papaverine has been researched along with Benign Neoplasms, Brain in 18 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The concentration of methotrexate (MTX) in tumor was measured in 18 patients with cerebral glioma, and 155 patients with malignant glioma were treated by intracarotid infusion of papaverine and Bis-chloronitrosourea (BCNU)." | 9.08 | Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma. ( Kong, L; Wang, H; Xue, H; Zhou, H, 1998) |
| "Papaverine is a potential anticancer drug in GBM treatment." | 5.51 | Anticancer Non-narcotic Opium Alkaloid Papaverine Suppresses Human Glioblastoma Cell Growth. ( Akasaki, Y; Ichimura, K; Inada, M; Sato, A; Shindo, M; Tanuma, SI; Yamamoto, Y, 2019) |
| "The concentration of methotrexate (MTX) in tumor was measured in 18 patients with cerebral glioma, and 155 patients with malignant glioma were treated by intracarotid infusion of papaverine and Bis-chloronitrosourea (BCNU)." | 5.08 | Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma. ( Kong, L; Wang, H; Xue, H; Zhou, H, 1998) |
| "Papaverine is a potential anticancer drug in GBM treatment." | 1.51 | Anticancer Non-narcotic Opium Alkaloid Papaverine Suppresses Human Glioblastoma Cell Growth. ( Akasaki, Y; Ichimura, K; Inada, M; Sato, A; Shindo, M; Tanuma, SI; Yamamoto, Y, 2019) |
| "Rat C 6 glioma is known to possess a beta-adrenergic receptor with which intracellular cyclic adenosine monophosphate (cAMP) levels are altered to control cell growth in vitro." | 1.27 | [Treatment of rat glioma with a beta-adrenergic agonist and a phosphodiesterase inhibitor in vivo]. ( Egawa, T; Hayakawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (72.22) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Inada, M | 1 |
| Sato, A | 1 |
| Shindo, M | 1 |
| Yamamoto, Y | 1 |
| Akasaki, Y | 1 |
| Ichimura, K | 1 |
| Tanuma, SI | 1 |
| Yang, ZH | 1 |
| Liu, LB | 2 |
| Zhao, LN | 1 |
| Liu, YH | 3 |
| Xue, YX | 3 |
| Wang, JE | 1 |
| Xia, CY | 1 |
| Zhang, Z | 1 |
| Wang, ZH | 1 |
| DELGUERCIO, R | 1 |
| Chelmicka-Schorr, E | 1 |
| Arnason, BG | 1 |
| Holshouser, SJ | 1 |
| Xue, H | 1 |
| Wang, H | 1 |
| Kong, L | 1 |
| Zhou, H | 1 |
| Perkins, JP | 1 |
| Moore, MM | 1 |
| Kalisker, A | 1 |
| Su, YF | 1 |
| Yoshida, T | 1 |
| Shimizu, K | 1 |
| Ushio, Y | 1 |
| Hayakawa, T | 1 |
| Mogami, H | 1 |
| Sakamoto, Y | 1 |
| Egawa, T | 1 |
| Wüllenweber, R | 1 |
| Rösler, H | 1 |
| Huber, P | 1 |
| Kinser, J | 1 |
| Stalder, A | 1 |
| Gibson, DA | 1 |
| Reichlin, S | 1 |
| Vernadakis, A | 1 |
| Heiss, WD | 1 |
| Prosenz, P | 1 |
| Bruck, J | 1 |
| Hadjiev, D | 1 |
| von Albert, HH | 1 |
| Marguth, F | 1 |
| Hemmer, R | 1 |
| Vidovszky, T | 1 |
| Barcia-Goyanes, JJ | 1 |
| Barcia-Salorio, JL | 1 |
2 reviews available for papaverine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Regulation of cyclic AMP content in normal and malignant brain cells.
Topics: Adenosine; Animals; Brain; Brain Neoplasms; Cerebral Cortex; Cyclic AMP; Hydroxydopamines; Isoproter | 1975 |
Impedance methods for investigation of cerebral circulation.
