pamidronate has been researched along with Rheumatoid Arthritis in 10 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the effects of 3-amino-1-hydroxypropylidine-1,1-bisphosphonate (pamidronate) in rheumatoid arthritis (RA)." | 9.07 | Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: a double blind placebo controlled study. ( Breedveld, FC; Dijkmans, BA; Eggelmeijer, F; Papapoulos, SE; van Paassen, HC, 1994) |
| "Rate of bone resorption was assessed by the biochemical markers: serum carboxy terminal cross-linked telopeptide of type I collagen, urinary carboxy terminal cross-linked telopeptide of type I collagen normalized to creatinine and urinary amino-terminal telopeptide of type I collagen normalized to creatinine; and rate of cartilage degradation by urinary carboxy terminal telopeptide of type II collagen normalized to creatinine." | 6.71 | Short term whole body retention in relation to rate of bone resorption and cartilage degradation after intravenous bisphosphonate (pamidronate) in rheumatoid arthritis. ( Cremers, SC; Den Hartigh, J; Dijkmans, BA; Lems, WF; Lodder, MC; Papapoulos, SE; Van Pelt, P; Vermeij, P, 2004) |
| "To assess the effects of 3-amino-1-hydroxypropylidine-1,1-bisphosphonate (pamidronate) in rheumatoid arthritis (RA)." | 5.07 | Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: a double blind placebo controlled study. ( Breedveld, FC; Dijkmans, BA; Eggelmeijer, F; Papapoulos, SE; van Paassen, HC, 1994) |
| "Continuous oral pamidronate (APD), 1000 mg/day, was administered to 14 patients with rheumatoid arthritis." | 5.07 | Double blind radiological assessment of continuous oral pamidronic acid in patients with rheumatoid arthritis. ( Caballero, LE; Di Giorgio, E; Maccagno, A; Perez Lloret, A; Roldan, EJ, 1994) |
| "Rate of bone resorption was assessed by the biochemical markers: serum carboxy terminal cross-linked telopeptide of type I collagen, urinary carboxy terminal cross-linked telopeptide of type I collagen normalized to creatinine and urinary amino-terminal telopeptide of type I collagen normalized to creatinine; and rate of cartilage degradation by urinary carboxy terminal telopeptide of type II collagen normalized to creatinine." | 2.71 | Short term whole body retention in relation to rate of bone resorption and cartilage degradation after intravenous bisphosphonate (pamidronate) in rheumatoid arthritis. ( Cremers, SC; Den Hartigh, J; Dijkmans, BA; Lems, WF; Lodder, MC; Papapoulos, SE; Van Pelt, P; Vermeij, P, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lodder, MC | 2 |
| Van Pelt, PA | 1 |
| Lems, WF | 2 |
| Kostense, PJ | 1 |
| Koks, CH | 1 |
| Dijkmans, BA | 4 |
| Cremers, SC | 1 |
| Den Hartigh, J | 1 |
| Vermeij, P | 1 |
| Van Pelt, P | 1 |
| Papapoulos, SE | 3 |
| Bijvoet, OL | 1 |
| Frijlink, WB | 1 |
| Jie, K | 1 |
| van der Linden, H | 1 |
| Meijer, CJ | 1 |
| Mulder, H | 1 |
| van Paassen, HC | 3 |
| Reitsma, PH | 1 |
| te Velde, J | 1 |
| de Vries, E | 1 |
| van der Wey, JP | 1 |
| Eggelmeijer, F | 2 |
| Breedveld, FC | 2 |
| Maccagno, A | 1 |
| Di Giorgio, E | 1 |
| Roldan, EJ | 1 |
| Caballero, LE | 1 |
| Perez Lloret, A | 1 |
| Valkema, R | 1 |
| Westedt, ML | 1 |
| Landman, JO | 1 |
| Pauwels, EK | 1 |
| Lindy, O | 1 |
| Konttinen, YT | 1 |
| Sorsa, T | 1 |
| Ding, Y | 1 |
| Santavirta, S | 1 |
| Ceponis, A | 1 |
| López-Otín, C | 1 |
| El-Shafei, A | 1 |
| Sheeran, T | 1 |
| Mulherin, D | 1 |
| Ralston, SH | 1 |
| Hacking, L | 1 |
| Willocks, L | 1 |
| Bruce, F | 1 |
| Pitkeathly, DA | 1 |
| Tan, PL | 1 |
| Ames, R | 1 |
| Yeoman, S | 1 |
| Ibbertson, HK | 1 |
| Caughey, DE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Teriparatide for Joint Erosions in Rheumatoid Arthritis: The TERA Trial[NCT01400516] | Phase 4 | 26 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
BMD was measured at the lumbosacral spine antero-posterior and at the femoral neck using a densitometer. A positive change from Baseline (increased bone density) indicates improvement. (NCT01400516)
