papaverine has been researched along with Arrhythmias, Cardiac in 29 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Intracoronary papaverine (PAP) is the most potent vasodilator used for the achievement of maximal hyperemia." | 4.02 | Clinical Efficacy of Intracoronary Papaverine After Nicorandil Administration for Safe and Optimal Fractional Flow Reserve Measurement. ( Anai, R; Araki, M; Inoue, K; Kataoka, M; Miura, T; Naka, Y; Okabe, H; Setoyama, K; Sonoda, S, 2021) |
| " Intrarenal papaverine neither prolonged the QT interval nor induced ventricular arrhythmias and the safety of which will need to be corroborated in a large study." | 3.76 | Physiological assessment of renal artery stenosis: comparisons of resting with hyperemic renal pressure measurements. ( Fahsah, I; Jevans, AJ; Kapoor, N; Karim, R; Leesar, MA, 2010) |
| "Papaverine, a vasodilator used as a therapeutic agent for a range of diseases, has been reported to increase the risk of occasional serious ventricular arrhythmias." | 3.74 | Papaverine, a vasodilator, blocks the pore of the HERG channel at submicromolar concentration. ( Choe, H; Hong, HK; Jo, SH; Kim, YJ; Lee, HS; Moh, SH; Park, JC, 2008) |
| " All compounds were evaluated for their ability to protect against chloroform-induced ventricular fibrillation in mice." | 3.65 | Isoquinolines. 5. Synthesis and antiarrhythmic activity of benzylisoquinoline derivatives. ( Neumeyer, JL; Perianayagam, C; Ruchirawat, S, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (86.21) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Neumeyer, JL | 1 |
| Perianayagam, C | 1 |
| Ruchirawat, S | 1 |
| Inoue, K | 1 |
| Sonoda, S | 1 |
| Naka, Y | 1 |
| Okabe, H | 1 |
| Setoyama, K | 1 |
| Miura, T | 1 |
| Anai, R | 1 |
| Araki, M | 1 |
| Kataoka, M | 1 |
| MELVILLE, KI | 2 |
| Kim, YJ | 1 |
| Hong, HK | 1 |
| Lee, HS | 1 |
| Moh, SH | 1 |
| Park, JC | 1 |
| Jo, SH | 1 |
| Choe, H | 1 |
| Kapoor, N | 1 |
| Fahsah, I | 1 |
| Karim, R | 1 |
| Jevans, AJ | 1 |
| Leesar, MA | 1 |
| GRUBER, CM | 2 |
| LEE, KS | 1 |
| SZEKERES, L | 2 |
| LENARD, G | 1 |
| LINDNER, A | 1 |
| SELZER, H | 1 |
| CLAASSEN, V | 1 |
| GANS, P | 1 |
| OFFRINGA, OR | 1 |
| ZWAGEMAKERS, JM | 1 |
| REISER, I | 1 |
| LESLIE, RE | 1 |
| DE JONGH, DK | 1 |
| VAN PROOSDIJ-HARTZEMA, EG | 1 |
| Roche, M | 1 |
| Lakermance, B | 1 |
| Denavit, M | 1 |
| Achard, F | 1 |
| Van Haecke, P | 1 |
| Lakestani, F | 1 |
| Mikaeloff, P | 1 |
| Lacroix, P | 1 |
| Linée, P | 1 |
| Le Pollés, JB | 1 |
| Whipple, GH | 1 |
| Schroeder, JS | 1 |
| Troup, PJ | 1 |
| Zipes, DP | 1 |
| Kipsidzen, N | 1 |
| Kikava, GM | 1 |
| Kern, MJ | 1 |
| Deligonul, U | 1 |
| Serota, H | 1 |
| Gudipati, C | 1 |
| Buckingham, T | 1 |
| Wilson, RF | 1 |
| White, CW | 1 |
| Fleckenstein, A | 1 |
| Grün, G | 1 |
| Döring, HJ | 1 |
| Haastert, HP | 1 |
| Tritthart, H | 1 |
| Zoli, I | 1 |
| Baroncini, S | 1 |
| Cornia, GL | 1 |
| Donato, S | 1 |
| Minore, G | 1 |
| Pigini, G | 1 |
| Pretolani, E | 1 |
| Papp, G | 1 |
| Szmolenszky, T | 1 |
| Grodzińska, L | 1 |
| Gomensoro, JB | 1 |
| Votcal, BE | 1 |
| Lozinskij, LG | 1 |
| Hanna, C | 1 |
| Schmid, JR | 1 |
| Haas, H | 2 |
| Stafford, A | 1 |
1 review available for papaverine and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Papaverine as an antiarrhythmic agent.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Evaluation; Drug Evaluation, Preclinical | 1977 |
4 trials available for papaverine and Arrhythmias, Cardiac
| Article | Year |
|---|---|
[Study of the effect of ethaverine and papaverine on post-ischemic arrhythmias in the awake dog].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Coronary Disease; D | 1977 |
Newer antiarrhythmic agents for patients with coronary artery disease.
