papaverine and Ache
papaverine has been researched along with Ache in 35 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of our work is to evaluate the efficacy of intracavernous sodium nitroprusside (SNP) in management of erectile dysfunction (ED) in a clinical comparative study with papaverine/phentolamine in ED patients." | 9.11 | Intracavernous sodium nitroprusside (SNP) versus papaverine/phentolamine in erectile dysfunction: a comparative study of short-term efficacy and side-effects. ( Abdelsalam, W; Atteya, A; Elnashaar, A; Gadallah, A; Shamloul, R; Zohdy, W, 2005) |
| "In an attempt to determine whether penile pain associated with intracorporeal injections could be due to the acidity of the medication, we performed a randomized study comparing the incidence of penile pain following intracorporeal injections with or without the addition of sodium bicarbonate to the intracorporeal medications." | 9.07 | Sodium bicarbonate alleviates penile pain induced by intracavernous injections for erectile dysfunction. ( Moriel, EZ; Rajfer, J, 1993) |
| "The efficacy of papaverine, and a combination of papaverine and phentolamine as a pharmacological treatment of impotence was compared in a double-blind, crossover trial." | 9.06 | Treatment of impotence by intrapenile injections. A comparison of papaverine versus papaverine and phentolamine: a double-blind, crossover trial. ( Carati, CJ; Earle, CM; Keogh, EJ; Lord, DJ; Tulloch, GS; Watters, GR; Wisniewski, ZS, 1989) |
| " The aim of the present study was to investigate whether papaverine, a novel RAGE inhibitor, could suppress inflammatory pain in mice after several time points, which was induced by the injection of complete Freund's adjuvant (CFA)." | 8.02 | Antinociceptive activity of the novel RAGE inhibitor, papaverine, in a mouse model of chronic inflammatory pain. ( Nakamura, T; Sato, A; Takahashi, Y; Takasawa, R; Takeuchi, K; Tanuma, SI; Ukai, S; Yoshizawa, K, 2021) |
| " In the IBS subjects, pain severity, as well as the sensory response to rectal balloon distention and rectal and sigmoid motility, were studied at baseline and after two weeks therapy with either oral buscopan (20 mg three times a day, n=37), a buscopan suppository (30 mg once daily, n=21), oral drotaverine (80 mg three times a day, n=30), calcium gluconate tablets (one three times a day, n=16) as a control for oral agents, or calendula suppository (once daily, n=14) as a control for those who received a suppository." | 5.14 | Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics). ( Dzhanayev, YA; Golovenko, OV; Khalif, IL; Makarchuk, PA; Podmarenkova, LF; Quigley, EM, 2009) |
| "The aim of our work is to evaluate the efficacy of intracavernous sodium nitroprusside (SNP) in management of erectile dysfunction (ED) in a clinical comparative study with papaverine/phentolamine in ED patients." | 5.11 | Intracavernous sodium nitroprusside (SNP) versus papaverine/phentolamine in erectile dysfunction: a comparative study of short-term efficacy and side-effects. ( Abdelsalam, W; Atteya, A; Elnashaar, A; Gadallah, A; Shamloul, R; Zohdy, W, 2005) |
| "A study comparing intracorporeal injection of prostaglandin E1 (one-drug solution) and papaverine plus prostaglandin E1 (2-drug solution) for treatment of impotence." | 5.08 | Papaverine plus prostaglandin E1 versus prostaglandin E1 alone for intracorporeal injection therapy. ( Zaher, TF, 1998) |
| "Transurethral alprostadil therapy is an effective therapeutic option for patients with erectile dysfunction and may even "rescue" some patients who have failed prior intracavernous injection therapy." | 5.08 | Transurethral alprostadil as therapy for patients who withdrew from or failed prior intracavernous injection therapy. ( Engel, JD; McVary, KT, 1998) |
| "In an attempt to determine whether penile pain associated with intracorporeal injections could be due to the acidity of the medication, we performed a randomized study comparing the incidence of penile pain following intracorporeal injections with or without the addition of sodium bicarbonate to the intracorporeal medications." | 5.07 | Sodium bicarbonate alleviates penile pain induced by intracavernous injections for erectile dysfunction. ( Moriel, EZ; Rajfer, J, 1993) |
