panobinostat has been researched along with Osteoarthritis--Knee* in 1 studies
1 other study(ies) available for panobinostat and Osteoarthritis--Knee
| Article | Year |
|---|---|
Chondroprotective Effects of a Histone Deacetylase Inhibitor, Panobinostat, on Pain Behavior and Cartilage Degradation in Anterior Cruciate Ligament Transection-Induced Experimental Osteoarthritic Rats.
Osteoarthritis (OA) is the most common articular degenerative disease characterized by chronic pain, joint inflammation, and movement limitations, which are significantly influenced by aberrant epigenetic modifications of numerous OA-susceptible genes. Recent studies revealed that both the abnormal activation and differential expression of histone deacetylases (HDACs) might contribute to OA pathogenesis. In this study, we investigated the chondroprotective effects of a marine-derived HDAC inhibitor, panobinostat, on anterior cruciate ligament transection (ACLT)-induced experimental OA rats. The intra-articular administration of 2 or 10 µg of panobinostat (each group, Topics: Animals; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; Cartilage Diseases; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Histone Deacetylase Inhibitors; Male; Osteoarthritis, Knee; Pain; Panobinostat; Rats; Rats, Wistar; Weight-Bearing | 2021 |