Topics: Acebutolol; Adult; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; | 1978 |
[On the efficacy of carbocromen in the treatment of myocardial infarction (author's transl)].
Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Blood Pressure; Chromonar; Clinical Trials as To | 1976 |
[Carbochromen in therapy of acute and chronic coronary insufficiency].
Topics: Acute Disease; Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Blood Pressure; Chronic Disease; | 1970 |
24 other studies available for papaverine and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Isoquinolines. 5. Synthesis and antiarrhythmic activity of benzylisoquinoline derivatives.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chloroform; Dogs; Female; Isoquinolines; Mice | 1977 |
Clinical Efficacy of Intracoronary Papaverine After Nicorandil Administration for Safe and Optimal Fractional Flow Reserve Measurement.
Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Case-Control Studies; Coronary Angiography; Coronary | 2021 |
The anti-fibrillation action of papaverine and its value in cardiac resuscitation after chloroform-adrenaline ventricular fibrillation in dogs.
Topics: Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Chloroform; Dogs | 1948 |
The anti-fibrillation action of papaverine and its value in cardiac resuscitation after chloroform-adrenaline ventricular fibrillation.
Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Chloroform; Epinephrine; | 1948 |
Papaverine, a vasodilator, blocks the pore of the HERG channel at submicromolar concentration.
Topics: Animals; Arrhythmias, Cardiac; Cell Line; Computer Simulation; Cricetinae; Dose-Response Relationshi | 2008 |
Physiological assessment of renal artery stenosis: comparisons of resting with hyperemic renal pressure measurements.
Topics: Aged; Aorta; Arrhythmias, Cardiac; Biomarkers; Blood Pressure; Blood Pressure Determination; Chi-Squ | 2010 |
Papaverine hydrochloride in thiobarbiturate anesthesia in dogs.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Barbiturates; Dogs; Papaverine; Thiobarbiturates | 1953 |
[Change in the fibrillation threshold of auricular and ventricular musculature of isolated mammalian heart after cooling and after administration of various pharmacological agents].
Topics: Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Heart; Heart Con | 1960 |
PHARMACOLOGICAL PROPERTIES OF MEBEVERINE, A SMOOTH-MUSCLE RELAXANT.
Topics: Arrhythmias, Cardiac; Blood Pressure; Blood Pressure Determination; Cats; Dogs; Esophageal Achalasia | 1963 |
THE ACTION OF PAPAVERINE IN CARDIAC ARRHYTHMIAS.
Topics: Arrhythmias, Cardiac; Biomedical Research; Drug Therapy; Papaverine; Toxicology | 1964 |
Studies on the action of papaverine and perparine on cardiac fibrillation.
Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Heart Conduction System; | 1952 |
[Experimental study in anesthetized dogs of the harmful effects of coronary microemboli and their prevention by drugs].
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Dogs; Embolism, Air; Extracorporeal Circulation; Ma | 1983 |
New antiarrhythmic drugs.
Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Humans; Lidocaine; Mexiletine; | 1978 |
Ventricular arrhythmia due to intracoronary papaverine: analysis of QT intervals and coronary vasodilatory reserve.
Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Flow Velocity; Coronary Vessels; Female; Hemodynamics; Huma | 1990 |
Serious ventricular dysrhythmias after intracoronary papaverine.
Topics: Aged; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Coronary Vessels; Female; Humans; Injectio | 1988 |
[Ethaverin, a coronary dilator with beta-receptor depressing and antiarrhythmia myocardial effects].
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Epinep | 1973 |
[Therapeutic possibilities in coronary disease].
Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Arteriosclerosis; Cardiomegaly; Coronary Disease | 1973 |
The effects of quinidine, ajmaline, papaverine and adrenergic beta-receptor inhibitors in experimental BaCl2-arrhythmia developed for the quantitative assay of antiarrhythmic drugs.
Topics: Alkaloids; Animals; Arrhythmias, Cardiac; Barium; Chlorides; Electrocardiography; Ethanolamines; Fem | 1967 |
The influence of pharmacological blockade of presynaptic and postsynaptic adrenergic structures on electrically induced arrhythmias of the guinea-pig atria.
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Depression, Chemical; Guanethidine; Guan | 1969 |
[Use of hydergine in acute ischemic pathology of the brain].
Topics: Acetazolamide; Adult; Aged; Aminophylline; Arrhythmias, Cardiac; Carbon Dioxide; Cerebrovascular Cir | 1967 |
Antiarrhythmic actions of coronary vasodilator agents papaverine, dioxyline and verapamil.
Topics: Aconitum; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Dogs; Epinephrine | 1970 |
[Studies on coronary-active substances].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Circulation; Calcium; Cell Membrane Per | 1970 |
[Studies on coronary-active substances].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Circulation; Calcium; Cell Membrane Per | 1970 |
Potentiation of adenosine and the adenine nucleotides by dipyridamole.
Topics: Acetylcholine; Adenine Nucleotides; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Azaguanin | 1966 |