papaverine has been researched along with Arteriosclerosis in 46 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of age, atherosclerosis, hypertension, and hypercholesterolemia on vascular function of the coronary circulation were studied by subselective intracoronary infusions of acetylcholine, which releases endothelium-derived relaxing factor, and papaverine, which directly relaxes vascular smooth muscle, in normal patients (n = 18; no risk factors for coronary artery disease), in patients with evidence of early atherosclerosis but normal cholesterol levels and normal blood pressure (n = 12), in patients with hypertension without left ventricular hypertrophy (n = 12), and in patients with hypercholesterolemia (n = 20)." | 3.68 | Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. ( Drexler, H; Just, H; Saurbier, B; Zeiher, AM, 1993) |
| " Pathological Doppler findings and weak response to locally administered papaverine or alpha-blocking agents in these impotent men led to pharmacoangiography in 17 of 372 patients with erectile dysfunction; of these 372 patients 130 (35%) had subnormal penile blood flow according to Doppler ultrasonography." | 3.67 | Severe arterial insufficiency in impotence confirmed with an improved angiographic technique: the impact of smoking and some other etiologic factors. ( Forsberg, L; Hederström, E; Olsson, AM, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (78.26) | 18.7374 |
| 1990's | 8 (17.39) | 18.2507 |
| 2000's | 2 (4.35) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Speel, TG | 1 |
| van Langen, H | 1 |
| Wijkstra, H | 1 |
| Meuleman, EJ | 1 |
| Nilovskaia, SN | 1 |
| WAHL, M | 1 |
| SANABRIA, J | 1 |
| Slovut, DP | 1 |
| Lookstein, R | 1 |
| Bacharach, JM | 1 |
| Olin, JW | 1 |
| Gunn, IG | 1 |
| Cowie, TN | 1 |
| Forrest, H | 1 |
| Quin, RO | 1 |
| Sheldon, C | 1 |
| Vallance, R | 1 |
| Brevetti, G | 1 |
| Chiariello, M | 1 |
| Verrienti, S | 1 |
| Spena, M | 1 |
| Desiderati, M | 1 |
| Condorelli, M | 1 |
| Zeiher, AM | 1 |
| Drexler, H | 1 |
| Saurbier, B | 1 |
| Just, H | 1 |
| Egashira, K | 1 |
| Inou, T | 1 |
| Hirooka, Y | 1 |
| Yamada, A | 1 |
| Maruoka, Y | 1 |
| Kai, H | 1 |
| Sugimachi, M | 1 |
| Suzuki, S | 1 |
| Takeshita, A | 1 |
| Park, K | 1 |
| Goldstein, I | 1 |
| Andry, C | 1 |
| Siroky, MB | 1 |
| Krane, RJ | 1 |
| Azadzoi, KM | 1 |
| Kelm, M | 1 |
| Preik-Steinhoff, H | 1 |
| Preik, M | 1 |
| Strauer, BE | 1 |
| Roberts, VC | 2 |
| Cotton, LT | 2 |
| Strano, A | 1 |
| Novo, S | 1 |
| Emanuel, MB | 1 |
| Sonnenfeld, T | 1 |
| Cronestrand, R | 1 |
| Nowak, J | 1 |
| Kukes, VG | 1 |
| Shvarts, GIa | 1 |
| Milovanova, NM | 1 |
| Chang, WW | 1 |
| Zisel'man, SB | 1 |
| Ekeström, S | 1 |
| Samnegård, H | 1 |
| Farrar, DJ | 1 |
| Malindzak, GS | 1 |
| Johnson, G | 1 |
| Dedichen, H | 5 |
| Baky, SH | 1 |
| Lee, RJ | 1 |
| Albrechtsen, D | 1 |
| Orekhov, AN | 2 |
| Andrianova, IV | 2 |
| Rekhter, MD | 2 |
| Tertov, VV | 2 |
| Andreeva, ER | 2 |
| Ragimov, SE | 1 |
| Mironov, AA | 2 |
| Gabrielian, ES | 1 |
| Akopov, SE | 1 |
| Ghazarian, AV | 1 |
| Gupta, SK | 1 |
| Veith, FJ | 1 |
| Kram, HB | 1 |
| Wengerter, KA | 1 |
| Forsberg, L | 1 |
| Hederström, E | 1 |
| Olsson, AM | 1 |
| Zoli, I | 1 |
| Baroncini, S | 1 |
| Cornia, GL | 1 |
| Donato, S | 1 |
| Minore, G | 1 |
| Pigini, G | 1 |
