papaverine has been researched along with Aging in 41 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated the hypothesis that aging selectively impairs endothelium-dependent function, which may be reversible by administration of L-arginine." | 7.69 | Aging-associated endothelial dysfunction in humans is reversed by L-arginine. ( Chauhan, A; More, RS; Mullins, PA; Petch, C; Schofield, PM; Taylor, G, 1996) |
| "The nitroglycerin plasters were applied on the skin of the penile shaft and a positive response was obtained in 12 men." | 5.28 | Transcutaneous nitroglycerin in the treatment of erectile dysfunction in spinal cord injured. ( Biering-Sørensen, F; Sønksen, J, 1992) |
| "This is the first double-blind study in outpatients to evaluate the effectiveness of dihydrogenated ergot alkaloids (DEA) (Hydergine) versus papaverine in the treatment of selected symptoms associated with mental aging." | 5.04 | Mental decline in the elderly: pharmacotherapy (ergot alkaloids versus papaverine). ( Rosen, HJ, 1975) |
| "This study investigated the hypothesis that aging selectively impairs endothelium-dependent function, which may be reversible by administration of L-arginine." | 3.69 | Aging-associated endothelial dysfunction in humans is reversed by L-arginine. ( Chauhan, A; More, RS; Mullins, PA; Petch, C; Schofield, PM; Taylor, G, 1996) |
| "Papaverine was administrated selectively via the vertebral artery on day 2, and serial angiography was performed for up to 2 hours." | 1.31 | Effects of aging on cerebral vasospasm after subarachnoid hemorrhage in rabbits. ( Asari, S; Date, I; Nakajima, M; Ninomiya, Y; Ohmoto, T; Takahashi, K, 2001) |
| "The nitroglycerin plasters were applied on the skin of the penile shaft and a positive response was obtained in 12 men." | 1.28 | Transcutaneous nitroglycerin in the treatment of erectile dysfunction in spinal cord injured. ( Biering-Sørensen, F; Sønksen, J, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (48.78) | 18.7374 |
| 1990's | 12 (29.27) | 18.2507 |
| 2000's | 6 (14.63) | 29.6817 |
| 2010's | 3 (7.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Noureini, SK | 1 |
| Wink, M | 1 |
| Aldemir, M | 1 |
| Ağras, K | 1 |
| Ener, K | 1 |
| Dehni, D | 1 |
| Kayıgil, O | 1 |
| Mandalà, M | 1 |
| Pedatella, AL | 1 |
| Morales Palomares, S | 1 |
| Cipolla, MJ | 1 |
| Osol, G | 1 |
| Martinez-Lemus, LA | 1 |
| Hester, RK | 1 |
| Becker, EJ | 1 |
| Ramirez, GA | 1 |
| Odom, TW | 1 |
| Tatchum-Talom, R | 1 |
| Martin, DS | 1 |
| Davila, HH | 1 |
| Rajfer, J | 2 |
| Gonzalez-Cadavid, NF | 1 |
| Miyazaki, M | 2 |
| Wittenborn, JR | 1 |
| Benzi, G | 6 |
| Arrigoni, E | 2 |
| Dagani, F | 3 |
| Marzatico, F | 3 |
| Curti, D | 4 |
| Raimondo, S | 1 |
| Dossena, M | 2 |
| Polgatti, M | 1 |
| Villa, RF | 4 |
| Stancheva, S | 1 |
| Cook, P | 1 |
| James, I | 1 |
| Rusterholz, DB | 1 |
| Mueller, SM | 1 |
| Le Poncin-Lafitte, M | 1 |
| Rapin, JR | 1 |
| Garbán, H | 1 |
| Vernet, D | 1 |
| Freedman, A | 1 |
| González-Cadavid, N | 1 |
| Egashira, K | 1 |
| Inou, T | 1 |
| Hirooka, Y | 1 |
| Kai, H | 1 |
| Sugimachi, M | 1 |
| Suzuki, S | 1 |
| Kuga, T | 1 |
| Urabe, Y | 1 |
| Takeshita, A | 1 |
