papaverine has been researched along with Akinetic-Rigid Variant of Huntington Disease in 1 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Papaverine treatment improved spatial and object recognition memories in R6/1 mice, and significantly increased pGluA1 and pCREB levels in R6/1 mice hippocampus." | 1.39 | PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model. ( Alberch, J; Arumí, H; Carretón, O; Giralt, A; Pérez-Navarro, E; Saavedra, A; Tyebji, S, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giralt, A | 1 |
| Saavedra, A | 1 |
| Carretón, O | 1 |
| Arumí, H | 1 |
| Tyebji, S | 1 |
| Alberch, J | 1 |
| Pérez-Navarro, E | 1 |
1 other study available for papaverine and Akinetic-Rigid Variant of Huntington Disease
| Article | Year |
|---|---|
PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model.
Topics: Analysis of Variance; Animals; CREB-Binding Protein; Disease Models, Animal; Gene Expression Regulat | 2013 |