| Pretolani, E | 1 |
| Reed, C | 1 |
| Inlis, MJ | 1 |
| Amplatz, K | 1 |
| Myhre, HO | 1 |
| Zubarev, VV | 2 |
| Dotsenko, IaN | 1 |
| Gilroy, J | 1 |
| Martynov, AI | 1 |
| Zadionchenko, VS | 1 |
| Amadini, S | 1 |
| Bagnoli, L | 1 |
| Moscatello, B | 1 |
| Cannata, D | 1 |
| Mingoia, E | 1 |
| Malarbi, A | 1 |
| Marchei, P | 1 |
| Sangiorgi, M | 1 |
| Födö, V | 1 |
| Villaverde, MM | 1 |
| Sadow, HS | 1 |
| Perlick, E | 1 |
| Barner, HB | 1 |
| Kaiser, GC | 1 |
| Willman, VL | 1 |
| Hanlon, CR | 1 |
| Weale, FE | 1 |
| Tibbs, EE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Treatment With the HMG-CoA-Reductase Inhibitor Fluvastatin on Erectile Function in Patients With Cardiovascular Risk-Factors and Erectile Dysfunction[NCT00382161] | Phase 3 | 20 participants (Anticipated) | Interventional | 2006-10-31 | Withdrawn (stopped due to not enough patients meeting inclusion criteria) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for papaverine and Arteriosclerosis
| Article | Year |
|---|---|
[Prospects of antiaggregant therapy in prevention of atherosclerosis].
Topics: Animals; Anti-Inflammatory Agents; Anticoagulants; Arteriosclerosis; Aspirin; Blood Coagulation Diso | 1979 |
1 trial available for papaverine and Arteriosclerosis
| Article | Year |
|---|---|
Serum nitrite sensitively reflects endothelial NO formation in human forearm vasculature: evidence for biochemical assessment of the endothelial L-arginine-NO pathway.
Topics: Acetylcholine; Adult; Analysis of Variance; Arginine; Arteriosclerosis; Biomarkers; Endothelium, Vas | 1999 |
44 other studies available for papaverine and Arteriosclerosis
| Article | Year |
|---|---|
Penile duplex pharmaco-ultrasonography revisited: revalidation of the parameters of the cavernous arterial response.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Arteries; Arteriosclerosis; Blood Flow Velocity; Carotid | 2003 |
[Comparative dilatating effect of rodanate, thiamine, papaverine, and their mixtures in cholesterine atherosclerosis].
Topics: Arteriosclerosis; Atherosclerosis; Papaverine; Thiamine | 1952 |
[Nicotinic acid and associated drugs during the development of arteriosclerosis].
Topics: Arteriosclerosis; Niacin; Nicotinic Acids; Papaverine; Vitamin B 6 | 1962 |
[BILATERAL THROMBOSIS OF THE INTERNAL CAROTID ARTERIES. APROPOS OF 5 PERSONAL CASES].
Topics: Arteriosclerosis; Arteritis; Carotid Artery Thrombosis; Carotid Artery, Internal; Cerebral Angiograp | 1964 |
Correlation between noninvasive and endovascular Doppler in patients with atherosclerotic renal artery stenosis: a pilot study.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Arteriosclerosis; Comorbidity; Endosonography; Female | 2006 |
Haemodynamic assessment following iliac artery dilatation.
Topics: Angioplasty, Balloon; Arteriosclerosis; Hemodynamics; Humans; Iliac Artery; Papaverine; Postoperativ | 1981 |
Beneficial effect of papaverine plus raubasine in peripheral arterial insufficiency.
Topics: Aged; Arteriosclerosis; Blood Pressure; Drug Combinations; Heart Rate; Humans; Leg; Middle Aged; Pap | 1983 |
Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension.
Topics: Acetylcholine; Adult; Age Factors; Arteriosclerosis; Blood Pressure; Cardiac Catheterization; Corona | 1993 |
Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions.
