Page last updated: 2024-11-02

pamidronate and Hypocalcemia

pamidronate has been researched along with Hypocalcemia in 35 studies

Hypocalcemia: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"This is a case report of a patient who developed severe, irreversible hypocalcemia after receiving one dose of pamidronate 90 mg for hypercalcemia of malignancy."7.91A case of severe, irreversible hypocalcemia after one dose of pamidronate administered for hypercalcemia of malignancy. ( Kim, S, 2019)
"The six patients, who had bone fractures either in utero or in their 1st month of life, were treated with cyclic pamidronate from a mean age of 2."7.80Cyclic pamidronate infusion for neonatal-onset osteogenesis imperfecta. ( Chien, CC; Chien, YH; Hwu, WL; Lee, CT; Lee, NC; Lin, CH; Peng, SF; Tsai, WY; Tung, YC, 2014)
"The purpose of this study is to evaluate the acute effect of pamidronate on plasma ionized calcium (iCa) level reduction and dynamic parathyroid hormone (PTH) secretion in postmenopausal hemodialysis-dependent women with secondary hyperparathyroidism."7.72Acute effect of pamidronate on PTH secretion in postmenopausal hemodialysis patients with secondary hyperparathyroidism. ( Chu, P; Lin, SH; Lin, YF; Lu, KC; Yeung, LK, 2003)
"A 62-yr-old woman with thyroid carcinoma metastatic to bone, and a history of subclinical hypoparathyroidism was admitted to the hospital in hypocalcemic crisis 5 wk after receiving iv pamidronate."7.71Prolonged, symptomatic hypocalcemia with pamidronate administration and subclinical hypoparathyroidism. ( Jonklaas, J; Mishra, A; Wong, L, 2001)
"A 65-year-old woman admitted for palliative care of metastatic renal/bladder carcinoma developed symptomatic hypocalcemia nine days following a single dose of pamidronate."7.69Symptomatic hypocalcemia after intravenous pamidronate. ( Bruera, E; McIntyre, E, 1996)
"Hypocalcemia is a potential adverse effect of these drugs, which is considered infrequent and rarely symptomatic."5.32Hypocalcemia following pamidronate administration for bone metastases of solid tumor: three clinical case reports. ( Basuyau, JP; Brunelle, P; Champallou, C; Chevrier, A; Chinet, P; Debled, M; Grongnet, MH; Veyret, C, 2003)
"Pamidronate is an effective drug used not only in patients with tumor-associated hypercalcemia, but also in normocalcemic patients with metastatic bone disease to relieve pains."5.30Symptomatic hypocalcemia in a patient with latent hypoparathyroidism and breast carcinoma with bone metastasis following administration of pamidronate. ( Alakavuklar, M; Biberoglu, S; Cömlekçi, A; Hekimsoy, Z; Okan, I; Pişkin, O; Sekeroglu, B, 1998)
"This is a case report of a patient who developed severe, irreversible hypocalcemia after receiving one dose of pamidronate 90 mg for hypercalcemia of malignancy."3.91A case of severe, irreversible hypocalcemia after one dose of pamidronate administered for hypercalcemia of malignancy. ( Kim, S, 2019)
" Calciphylaxis process started when she received calcium gluconate intravenously the day before the surgery to correct hypocalcemia and continued progressively despite peritoneal dialysis and forced stopping calcium-containing medication."3.81Successful treatment of calciphylaxis with pamidronate. ( Hooman, N; Jahangiri, F; Mehrazma, M; Naghshi-Zadiyan, R, 2015)
"The six patients, who had bone fractures either in utero or in their 1st month of life, were treated with cyclic pamidronate from a mean age of 2."3.80Cyclic pamidronate infusion for neonatal-onset osteogenesis imperfecta. ( Chien, CC; Chien, YH; Hwu, WL; Lee, CT; Lee, NC; Lin, CH; Peng, SF; Tsai, WY; Tung, YC, 2014)
"The purpose of this study is to evaluate the acute effect of pamidronate on plasma ionized calcium (iCa) level reduction and dynamic parathyroid hormone (PTH) secretion in postmenopausal hemodialysis-dependent women with secondary hyperparathyroidism."3.72Acute effect of pamidronate on PTH secretion in postmenopausal hemodialysis patients with secondary hyperparathyroidism. ( Chu, P; Lin, SH; Lin, YF; Lu, KC; Yeung, LK, 2003)
"The pregnancies of two women with osteogenesis imperfecta who received intravenous pamidronate before conception are reported."3.72Maternal and fetal outcome after long-term pamidronate treatment before conception: a report of two cases. ( Glorieux, FH; Munns, CF; Rauch, F; Ward, L, 2004)
