papaverine has been researched along with Autosomal Dominant Juvenile Parkinson Disease in 1 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Papaverine (PAP) was utilized as a selective inhibitor of PDE10." | 1.51 | The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson's disease mouse models. ( Choi, YH; Kang, JL; Kim, DY; Kim, HS; Lee, YY; Leem, YH; Park, EM; Park, JE; Park, JS, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, YY | 1 |
| Park, JS | 1 |
| Leem, YH | 1 |
| Park, JE | 1 |
| Kim, DY | 1 |
| Choi, YH | 1 |
| Park, EM | 1 |
| Kang, JL | 1 |
| Kim, HS | 1 |
1 other study available for papaverine and Autosomal Dominant Juvenile Parkinson Disease
| Article | Year |
|---|---|
The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson's disease mouse models.
Topics: Animals; Anti-Inflammatory Agents; Cell Line, Transformed; Cyclic AMP-Dependent Protein Kinases; Lip | 2019 |