papaverine has been researched along with Brain Ischemia in 27 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mechanism of the papaverine (PV) for the treatment of cerebral ischemia remains unclear." | 7.96 | Pluripotent anti-inflammatory immunomodulatory effects of papaverine against cerebral ischemic-reperfusion injury. ( Gu, H; Guan, S; Liu, J; Liu, Q; Qi, YF; Wang, Z; Wei, PL; Zhang, YY, 2020) |
| "This small study suggests that intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after mechanical thrombectomy in acute ischemic stroke is effective and safe." | 7.81 | Intra-arterial administration of papaverine during mechanical thrombectomy for acute ischemic stroke. ( Al Shameri, RA; Baltsavias, G; Luft, A; Valavanis, A; Yella, S, 2015) |
| "Selective intraarterial infusion of papaverine is used in the treatment of symptomatic cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage (SAH)." | 7.71 | Reversal of radiographically impending stroke with multiple intraarterial papaverine infusions in severe diffuse cerebral vasospasm induced by subarachnoid hemorrhage. ( Couldwell, WT; Liu, JK; Oestreich, HM; Tenner, MS, 2001) |
| " In the present study, the effects of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) on neurological signs, such as ischemic seizures, lactate and ATP contents of the cerebral cortex, and local cerebral blood flow, were assessed in stroke-prone spontaneously hypertensive rats (SHRSP) with experimentally induced cerebral ischemia." | 7.67 | Effects of idebenone on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia. ( Kakihana, M; Nagaoka, A; Shibota, M; Suno, M, 1989) |
| "r-CBF was reduced by 40% during cerebral ischemia." | 5.26 | [Effects of dilazep on cerebral blood flow under normal conditions and recirculation impairment after cerebral ischemia (author's transl)]. ( Kawada, M; Kondo, S; Sano, N, 1981) |
| "A preliminary analysis of the effect of long-term therapy with oral papaverine has been made in 11 patients with chronic cerebral ischemia due to cerebral arteriosclerosis." | 5.04 | Double-blind trial of oral papaverine in chronic cerebrovascular ischemia. ( Meyer, JS; Shaw, TG, 1978) |
| "The mechanism of the papaverine (PV) for the treatment of cerebral ischemia remains unclear." | 3.96 | Pluripotent anti-inflammatory immunomodulatory effects of papaverine against cerebral ischemic-reperfusion injury. ( Gu, H; Guan, S; Liu, J; Liu, Q; Qi, YF; Wang, Z; Wei, PL; Zhang, YY, 2020) |
| "This small study suggests that intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after mechanical thrombectomy in acute ischemic stroke is effective and safe." | 3.81 | Intra-arterial administration of papaverine during mechanical thrombectomy for acute ischemic stroke. ( Al Shameri, RA; Baltsavias, G; Luft, A; Valavanis, A; Yella, S, 2015) |
| "Selective intraarterial infusion of papaverine is used in the treatment of symptomatic cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage (SAH)." | 3.71 | Reversal of radiographically impending stroke with multiple intraarterial papaverine infusions in severe diffuse cerebral vasospasm induced by subarachnoid hemorrhage. ( Couldwell, WT; Liu, JK; Oestreich, HM; Tenner, MS, 2001) |
| " In the present study, the effects of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) on neurological signs, such as ischemic seizures, lactate and ATP contents of the cerebral cortex, and local cerebral blood flow, were assessed in stroke-prone spontaneously hypertensive rats (SHRSP) with experimentally induced cerebral ischemia." | 3.67 | Effects of idebenone on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia. ( Kakihana, M; Nagaoka, A; Shibota, M; Suno, M, 1989) |
| "Two patients showed signs of elevated intracranial pressure after the procedures and also had ASrO2 readings exceeding 15%; measures to lower arterial hypertension reduced SrO2 in these patients." | 2.72 | [Behaviour of near-infrared cerebral oximetry readings during percutaneous carotid angioplasty]. ( Carrero, E; Fàbregas, N; Fontanals, J; Rodríguez, L; Salvador, L; Valero, R, 2006) |