"A 62-yr-old woman with thyroid carcinoma metastatic to bone, and a history of subclinical hypoparathyroidism was admitted to the hospital in hypocalcemic crisis 5 wk after receiving iv pamidronate."3.71Prolonged, symptomatic hypocalcemia with pamidronate administration and subclinical hypoparathyroidism. ( Jonklaas, J; Mishra, A; Wong, L, 2001)
"A 65-year-old woman admitted for palliative care of metastatic renal/bladder carcinoma developed symptomatic hypocalcemia nine days following a single dose of pamidronate."3.69Symptomatic hypocalcemia after intravenous pamidronate. ( Bruera, E; McIntyre, E, 1996)
"Hypocalcemia was treated with calcium and vitamin D3 supplements."2.44[Zoledronate-associated end stage renal failure and hypocalcaemia]. ( Bodmer, M; Kummer, O; Ramazzina, C; Rätz Bravo, AE; Zysset Aschmann, Y, 2007)
"Primary hyperparathyroidism is characterized by hypercalcemia with loss of bone mass."1.33Bisphosphonate pretreatment attenuates hungry bone syndrome postoperatively in subjects with primary hyperparathyroidism. ( Kuo, SW; Lee, IT; Pei, D; Sheu, WH; Tu, ST, 2006)
"Hypocalcemia is a potential adverse effect of these drugs, which is considered infrequent and rarely symptomatic."1.32Hypocalcemia following pamidronate administration for bone metastases of solid tumor: three clinical case reports. ( Basuyau, JP; Brunelle, P; Champallou, C; Chevrier, A; Chinet, P; Debled, M; Grongnet, MH; Veyret, C, 2003)
"Pamidronate is an effective drug used not only in patients with tumor-associated hypercalcemia, but also in normocalcemic patients with metastatic bone disease to relieve pains."1.30Symptomatic hypocalcemia in a patient with latent hypoparathyroidism and breast carcinoma with bone metastasis following administration of pamidronate. ( Alakavuklar, M; Biberoglu, S; Cömlekçi, A; Hekimsoy, Z; Okan, I; Pişkin, O; Sekeroglu, B, 1998)
" In osteoporotic syndromes, APD is prescribed at a lower dosage (200 mg/day) and currently calcium or vitamin D are also systematically added."1.29[Effect of low doses of oral pamidronate (APD) on the calcemia of osteopenic or osteoporotic patients]. ( Castelli, G; Kerzberg, EM; Lloret, AP; Roldan, EJ, 1996)
"There were seven patients with breast cancer, eight with lung cancer, and ten with a variety of other cancers."1.28Single high-dose (45 mg) infusions of aminohydroxypropylidene diphosphonate for severe malignant hypercalcemia. ( Cantwell, BM; Carmichael, J; Harris, AL; Mannix, KA, 1989)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19903 (8.57)18.7374
1990's12 (34.29)18.2507
2000's14 (40.00)29.6817
2010's6 (17.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jain, N1
Reilly, RF1
Kim, S1
Boumans, D1
de Vries, PA1
Rikken, NE1
Laverman, GD1
Lin, CH1
Chien, YH1
Peng, SF1
Tsai, WY1
Tung, YC1
Lee, CT1
Chien, CC1
Hwu, WL1
Lee, NC1
McKay, RR1
Lin, X1
Perkins, JJ1
Heng, DY1
Simantov, R1
Choueiri, TK1
Hooman, N1
Naghshi-Zadiyan, R1
Mehrazma, M1
Jahangiri, F1
Singh, R1
Menon, Y1
Cuchacovich, R1
Espinoza, LR1
Champallou, C1
Basuyau, JP1
Veyret, C1
Chinet, P1
Debled, M1
Chevrier, A1
Grongnet, MH1
Brunelle, P1
Rosen, CJ1
Brown, S1
Lu, KC1
Yeung, LK1
Lin, SH1
Lin, YF1
Chu, P1
Altundag, O1
Altundag, K1
Munns, CF1
Rauch, F1
Ward, L1
Glorieux, FH1
Tralongo, P1
Repetto, L1
Di Mari, A1
Mauceri, G1
Bollina, R1
Ferrau', F1
Conti, G1
Henley, D1
Kaye, J1
Walsh, J1
Cull, G1
Lee, IT1
Sheu, WH1
Tu, ST1
Kuo, SW1
Pei, D1
Ramazzina, C1
Zysset Aschmann, Y1
Kummer, O1
Rätz Bravo, AE1
Bodmer, M1
Davenport, A1
Stearns, MP1
Gurevich, Y1
Poretsky, L1
Adami, S1
Frijlink, WB1
Bijvoet, OL1
O'Riordan, JL1
Clemens, TL1
Papapoulos, SE2
Landman, JO1
Schweitzer, DH1
Frölich, M1
Hamdy, NA1
Purohit, OP1
Anthony, C1
Radstone, CR1
Owen, J1
Coleman, RE1
Varma, N1
Kerrigan, GN1
McIntyre, E1
Bruera, E1
Roldan, EJ1
Kerzberg, EM1
Castelli, G1
Lloret, AP1
Kutluk, T1
Akyüz, C1
Yalçin, B1
Varan, A1
Büyükpamuküçu, M1
Cömlekçi, A1
Biberoglu, S1
Hekimsoy, Z1
Okan, I1
Pişkin, O1
Sekeroglu, B1
Alakavuklar, M1
Sims, EC1
Rogers, PB1
Besser, GM1
Plowman, PN1
Chong, G1
Hoang, T1
Davis, ID1
De Schepper, J1
de Pont, S1
Smitz, J1
De Coster, D1
Schots, R1
Otten, J1
Malberti, F1
Farina, M1
Imbasciati, E1
Mishra, A1
Wong, L1
Jonklaas, J1
Stuckey, BG1
Lim, EM1
Kent, GN1
Ward, LC1
Gutteridge, DH1
Body, JJ1
Mannix, KA1
Carmichael, J1
Harris, AL1
Cantwell, BM1
Jodrell, DI1
Iveson, TJ1
Smith, IE1