| Purvis, K | 1 |
| Brekke, I | 1 |
| Christiansen, E | 1 |
| Chauhan, A | 1 |
| More, RS | 1 |
| Mullins, PA | 1 |
| Taylor, G | 1 |
| Petch, C | 1 |
| Schofield, PM | 1 |
| Carrier, S | 1 |
| Nagaraju, P | 1 |
| Morgan, DM | 1 |
| Baba, K | 1 |
| Nunes, L | 1 |
| Lue, TF | 1 |
| Nakajima, M | 2 |
| Date, I | 2 |
| Takahashi, K | 2 |
| Ninomiya, Y | 2 |
| Asari, S | 2 |
| Ohmoto, T | 2 |
| Richter, S | 1 |
| Vardi, Y | 1 |
| Ringel, A | 1 |
| Shalev, M | 1 |
| Nissenkorn, I | 1 |
| Ono, S | 1 |
| Satoh, M | 1 |
| Iseda, K | 1 |
| Manabe, H | 1 |
| Manzini, A | 1 |
| Nandy, K | 1 |
| Baste, C | 1 |
| Schneider, FH | 1 |
| Prewitt, RL | 1 |
| Dowell, RF | 1 |
| Godfraind, T | 1 |
| Rosen, HJ | 1 |
| Feine-Haake, G | 1 |
| Neiss, A | 1 |
| Weinert, W | 1 |
| Sønksen, J | 1 |
| Biering-Sørensen, F | 1 |
| Fike, CD | 1 |
| Kaplowitz, MR | 1 |
| Kaapa, P | 1 |
| Raj, JU | 1 |
| Ibe, BO | 1 |
| Anderson, J | 1 |
| Nyborg, NC | 1 |
| Nielsen, PJ | 1 |
| Aoki, M | 1 |
| Kumamoto, Y | 1 |
| Pastoris, O | 2 |
| Rousseau, P | 1 |
| Cohen, ML | 1 |
| Berkowitz, BA | 1 |
| Boismare, F | 1 |
| Streichenberger, G | 1 |
| Paux, G | 1 |
| Losson, M | 1 |
| Losson, JP | 1 |
3 reviews available for papaverine and Aging
| Article | Year |
|---|---|
Pharmacotherapy for age-related behavioral deficiencies.
Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Brain; Central | 1981 |
Drug therapy: cerebral vasodilators (first of two parts).
Topics: Aged; Aging; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as Topic; Cycla | 1981 |
Impotence in elderly men.
Topics: Aged; Aging; Erectile Dysfunction; Humans; Male; Papaverine; Penis; Phentolamine; Physical Examinati | 1988 |
4 trials available for papaverine and Aging
| Article | Year |
|---|---|
Drug therapy: cerebral vasodilators (first of two parts).
Topics: Aged; Aging; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as Topic; Cycla | 1981 |
Determinants of satisfactory rigidity after intracavernosal injection with prostaglandin E1 in men with erectile failure.
Topics: Adrenergic alpha-Antagonists; Aging; Alprostadil; Drug Combinations; Erectile Dysfunction; Gonadal S | 1996 |
Mental decline in the elderly: pharmacotherapy (ergot alkaloids versus papaverine).
Topics: Aged; Aging; Clinical Trials as Topic; Confusion; Dementia; Depression; Dihydroergotoxine; Ergoloid | 1975 |
[The treatment of cerebrovascular insufficiency. Their evaluation in a double-blind study].
Topics: Aged; Aging; Cerebrovascular Disorders; Clinical Trials as Topic; Confusion; Drug Combinations; Drug | 1975 |
35 other studies available for papaverine and Aging
| Article | Year |
|---|---|
Antiproliferative effect of the isoquinoline alkaloid papaverine in hepatocarcinoma HepG-2 cells--inhibition of telomerase and induction of senescence.
Topics: Aging; Alkaloids; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; C | 2014 |
Corpus cavernosum electromyography: could it be a parameter to predict ageing?
Topics: Adult; Aged; Aging; Electromyography; Erectile Dysfunction; Humans; Male; Middle Aged; Muscle, Smoot | 2010 |
Maturation is associated with changes in rat cerebral artery structure, biomechanical properties and tone.
