pantetheine and Arteriosclerosis

Topics: Arteriosclerosis; Cholesterol; Diet; Epoprostenol; Female; Humans; Lipoproteins; Male; Pantetheine; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Risk; Thromboxanes; Triglycerides

Topics: Aged; Arteriosclerosis; Choline; Double-Blind Method; Drug Combinations; Drug Evaluation; Female; Humans; Male; Middle Aged; Pantetheine; Phosphorylcholine; Sulfhydryl Compounds

A randomized and double blind experiment has been made over 50 patients and 25 checks, by giving a dosage of 3 Fosfolip (calcium salt of phosphorylcholine chlorid with pantethine) capsules a day. The analysis results has been reported in the work. In none case the product had secondary no desired effects; while therapeutical possibilities have been resulted in hepatosis, dyslipidosis and as energetic tonic in atherosclerotic subjects.

Topics: Adult; Aged; Arteriosclerosis; Choline; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hyperlipidemias; Lipids; Liver Diseases; Male; Middle Aged; Pantetheine; Phosphorylcholine; Sulfhydryl Compounds

Topics: Arteriosclerosis; Carnitine; Cholestyramine Resin; Glomerulonephritis; Humans; Hyperlipidemias; Kidney Failure, Chronic; Niceritrol; Pantetheine; Pravastatin; Probucol; Vitamin E

After a review of the clinical studies on the treatment of diabetic patients with pantethine, the authors discuss the results obtained in a postmarketing surveillance (PMS) study on 1045 hyperlipidemic patients receiving pantethine (900 mg/day on average). Of these patients, 57 were insulin-dependent (Type I) and 241 were non insulin-dependent (Type II) diabetics. Beyond the epidemiological considerations made possible by a PMS study, the authors show that pantethine brought about a statistically significant and comparable improvement of lipid metabolism in the three groups of patients, with very good tolerability. Pantethine should therefore be considered for the treatment of lipid abnormalities also in patients at risk such as those with diabetes mellitus.

Topics: Arteriosclerosis; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Hyperlipoproteinemias; Male; Middle Aged; Pantetheine; Product Surveillance, Postmarketing; Sulfhydryl Compounds

Effect of probucol, pantethine and their combinations on serum lipoprotein metabolism and on the incidence of atheromatous lesions in aorta and coronary artery was studied in cholesterol-fed rabbits. Probucol treatment (0.5% in diet) resulted in reducing HDL cholesterol and serum apo A-I levels significantly, while pantethine treatment (0.25%-0.75% in diet) tended to increase HDL cholesterol and serum apo A-I levels. Combined treatment with these two drugs showed a significant prevention in the reduction of HDL cholesterol and serum apo A-I levels by probucol alone. Probucol or pantethine treatment reduced effectively (V) LDL cholesterol and serum apo B levels, and these effects were accelerated additively when the two drugs were given concurrently. Atheromatous lesions in aorta and coronary artery in cholesterol-fed rabbits were prevented by the treatment with probucol (0.5% in diet) or pantethine (0.75% in diet) for 24 weeks. The combined treatment with these two drugs showed more marked prevention than either drug alone. From these findings, it is concluded that the combined treatment of probucol with pantethine is effective for improvement of serum lipoprotein disorders and for prevention of the incidence of atheromatous lesions in aorta and coronary artery in cholesterol-fed rabbits.

Topics: Animals; Apolipoproteins; Arteriosclerosis; Cholesterol, HDL; Drug Synergism; Lipoproteins; Male; Pantetheine; Phenols; Probucol; Rabbits; Sulfhydryl Compounds

The hypolipidemizing effects of Pantethine were investigated by the Authors in 37 hypercholesterolemic and/or hypertriglyceridemic patients. Of these, 21 were also diabetic, in a satisfying glucidic compensation, in order to verify the action of this drug also in this metabolic condition. The study was carried out for three months and during this period the patients were given Pantethine at the dose of 600 mg/die orally. At the 30th, the 60th, the 90th day of treatment the following parameters were controlled: cholesterolemia, HDL cholesterol, apolipoproteins A and B, triglyceridemia, systolic and diastolic arterial pressure, uricemia, body weight. Thirty days after suspending the treatment, the parameters were controlled again to detect a possible "rebound" effect. The results were analyzed on the whole case-record, subdividing the patients in dislipidemic and diabetic-dislipidemic, and on the basis of the Fredrickson's classification. Pantethine induced in all groups a quick and progressive decrease of cholesterolemia, triglyceridemia, LDL cholesterol and Apolipoproteins B with increased HDL cholesterol and Apolipoproteins A. After suspending the treatment, there is a clear inversion of the state of these parameters. The Authors conclude that the present work shows that Pantethine, a natural and atoxic substance, an important component of Coenzyme A, is efficacious in determining a clear tendency towards normalization of the lipidic values.

Topics: Adolescent; Adult; Aged; Apolipoproteins; Arteriosclerosis; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Complications; Female; Humans; Hypercholesterolemia; Hyperlipoproteinemias; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Pantetheine; Sulfhydryl Compounds

Topics: Adult; Aged; Arteriosclerosis; Choline; Drug Therapy, Combination; Female; Humans; Lipidoses; Male; Middle Aged; Pantetheine; Phosphorylcholine; Research Design; Sulfhydryl Compounds

Topics: Adult; Arteriosclerosis; Drug Therapy, Combination; Humans; Kidney Diseases; Male; Pantetheine; Phosphatidylcholine-Sterol O-Acyltransferase; Phosphatidylcholines

Increase of acyl-CoA synthesis was observed when extracts of rat arterial wall were incubated with pantetheine [D-bis-(N-pantothenyl-beta-aminoethyl)-disulfide]. Cholesteryl ester synthesis from palmitate in the arterial wall extract in vitro was higher with arteries from rats on high cholesterol diet than with those from rats on normal diet, but the synthesis was reduced in the arteries of rats on high cholesterol diet with pantetheine. Triglyceride synthesis was higher with arterial wall extracts of rats on high cholesterol diet than with preparations from rats on normal diet and was not reduced with those of rats on high cholesterol diet plus pantetheine. The value of the effects of pantetheine on lipid metabolism in the prevention of atherosclerosis is pointed out.

Topics: Acyl Coenzyme A; Animals; Arteries; Arteriosclerosis; Cholesterol Esters; Cholesterol, Dietary; Male; Pantetheine; Phospholipids; Rats; Sulfhydryl Compounds; Triglycerides