papaverine has been researched along with Alloxan Diabetes in 12 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with melatonin (EC(50) 4." | 1.32 | Melatonin treatment protects against diabetes-induced functional and biochemical changes in rat aorta and corpus cavernosum. ( Ayanğolu-Dülger, G; Paskaloglu, K; Sener, G, 2004) |
| " Dose-response curves to KCl and phenylephrine (PE) were constructed; the response to PE was significantly higher in DM than control arteries." | 1.28 | Contribution of the arterial tissue to vascular pathology in diabetes mellitus. ( Carrara, MC, 1990) |
| " Statistically significant dose-response relationships were always observed, but with one exception, no differences were found between the contractile responses (norepinephrine, serotonin, prostaglandin F2 alpha) or the dilating responses (papaverine) in diabetic vs normal mice." | 1.27 | Microvascular responses of intermediate-size arterioles on the cerebral surface of diabetic mice. ( Levasseur, JE; Rosenblum, WI, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hill, JV | 1 |
| Findon, G | 1 |
| Appelhoff, RJ | 1 |
| Endre, ZH | 1 |
| Paskaloglu, K | 1 |
| Sener, G | 1 |
| Ayanğolu-Dülger, G | 1 |
| Rosenblum, WI | 1 |
| Levasseur, JE | 1 |
| Fortes, ZB | 2 |
| Garcia Leme, J | 1 |
| Scivoletto, R | 2 |
| Miller, MA | 1 |
| Morgan, RJ | 1 |
| Thompson, CS | 1 |
| Mikhailidis, DP | 1 |
| Jeremy, JY | 1 |
| Sikorski, BW | 1 |
| James, GM | 1 |
| Glance, SD | 1 |
| Hodgson, WC | 1 |
| King, RG | 1 |
| Simopoulos, DN | 1 |
| Gibbons, SJ | 1 |
| Malysz, J | 1 |
| Szurszewski, JH | 1 |
| Farrugia, G | 1 |
| Ritman, EL | 1 |
| Moreland, RB | 1 |
| Nehra, A | 1 |
| Azadzoi, KM | 1 |
| Saenz de Tejada, I | 1 |
| Umemura, K | 1 |
| Takiguchi, Y | 1 |
| Nakashima, M | 1 |
| Carrara, MC | 1 |
| Garcia-Leme, J | 1 |
| Pieper, GM | 1 |
| Gross, GJ | 1 |
12 other studies available for papaverine and Alloxan Diabetes
| Article | Year |
|---|---|
Renal autoregulation and passive pressure-flow relationships in diabetes and hypertension.
Topics: Angiotensin II; Animals; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Di | 2010 |
Melatonin treatment protects against diabetes-induced functional and biochemical changes in rat aorta and corpus cavernosum.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental | 2004 |
Microvascular responses of intermediate-size arterioles on the cerebral surface of diabetic mice.
Topics: Animals; Arteries; Arterioles; Brain; Diabetes Mellitus, Experimental; Dinoprost; Dose-Response Rela | 1984 |
Vascular reactivity in diabetes mellitus: role of the endothelial cell.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Bradykinin; Capillary Permeability; Diabetes Mellitus, Expe | 1983 |
Effects of papaverine and vasointestinal polypeptide on penile and vascular cAMP and cGMP in control and diabetic animals: an in vitro study.
Topics: Animals; Aorta; Arteries; Carotid Arteries; Cyclic AMP; Cyclic GMP; Diabetes Mellitus, Experimental; | 1995 |
Effect of endothelium on diabetes-induced changes in constrictor responses mediated by 5-hydroxytryptamine in rat aorta.
Topics: Amphetamines; Animals; Aorta; Arginine; Body Weight; Diabetes Mellitus, Experimental; Endothelium; I | 1993 |
Corporeal structural and vascular micro architecture with X-ray micro computerized tomography in normal and diabetic rabbits: histopathological correlation.
Topics: Angiography; Animals; Arteries; Blood Volume; Diabetes Mellitus, Experimental; Diabetic Angiopathies | 2001 |
Diabetes mellitus impairs neurogenic and endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle.
Topics: Acetylcholine; Animals; Diabetes Mellitus, Experimental; Electric Stimulation; Endothelium, Vascular | 1992 |
Altered effect of arachidonic acid on inner ear blood flow in rats with streptozotocin-induced diabetes.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Audiometry, Evoked Response; Diabetes Mellitus, Experi | 1991 |
Contribution of the arterial tissue to vascular pathology in diabetes mellitus.
Topics: Animals; Arteries; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Papaverine; Phenyleph | 1990 |
Functional changes in the microcirculation of alloxan-induced diabetic rats.
Topics: Acetylcholine; Animals; Arterioles; Diabetes Mellitus, Experimental; Histamine; Male; Microcirculati | 1989 |
Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Aorta, Thoracic; Ascorbic Acid; Catalase; Diabetes Me | 1988 |