pamidronate has been researched along with Menkes Kinky Hair Syndrome in 1 studies
Menkes Kinky Hair Syndrome: An inherited disorder of copper metabolism transmitted as an X-linked trait and characterized by the infantile onset of HYPOTHERMIA, feeding difficulties, hypotonia, SEIZURES, bony deformities, pili torti (twisted hair), and severely impaired intellectual development. Defective copper transport across plasma and endoplasmic reticulum membranes results in copper being unavailable for the synthesis of several copper containing enzymes, including PROTEIN-LYSINE 6-OXIDASE; CERULOPLASMIN; and SUPEROXIDE DISMUTASE. Pathologic changes include defects in arterial elastin, neuronal loss, and gliosis. (From Menkes, Textbook of Child Neurology, 5th ed, p125)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pamidronate treatment was associated with an increase in bone mineral density and may be an effective treatment modality for the management of osteoporosis in children with Menkes disease." | 2.70 | Pamidronate treatment improves bone mineral density in children with Menkes disease. ( Boneh, A; Kanumakala, S; Zacharin, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kanumakala, S | 1 |
| Boneh, A | 1 |
| Zacharin, M | 1 |
1 trial available for pamidronate and Menkes Kinky Hair Syndrome
| Article | Year |
|---|---|
Pamidronate treatment improves bone mineral density in children with Menkes disease.
Topics: Adolescent; Bone Density; Calcium; Child, Preschool; Diphosphonates; Humans; Infusions, Intravenous; | 2002 |