| "The efficacy of papaverine, and a combination of papaverine and phentolamine as a pharmacological treatment of impotence was compared in a double-blind, crossover trial." | 5.06 | Treatment of impotence by intrapenile injections. A comparison of papaverine versus papaverine and phentolamine: a double-blind, crossover trial. ( Carati, CJ; Earle, CM; Keogh, EJ; Lord, DJ; Tulloch, GS; Watters, GR; Wisniewski, ZS, 1989) |
| " The aim of the present study was to investigate whether papaverine, a novel RAGE inhibitor, could suppress inflammatory pain in mice after several time points, which was induced by the injection of complete Freund's adjuvant (CFA)." | 4.02 | Antinociceptive activity of the novel RAGE inhibitor, papaverine, in a mouse model of chronic inflammatory pain. ( Nakamura, T; Sato, A; Takahashi, Y; Takasawa, R; Takeuchi, K; Tanuma, SI; Ukai, S; Yoshizawa, K, 2021) |
| "A total of 78 patients 17 to 84 years old reported their experience via questionnaire with the papaverine-phentolamine injection technique for impotence." | 3.67 | Intracavernous self-injection for impotence: a long-term therapeutic option? Experience in 78 patients. ( Bruskewitz, RC; Feyzi, J; Gasser, TC; Girdley, FM; Graversen, PH, 1988) |
Research
Studies (35)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (60.00) | 18.7374 |
| 1990's | 5 (14.29) | 18.2507 |
| 2000's | 7 (20.00) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Yoshizawa, K | 1 |
| Takeuchi, K | 1 |
| Nakamura, T | 1 |
| Ukai, S | 1 |
| Takahashi, Y | 1 |
| Sato, A | 1 |
| Takasawa, R | 1 |
| Tanuma, SI | 1 |
| Nelson, CJ | 1 |
| Hsiao, W | 1 |
| Balk, E | 1 |
| Narus, J | 1 |
| Tal, R | 1 |
| Bennett, NE | 1 |
| Mulhall, JP | 1 |
| Osman, F | 1 |
| Buller, N | 1 |
| Steeds, R | 1 |
| Khalif, IL | 1 |
| Quigley, EM | 1 |
| Makarchuk, PA | 1 |
| Golovenko, OV | 1 |
| Podmarenkova, LF | 1 |
| Dzhanayev, YA | 1 |
| Kruuse, C | 1 |
| Thomsen, LL | 1 |
| Jacobsen, TB | 1 |
| Olesen, J | 1 |
| MERCIER, F | 1 |
| MARINACCE, P | 1 |
| RICHAUD, L | 1 |
| STOLL, P | 1 |
| MACRIS, SG | 1 |
| GRAVENSTEIN, JS | 1 |
| REICHLE, CW | 1 |
| BEECHER, HK | 1 |
| HAKANSSON, B | 1 |
| DIGGS, LW | 1 |
| WILLIAMS, DL | 1 |
| MUFSON, I | 1 |
| Ukhal', MI | 1 |
| Melenevskiĭ, DA | 1 |
| Lane, BR | 1 |
| Lane, BZ | 1 |
| Ausmundson, SJ | 1 |
| Butler, RS | 1 |
| Zippe, CD | 1 |
| Jones, JS | 1 |
| Lakin, MM | 1 |
| Shamloul, R | 1 |
| Atteya, A | 1 |
| Elnashaar, A | 1 |
| Gadallah, A | 1 |
| Zohdy, W | 1 |
| Abdelsalam, W | 1 |
| Juan, H | 1 |
| Seewann, S | 1 |
| Barta, O | 1 |
| Temesi, M | 1 |
| Varró, J | 1 |
| Zaĭtsev, AA | 1 |
| Ignatov, IuD | 1 |
| Dmitriev, AV | 1 |
| Moriel, EZ | 1 |
| Rajfer, J | 1 |
| Zaher, TF | 1 |
| Engel, JD | 1 |
| McVary, KT | 1 |
| Aikawa, N | 1 |
| Ohmori, K | 1 |
| Baniel, J | 1 |
| Israilov, S | 1 |
| Engelstein, D | 1 |
| Shmueli, J | 1 |
| Segenreich, E | 1 |
| Livne, PM | 1 |
| Bányász, T | 1 |
| Karpiák, I | 1 |
| Kocián, J | 1 |
| Kociánová, J | 1 |
| Gelin, LE | 1 |
| Pallan, T | 1 |
| Wulkan, IA | 1 |
| Flores, L | 1 |
| Chaudhry, MR | 1 |
| Gintautas, J | 1 |
| Abadir, AR | 1 |
| Keogh, EJ | 1 |
| Watters, GR | 1 |
| Earle, CM | 1 |
| Carati, CJ | 1 |
| Wisniewski, ZS | 1 |
| Tulloch, GS | 1 |
| Lord, DJ | 1 |
| Girdley, FM | 1 |
| Bruskewitz, RC | 1 |
| Feyzi, J | 1 |
| Graversen, PH | 1 |
| Gasser, TC | 1 |
| Jönsson, PE | 1 |
| Olsson, AM | 1 |
| Petersson, BA | 1 |
| Johansson, K | 1 |
| Zoli, I | 1 |
| Baroncini, S | 1 |
| Cornia, GL | 1 |
| Donato, S | 1 |
| Minore, G | 1 |
| Pigini, G | 1 |
| Pretolani, E | 1 |
| Kocher, R | 1 |
| Rohrer, G | 1 |
| Votcal, BE | 1 |
| Lozinskij, LG | 1 |
| Schnell, U | 1 |
| Nakanishi, M | 1 |
| Imamura, H | 1 |
| Maruyama, Y | 1 |
| Taira, N | 1 |
| Nakayama, K | 1 |
| Hashimoto, K | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Tramadol Hcl in the Treatment of Renal Colic[NCT00310908] | Phase 4 | 100 participants (Anticipated) | Interventional | 2006-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trials
13 trials available for papaverine and Ache
| Article | Year |
|---|---|
Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics).