Reviews

3 reviews available for pamidronate and Hypocalcemia

ArticleYear
Hungry bone syndrome.
    Current opinion in nephrology and hypertension, 2017, Volume: 26, Issue:4

    Topics: Bone Density Conservation Agents; Bone Diseases, Metabolic; Calcitriol; Calcium; Diphosphonates; Hum

2017
[Zoledronate-associated end stage renal failure and hypocalcaemia].
    Praxis, 2007, Apr-25, Volume: 96, Issue:17

    Topics: Acute Kidney Injury; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Aged, 80 and over;

2007
Bone metastases and tumor-induced hypercalcemia.
    Current opinion in oncology, 1992, Volume: 4, Issue:4

    Topics: Antineoplastic Agents; Bone Neoplasms; Bone Resorption; Calcitonin; Combined Modality Therapy; Dipho

1992

Trials

2 trials available for pamidronate and Hypocalcemia

ArticleYear
Recovery of serum calcium concentrations following acute hypocalcemia in patients with osteoporosis on long-term oral therapy with the bisphosphonate pamidronate.
    The Journal of clinical endocrinology and metabolism, 1995, Volume: 80, Issue:2

    Topics: Acute Disease; Administration, Oral; Aged; Calcium; Diphosphonates; Edetic Acid; Female; Humans; Hyp

1995
High-dose intravenous pamidronate for metastatic bone pain.
    British journal of cancer, 1994, Volume: 70, Issue:3

    Topics: Bone and Bones; Bone Neoplasms; Diphosphonates; Dose-Response Relationship, Drug; Female; Humans; Hy

1994

Other Studies

30 other studies available for pamidronate and Hypocalcemia

ArticleYear
A case of severe, irreversible hypocalcemia after one dose of pamidronate administered for hypercalcemia of malignancy.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2019, Volume: 25, Issue:7

    Topics: Bone Neoplasms; Calcium; Humans; Hypercalcemia; Hypocalcemia; Male; Middle Aged; Pamidronate; Risk F

2019
Prolonged hypocalcaemia after pamidronate infusion in Riedel's thyroiditis associated hypoparathyroidism.
    The Netherlands journal of medicine, 2013, Volume: 71, Issue:8

    Topics: Bone Density Conservation Agents; Calcium Carbonate; Dihydrotachysterol; Diphosphonates; Female; Gas

