pancuronium and Heart-Septal-Defects--Ventricular

Patients with congenital heart disease characterized by a functional single ventricle make up an increasing number of patients presenting for cardiac or noncardiac surgery. Conventional echocardiographic methods to measure left ventricular function, i.e., ejection fraction, are invalid in these patients because of altered ventricular geometry. Two recently described Doppler echocardiographic modalities, the myocardial performance index and Doppler tissue imaging, can be applied to single-ventricle patients because they are independent of ventricular geometry. This study assessed the changes in myocardial performance index and Doppler tissue imaging in response to two anesthetic regimens, fentanyl-midazolam-pancuronium and sevoflurane-pancuronium.. Thirty patients aged 4-12 months with a functional single ventricle were randomized to receive fentanyl-midazolam or sevoflurane. Myocardial performance index and Doppler tissue imaging were measured by transthoracic echocardiography at baseline and two clinically relevant dose levels.. Sixteen patients receiving sevoflurane and 14 receiving fentanyl-midazolam were studied. Myocardial performance index was unchanged from baseline with either agent (fentanyl-midazolam: 0.50 +/- 15 baseline vs. 0.51 +/- 0.15 at dose 2; sevoflurane: 0.42 +/- 0.14 baseline vs. 0.46 +/- 0.09 at dose 2). Doppler tissue imaging S (systolic)- and E (early diastolic)-wave velocities in the lateral ventricular walls at the level of the atrioventricular valve annulus were unchanged in the sevoflurane group; however, both Doppler tissue imaging S- and E-wave velocities were decreased significantly from baseline at dose 1 and dose 2 with fentanyl-midazolam, consistent with decreased longitudinal systolic and diastolic ventricular function.. Myocardial performance index, a global measurement of combined systolic and diastolic ventricular function, is not affected by commonly used doses of fentanyl-midazolam or sevoflurane in infants with a functional single ventricle.

Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Coronary Angiography; Dose-Response Relationship, Drug; Echocardiography; Echocardiography, Doppler; Female; Fentanyl; Heart; Heart Bypass, Right; Heart Function Tests; Heart Septal Defects, Ventricular; Hemodynamics; Humans; Infant; Male; Methyl Ethers; Midazolam; Neuromuscular Nondepolarizing Agents; Oxygen; Pancuronium; Sample Size; Sevoflurane

Topics: Analgesics; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Child, Preschool; Ductus Arteriosus, Patent; Fentanyl; Heart Septal Defects, Ventricular; Humans; Hypertension; Intubation, Intratracheal; Isoflurane; Ketamine; Male; Monitoring, Intraoperative; Neuromuscular Nondepolarizing Agents; Oxygen; Pancuronium; Pulmonary Artery; Radiography

Topics: Anesthesia, General; Child; Child, Preschool; Ductus Arteriosus, Patent; Heart Defects, Congenital; Heart Rate; Heart Septal Defects, Atrial; Heart Septal Defects, Ventricular; Hemodynamics; Humans; Pancuronium; Tetralogy of Fallot