Topics: Adenosine Triphosphate; Animals; Brain Neoplasms; Carbon Dioxide; Carotid Artery Diseases; Cerebral | 1972 |
2 trials available for papaverine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Blood-Brain Barrier; Brain Neoplasms; Caro | 1998 |
Effect of proxazole on total and regional cerebral blood flow.
Topics: Adolescent; Adult; Aged; Blood Pressure; Brain; Brain Injuries; Brain Neoplasms; Cerebrovascular Cir | 1973 |
14 other studies available for papaverine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Anticancer Non-narcotic Opium Alkaloid Papaverine Suppresses Human Glioblastoma Cell Growth.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cel | 2019 |
Permeability of the blood-tumor barrier is enhanced by combining vascular endothelial growth factor with papaverine.
Topics: Animals; Blotting, Western; Brain Neoplasms; Capillary Permeability; Cell Line, Tumor; Enzyme-Linked | 2014 |
Effects of combining low frequency ultrasound irradiation with papaverine on the permeability of the blood-tumor barrier.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Brain Neoplasms; Capillary Permeability; Claudin-5; | 2011 |
The modulation of protein kinase A and heat shock protein 70 is involved in the reversible increase of blood-brain tumor barrier permeability induced by papaverine.
Topics: Actins; Analysis of Variance; Animals; Blood-Brain Barrier; Brain Neoplasms; Claudin-5; Cyclic AMP-D | 2010 |
[CONSIDERATIONS ON CEREBRAL HEMODYNAMICS STUDIED BY COMPARATIVE RHEOGRAPHIC AND ELECTROENCEPHALOGRAPHIC EXAMINATIONS. II. ACTION OF PAPAVERINE IN SUBJECTS WITH CEREBRAL VASCULAR DISORDERS].
Topics: Brain Neoplasms; Cerebral Hemorrhage; Cerebrovascular Circulation; Cerebrovascular Disorders; Electr | 1963 |
C-6 glioma growth in rats: suppression with a beta-adrenergic agonist and a phosphodiesterase inhibitor.
Topics: Animals; Brain Neoplasms; Cell Line; Cyclic AMP; Drug Therapy, Combination; Glioma; Humans; Isoprote | 1980 |
[Treatment of rat glioma with a beta-adrenergic agonist and a phosphodiesterase inhibitor in vivo].
Topics: Animals; Brain Neoplasms; Cyclic AMP; Glioma; Injections, Spinal; Isoproterenol; Meningeal Neoplasms | 1987 |
"Intracerebral steal" in man recorded by a heat clearance technique.
Topics: Aminophylline; Animals; Astrocytoma; Blood Pressure; Brain Edema; Brain Injuries; Brain Neoplasms; C | 1968 |
Functional radioangiographic studies of cerebral vascular haemodynamics (preliminary report).
Topics: Blood Pressure; Brain Neoplasms; Cerebral Arteries; Cerebrovascular Circulation; Glioblastoma; Heman | 1972 |
(3H)Uridine uptake and incorporation into RNA in the C-6 glial cells following dibutyryl cyclic AMP treatment.
Topics: Animals; Astrocytoma; Brain Neoplasms; Bucladesine; Cell Line; DNA, Neoplasm; Models, Biological; Ne | 1974 |
[Therapy of headaches, including migraine].
Topics: Analgesics; Brain Injuries; Brain Neoplasms; Drug Synergism; Ergoloid Mesylates; Eye Diseases; Heada | 1969 |
[Therapy of space-occupying intracranial processes (brain edema, brain tumor) and low cerebrospinal fluid pressure].
Topics: Adrenal Cortex Hormones; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Cerebrospinal Fluid Shun | 1969 |
[Comparative study on the vasodilatory activities of bencyclane and papaverine by cerebral angiography].
Topics: Adult; Aged; Brain Neoplasms; Cerebral Angiography; Cycloheptanes; Diagnosis, Differential; Female; | 1970 |
Pallencephalography.
Topics: Aminopyrine; Brain Neoplasms; Carbon Dioxide; Cerebrovascular Circulation; Cerebrovascular Disorders | 1968 |