Topics: Administration, Oral; Administration, Rectal; Adult; Butylscopolammonium Bromide; Calcium Gluconate; | 2009 |
The phosphodiesterase 5 inhibitor sildenafil has no effect on cerebral blood flow or blood velocity, but nevertheless induces headache in healthy subjects.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adult; Brain; Cerebral Arteries; Cerebrovascular Circulation; C | 2002 |
[Using prostaglandin inhibitor dicloberl in patients with ureteral calculi].
Topics: Adult; Aged; Analgesics, Opioid; Diclofenac; Drug Therapy, Combination; Female; Humans; Male; Middle | 2004 |
Intracavernous sodium nitroprusside (SNP) versus papaverine/phentolamine in erectile dysfunction: a comparative study of short-term efficacy and side-effects.
Topics: Adrenergic alpha-Antagonists; Adult; Drug Therapy, Combination; Erectile Dysfunction; Humans; Inject | 2005 |
Sodium bicarbonate alleviates penile pain induced by intracavernous injections for erectile dysfunction.
Topics: Adult; Aged; Alprostadil; Bicarbonates; Double-Blind Method; Drug Combinations; Erectile Dysfunction | 1993 |
Papaverine plus prostaglandin E1 versus prostaglandin E1 alone for intracorporeal injection therapy.
Topics: Adult; Aged; Alprostadil; Drug Therapy, Combination; Erectile Dysfunction; Humans; Injections; Middl | 1998 |
Transurethral alprostadil as therapy for patients who withdrew from or failed prior intracavernous injection therapy.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Alprostadil; | 1998 |
Three-year outcome of a progressive treatment program for erectile dysfunction with intracavernous injections of vasoactive drugs.
Topics: Adult; Aged; Aged, 80 and over; Alprostadil; Drug Therapy, Combination; Erectile Dysfunction; Follow | 2000 |
[Clinical experiences with preparation Hylakombun in gastroenterology].
Topics: Adult; Aged; Clinical Trials as Topic; Constipation; Diarrhea; Drug Combinations; Drug Evaluation; D | 1975 |
Treatment of impotence by intrapenile injections. A comparison of papaverine versus papaverine and phentolamine: a double-blind, crossover trial.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Erectile Dysfunction; | 1989 |
Intravenous indomethacin and oxycone-papaverine in the treatment of acute renal colic. A double-blind study.
Topics: Acute Disease; Adult; Aged; Clinical Trials as Topic; Codeine; Colic; Double-Blind Method; Drug Comb | 1987 |
[Treatment of severe chronic pains with a combination of thymoleptics and neuroleptics (author's transl)].
Topics: Adult; Antidepressive Agents; Atropine; Chlorpromazine; Clinical Trials as Topic; Clomipramine; Drug | 1974 |
[Carbochromen in therapy of acute and chronic coronary insufficiency].
Topics: Acute Disease; Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Blood Pressure; Chronic Disease; | 1970 |
Other Studies
22 other studies available for papaverine and Ache
| Article | Year |
|---|---|
Antinociceptive activity of the novel RAGE inhibitor, papaverine, in a mouse model of chronic inflammatory pain.
Topics: Analgesics; Animals; Disease Models, Animal; Mice; Pain; Papaverine; Receptor for Advanced Glycation | 2021 |
Injection anxiety and pain in men using intracavernosal injection therapy after radical pelvic surgery.
Topics: Aged; Alprostadil; Anxiety; Drug Combinations; Erectile Dysfunction; Humans; Injections; Male; Middl | 2013 |
Use of intra-arterial papaverine for severe arterial spasm during radial cardiac catheterization.
