papaverine has been researched along with Brain Injuries in 12 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Armstead, WM | 1 |
| Kiessling, JW | 1 |
| Riley, J | 1 |
| Cines, DB | 1 |
| Higazi, AA | 1 |
| Zhang, F | 1 |
| Sprague, SM | 1 |
| Farrokhi, F | 1 |
| Henry, MN | 1 |
| Son, MG | 1 |
| Vollmer, DG | 1 |
| SOMMER, H | 1 |
| FISCHER, EK | 1 |
| VERBEEK, CA | 1 |
| Vardiman, AB | 1 |
| Kopitnik, TA | 1 |
| Purdy, PD | 1 |
| Batjer, HH | 1 |
| Samson, DS | 1 |
| Kongstad, L | 1 |
| Grände, PO | 1 |
| Wüllenweber, R | 1 |
| Heiss, WD | 1 |
| Prosenz, P | 1 |
| Bruck, J | 1 |
| Borzeix, MG | 1 |
| Labos, M | 1 |
| Cahn, J | 1 |
| von Albert, HH | 1 |
| Marguth, F | 1 |
| Langanke, D | 1 |
| Keller, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Non Invasive and Non-Contact Dual-modal Imaging Of Tissue Oxygenation and Vascular Reactivity Dynamic Imaging Of Tissue Metabolism and Vascular Function.[NCT01573390] | 0 participants (Actual) | Observational | Withdrawn (stopped due to most of the study team left the institution prior to study initiation) | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for papaverine and Brain Injuries
| Article | Year |
|---|---|
Effect of proxazole on total and regional cerebral blood flow.
Topics: Adolescent; Adult; Aged; Blood Pressure; Brain; Brain Injuries; Brain Neoplasms; Cerebrovascular Cir | 1973 |
11 other studies available for papaverine and Brain Injuries
| Article | Year |
|---|---|
tPA contributes to impaired NMDA cerebrovasodilation after traumatic brain injury through activation of JNK MAPK.
Topics: Animals; Animals, Newborn; Anthracenes; Brain Injuries; Butadienes; Drug Interactions; Female; Imida | 2011 |
Reversal of attenuation of cerebrovascular reactivity to hypercapnia by a nitric oxide donor after controlled cortical impact in a rat model of traumatic brain injury.
Topics: Animals; Blood Pressure; Brain Injuries; Carbon Dioxide; Cerebrovascular Circulation; Cortical Sprea | 2002 |
[Studies on the use of a combined papaverine-quinine medication].
Topics: Brain; Brain Injuries; Humans; Meniere Disease; Papaverine; Quinine | 1958 |
[Causes and nyxanthan therapy of cerebral decompensation in brain injuries].
Topics: Barbiturates; Brain; Brain Injuries; Humans; Papaverine; Theophylline | 1958 |
[Personal experiences with the use of monotrean in the treatment of brain concussion and its sequelae].
Topics: Brain Concussion; Brain Injuries; Papaverine; Quinine | 1950 |
Treatment of traumatic arterial vasospasm with intraarterial papaverine infusion.
Topics: Brain; Brain Injuries; Carotid Artery, Internal; Cerebral Angiography; Humans; Infusions, Intra-Arte | 1995 |
The role of arterial and venous pressure for volume regulation of an organ enclosed in a rigid compartment with application to the injured brain.
Topics: Animals; Blood Pressure; Brain; Brain Injuries; Capillaries; Cats; Cerebrospinal Fluid Pressure; Cer | 1999 |
"Intracerebral steal" in man recorded by a heat clearance technique.
Topics: Aminophylline; Animals; Astrocytoma; Blood Pressure; Brain Edema; Brain Injuries; Brain Neoplasms; C | 1968 |
[Experimental model of brain edema for the study of drugs acting on blood flow and-or brain metabolism].
Topics: Animals; Arachnoid; Biological Assay; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Cere | 1972 |
[Therapy of headaches, including migraine].
Topics: Analgesics; Brain Injuries; Brain Neoplasms; Drug Synergism; Ergoloid Mesylates; Eye Diseases; Heada | 1969 |
[Effect of papaquine on the course of labor and puerperium in comparison with dolcontral and spasmonal].
Topics: Analgesics; Brain Injuries; Dystocia; Female; Humans; Infant Mortality; Infant, Newborn; Obstetric L | 1965 |