| "For survivors of aneurysmal subarachnoid hemorrhage, cerebral vasospasm significantly contributes to its morbidity and mortality by causing delayed ischemic neurological deficit." | 2.40 | Neuroradiologic diagnosis and treatment of vasospasm. ( Elliott, JP; Eskridge, JM; Song, JK, 1997) |
| "The grave course of epilepsy is associated with a decrease of the LCBF on the side of the focus." | 1.28 | [Changes in cerebral blood circulation and their correction in the interparoxysmal period of epilepsy]. ( Shestakov, VV; Shutov, AA, 1990) |
| "r-CBF was reduced by 40% during cerebral ischemia." | 1.26 | [Effects of dilazep on cerebral blood flow under normal conditions and recirculation impairment after cerebral ischemia (author's transl)]. ( Kawada, M; Kondo, S; Sano, N, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (66.67) | 18.7374 |
| 1990's | 4 (14.81) | 18.2507 |
| 2000's | 2 (7.41) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Guan, S | 1 |
| Liu, Q | 1 |
| Gu, H | 1 |
| Zhang, YY | 1 |
| Wei, PL | 1 |
| Qi, YF | 1 |
| Liu, J | 1 |
| Wang, Z | 1 |
| Baltsavias, G | 1 |
| Yella, S | 1 |
| Al Shameri, RA | 1 |
| Luft, A | 1 |
| Valavanis, A | 1 |
| Kerz, T | 1 |
| Boor, S | 1 |
| Beyer, C | 1 |
| Welschehold, S | 1 |
| Schuessler, A | 1 |
| Oertel, J | 1 |
| FAZEKAS, JF | 2 |
| ALMAN, RW | 2 |
| TICKTIN, HE | 1 |
| EHRMANTRAUT, WR | 1 |
| SAVARESE, CJ | 1 |
| MISKO, JC | 1 |
| Rodríguez, L | 1 |
| Salvador, L | 1 |
| Valero, R | 1 |
| Carrero, E | 1 |
| Fontanals, J | 1 |
| Fàbregas, N | 1 |
| Carter, LP | 1 |
| Erspamer, R | 1 |
| Date, H | 1 |
| Hossmann, KA | 1 |
| Gygax, P | 1 |
| Wiernsperger, N | 1 |
| Niimi, T | 1 |
| Sawada, T | 1 |
| Kondo, S | 1 |
| Kawada, M | 1 |
| Sano, N | 1 |
| Nico, F | 1 |
| Guercini, F | 1 |
| Biagi, A | 1 |
| Fanfoni, S | 1 |
| Zhang, F | 1 |
| White, JG | 1 |
| Iadecola, C | 1 |
| Song, JK | 1 |
| Elliott, JP | 1 |
| Eskridge, JM | 1 |
| Polin, RS | 1 |
| Hansen, CA | 1 |
| German, P | 1 |
| Chadduck, JB | 1 |
| Kassell, NF | 1 |
| Liu, JK | 1 |
| Tenner, MS | 1 |
| Oestreich, HM | 1 |
| Couldwell, WT | 1 |
| Takenaka, T | 1 |
| Handa, J | 1 |
| Shaw, TG | 1 |
| Meyer, JS | 1 |
| Shutov, AA | 2 |
| Pleshkova, NM | 1 |
| Shestakov, VV | 2 |
| Cacciatori, D | 1 |
| Villa, RF | 1 |
| Strada, P | 1 |
| Marzatico, F | 1 |
| Dagani, F | 1 |
| Nagaoka, A | 1 |
| Suno, M | 1 |
| Shibota, M | 1 |
| Kakihana, M | 1 |
| Vinichuk, SM | 1 |
| Kalishchuk, TN | 1 |
| Sutov, AA | 1 |
| Pleskova, NM | 1 |
| Simovic, TA | 1 |
| Galli, C | 1 |
| Petroni, A | 1 |
| Borghi, A | 1 |
2 reviews available for papaverine and Brain Ischemia
| Article | Year |
|---|---|
CURRENT THERAPEUTIC CONCEPTS OF CEREBRAL AND MYOCARDIAL VASCULAR DISEASE.
Topics: Acetazolamide; Anticoagulants; Brain Ischemia; Cerebrovascular Disorders; Coronary Disease; Histamin | 1964 |
Neuroradiologic diagnosis and treatment of vasospasm.
Topics: Angioplasty, Balloon; Brain Ischemia; Combined Modality Therapy; Decision Making; Humans; Injections | 1997 |
3 trials available for papaverine and Brain Ischemia
| Article | Year |
|---|---|
[Behaviour of near-infrared cerebral oximetry readings during percutaneous carotid angioplasty].
Topics: Aged; Angioplasty, Balloon; Blood Pressure; Brain Ischemia; Carotid Artery, Internal; Carotid Stenos | 2006 |
Intra-arterially administered papaverine for the treatment of symptomatic cerebral vasospasm.
Topics: Adult; Aged; Brain Ischemia; Female; Glasgow Coma Scale; Humans; Injections, Intra-Arterial; Ischemi | 1998 |
Double-blind trial of oral papaverine in chronic cerebrovascular ischemia.
Topics: Administration, Oral; Aged; Behavior; Brain; Brain Ischemia; Carbon Dioxide; Chronic Disease; Clinic | 1978 |
22 other studies available for papaverine and Brain Ischemia
| Article | Year |
|---|---|
Pluripotent anti-inflammatory immunomodulatory effects of papaverine against cerebral ischemic-reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cytokines; Disease Models, Animal; Gene Expressio | 2020 |
Intra-arterial administration of papaverine during mechanical thrombectomy for acute ischemic stroke.
