pancuronium and Hypocalcemia

We examine two cases of prolonged neuromuscular blockade (NMB) after cardiac surgery. To the best of our knowledge, these are the first reported cases of complete paralysis lasting more than ten hours after surgery.. We attribute the extended durations of NMB (more than ten hours) to high doses of NMB drugs in combination with magnesium sulphate and moderate renal failure. Advanced age, hepatic disease, aminoglycoside exposure, hypocalcemia, and possible interaction between rocuronium and pancuronium may have played minor roles.. We should avoid administering large doses of NMB agents, even in the context of planned postoperative ventilation. If NMB is not monitored intraoperatively in patients who are at risk of prolonged NMB, then train-of-four response should be measured in the intensive care unit. Adequate sedation should be provided until proper recovery of neuromuscular function is documented.

Topics: Acute Kidney Injury; Aged; Aminoglycosides; Androstanols; Anesthesia Recovery Period; Aorta; Aortic Valve; Cardiac Surgical Procedures; Coronary Artery Bypass; Drug Interactions; Female; Heart Valve Prosthesis Implantation; Humans; Hypocalcemia; Liver Diseases; Magnesium Sulfate; Mitral Valve; Neuromuscular Blockade; Neuromuscular Nondepolarizing Agents; Pancuronium; Paralysis; Rocuronium