pancuronium and Drug-Overdose

pancuronium has been researched along with Drug-Overdose* in 1 studies

Other Studies

1 other study(ies) available for pancuronium and Drug-Overdose

Article	Year
Pancuronium bromide (Pavulon) isolation and identification in aged autopsy tissues and fluids. Journal of forensic sciences, 2005, Volume: 50, Issue:1 The isolation and detection of pancuronium bromide was developed for aged autopsy samples to identify and confirm this compound in questioned tissue samples. A novel protocol was optimized for the isolation of the target drug in highly decomposed tissues. Solid-phase extraction (SPE) cartridges containing styrene-divinylbenzene were investigated. This polymer retained quaternary drugs and facilitated sequential elution upon washing with commonly available solvents. The semi-purified SPE samples were prescreened by pyrolysis GC-MS. A candidate specimen was then confirmed by microbore high-performance liquid chromatography/electrospray-ionization/mass spectrometry (microHPLC-ESI-MS/MS) with a triple-quadrupole mass spectrometer. The developed procedures provided a qualitative or semiquantitative (at best) basis for the investigation of difficult cases involving overdoses of polar drugs. Topics: Autopsy; Chemistry Techniques, Analytical; Drug Overdose; Exhumation; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Humans; Nicotinic Antagonists; Pancuronium; Postmortem Changes; Solvents; Specimen Handling; Time Factors; Tissue Distribution	2005

Article

Year

Pancuronium bromide (Pavulon) isolation and identification in aged autopsy tissues and fluids.

Journal of forensic sciences, 2005, Volume: 50, Issue:1

The isolation and detection of pancuronium bromide was developed for aged autopsy samples to identify and confirm this compound in questioned tissue samples. A novel protocol was optimized for the isolation of the target drug in highly decomposed tissues. Solid-phase extraction (SPE) cartridges containing styrene-divinylbenzene were investigated. This polymer retained quaternary drugs and facilitated sequential elution upon washing with commonly available solvents. The semi-purified SPE samples were prescreened by pyrolysis GC-MS. A candidate specimen was then confirmed by microbore high-performance liquid chromatography/electrospray-ionization/mass spectrometry (microHPLC-ESI-MS/MS) with a triple-quadrupole mass spectrometer. The developed procedures provided a qualitative or semiquantitative (at best) basis for the investigation of difficult cases involving overdoses of polar drugs.

Topics: Autopsy; Chemistry Techniques, Analytical; Drug Overdose; Exhumation; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Humans; Nicotinic Antagonists; Pancuronium; Postmortem Changes; Solvents; Specimen Handling; Time Factors; Tissue Distribution

2005