Page last updated: 2024-11-02

pamidronate and Conus Medullaris Syndrome

pamidronate has been researched along with Conus Medullaris Syndrome in 11 studies

Research Excerpts

ExcerptRelevanceReference
"Treatment with zoledronic acid (Zol) was compared with a dose of 90 mg of pamidronate (Pam) in breast carcinoma (BC) patients with at least 1 osteolytic lesion based on data from a Phase III, randomized trial."9.11Zoledronic acid is superior to pamidronate for the treatment of bone metastases in breast carcinoma patients with at least one osteolytic lesion. ( Chen, BL; Coleman, RE; Dugan, W; Eisenberg, PD; Gordon, DH; Kaminski, M; Major, P; Provencher, L; Rosen, LS; Seaman, J; Simeone, J, 2004)
"Patients with stage III multiple myeloma and at least one lytic lesion received either placebo or pamidronate (90 mg) as a four-hour intravenous infusion given every four weeks for nine cycles in addition to antimyeloma therapy."9.08Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group. ( Ballester, O; Bell, R; Berenson, JR; Blacklock, HA; Bordoni, R; Dimopoulos, MA; George, S; Heffernan, M; Keller, A; Knight, RD; Kovacs, MJ; Lichtenstein, A; Lipton, A; Porter, L; Reitsma, DJ; Seaman, J; Simeone, J, 1996)
"Treatment with zoledronic acid (Zol) was compared with a dose of 90 mg of pamidronate (Pam) in breast carcinoma (BC) patients with at least 1 osteolytic lesion based on data from a Phase III, randomized trial."5.11Zoledronic acid is superior to pamidronate for the treatment of bone metastases in breast carcinoma patients with at least one osteolytic lesion. ( Chen, BL; Coleman, RE; Dugan, W; Eisenberg, PD; Gordon, DH; Kaminski, M; Major, P; Provencher, L; Rosen, LS; Seaman, J; Simeone, J, 2004)
"Patients with stage III multiple myeloma and at least one lytic lesion received either placebo or pamidronate (90 mg) as a four-hour intravenous infusion given every four weeks for nine cycles in addition to antimyeloma therapy."5.08Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group. ( Ballester, O; Bell, R; Berenson, JR; Blacklock, HA; Bordoni, R; Dimopoulos, MA; George, S; Heffernan, M; Keller, A; Knight, RD; Kovacs, MJ; Lichtenstein, A; Lipton, A; Porter, L; Reitsma, DJ; Seaman, J; Simeone, J, 1996)
", oral clodronate and intravenous pamidronate and zoledronic acid) can inhibit osteoclast-mediated osteolysis, thereby reducing the risk of SREs, ameliorating bone pain, and potentially prolonging survival in patients with MM."4.87Established role of bisphosphonate therapy for prevention of skeletal complications from myeloma bone disease. ( Berenson, J; Dimopoulos, MA; Terpos, E, 2011)
"Our results show that the majority of patients with breast cancer, who develop bony metastases in Newfoundland and Labrador, are initially treated with the bisphosphonate, pamidronate."3.79Use of bisphosphonates in metastatic breast cancer: single institution review at the Dr. H. Bliss Murphy Cancer Centre. ( Edwards, S; Laing, K; McCarthy, J; McCrate, F; Murphy, L; Powell, E; Seal, M, 2013)
" In a randomized phase III trial of 377 patients with multiple myeloma, Aredia was administered in a dosage of 90 mg i."2.68The role of bisphosphonates in the treatment of bone metastases--the U.S. experience. ( Harvey, HA; Lipton, A, 1996)
"To find an effective symptomatic treatment for osteogenesis imperfecta (OI)."1.31Beneficial effect of long term intravenous bisphosphonate treatment of osteogenesis imperfecta. ( Aström, E; Söderhäll, S, 2002)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (18.18)18.2507
2000's6 (54.55)29.6817
2010's3 (27.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, Z1
Qiao, D1
Lu, Y1
Curtis, D1
Wen, X1
Yao, Y1
Zhao, H1
Crawford, BS1
McNulty, RM1
Kraut, EH1
Turowski, RC1
Terpos, E1
Dimopoulos, MA2
Berenson, J1
Murphy, L1
McCarthy, J1
McCrate, F1
Laing, K1
Powell, E1
Seal, M1
Edwards, S1
Major, PP1
Cook, R1
Rosen, LS1
Gordon, DH1
Dugan, W1
Major, P1
Eisenberg, PD1
Provencher, L1
Kaminski, M1
Simeone, J2
Seaman, J2
Chen, BL1
Coleman, RE1
Berenson, JR1
Lichtenstein, A1
Porter, L1
Bordoni, R1
George, S1
Lipton, A2
Keller, A1
Ballester, O1
Kovacs, MJ1
Blacklock, HA1
Bell, R1
Reitsma, DJ1
Heffernan, M1
Knight, RD1
Harvey, HA1
Paule, B1
Clerc, D1
Brion, N1
Godfrin, B1
Alvarez, M1
Laroche, M1
Ollier, S1
Dingremont, C1
Sailler, L1
Arlet, P1
Aström, E1
Söderhäll, S1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Zoledronic Acid Combined Radiotherapy for Bone Metastasis of Non-small Cell Lung Cancer: A Non-inferiority, Randomized, Open, Parallel and Controlled Prospective Clinical Study[NCT02480634]Phase 4280 participants (Anticipated)Interventional2019-06-30Not yet recruiting
A Phase I Pilot Trial to Study the Safety and Efficacy of Concomitant Radiotherapy and Zoledronic Acid for the Palliation of Bone Metastases From Breast Cancer, Prostate Cancer and Lung Cancer[NCT00264420]Phase 14 participants (Actual)Interventional2005-12-31Completed
Bone Biopsy for Histomorphometry and Analysis of Bone Marrow Derived Osteoblast and Osteoclast Progenitors to Explore Mechanisms of Decreased Bone Mineral Density in Depression[NCT00001916]17 participants Observational1999-03-31Completed
Prevention of Bone Loss After Pediatric Hematopoietic Cell Transplantation[NCT02074631]Phase 280 participants (Actual)Interventional2015-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for pamidronate and Conus Medullaris Syndrome