Timeframe: Baseline and Month 12
| Intervention | grams/centimeters squared (g/cm^2) (Mean) | |||
|---|---|---|---|---|
| Spine, Baseline | Spine, Change from Baseline at Month12 | Femoral neck, Baseline | Femoral neck, Change from Baseline at Month 12 | |
| Control Arm | 0.93 | -0.002 | 0.73 | -0.03 |
| Teriparatide | 0.91 | 0.06 | 0.68 | 0.03 |
The DAS28 score is a measure of the patient's disease activity calculated using the tender joint count (TJC) [28 joints], swollen joint count (SJC) [28 joints], patient's global assessment of disease activity [visual analog scale: 0=no disease activity to 100=maximum disease activity] and C-Reactive Protein (CRP) for a total possible score of 2 to 10. Higher values indicate higher disease activity. A negative change from baseline indicates improvement. (NCT01400516)
Timeframe: Baseline and Month 12
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Baseline | Change from Baseline at Month 12 | |
| Control Arm | 2.73 | -0.50 |
| Teriparatide | 2.66 | 0.42 |
Both hands were scanned using a CT scanner. A semi-automated software tool was used to segment the erosion margins in 3D. A board certified radiologist identified the individual erosions in six sub-regions: radius, ulna, proximal carpals, distal carpals, metacarpophalangeal (MCP) joints and proximal interphalangeal (PIP) joints. The average total in a single hand/wrist was calculated. A negative change from Baseline(less joint erosions) indicates improvement. (NCT01400516)
Timeframe: Baseline and Month 12
| Intervention | cubic millimeter (mm^3) (Median) | |
|---|---|---|
| Baseline | Change from Baseline at Month 12 | |
| Control Arm | 571.4 | 9.1 |
| Teriparatide | 369.8 | -0.4 |
6 trials available for pamidronate and Rheumatoid Arthritis
| Article | Year |
|---|---|
Effects of high dose IV pamidronate on disease activity and bone metabolism in patients with active RA: a randomized, double-blind, placebo-controlled trial.
Topics: Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Bone and Bones; Diphosphonates; Dose-Response | 2003 |
Short term whole body retention in relation to rate of bone resorption and cartilage degradation after intravenous bisphosphonate (pamidronate) in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Biomarkers; Bone Resorption; Cartilage | 2004 |
Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: a double blind placebo controlled study.
Topics: Adult; Arthritis, Rheumatoid; Bone and Bones; Bone Resorption; Calcium; Diphosphonates; Double-Blind | 1994 |
Double blind radiological assessment of continuous oral pamidronic acid in patients with rheumatoid arthritis.
Topics: Administration, Oral; Adult; Arthritis, Rheumatoid; Cartilage, Articular; Diphosphonates; Double-Bli | 1994 |
Increased bone mass with pamidronate treatment in rheumatoid arthritis. Results of a three-year randomized, double-blind trial.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Bone and Bones; Bone De | 1996 |
Clinical, biochemical, and radiographic effects of aminohydroxypropylidene bisphosphonate treatment in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Calcium; Clinical Trials as Topic; Creatinine; Diphosphonates; Double-Blind M | 1989 |
4 other studies available for pamidronate and Rheumatoid Arthritis
| Article | Year |
|---|---|
APD in Paget's disease of bone. Role of the mononuclear phagocyte system?
Topics: Animals; Arthritis, Rheumatoid; Calcitonin; Clodronic Acid; Diphosphonates; Drug Therapy, Combinatio | 1980 |
Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Cartilage, Articular; Clodronic Acid; Collage | 1997 |
Is pamidronate effective for acute rheumatic pain?
Topics: Adult; Analgesics; Arthritis, Rheumatoid; Diphosphonates; Female; Humans; Infusions, Parenteral; Mal | 2002 |
Effects of aminobisphosphonate infusion on biochemical indices of bone metabolism in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Bone and Bones; Calcium; Calcium-Binding Proteins; Creatinine; D | 1989 |