Topics: Acetylcholine; Adult; Age Factors; Aged; Analysis of Variance; Arteriosclerosis; Blood Pressure; Cor | 1993 |
Vasculogenic female sexual dysfunction: the hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency.
Topics: Adrenergic alpha-Antagonists; Animals; Arteriosclerosis; Blood Pressure; Blood Vessels; Cholesterol; | 1997 |
Electromagnetic blood flow measurement during extended deep femoral angioplasty.
Topics: Arteriosclerosis; Blood Circulation; Blood Flow Velocity; Electromagnetic Phenomena; Femoral Artery; | 1977 |
Specific calcium antagonists in the treatment of peripheral vascular disease.
Topics: Arterial Occlusive Diseases; Arteriosclerosis; Biological Transport; Blood Viscosity; Calcium; Cell | 1979 |
Leg haemodynamics during reconstructive vascular surgery.
Topics: Aged; Arteriosclerosis; Blood Pressure; Blood Transfusion; Femoral Artery; Hemodynamics; Humans; Leg | 1979 |
[Efficacy of tiphen].
Topics: Adult; Aged; Animals; Arteriosclerosis; Bronchial Spasm; Female; Gastrointestinal Diseases; Guinea P | 1979 |
Influence of Xantinoli nicotans (Complamin) and papaverine upon internal carotid artery blood flow after arterial reconstruction.
Topics: Aged; Arteriosclerosis; Blood Pressure; Brachial Artery; Carbon Dioxide; Carotid Artery Diseases; Ca | 1977 |
Large vessel impedance in peripheral atherosclerosis.
Topics: Adult; Aged; Animals; Arteriosclerosis; Blood Flow Velocity; Female; Femoral Artery; Humans; Male; M | 1977 |
The papaverine test for blood flow potential of ileo-femoral arteries.
Topics: Adult; Aged; Arteriosclerosis; Blood Pressure; Dose-Response Relationship, Drug; Femoral Artery; Hum | 1976 |
Hemodynamics in arterial reconstructions of the lower limb. I. blood flow.
Topics: Adult; Aged; Arteriosclerosis; Female; Femoral Artery; Follow-Up Studies; Humans; Iliac Artery; Leg; | 1976 |
Hemodynamics in arterial reconstructions of the lower limb. II. Blood pressure.
Topics: Adult; Aged; Arteriosclerosis; Blood Pressure; Female; Femoral Artery; Follow-Up Studies; Humans; Il | 1976 |
Effects of several antianginal agents on pacing-induced S-T Segment depression in the atherosclerotic rabbit.
Topics: Angina Pectoris; Animals; Arteriosclerosis; Autonomic Agents; Cardiac Catheterization; Chromonar; De | 1975 |
Intra-operative haemodynamic findings and their prognostic significance in femoropopliteal reversed saphenous vein graft bypass operations.
Topics: Arteriosclerosis; Blood Pressure; Femoral Artery; Humans; Leg; Middle Aged; Papaverine; Popliteal Ar | 1976 |
Beta-blockers: propranolol, metoprolol, atenolol, pindolol, alprenolol and timolol, manifest atherogenicity on in vitro, ex vivo and in vivo models. Elimination of propranolol atherogenic effects by papaverine.
Topics: Adrenergic beta-Antagonists; Animals; Aorta, Abdominal; Arteriosclerosis; Cells, Cultured; Cholester | 1992 |
[Elimination of the atherogenic effect of beta blocker propranolol by papaverine].
Topics: Animals; Aorta; Arteriosclerosis; Cell Count; Cells, Cultured; Cholesterol; Lipid Metabolism; Macrop | 1992 |
Cerebral-artery spasm in vitro.
Topics: Arteriosclerosis; Cerebral Arteries; Dinoprost; Humans; In Vitro Techniques; Muscle Contraction; Nif | 1990 |
Significance and management of inflow gradients unexpectedly generated after femorofemoral, femoropopliteal, and femoroinfrapopliteal bypass grafting.
Topics: Aged; Arteriosclerosis; Blood Pressure; Blood Vessel Prosthesis; Constriction, Pathologic; Femoral A | 1990 |
Severe arterial insufficiency in impotence confirmed with an improved angiographic technique: the impact of smoking and some other etiologic factors.
