panduratin-a has been researched along with Carcinoma--Hepatocellular* in 1 studies
1 other study(ies) available for panduratin-a and Carcinoma--Hepatocellular
| Article | Year |
|---|---|
Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase.
Three new prenylated dihydrochalcones, (+/-)-nicolaioidesins A, B, and C (1-3), as well as a new natural product, 5-styrylfuran-2-carboxylic acid methyl ester (4), along with four known compounds, 2'-hydroxy-4',6'-dimethoxychalcone (5), (+/-)-5-hydroxy-7-methoxyflavanone (6), (+/-)-5-hydroxy-7,4'-dimethoxyflavanone, and panduratin A, were isolated from the roots of Renealmia nicolaioides, using a bioassay to determine the induction of quinone reductase (QR) activity with cultured Hepa lclc7 mouse hepatoma cells. Among these isolates, 5 and 6 induced QR activity, with observed concentrations to double activity (CD) values of 1.7 and 0.9 microg/mL, respectively, while the other constituents were not regarded as being active (CD >10 microg/mL). The chemical structures of 1-4 were elucidated by spectroscopic methods. A biogenetic pathway for the formation of (+/-)-nicolaioidins A-C (1-3) is proposed. Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Chalcone; Chalcones; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Inhibitory Concentration 50; Mice; Molecular Conformation; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); Peru; Plant Roots; Plants, Medicinal; Structure-Activity Relationship; Tumor Cells, Cultured; Zingiberaceae | 2002 |