papaverine has been researched along with Brain Neoplasms in 18 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The concentration of methotrexate (MTX) in tumor was measured in 18 patients with cerebral glioma, and 155 patients with malignant glioma were treated by intracarotid infusion of papaverine and Bis-chloronitrosourea (BCNU)." | 9.08 | Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma. ( Kong, L; Wang, H; Xue, H; Zhou, H, 1998) |
| "Papaverine is a potential anticancer drug in GBM treatment." | 5.51 | Anticancer Non-narcotic Opium Alkaloid Papaverine Suppresses Human Glioblastoma Cell Growth. ( Akasaki, Y; Ichimura, K; Inada, M; Sato, A; Shindo, M; Tanuma, SI; Yamamoto, Y, 2019) |
| "The concentration of methotrexate (MTX) in tumor was measured in 18 patients with cerebral glioma, and 155 patients with malignant glioma were treated by intracarotid infusion of papaverine and Bis-chloronitrosourea (BCNU)." | 5.08 | Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma. ( Kong, L; Wang, H; Xue, H; Zhou, H, 1998) |
| "Papaverine is a potential anticancer drug in GBM treatment." | 1.51 | Anticancer Non-narcotic Opium Alkaloid Papaverine Suppresses Human Glioblastoma Cell Growth. ( Akasaki, Y; Ichimura, K; Inada, M; Sato, A; Shindo, M; Tanuma, SI; Yamamoto, Y, 2019) |
| "Rat C 6 glioma is known to possess a beta-adrenergic receptor with which intracellular cyclic adenosine monophosphate (cAMP) levels are altered to control cell growth in vitro." | 1.27 | [Treatment of rat glioma with a beta-adrenergic agonist and a phosphodiesterase inhibitor in vivo]. ( Egawa, T; Hayakawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (72.22) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Inada, M | 1 |
| Sato, A | 1 |
| Shindo, M | 1 |
| Yamamoto, Y | 1 |
| Akasaki, Y | 1 |
| Ichimura, K | 1 |
| Tanuma, SI | 1 |
| Yang, ZH | 1 |
| Liu, LB | 2 |
| Zhao, LN | 1 |
| Liu, YH | 3 |
| Xue, YX | 3 |
| Wang, JE | 1 |
| Xia, CY | 1 |
| Zhang, Z | 1 |
| Wang, ZH | 1 |
| DELGUERCIO, R | 1 |
| Chelmicka-Schorr, E | 1 |
| Arnason, BG | 1 |
| Holshouser, SJ | 1 |
| Xue, H | 1 |
| Wang, H | 1 |
| Kong, L | 1 |
| Zhou, H | 1 |
| Perkins, JP | 1 |
| Moore, MM | 1 |
| Kalisker, A | 1 |
| Su, YF | 1 |
| Yoshida, T | 1 |
| Shimizu, K | 1 |
| Ushio, Y | 1 |
| Hayakawa, T | 1 |
| Mogami, H | 1 |
| Sakamoto, Y | 1 |
| Egawa, T | 1 |
| Wüllenweber, R | 1 |
| Rösler, H | 1 |
| Huber, P | 1 |
| Kinser, J | 1 |
| Stalder, A | 1 |
| Gibson, DA | 1 |
| Reichlin, S | 1 |
| Vernadakis, A | 1 |
| Heiss, WD | 1 |
| Prosenz, P | 1 |
| Bruck, J | 1 |
| Hadjiev, D | 1 |
| von Albert, HH | 1 |
| Marguth, F | 1 |
| Hemmer, R | 1 |
| Vidovszky, T | 1 |
| Barcia-Goyanes, JJ | 1 |
| Barcia-Salorio, JL | 1 |
2 reviews available for papaverine and Brain Neoplasms
| Article | Year |
|---|---|
Regulation of cyclic AMP content in normal and malignant brain cells.
Topics: Adenosine; Animals; Brain; Brain Neoplasms; Cerebral Cortex; Cyclic AMP; Hydroxydopamines; Isoproter | 1975 |
Impedance methods for investigation of cerebral circulation.
