Page last updated: 2024-11-02

pamidronate and Bisphosphonate Osteonecrosis

pamidronate has been researched along with Bisphosphonate Osteonecrosis in 26 studies

Research Excerpts

ExcerptRelevanceReference
"Few reports have investigated medication-related osteonecrosis of the jaws (MRONJ) in the pediatric population."8.12Medication-Related Osteonecrosis of the Jaws in the Pediatric Population. ( Neal, TW; Schlieve, T, 2022)
"Few reports have investigated medication-related osteonecrosis of the jaws (MRONJ) in the pediatric population."4.12Medication-Related Osteonecrosis of the Jaws in the Pediatric Population. ( Neal, TW; Schlieve, T, 2022)
"The study objective was to evaluate the effect on osteoblast growth of high concentrations of three nitrogen-containing bisphosphonates (pamidronate, alendronate, and ibandronate) and one non-nitrogen-containing bisphosphonate (clodronate), using the MG-63 cell line as an osteoblast model, in order to determine the role of osteoblasts in bisphosphonate-related osteonecrosis of the jaw (BRONJ)."3.81High doses of bisphosphonates reduce osteoblast-like cell proliferation by arresting the cell cycle and inducing apoptosis. ( De Luna-Bertos, E; García-Martínez, O; Manzano-Moreno, FJ; Ramos-Torrecillas, J; Ruiz, C, 2015)
"Recently, some reports indicate that osteonecrosis of the jaws could occur after taking drugs containing hisphosphonates, including alendronate, pamidronate and zolendronate, which are widely used to treat osteoporosis and metastatic skeletal lesions in clinic."3.73[Advances in the research of bisphosphonate-associated osteonecrosis of the jaws]. ( Ji, T; Ruan, M; Zhang, CP, 2006)
"Treatment with zoledronic acid probably neither reduces nor increases the proportion of participants with pain response when compared to no treatment/placebo (risk ratio (RR) 1."2.66Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis. ( Adams, A; Heidenreich, A; Jakob, T; Kuhr, K; Macherey, S; Monsef, I; Skoetz, N; Tesfamariam, YM, 2020)
"Using the Pmetrics package and published data, we designed a population pharmacokinetic model of pamidronate concentration in plasma and bone and derived a toxic bone BP threshold of 0."1.39Population pharmacokinetic and pharmacodynamic modeling for assessing risk of bisphosphonate-related osteonecrosis of the jaw. ( Jelliffe, RW; Jones, AC; Kiss, A; LaVallee, C; Le, AD; Lee, P; Neely, M; Sedghizadeh, PP, 2013)
" Long term use of bisphosphonates has recently been associated with osteonecrosis of the jaw (ONJ) defined as a three month non-healing defect in the jaw."1.36Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphanates. ( Cevreska, L; Jovanovic, R; Karanfilski, O; Pavkovic, M; Petrushevska, G; Stankovic, S; Stojanovic, A, 2010)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (3.85)29.6817
2010's22 (84.62)24.3611
2020's3 (11.54)2.80