2013
Cyclic pamidronate infusion for neonatal-onset osteogenesis imperfecta.
    Pediatrics and neonatology, 2014, Volume: 55, Issue:4

    Topics: Bone Density; Child; Child, Preschool; Diphosphonates; Drug Administration Schedule; Female; Fractur

2014
Prognostic significance of bone metastases and bisphosphonate therapy in patients with renal cell carcinoma.
    European urology, 2014, Volume: 66, Issue:3

    Topics: Aged; Antineoplastic Agents; Axitinib; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Dens

2014
Successful treatment of calciphylaxis with pamidronate.
    Iranian journal of kidney diseases, 2015, Volume: 9, Issue:1

    Topics: Biopsy; Calciphylaxis; Calcium Gluconate; Debridement; Diphosphonates; Female; Humans; Hypocalcemia;

2015
A six-month randomized, controlled, double-blind, dose-response comparison of intravenous pamidronate (60 mg versus 10 mg) in the treatment of nonsteroidal antiinflammatory drug-refractory ankylosing spondylitis: comment on the article by Maksymowych et a
    Arthritis and rheumatism, 2003, Volume: 48, Issue:2

    Topics: Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Diphosphonates; Double-Bli

2003
Hypocalcemia following pamidronate administration for bone metastases of solid tumor: three clinical case reports.
    Journal of pain and symptom management, 2003, Volume: 25, Issue:2

    Topics: Antineoplastic Agents; Bone Neoplasms; Diphosphonates; Female; Humans; Hypocalcemia; Male; Middle Ag

2003
Severe hypocalcemia after intravenous bisphosphonate therapy in occult vitamin D deficiency.
    The New England journal of medicine, 2003, Apr-10, Volume: 348, Issue:15

    Topics: Diphosphonates; Female; Gastroplasty; Humans; Hypocalcemia; Infusions, Intravenous; Malabsorption Sy

2003
Acute effect of pamidronate on PTH secretion in postmenopausal hemodialysis patients with secondary hyperparathyroidism.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2003, Volume: 42, Issue:6

    Topics: Aged; Chronic Kidney Disease-Mineral and Bone Disorder; Diphosphonates; Female; Humans; Hypercalcemi

2003
Pamidronate, hypocalcemia, and calcium and vitamin D supplementation.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, May-15, Volume: 22, Issue:10

    Topics: Bone Neoplasms; Confounding Factors, Epidemiologic; Diphosphonates; Humans; Hypocalcemia; Male; Pami

2004
Maternal and fetal outcome after long-term pamidronate treatment before conception: a report of two cases.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2004, Volume: 19, Issue:10

    Topics: Adult; Anti-Inflammatory Agents; Clubfoot; Diphosphonates; Female; Humans; Hypocalcemia; Infant; Inj

2004
Safety of long-term administration of bisphosphonates in elderly cancer patients.
    Oncology, 2004, Volume: 67, Issue:2

    Topics: Aged; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Diphosphonates; Drug Administration S

2004
Symptomatic hypocalcaemia and renal impairment associated with bisphosphonate treatment in patients with multiple myeloma.
    Internal medicine journal, 2005, Volume: 35, Issue:12

    Topics: Acute Kidney Injury; Aged; Bone Density Conservation Agents; Calcitriol; Calcium Carbonate; Diphosph

2005
Bisphosphonate pretreatment attenuates hungry bone syndrome postoperatively in subjects with primary hyperparathyroidism.
    Journal of bone and mineral metabolism, 2006, Volume: 24, Issue:3

    Topics: Adult; Aged; Calcium; Clodronic Acid; Diphosphonates; Female; Humans; Hyperparathyroidism, Primary;

2006
Administration of pamidronate helps prevent immediate postparathyroidectomy hungry bone syndrome.
    Nephrology (Carlton, Vic.), 2007, Volume: 12, Issue:4

    Topics: Bone Density Conservation Agents; Diphosphonates; Female; Humans; Hypocalcemia; Male; Middle Aged; P

2007
Possible prevention of hungry bone syndrome following parathyroidectomy by preoperative use of pamidronate.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2008, Volume: 138, Issue:3

    Topics: Adenoma; Aged; Bone Density Conservation Agents; Diphosphonates; Female; Humans; Hypocalcemia; Pamid

