pancuronium and Cyanosis

Infantile tracheomalacia is a potentially life-threatening disease requiring prolonged artificial respiratory support. Diagnosis and management of this disease may be further improved by establishing a suitable objective and quantitative assessment protocol for tracheal collapsibility. It is our hypothesis that tracheal collapsibility can be represented by the relationship between intraluminal pressure and the cross-sectional area of the trachea. To test this hypothesis, static pressure/area relationships of the trachea were obtained from anesthetized and paralyzed infants, who were diagnosed as having tracheomalacia by endoscopic observation. These relationships were fitted on a linear regression model, followed by calculation of the estimated closing pressure. The tracheal closing pressure ranged from -8 to -27 cm H(2)O, suggesting easy collapsibility of the trachea during crying or coughing and noncollapsibility during the spontaneous respiratory cycle, which coincided with the infants' symptoms. It is our conclusion that tracheal collapsibility of infants with tracheomalacia can be quantitatively assessed by the static pressure/area relationship of the trachea obtained under general anesthesia and paralysis.

Topics: Airway Resistance; Anesthesia, General; Body Weight; Bronchoscopy; Case-Control Studies; Compliance; Cough; Crying; Cyanosis; Female; Gestational Age; Humans; Hypnotics and Sedatives; Infant; Linear Models; Male; Manometry; Midazolam; Neuromuscular Nondepolarizing Agents; Pancuronium; Predictive Value of Tests; Pressure; Respiratory Mechanics; Tracheal Diseases; Video Recording

Topics: Cyanosis; Humans; Infant, Newborn; Infant, Premature, Diseases; Intensive Care Units, Neonatal; Pancuronium; Pulmonary Emphysema

Topics: Bronchial Spasm; Cyanosis; Histamine Release; Humans; Hypotension; Male; Middle Aged; Pancuronium; Pulmonary Edema