Topics: Cardiac Catheterization; Coronary Angiography; Female; Humans; Middle Aged; Pain; Papaverine; Radial | 2008 |
[Experimental analgesia with papaverine and certain of its derivatives].
Topics: Analgesia; Humans; Pain; Pain Management; Papaverine | 1952 |
[The treatment of painful conditions in the true pelvis of the female with ichthobellol compositum].
Topics: Aminopyrine; Belladonna Alkaloids; Disease; Female; Humans; Lesser Pelvis; Pain; Papaverine; Pelvis; | 1957 |
Drug synergism (potentiation) in pain relief in man: papaverine and morphine.
Topics: Drug Synergism; Humans; Male; Morphine; Pain; Papaverine | 1958 |
[Analgetic reducing therapy for pain associated with circulatory insufficiency].
Topics: Baths; Geriatrics; Heparin; Humans; Lidocaine; Pain; Papaverine; Vascular Diseases | 1962 |
Treatment of painful sickle cell crises with papaverine: preliminary report.
Topics: Anemia; Anemia, Sickle Cell; Erythrocytes, Abnormal; Humans; Pain; Papaverine | 1963 |
Responses of the abnormal arterial circulation to various stimuli, as studied by the use of radioactive sodium. II. Intraarterial histamine, papaverine, aminophylline and adrenaline; sympathectomy and etamon; pain.
Topics: Aminophylline; Arteries; Blood Vessels; Epinephrine; Histamine; Humans; Pain; Papaverine; Sodium; So | 1951 |
Use of a visual analog scale to assess pain of injection with intracavernous injection therapy.
Topics: Adult; Aged; Alprostadil; Diabetes Mellitus; Drug Administration Routes; Humans; Injections; Male; M | 2005 |
Selective reduction by some vasodilators and the prostaglandin antagonist SC-19220 of a response to the algesic effect of bradykinin.
Topics: Acetylcholine; Aminophylline; Animals; Bradykinin; Depression, Chemical; Dibenz(b,f)(1,4)oxazepine-1 | 1980 |
Examination of the pain relieving-effect of intra-arterial No-Spa treatment of coxarthrosis.
Topics: Adult; Aged; Female; Hip Joint; Humans; Injections, Intra-Arterial; Male; Middle Aged; Osteoarthriti | 1982 |
[Analgesic effect of clopheline].
Topics: Analgesics; Animals; Behavior, Animal; Cats; Clonidine; Drug Interactions; Hemodynamics; Naloxone; P | 1981 |
Effect of zaldaride maleate, an antidiarrheal compound, on visceral pain reflex induced by small intestinal distention in anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Animals, Newborn; Antidiarrheals; Atropine; Benzi | 1999 |
The effect of Quarelin on pain in old age.
Topics: Age Factors; Aged; Aminopyrine; Analgesics; Dipyrone; Drug Combinations; Female; Humans; Male; Pain; | 1977 |
[Control of pain in the pre-clinical phase].
Topics: Acute Disease; Analgesics; Autonomic Nerve Block; Colchicine; Hospitalization; Humans; Hypnotics and | 1975 |
Radiologic contrast material and a vasodilator can produce arterial thrombosis.
Topics: Arm; Brachial Artery; Contrast Media; Drug Incompatibility; Female; Humans; Iopamidol; Middle Aged; | 1991 |
Intracavernous self-injection for impotence: a long-term therapeutic option? Experience in 78 patients.
Topics: Consumer Behavior; Drug Combinations; Erectile Dysfunction; Humans; Male; Middle Aged; Pain; Papaver | 1988 |
[Therapeutic possibilities in coronary disease].
Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Arteriosclerosis; Cardiomegaly; Coronary Disease | 1973 |
[Dolo-Eupaco as an analgesic in gynecology].
Topics: Adult; Aminopyrine; Analgesics; Benzilates; Codeine; Esters; Female; Genital Diseases, Female; Genit | 1970 |
[Studies on anti-inflammatory agents. II. Analgesic and anti-edematous activities of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6, 7-tetrahydrothieno (2,3-c)pyridine (Y-3642)].
Topics: Aminopyrine; Amphetamine; Analgesics; Animals; Anti-Inflammatory Agents; Edema; Imipramine; Male; Mi | 1970 |
Vocalization response of puppies to intra-arterial administration of bradykinin and other algesic agents, and mode of actions of blocking agents.
Topics: Acetylcholine; Age Factors; Analgesics; Animals; Atropine; Barium; Bradykinin; Catheterization; Chlo | 1968 |