pancuronium and Bronchial-Spasm

Topics: Aged; Anaphylaxis; Anesthesia, Intravenous; Anesthetics, Intravenous; Bronchial Spasm; Humans; Hypotension; Male; Neuromuscular Nondepolarizing Agents; Pancuronium; Propofol; Tachycardia; Thiopental

The ability of adenosine to potentiate the airway narrowing induced by histamine in anaesthetized and curarized guinea pigs has been investigated in order to establish whether it could be ascribed to a modulatory activity by the nucleoside at the neuronal level. Bilateral vagotomy, atropine (2 mg/kg i.v.), and pretreatment with capsaicin (52 mg/kg s.c. 6 days before the experiment) did not result in any significant protection against the enhancement provoked by the nucleoside of the bronchocontractile effect of histamine. On the contrary, the latter was significantly reduced by the ganglionic blocking agent, hexamethonium (10 mg/kg i.v.). Moreover, the effect of adenosine on airway responsiveness to histamine was not modified in animals treated with propranolol (1 mg/kg i.v.) or guanethidine (20 mg/kg s.c. over a period of 2 days). In conclusion, current data suggest that the purine is able, in our experimental model, to potentiate the bronchospasm induced by histamine by means of a mechanism mediated, at least partly, by non-adrenergic-non-cholinergic nerves not related to capsaicin-sensitive afferent neurons.

Topics: Adenosine; Anesthesia; Animals; Atropine; Blood Pressure; Bronchi; Bronchial Spasm; Bronchoconstriction; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Hexamethonium Compounds; Histamine; Histamine Antagonists; Male; Pancuronium; Vagotomy; Vagus Nerve

Three doses of salbutamol 125 micrograms iv were given, over 3.5 hr, to a 28-yr-old healthy, previously non-asthmatic man during thiopentone-O2/N2O-isoflurane anaesthesia for treatment and prophylaxis of bronchospasm. Force of contraction of the adductor pollicis was measured before and after the last two injections. Initially, the patient was given pancuronium, 5 mg. Salbutamol, 125 micrograms iv, was given when T1 blockade was 45%. Blockade increased to 66% over five minutes and returned to 45% after 18 min. Vecuronium was subsequently used to maintain relaxation. At the end of surgery, salbutamol was followed by an increase in T1 blockade, from 66% to 86%, over five minutes which returned to 66% after ten minutes. It is concluded that intravenous salbutamol potentiates the neuromuscular blocking effect of nondepolarizing muscle relaxants.

Topics: Adult; Albuterol; Anesthesia, Inhalation; Anesthesia, Intravenous; Blood Pressure; Bronchial Spasm; Drug Synergism; Electric Stimulation; Heart Rate; Humans; Injections, Intravenous; Intraoperative Complications; Isoflurane; Male; Muscle Contraction; Neuromuscular Junction; Pancuronium; Vecuronium Bromide

Topics: Asthma; Bronchial Spasm; Conscious Sedation; Female; Humans; Infusions, Intravenous; Ketamine; Midazolam; Middle Aged; Myocardial Infarction; Pancuronium; Respiration, Artificial; Status Asthmaticus

A review of clinical and experimental data pertaining to drug-induced asthma is presented. Various drugs and drug additives causing asthma are classified and their possible modes of action in inducing asthma are discussed. Practical recommendations for diagnosis and prevention of drug-induced asthma are enumerated.

Topics: Alfaxalone Alfadolone Mixture; Aspirin; Asthma; Azo Compounds; Bronchial Spasm; Coloring Agents; Contrast Media; Cromolyn Sodium; Humans; Isoproterenol; Pancuronium

Topics: Bronchial Spasm; Cyanosis; Histamine Release; Humans; Hypotension; Male; Middle Aged; Pancuronium; Pulmonary Edema

A detailed review of drug-induced bronchospasm is presented. Four types of reactions are described. Furthermore, pathogenesis, clinical picture, treatment and prophylaxis of the "Aspirin-induced asthma" are demonstrated.

Topics: Adrenal Cortex Hormones; Aspirin; Asthma; Bronchi; Bronchial Spasm; Drug Hypersensitivity; Female; Humans; Male; Pancuronium; Peptide Hydrolases; Proteins; Tartrazine; Thiopental

Topics: Anesthetics; Bronchial Spasm; Drug Combinations; Drug Hypersensitivity; Humans; Hydroxysteroids; Molecular Conformation; Pancuronium; Pregnanediones; Protein Binding

Topics: Adult; Aminophylline; Androstanes; Blood Pressure; Bronchial Spasm; Female; Histamine Release; Humans; Neuromuscular Nondepolarizing Agents; Pancuronium; Pulse; Skin Tests

Topics: Aminophylline; Androstanes; Asthma; Bronchial Spasm; Ephedrine; Humans; Male; Middle Aged; Neuromuscular Nondepolarizing Agents; Oxygen; Pancuronium; Respiration, Artificial; Skin Tests

Topics: Androstanes; Anesthetics; Animals; Bronchial Spasm; Humans; Ketones; Neuromuscular Nondepolarizing Agents; Pancuronium; Pregnanes

Topics: Anesthetics; Bronchial Spasm; Drug Hypersensitivity; Humans; Ketones; Pancuronium; Pregnanes; Skin Tests

Topics: Adult; Anesthetics; Bronchial Spasm; Female; Humans; Hydroxysteroids; Intubation, Intratracheal; Pancuronium; Pregnanediones; Spirometry

Topics: Anesthesia; Arrhythmias, Cardiac; Body Weight; Bronchial Spasm; Female; Histamine Release; Humans; Hypotension; Infant; Infant, Newborn; Injections, Intramuscular; Male; Muscle Relaxants, Central; Neuromuscular Depolarizing Agents; Pancuronium; Postoperative Complications; Respiratory Insufficiency; Succinylcholine; Time Factors; Tubocurarine