Topics: Adenosine Triphosphate; Animals; Brain Neoplasms; Carbon Dioxide; Carotid Artery Diseases; Cerebral | 1972 |
2 trials available for papaverine and Brain Neoplasms
| Article | Year |
|---|---|
Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Blood-Brain Barrier; Brain Neoplasms; Caro | 1998 |
Effect of proxazole on total and regional cerebral blood flow.
Topics: Adolescent; Adult; Aged; Blood Pressure; Brain; Brain Injuries; Brain Neoplasms; Cerebrovascular Cir | 1973 |
14 other studies available for papaverine and Brain Neoplasms
| Article | Year |
|---|---|
Anticancer Non-narcotic Opium Alkaloid Papaverine Suppresses Human Glioblastoma Cell Growth.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cel | 2019 |
Permeability of the blood-tumor barrier is enhanced by combining vascular endothelial growth factor with papaverine.
Topics: Animals; Blotting, Western; Brain Neoplasms; Capillary Permeability; Cell Line, Tumor; Enzyme-Linked | 2014 |
Effects of combining low frequency ultrasound irradiation with papaverine on the permeability of the blood-tumor barrier.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Brain Neoplasms; Capillary Permeability; Claudin-5; | 2011 |
The modulation of protein kinase A and heat shock protein 70 is involved in the reversible increase of blood-brain tumor barrier permeability induced by papaverine.
Topics: Actins; Analysis of Variance; Animals; Blood-Brain Barrier; Brain Neoplasms; Claudin-5; Cyclic AMP-D | 2010 |
[CONSIDERATIONS ON CEREBRAL HEMODYNAMICS STUDIED BY COMPARATIVE RHEOGRAPHIC AND ELECTROENCEPHALOGRAPHIC EXAMINATIONS. II. ACTION OF PAPAVERINE IN SUBJECTS WITH CEREBRAL VASCULAR DISORDERS].
Topics: Brain Neoplasms; Cerebral Hemorrhage; Cerebrovascular Circulation; Cerebrovascular Disorders; Electr | 1963 |
C-6 glioma growth in rats: suppression with a beta-adrenergic agonist and a phosphodiesterase inhibitor.
Topics: Animals; Brain Neoplasms; Cell Line; Cyclic AMP; Drug Therapy, Combination; Glioma; Humans; Isoprote | 1980 |
[Treatment of rat glioma with a beta-adrenergic agonist and a phosphodiesterase inhibitor in vivo].
Topics: Animals; Brain Neoplasms; Cyclic AMP; Glioma; Injections, Spinal; Isoproterenol; Meningeal Neoplasms | 1987 |
"Intracerebral steal" in man recorded by a heat clearance technique.
Topics: Aminophylline; Animals; Astrocytoma; Blood Pressure; Brain Edema; Brain Injuries; Brain Neoplasms; C | 1968 |
Functional radioangiographic studies of cerebral vascular haemodynamics (preliminary report).
Topics: Blood Pressure; Brain Neoplasms; Cerebral Arteries; Cerebrovascular Circulation; Glioblastoma; Heman | 1972 |
(3H)Uridine uptake and incorporation into RNA in the C-6 glial cells following dibutyryl cyclic AMP treatment.
Topics: Animals; Astrocytoma; Brain Neoplasms; Bucladesine; Cell Line; DNA, Neoplasm; Models, Biological; Ne | 1974 |
[Therapy of headaches, including migraine].
Topics: Analgesics; Brain Injuries; Brain Neoplasms; Drug Synergism; Ergoloid Mesylates; Eye Diseases; Heada | 1969 |
[Therapy of space-occupying intracranial processes (brain edema, brain tumor) and low cerebrospinal fluid pressure].
Topics: Adrenal Cortex Hormones; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Cerebrospinal Fluid Shun | 1969 |
[Comparative study on the vasodilatory activities of bencyclane and papaverine by cerebral angiography].
Topics: Adult; Aged; Brain Neoplasms; Cerebral Angiography; Cycloheptanes; Diagnosis, Differential; Female; | 1970 |
Pallencephalography.
Topics: Aminopyrine; Brain Neoplasms; Carbon Dioxide; Cerebrovascular Circulation; Cerebrovascular Disorders | 1968 |