oxygen balance of ischemic heart disease patients in the initial stage of heart failure].
Topics: Adult; Aged; Bradykinin; Chromonar; Coronary Disease; Diphenhydramine; Dipyrone; Drug Therapy, Combi | 1983 |
The search for a digitalis substitute II milrinone (Win 47203). Its action on the heart-lung preparation of the dog.
Topics: Animals; Cardiotonic Agents; Dinitrophenols; Dogs; Heart; Heart Failure; Milrinone; Nifedipine; Papa | 1983 |
[Clinical and statistical study of 121 cases of acute myocardial infarct from 1976 to 1981 (month of April). Critical review].
Topics: Adult; Aged; Aspirin; Coronary Vessels; Erythrityl Tetranitrate; Female; Heart Failure; Humans; Lysi | 1982 |
[Changes in renal hemodynamics and renal function in patients with cardiac insufficiency treated with vasodilators].
Topics: Bencyclane; Dipyridamole; Heart Failure; Humans; Kidney; Papaverine; Renal Circulation; Vasodilator | 1981 |
Sympathetic modulation of radial artery compliance in congestive heart failure.
Topics: Adult; Blood Pressure; Compliance; Heart Failure; Humans; Hypertension; Papaverine; Phenylephrine; R | 1995 |
Endothelial control of lower limb blood flow in chronic heart failure.
Topics: Acetylcholine; Female; Heart Failure; Humans; Leg; Male; Middle Aged; Muscle, Skeletal; Nitric Oxide | 1996 |
Selective renal vasodilation and active renal artery perfusion improve renal function in dogs with acute heart failure.
Topics: Acute Disease; Animals; Diuretics; Dogs; Drug Synergism; Furosemide; Heart Failure; Injections; Kidn | 2001 |
Humoral regulation of vascular resistance after 30 days of pulmonary artery constriction.
Topics: Angiotensin II; Animals; Cardiomegaly; Catecholamines; Dopamine; Epinephrine; Guinea Pigs; Heart Fai | 1979 |
Differences in the regulation of vascular resistance in guinea pigs with right and left heart failure.
Topics: Angiotensin II; Animals; Aorta; Arterial Occlusive Diseases; Blood Gas Analysis; Cardiomegaly; Elect | 1977 |
Mechanisms regulating renin release in dogs with thoracic caval constriction.
Topics: Angiotensin II; Animals; Ascites; Blood Pressure; Constriction; Creatinine; Disease Models, Animal; | 1972 |
[On the effect of mepyramine and papaverine on guinea pig anaphylactic shock, with special attention to protracted shock].
Topics: Anaphylaxis; Animals; Guinea Pigs; Heart; Heart Failure; Histamine H1 Antagonists; Lung; Ovalbumin; | 1967 |