Topics: Aged; Angiography; Arteriosclerosis; Erectile Dysfunction; Humans; Male; Middle Aged; Papaverine; Pe | 1989 |
Prognostic significance of intra-operative flow and pressure measurements in reconstructive vascular surgery.
Topics: Arteriosclerosis; Arteriovenous Shunt, Surgical; Blood Flow Velocity; Blood Pressure; Depression, Ch | 1973 |
[Therapeutic possibilities in coronary disease].
Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Arteriosclerosis; Cardiomegaly; Coronary Disease | 1973 |
The value of blood flow measurement in reconstructive arterial surgery.
Topics: Arteries; Arteriosclerosis; Blood Circulation Time; Blood Flow Velocity; Femoral Artery; Humans; Pap | 1974 |
Acute massive gangrene of tongue.
Topics: Aged; Arteriosclerosis; Carotid Artery Diseases; Diagnosis, Differential; Ganglionic Blockers; Gangr | 1965 |
Angiography in assessing renovascular hypertension: past and present.
Topics: Angiography; Arteriosclerosis; Arteriovenous Fistula; Catheterization; Child; Contrast Media; Histor | 1974 |
Haemodynamic factors in the oedema of arterial reconstructions.
Topics: Arteriosclerosis; Blood Flow Velocity; Blood Pressure; Edema; Foot; Hemodynamics; Humans; Hyperemia; | 1972 |
[Changes in peripheral arterial circulation under the effect of papaverine depending upon the initial condition of patients with coronary insufficiency due to coronary atherosclerosis].
Topics: Aged; Angiography; Arteriosclerosis; Blood Circulation; Brachial Artery; Coronary Circulation; Coron | 1972 |
[Dependence of the pharmacodynamics of papaverine on the initial state of circulatory system and external respiration in patients with arteriosclerotic myocardiosclerosis].
Topics: Arteriosclerosis; Blood Circulation; Coronary Disease; Hemodynamics; Humans; Papaverine; Respiration | 1973 |
Medical management of extracranial vascular disease: indications and results.
Topics: Arteriosclerosis; Cardiovascular Diseases; Carotid Artery Diseases; Cerebral Angiography; Cerebrovas | 1971 |
[A comparative evaluation of the effects of drugs used in the treatment of coronary insufficiency on cerebral circulation and the electrical activity of the brain].
Topics: Adult; Aged; Arteriosclerosis; Blood Pressure; Brain Chemistry; Cerebrovascular Circulation; Chronic | 1971 |
[Clinical studies with a new anticoronaritis preparation].
Topics: Arteriosclerosis; Arteritis; Coronary Disease; Electrocardiography; Humans; Myocardial Infarction; P | 1969 |
[Pharmacodynamic study of stenocardia of effort. IV. Effect of papaverine].
Topics: Adult; Aged; Angina Pectoris; Arteriosclerosis; Blood Pressure; Coronary Disease; Electrocardiograph | 1970 |
[Ophthalmological use of bencyclane and ophthalmodynamometric recording of its effect on cerebral vessels].
Topics: Aged; Arteriosclerosis; Cerebrovascular Circulation; Cerebrovascular Disorders; Cycloheptanes; Eye D | 1970 |
[Treatment of atherosclerosis].
Topics: Anticholesteremic Agents; Anticoagulants; Arteriosclerosis; Diet Therapy; Fibrinolytic Agents; Human | 1967 |
[Thrombophilia in early and late sclerosis].
Topics: Age Factors; Anticoagulants; Arteries; Arteriosclerosis; Dipyridamole; Humans; Lipid Metabolism; Nuc | 1968 |
Intermittent claudication with pedal pulses.
Topics: Adult; Aged; Angiography; Aortic Coarctation; Aortic Diseases; Aortography; Arteries; Arterioscleros | 1968 |
The hemodynamic assessment of the arterial tree during reconstructive surgery.
Topics: Arteries; Arteriosclerosis; Blood Flow Velocity; Blood Pressure; Blood Vessel Prosthesis; Femoral Ar | 1969 |
Sustained release papaverine in peripheral ischemia: report of 21 ambulatory cases with oscillometric studies.
Topics: Adult; Aged; Arteriosclerosis; Delayed-Action Preparations; Female; Humans; Intermittent Claudicatio | 1969 |