Topics: Aged; Brain Ischemia; Combined Modality Therapy; Female; Fibrinolytic Agents; Humans; Infusions, Int | 2015 |
Effect of intraarterial papaverine or nimodipine on vessel diameter in patients with cerebral vasospasm after subarachnoid hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Brain Ischemia; Capillaries; Carotid Artery, I | 2012 |
THERAPEUTIC MODALITIES IN THE MANAGEMENT OF CEREBRAL VASCULAR INSUFFICIENCY.
Topics: Anticoagulants; Brain Ischemia; Cerebral Infarction; Cerebrovascular Disorders; Classification; Hist | 1963 |
SELECTIVE CEREBRAL HYPOTHERMIA: PHYSIOLOGY AND TECHNIC.
Topics: Blood; Brain; Brain Ischemia; Dogs; Electrocardiography; Hydrogen-Ion Concentration; Hypotension; Hy | 1965 |
Dynamic quantitative assessment of cortical blood flow.
Topics: Animals; Brain Ischemia; Cats; Cerebral Cortex; Cerebrovascular Circulation; Energy Metabolism; Epin | 1980 |
Effect of vasodilating drugs on intracortical and extracortical vascular resistance following middle cerebral artery occlusion in cats.
Topics: Animals; Blood Flow Velocity; Brain Ischemia; Calcium Channel Blockers; Cats; Cerebrovascular Circul | 1984 |
Hypotension induced changes in cerebral microflow and EEG and their pharmacological alterations.
Topics: Animals; Blood Pressure; Brain Ischemia; Cats; Cerebrovascular Circulation; Electroencephalography; | 1983 |
[Vasodilating agents in the management of ischemic cerebrovascular disorders].
Topics: Brain Ischemia; Cerebrovascular Disorders; Humans; Papaverine; Vasodilator Agents | 1982 |
[Effects of dilazep on cerebral blood flow under normal conditions and recirculation impairment after cerebral ischemia (author's transl)].
Topics: Animals; Azepines; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Cerebrovascular Dis | 1981 |
[Cerebral ischemic vasculopathy: clinical and thermographic study in patients treated with papaveroline].
Topics: Aged; Brain Ischemia; Female; Humans; Male; Nicergoline; Papaverine; Tetrahydropapaveroline; Vasodil | 1981 |
Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: evidence that nitric oxide is beneficial in the early stages of cerebral ischemia.
Topics: Animals; Arterial Occlusive Diseases; Brain; Brain Ischemia; Cerebral Arteries; Cerebral Infarction; | 1994 |
Reversal of radiographically impending stroke with multiple intraarterial papaverine infusions in severe diffuse cerebral vasospasm induced by subarachnoid hemorrhage.
Topics: Adult; Brain Ischemia; Female; Humans; Infusions, Intra-Arterial; Male; Papaverine; Stroke; Subarach | 2001 |
Cerebrovascular effects of YC-93, a new vasodilator, in dogs, monkeys and human patients.
Topics: Adolescent; Adult; Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Dogs; Femal | 1979 |
[Disorders of cerebral hemodynamics and their correction in epilepsy].
Topics: Brain Ischemia; Caffeine; Cerebrovascular Circulation; Epilepsy; Humans; Papaverine; Phenobarbital | 1979 |
[Experience with the combination of vincamine and papaverine in chronic brain syndrome].
Topics: Aged; Brain Ischemia; Cerebrovascular Disorders; Chronic Disease; Drug Therapy, Combination; Female; | 1979 |
Effect of (-)eburnamonine, papaverine and UDP-glucose on cerebral energy state during and after experimental hypoxia and ischaemia in beagle dog.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Brain; Brain Ischem | 1978 |
[Changes in cerebral blood circulation and their correction in the interparoxysmal period of epilepsy].
Topics: Adolescent; Adult; Brain Ischemia; Caffeine; Cerebrovascular Circulation; Drug Therapy, Combination; | 1990 |
Effects of idebenone on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia.
Topics: Animals; Benzoquinones; Brain; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; | 1989 |
[Effect of various spasmolytic agents on systemic and cerebral hemodynamics in patients with ischemic stroke].
Topics: Adult; Aged; Aminophylline; Bencyclane; Brain Ischemia; Cerebrovascular Circulation; Cycloheptanes; | 1986 |
[Radiocerebrocardiography for the study of central and cerebral circulation and the hemocirculatory effects of vasoactive agents in an ischemic insult].
Topics: Adult; Aged; Aminophylline; Brain Ischemia; Cerebrovascular Circulation; Hemodynamics; Humans; Iodin | 1986 |
Modification of brain vascular eicosanoids after pharmacological treatment and ischemia in the rat: drugs and brain vascular eicosanoids.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Brain Ischemia; Cerebral Cortex; Chromonar; Eicosanoic Acids; | 1985 |