2008
Regulation of calcium absorption by 1,25,dihydroxy-vitamin D--studies of the effects of a bisphosphonate treatment.
    Calcified tissue international, 1982, Volume: 34, Issue:4

    Topics: Aged; Bone Resorption; Calcitriol; Calcium; Diphosphonates; Humans; Hypocalcemia; Middle Aged; Ostei

1982
Electrocardiographic Q-Tc prolongation associated with infusion of intravenous pamidronate disodium.
    Postgraduate medical journal, 1993, Volume: 69, Issue:812

    Topics: Aged; Arrhythmias, Cardiac; Diphosphonates; Electrocardiography; Female; Humans; Hypocalcemia; Infus

1993
Symptomatic hypocalcemia after intravenous pamidronate.
    Journal of palliative care, 1996,Spring, Volume: 12, Issue:1

    Topics: Aged; Alberta; Carcinoma, Transitional Cell; Diphosphonates; Female; Humans; Hypercalcemia; Hypocalc

1996
[Effect of low doses of oral pamidronate (APD) on the calcemia of osteopenic or osteoporotic patients].
    Medicina, 1996, Volume: 56, Issue:2

    Topics: Administration, Oral; Analysis of Variance; Bone Diseases, Metabolic; Bone Resorption; Calcium, Diet

1996
Use of pamidronate in the management of acute cancer-related hypercalcemia in children.
    Medical and pediatric oncology, 1998, Volume: 31, Issue:1

    Topics: Antineoplastic Agents; Child; Diphosphonates; Humans; Hypercalcemia; Hypocalcemia; Hypophosphatemia;

1998
Symptomatic hypocalcemia in a patient with latent hypoparathyroidism and breast carcinoma with bone metastasis following administration of pamidronate.
    Internal medicine (Tokyo, Japan), 1998, Volume: 37, Issue:4

    Topics: Adult; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Calcium; Carcinoma; Diphosphonates;

1998
Severe prolonged hypocalcaemia following pamidronate for malignant hypercalcaemia.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 1998, Volume: 10, Issue:6

    Topics: Adenocarcinoma; Adenoma; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols

1998
Symptomatic hypocalcaemia following intravenous pamidronate in cancer patients.
    Australian and New Zealand journal of medicine, 1999, Volume: 29, Issue:1

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Diphosphonates; Female; Humans; Hypocalcemia; Infusi

1999
Metabolic disturbances after a single dose of 30 mg pamidronate for leukaemia-associated hypercalcaemia in a 11-year-old boy.
    European journal of pediatrics, 1999, Volume: 158, Issue:9

    Topics: Antineoplastic Agents; Calcium; Child; Diphosphonates; Humans; Hypercalcemia; Hypocalcemia; Leukemia

1999
The PTH-calcium curve and the set point of calcium in primary and secondary hyperparathyroidism.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1999, Volume: 14, Issue:10

    Topics: Calcium; Diphosphonates; Humans; Hyperparathyroidism; Hypocalcemia; Ions; Osmolar Concentration; Pam

1999
Prolonged, symptomatic hypocalcemia with pamidronate administration and subclinical hypoparathyroidism.
    Endocrine, 2001, Volume: 14, Issue:2

    Topics: Antineoplastic Agents; Bone Neoplasms; Calcitonin; Calcium Carbonate; Diphosphonates; Female; Humans

2001
Bisphosphonate therapy for Paget's disease in a patient with hypoparathyroidism: profound hypocalcemia, rapid response, and prolonged remission.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2001, Volume: 16, Issue:9

    Topics: Alendronate; Calcitriol; Calcium; Cervical Vertebrae; Diphosphonates; Female; Humans; Hypocalcemia;

2001
Single high-dose (45 mg) infusions of aminohydroxypropylidene diphosphonate for severe malignant hypercalcemia.
    Cancer, 1989, Sep-15, Volume: 64, Issue:6

    Topics: Adult; Aged; Diphosphonates; Female; Follow-Up Studies; Humans; Hypercalcemia; Hypocalcemia; Infusio

1989
Symptomatic hypocalcaemia after treatment with high-dose aminohydroxypropylidene diphosphonate.
    Lancet (London, England), 1987, Mar-14, Volume: 1, Issue:8533

    Topics: Diphosphonates; Female; Humans; Hypercalcemia; Hypocalcemia; Middle Aged; Pamidronate

1987