pancuronium and Movement-Disorders

pancuronium has been researched along with Movement-Disorders* in 1 studies

Other Studies

1 other study(ies) available for pancuronium and Movement-Disorders

ArticleYear
A quantitative study of the pancuronium antagonism at the motor endplate in human organophosphorus intoxication.
    Muscle & nerve, 1995, Volume: 18, Issue:9

    Nine patients with organophosphorus (OP) intoxication developing neuromuscular transmission defects were given pancuronium 1, 2, or 4 mg intravenously (IV). Thirteen patient controls with hypoxic encephalopathy received similar dosages. The responses were monitored electrophysiologically using single and repetitive nerve stimulation (20 and 50 Hz). In OP patients, pancuronium did not alter the amplitude of the single CMAP, whereas its repetitive discharges were reduced. Severe neuromuscular blocks were reversed only partially by pancuronium 4 mg. In less severe blocks, 1 and 2 mg resulted in marked improvement. In the patient controls, pancuronium 4 mg induced a severe neuromuscular block but not with 1 and 2 mg. Pancuronium dosages necessary to reverse severe OP-induced neuromuscular blockade produce a neuromuscular block when AChE activity is normal. Low dosages have little effect on normal neuromuscular transmission, but improve the block to a mild degree and may be useful as part of treatment in OP intoxications.

    Topics: Acetylcholinesterase; Action Potentials; Adult; Dose-Response Relationship, Drug; Electric Stimulation; Humans; Injections, Intravenous; Motor Endplate; Movement Disorders; Neuromuscular Diseases; Organophosphate Poisoning; Pancuronium; Synaptic Transmission; Time Factors

1995