Topics: Aging; Animals; Biomechanical Phenomena; Blood Pressure; Cerebral Arteries; Collagen; Diltiazem; Ela | 2012 |
Pulmonary artery vasoactivity in broiler and Leghorn chickens: an age profile.
Topics: Acetylcholine; Aging; Animals; Body Weight; Chick Embryo; Chickens; Endothelin-1; Organ Size; Papave | 2003 |
Tempol improves vascular function in the mesenteric vascular bed of senescent rats.
Topics: Administration, Oral; Aging; Animals; Blood Pressure; Body Weight; Cyclic N-Oxides; Dose-Response Re | 2004 |
Corporal veno-occlusive dysfunction in aging rats: evaluation by cavernosometry and cavernosography.
Topics: Absorptiometry, Photon; Aging; Animals; Castration; Disease Models, Animal; Erectile Dysfunction; Ma | 2004 |
Measurement of cerebral blood flow by ultasonic Doppler technique. Hemodynamic correlation of internal carotid artery and vertebral artery.
Topics: Adult; Aged; Aging; Blood Flow Velocity; Carotid Arteries; Cerebral Hemorrhage; Cerebrovascular Circ | 1966 |
Measurement of cerebral blood flow by ultrasonic Doppler technique. Hemodynamic correlation between cerebral and peripheral-ophthalmic artery.
Topics: Adult; Aged; Aging; Brachial Artery; Carotid Arteries; Cerebral Arteries; Cerebrovascular Circulatio | 1966 |
Age-dependent modification of drug interference on the enzymatic activities of the rat brain.
Topics: Age Factors; Aging; Animals; Brain; Cytidine Diphosphate Choline; Dihydroergotoxine; Male; Nicergoli | 1980 |
Pharmacological and biochemical study in ontogenetic aspect of 3'-5'-adenosinemonophosphate phosphodiesterases with low and high Km.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Animals, Newborn; Brain; Ileum; Isoenzymes; Kin | 1981 |
Sympathetic nerves exert a chronic influence on the intact vasculature that is age related.
Topics: Aging; Animals; Denervation; Ear; Functional Laterality; Ganglia, Sympathetic; Male; Norepinephrine; | 1982 |
Age-associated changes in deoxyglucose uptake in whole brain.
Topics: Aging; Animals; Blood Glucose; Blood-Brain Barrier; Brain; Cerebrovascular Circulation; Deoxyglucose | 1980 |
Effect of aging on nitric oxide-mediated penile erection in rats.
Topics: Aging; Amino Acid Oxidoreductases; Animals; Arginine; Dose-Response Relationship, Drug; Egtazic Acid | 1995 |
Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans.
Topics: Acetylcholine; Adult; Aged; Aging; Angina Pectoris; Cardiac Catheterization; Coronary Angiography; C | 1993 |
Aging-associated endothelial dysfunction in humans is reversed by L-arginine.
Topics: Acetylcholine; Adult; Aged; Aging; Arginine; Coronary Circulation; Coronary Vessels; Endothelium, Va | 1996 |
Age decreases nitric oxide synthase-containing nerve fibers in the rat penis.
Topics: Aging; Animals; Apomorphine; Dopamine Agonists; Electric Stimulation; Male; Nerve Fibers; Nitric Oxi | 1997 |
Effects of aging on cerebral vasospasm after subarachnoid hemorrhage in rabbits.
Topics: Age Factors; Aging; Animals; Basilar Artery; Blood Pressure; Cerebral Angiography; Infusions, Intra- | 2001 |
Intracavernous injections: still the gold standard for treatment of erectile dysfunction in elderly men.
Topics: Aged; Aged, 80 and over; Aging; Alprostadil; Case-Control Studies; Dose-Response Relationship, Drug; | 2001 |
Comparison of cerebral vasospasm between young and old animals: preliminary report.
Topics: Aging; Animals; Basilar Artery; Cerebral Angiography; Male; Papaverine; Rabbits; Time Factors; Vasod | 2001 |
Effect of chronic treatment with some drugs on the enzymatic activities of the rat brain.
