Page last updated: 2024-11-02

pantoprazole and Liver Cirrhosis

pantoprazole has been researched along with Liver Cirrhosis in 7 studies

Pantoprazole: 2-pyridinylmethylsulfinylbenzimidazole proton pump inhibitor that is used in the treatment of GASTROESOPHAGEAL REFLUX and PEPTIC ULCER.
pantoprazole : A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a difluoromethoxy group at position 5 and a [(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl group at position 2.

Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.

Research Excerpts

ExcerptRelevanceReference
"This observation further supports the notion that pantoprazole can induce acute hepatocellular hepatitis, and it strongly suggests that it may trigger acute cholangitis and autoimmune liver injury."7.88Pantoprazole-induced autoimmune chronic hepatitis. ( Larrey, D; Meunier, L; Pageaux, GP; Ursic-Bedoya, J, 2018)
"This observation further supports the notion that pantoprazole can induce acute hepatocellular hepatitis, and it strongly suggests that it may trigger acute cholangitis and autoimmune liver injury."3.88Pantoprazole-induced autoimmune chronic hepatitis. ( Larrey, D; Meunier, L; Pageaux, GP; Ursic-Bedoya, J, 2018)
" Following a single oral dose of 40 mg, Cmax is approximately 2."2.68Pharmacokinetics of pantoprazole in man. ( Bliesath, H; Hartmann, M; Huber, R; Lühmann, R; Steinijans, VW; Zech, K, 1996)
"In 84 consecutive cirrhotic patients, bacterial infection risk was prospectively assessed and related to PPI use."1.38Bacterial infections in cirrhosis: role of proton pump inhibitors and intestinal permeability. ( de Rooij, FW; Huisman, EJ; Renooij, W; Siersema, PD; van Erpecum, KJ; van Hoek, B; van Vlerken, LG, 2012)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's0 (0.00)29.6817
2010's5 (71.43)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Labenz, C1
Kostev, K1
Galle, PR1
Wörns, MA1
Labenz, J1
Tanislav, C1
Adarkwah, CC1
Meunier, L1
Ursic-Bedoya, J1
Pageaux, GP1
Larrey, D1
Yang, SC1
Chen, JC1
Tai, WC1
Wu, CK1
Lee, CH1
Wu, KL1
Chiu, YC1
Wang, JH1
Lu, SN1
Chuah, SK1
Calcagno, A1
Trentalange, A1
Simiele, M1
Marinaro, L1
Patti, F1
Tettoni, MC1
Trentini, L1
Di Perri, G1
DʼAvolio, A1
Bonora, S1
Tsai, CF1
Chen, MH1
Wang, YP1
Chu, CJ1
Huang, YH1
Lin, HC1
Hou, MC1
Lee, FY1
Su, TP1
Lu, CL1
van Vlerken, LG1
Huisman, EJ1
van Hoek, B1
Renooij, W1
de Rooij, FW1
Siersema, PD1
van Erpecum, KJ1
Huber, R1
Hartmann, M1
Bliesath, H1
Lühmann, R1
Steinijans, VW1
Zech, K1

Trials

1 trial available for pantoprazole and Liver Cirrhosis

ArticleYear
Pharmacokinetics of pantoprazole in man.
    International journal of clinical pharmacology and therapeutics, 1996, Volume: 34, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adolescent; Adult; Aged; Anti-Ulcer A

1996

Other Studies

6 other studies available for pantoprazole and Liver Cirrhosis

ArticleYear
Proton pump inhibitor use is associated with a variety of infections in patients with liver cirrhosis.
    Medicine, 2020, Dec-11, Volume: 99, Issue:50

    Topics: Bacterial Infections; Case-Control Studies; Databases, Factual; Female; Germany; Humans; Liver Cirrh

2020
Pantoprazole-induced autoimmune chronic hepatitis.
    Liver international : official journal of the International Association for the Study of the Liver, 2018, Volume: 38, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Cholangitis; Cholestasis; Female; Hepatitis, Autoimmune; Hum

2018
The influential roles of antibiotics prophylaxis in cirrhotic patients with peptic ulcer bleeding after initial endoscopic treatments.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Bacterial Agents; Anti-Ulcer Agents; Antibiotic

2014
Rilpivirine Pharmacokinetics in 3 HIV-Positive Patients With Liver Cirrhosis Concomitantly Receiving Pantoprazole.
    Therapeutic drug monitoring, 2015, Volume: 37, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-HIV Agents; Drug Interactions; HIV Infections; Humans;

2015
Proton Pump Inhibitors Increase Risk for Hepatic Encephalopathy in Patients With Cirrhosis in A Population Study.
    Gastroenterology, 2017, Volume: 152, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administrative Claims, Healthcare; Adult; Aged; Case-Contro

2017
Bacterial infections in cirrhosis: role of proton pump inhibitors and intestinal permeability.
    European journal of clinical investigation, 2012, Volume: 42, Issue:7

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Animals; Bacteria; Bacterial Infections; Cohor

2012