ArticleYear
Systematic literature review and network meta-analysis comparing bone-targeted agents for the prevention of skeletal-related events in cancer patients with bone metastasis.
    The oncologist, 2015, Volume: 20, Issue:4

    Topics: Bone Density Conservation Agents; Bone Diseases; Bone Neoplasms; Denosumab; Diphosphonates; Humans;

2015
Established role of bisphosphonate therapy for prevention of skeletal complications from myeloma bone disease.
    Critical reviews in oncology/hematology, 2011, Volume: 77 Suppl 1

    Topics: Animals; Bone and Bones; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Clinica

2011
Efficacy of bisphosphonates in the management of skeletal complications of bone metastases and selection of clinical endpoints.
    American journal of clinical oncology, 2002, Volume: 25, Issue:6 Suppl 1

    Topics: Bone Neoplasms; Breast Neoplasms; Clodronic Acid; Data Interpretation, Statistical; Diphosphonates;

2002

Trials

4 trials available for pamidronate and Conus Medullaris Syndrome

ArticleYear
Zoledronic acid is superior to pamidronate for the treatment of bone metastases in breast carcinoma patients with at least one osteolytic lesion.
    Cancer, 2004, Jan-01, Volume: 100, Issue:1

    Topics: Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Carcinoma; Diphosphonates; Dose-Response Re

2004
Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group.
    The New England journal of medicine, 1996, Feb-22, Volume: 334, Issue:8

    Topics: Aged; Diphosphonates; Disease-Free Survival; Double-Blind Method; Female; Fractures, Bone; Humans; H

1996
Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group.
    The New England journal of medicine, 1996, Feb-22, Volume: 334, Issue:8

    Topics: Aged; Diphosphonates; Disease-Free Survival; Double-Blind Method; Female; Fractures, Bone; Humans; H

1996
Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group.
    The New England journal of medicine, 1996, Feb-22, Volume: 334, Issue:8

    Topics: Aged; Diphosphonates; Disease-Free Survival; Double-Blind Method; Female; Fractures, Bone; Humans; H

1996
Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group.
    The New England journal of medicine, 1996, Feb-22, Volume: 334, Issue:8

    Topics: Aged; Diphosphonates; Disease-Free Survival; Double-Blind Method; Female; Fractures, Bone; Humans; H

1996
The role of bisphosphonates in the treatment of bone metastases--the U.S. experience.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 1996, Volume: 4, Issue:3

    Topics: Antineoplastic Agents; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Clinical Trials as Topic;

1996
[Analgesic effect of a diphosphonate perfusion during the acute phase of vertebral compression in the elderly subject].
    La Revue de medecine interne, 2000, Volume: 21, Issue:11

    Topics: Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Clodronic Acid; Diphosphonates; Female; Hu

2000

Other Studies

4 other studies available for pamidronate and Conus Medullaris Syndrome

ArticleYear
Extended use of intravenous bisphosphonate therapy for the prevention of skeletal complications in patients with cancer.
    Cancer investigation, 2009, Volume: 27, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms;

2009
Use of bisphosphonates in metastatic breast cancer: single institution review at the Dr. H. Bliss Murphy Cancer Centre.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013, Volume: 21, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Bone Density Conservation Agents; Bone Diseases; Bone Neoplasms; Bre

2013
[Biosphonates in oncology].
    Presse medicale (Paris, France : 1983), 2000, Apr-08, Volume: 29, Issue:13

    Topics: Bone Neoplasms; Clodronic Acid; Diphosphonates; Fractures, Bone; Humans; Neoplasms; Osteolysis; Pain

2000
Beneficial effect of long term intravenous bisphosphonate treatment of osteogenesis imperfecta.
    Archives of disease in childhood, 2002, Volume: 86, Issue:5

    Topics: Absorptiometry, Photon; Adolescent; Biomarkers; Bone Density; Bone Remodeling; Child; Child, Prescho

2002