pamidronate has been researched along with Carcinoma 256, Walker in 10 studies
Carcinoma 256, Walker: A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "PTHrP stimulates osteoclastic bone resorption and renal calcium reabsorption through the activation of a receptor similar to that of PTH (PTH-R)." | 1.30 | Pamidronate corrects the down-regulation of the renal parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor mRNA in rats bearing Walker tumors. ( Bouizar, Z; de Vernejoul, MC; Denne, MA; Morieux, C; Ureña, P; Yaghoobian, J, 1998) |
| "To validate our hypothesis that a bisphosphonate (BP) having a nitrogen-containing heterocyclic ring on the side chain, and with no hydroxyl on the geminal carbon would possess increased activity, and better oral bioavailability due to enhanced solubility of its calcium complexes/salts and weaker Ca chelating properties." | 1.30 | Synthesis and preclinical pharmacology of 2-(2-aminopyrimidinio) ethylidene-1,1-bisphosphonic acid betaine (ISA-13-1)-a novel bisphosphonate. ( Alferiev, IS; Breuer, E; Cohen, H; Ezra, A; Golomb, G; Hägele, G; Hoffman, A; Mönkkönen, J; Ornoy, A; Patlas, N; Pinto, T; Sagi, H; Seibel, MJ; Solomon, V; Stepensky, D, 1999) |
| "The rat Walker carcinosarcoma 256 is an animal model for humoral hypercalcaemia of malignancy (HHM)." | 1.28 | Relative role of bone and kidney in the hypercalcaemia associated with the rat Walker carcinosarcoma 256. ( Esbrit, P; Hurtado, J; Rapado, A, 1991) |
| " The LD50 of i." | 1.27 | Synthesis, antitumor activity, distribution and toxicity of 4-[4-[bis(2-chloroethyl)amino]phenyl]-1-hydroxybutane-1 1-bisphosphonic acid (BAD), a new lost derivative with increased accumulation in rat osteosarcoma. ( Blum, H; Möller, H; Pittermann, W; Pool, BL; Schmähl, D; Sinn, HJ; Spring, H; Sterz, H; Wingen, F, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jung, A | 1 |
| Bornand, J | 1 |
| Mermillod, B | 1 |
| Edouard, C | 1 |
| Meunier, PJ | 1 |
| Kostenuik, PJ | 1 |
| Orr, FW | 1 |
| Suyama, K | 1 |
| Singh, G | 1 |
| Van Gelder, JM | 1 |
| Breuer, E | 2 |
| Schlossman, A | 1 |
| Ornoy, A | 2 |
| Mönkkönen, J | 2 |
| Similä, J | 1 |
| Klenner, T | 2 |
| Stadler, H | 1 |
| Krempien, B | 4 |
| Patlas, N | 2 |
| Golomb, G | 2 |
| Yaghoobian, J | 1 |
| Morieux, C | 1 |
| Denne, MA | 1 |
| Bouizar, Z | 1 |
| Ureña, P | 1 |
| de Vernejoul, MC | 1 |
| Cohen, H | 1 |
| Alferiev, IS | 1 |
| Seibel, MJ | 1 |
| Pinto, T | 1 |
| Ezra, A | 1 |
| Solomon, V | 1 |
| Stepensky, D | 1 |
| Sagi, H | 1 |
| Hägele, G | 1 |
| Hoffman, A | 1 |
| Hurtado, J | 1 |
| Esbrit, P | 1 |
| Rapado, A | 1 |
| Wingen, F | 4 |
| Keppler, BK | 1 |
| Schmähl, D | 3 |
| Eichmann, T | 2 |
| Müller, M | 1 |
| Sterz, H | 1 |
| Blum, H | 1 |
| Möller, H | 1 |
| Pittermann, W | 1 |
| Pool, BL | 1 |
| Sinn, HJ | 1 |
| Spring, H | 1 |
| Manegold, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Pilot Trial to Study the Safety and Efficacy of Concomitant Radiotherapy and Zoledronic Acid for the Palliation of Bone Metastases From Breast Cancer, Prostate Cancer and Lung Cancer[NCT00264420] | Phase 1 | 4 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 other studies available for pamidronate and Carcinoma 256, Walker
| Article | Year |
|---|---|
Inhibition by diphosphonates of bone resorption induced by the Walker tumor of the rat.
Topics: Animals; Bone and Bones; Bone Resorption; Carcinoma 256, Walker; Clodronic Acid; Diphosphonates; Eti | 1984 |
Increased growth rate and tumor burden of spontaneously metastatic Walker 256 cancer cells in the skeleton of bisphosphonate-treated rats.
Topics: Acid Phosphatase; Animals; Bone and Bones; Bone Neoplasms; Carcinoma 256, Walker; Cell Division; Dip | 1993 |
In vitro and in vivo effects of tetrakisphosphonates on bone resorption, tumor osteolysis, ectopic calcification, and macrophages.
Topics: Animals; Bioprosthesis; Bone Resorption; Calcinosis; Carcinoma 256, Walker; Cell Line; Cell Survival | 1997 |
Pamidronate corrects the down-regulation of the renal parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor mRNA in rats bearing Walker tumors.
Topics: Adenylyl Cyclases; Animals; Anti-Inflammatory Agents; Blotting, Northern; Body Weight; Bone Resorpti | 1998 |
Synthesis and preclinical pharmacology of 2-(2-aminopyrimidinio) ethylidene-1,1-bisphosphonic acid betaine (ISA-13-1)-a novel bisphosphonate.
Topics: Administration, Oral; Alendronate; Animals; Antineoplastic Agents; Betaine; Bone Diseases; Bone Neop | 1999 |
Relative role of bone and kidney in the hypercalcaemia associated with the rat Walker carcinosarcoma 256.
Topics: Amifostine; Animals; Bone and Bones; Calcium; Carcinoma 256, Walker; Diphosphonates; Female; Hyperca | 1991 |
Anticancer-agent-linked phosphonates with antiosteolytic and antineoplastic properties: a promising perspective in the treatment of bone-related malignancies?
Topics: Animals; Bone and Bones; Bone Neoplasms; Carcinoma 256, Walker; Diphosphonates; Drug Evaluation, Pre | 1990 |
Protective effects of a prophylactic treatment with the bisphosphonate 3-amino-1-hydroxypropane-1,1-bisphosphonic acid on the development of tumor osteopathies in the rat: experimental studies with the Walker carcinosarcoma 256.
Topics: Animals; Carcinoma 256, Walker; Diphosphonates; Male; Osteolysis; Pamidronate; Rats | 1988 |
Synthesis, antitumor activity, distribution and toxicity of 4-[4-[bis(2-chloroethyl)amino]phenyl]-1-hydroxybutane-1 1-bisphosphonic acid (BAD), a new lost derivative with increased accumulation in rat osteosarcoma.
Topics: Animals; Antineoplastic Agents; Body Temperature; Body Weight; Bone and Bones; Bone Development; Bro | 1986 |
Effects of new bisphosphonic acids on tumor-induced bone destruction in the rat.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Carcinoma 256, Walker; Diphosphonates; Male; Organop | 1986 |