Topics: Aging; Animals; Brain; Electron Transport Complex IV; Energy Transfer; Ethanolamines; L-Lactate Dehy | 1979 |
Further studies on the effects of centrophenoxine on lipofuscin pigment in neuroblastoma cells in culture: an electron microscopic study.
Topics: Aging; Animals; Cells, Cultured; Glycolates; Lipofuscin; Meclofenoxate; Mice; Neoplasms, Experimenta | 1978 |
Structural vascular adaptations during the developmental stages of hypertension in the spontaneously hypertensive rat.
Topics: Aging; Animals; Blood Pressure; Captopril; Cardiac Output; Hypertension; Male; Papaverine; Pentolini | 1979 |
Alternative mechanisms for the potentiation of the relaxation evoked by isoprenaline in aortae from young and aged rats.
Topics: Aging; Animals; Aorta, Thoracic; Blood Vessels; Cinnarizine; Drug Synergism; Isoproterenol; Muscle C | 1979 |
Transcutaneous nitroglycerin in the treatment of erectile dysfunction in spinal cord injured.
Topics: Administration, Cutaneous; Adult; Aging; Erectile Dysfunction; Humans; Male; Middle Aged; Nitroglyce | 1992 |
Longitudinal distribution of pulmonary vascular pressures as a function of postnatal age in rabbits.
Topics: Aging; Animals; Arterioles; Blood Flow Velocity; Blood Pressure; Female; Lung; Male; Microcirculatio | 1991 |
Effect of pentoxifylline in rabbit pulmonary circulation: influence of age and vasomotor tone.
Topics: Aging; Animals; Epoprostenol; Indomethacin; Papaverine; Pentoxifylline; Potassium Chloride; Prostagl | 1991 |
Role of synaptosomal enzymatic alterations and drug treatment in brain aging.
Topics: Aging; Almitrine; Animals; Brain; Citrate (si)-Synthase; Electron Transport Complex IV; Glucosephosp | 1990 |
The level of spontaneous myogenic tone in isolated human posterior ciliary arteries decreases with age.
Topics: Acetylcholine; Adult; Aged; Aging; Arteries; Ciliary Body; Dose-Response Relationship, Drug; Endothe | 1990 |
[Analyses of factors contributing to the erectile dysfunction with aging by nocturnal penile tumescence, penile blood pressure index and papaverine test].
Topics: Adult; Aged; Aged, 80 and over; Aging; Blood Pressure; Humans; Male; Middle Aged; Papaverine; Penile | 1990 |
Factors involved in the age-related alteration in the efficiency of the brain bioenergetics.
Topics: Adenine Nucleotides; Aging; Animals; Brain; Electron Transport; Energy Metabolism; gamma-Aminobutyri | 1990 |
Age-related modification of enzyme activities in synaptosomes isolated from rat cerebral cortex.
Topics: Aging; Animals; Cerebral Cortex; Electron Transport Complex IV; Energy Metabolism; Male; Papaverine; | 1989 |
Changes induced by aging and drug treatment on cerebral enzymatic antioxidant system.
Topics: Aging; Animals; Brain; Ergot Alkaloids; Glucosephosphate Dehydrogenase; Glutathione Peroxidase; Glut | 1988 |
Age-related changes in vascular responsiveness to cyclic nucleotides and contractile agonists.
Topics: Aging; Animals; Aorta, Thoracic; Benzyl Compounds; Bucladesine; Cyclic AMP; Cyclic GMP; Dose-Respons | 1974 |
[Rheographical study of effects of different vasodilators at the level of encephalic and peripheral vessels as a function of age].
Topics: Adenosine Monophosphate; Adolescent; Adult; Age Factors; Aged; Aging; Carbon Dioxide; Cerebral Arter | 1974 |
[Attempt at psychometric evaluation of aging: study of a vascular drug].
Topics: Aged; Aging; Cerebrovascular Disorders; Drug Synergism; Ergoloid Mesylates; Female; Humans; Male; Mi | 1969 |