Authors

AuthorsStudies
Fusco, V1
Campisi, G1
Bedogni, A1
Neal, TW1
Schlieve, T1
de Souza Tolentino, E1
de Castro, TF1
Michellon, FC1
Passoni, ACC1
Ortega, LJA1
Iwaki, LCV1
da Silva, MC1
Jakob, T1
Tesfamariam, YM1
Macherey, S1
Kuhr, K1
Adams, A1
Monsef, I1
Heidenreich, A1
Skoetz, N1
Owosho, AA1
Liang, STY1
Sax, AZ1
Wu, K1
Yom, SK1
Huryn, JM2
Estilo, CL2
Kos, M1
Junka, A1
Smutnicka, D1
Bartoszewicz, M1
Kurzynowski, T1
Gluza, K1
Favot, CL1
Forster, C1
Glogauer, M1
Soydan, SS1
Uckan, S1
Ngan, KK1
Bowe, J1
Goodger, N1
Hamada, H1
Matsuo, A1
Koizumi, T1
Satomi, T1
Chikazu, D1
McKay, RR1
Lin, X1
Perkins, JJ1
Heng, DY1
Simantov, R1
Choueiri, TK1
Hagelauer, N1
Pabst, AM1
Ziebart, T1
Ulbrich, H1
Walter, C1
Ma, ZY1
Wang, YX1
Manzano-Moreno, FJ1
Ramos-Torrecillas, J1
De Luna-Bertos, E1
Ruiz, C1
García-Martínez, O1
Movila, A1
Mawardi, H1
Nishimura, K1
Kiyama, T1
Egashira, K1
Kim, JY1
Villa, A1
Sasaki, H1
Woo, SB1
Kawai, T1
Pavkovic, M1
Petrushevska, G1
Jovanovic, R1
Karanfilski, O1
Cevreska, L1
Stankovic, S1
Stojanovic, A1
Ohe, JY1
Kwon, YD1
Lee, HW1
Moretti, F1
Pelliccioni, GA1
Montebugnoli, L1
Marchetti, C1
Mast, G1
Otto, S1
Mücke, T1
Schreyer, C1
Bissinger, O1
Kolk, A1
Wolff, KD1
Ehrenfeld, M1
Stürzenbaum, SR1
Pautke, C1
Jacobsen, C1
Metzler, P1
Rössle, M1
Obwegeser, J1
Zemann, W1
Grätz, KW1
Hewson, I1
Syme, D1
Bruscino-Raiola, F1
Balmor, GR1
Yarom, N1
Weitzen, R1
Freiberger, JJ1
Padilla-Burgos, R1
McGraw, T1
Suliman, HB1
Kraft, KH1
Stolp, BW1
Moon, RE1
Piantadosi, CA1
Watters, AL1
Hansen, HJ1
Williams, T1
Chou, JF1
Riedel, E1
Halpern, J1
Tunick, S1
Bohle, G1
Sedghizadeh, PP1
Jones, AC1
LaVallee, C1
Jelliffe, RW1
Le, AD1
Lee, P1
Kiss, A1
Neely, M1
Ruan, M1
Ji, T1
Zhang, CP1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase II Randomized Study of High-Dose Ketoconazole With or Without Alendronate Sodium in Patients With Androgen-Independent Metastastic Adenocarinoma of the Prostate[NCT00019695]Phase 20 participants Interventional1999-03-31Terminated
Atrasentan and Zometa for Men With Androgen Independent Prostate Cancer Metastatic to Bone: A Randomized Pilot Study[NCT00181558]Phase 244 participants Interventional2001-12-31Completed
A Randomized Double-Blind, Placebo-Controlled Phase III Study of Early Versus Standard Zoledronic Acid to Prevent Skeletal Related Events in Men With Prostate Cancer Metastatic to Bone[NCT00079001]Phase 3645 participants (Actual)Interventional2004-01-31Completed
A Randomized, Open Label, Active Controlled Study of AMG 162 in Subjects With Advanced Cancer Currently Being Treated With Intravenous Bisphosphonates[NCT00104650]Phase 2111 participants (Actual)Interventional2005-01-31Completed
Randomized Placebo-Controlled Trial of Mitoxantrone/Prednisone and Clodronate Versus Mitoxantrone/Prednisone Alone in Patients With Hormone Refractory Metastatic Prostate Cancer and Pain[NCT00003232]Phase 3227 participants (Actual)Interventional1997-11-24Completed
A Phase III, Multicenter, Randomized, Controlled Study of Maximum Androgen Blockade With vs. Without Zoledronic Acid in Prostatic Cancer Patients With Metastatic Bone Disease[NCT00685646]Phase 3227 participants (Actual)Interventional2008-05-31Completed
A Randomised Phase II Feasibility Study of Docetaxel (Taxotere®) Plus Prednisolone vs. Docetaxel (Taxotere®) Plus Prednisolone Plus Zoledronic Acid (Zometa®) vs. Docetaxel (Taxotere®) Plus Prednisolone Plus Strontium-89 vs. Docetaxel (Taxotere®) Plus Pred[NCT00554918]Phase 2300 participants (Anticipated)Interventional2005-02-28Completed
A Randomized, Double-Blind, Multicenter Study of Denosumab Compared With Zoledronic Acid (Zometa®) in the Treatment of Bone Metastases in Men With Hormone-Refractory Prostate Cancer[NCT00321620]Phase 31,904 participants (Actual)Interventional2006-04-01Completed
A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating the Ability of Risedronate to Prevent Skeletal Related Events in Patients With Metastatic Prostate Cancer Commencing Hormonal Therapy: Hoosier Oncology Group GU02-41[NCT00216060]Phase 363 participants (Actual)Interventional2003-10-31Terminated (stopped due to Terminated due to low accrual)
STAMPEDE: Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy: A Multi-Stage Multi-Arm Randomised Controlled Trial[NCT00268476]Phase 2/Phase 311,992 participants (Actual)Interventional2005-07-08Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Overall Survival

Overall survival (OS) was defined as the time from randomization to death of any cause. Surviving patients were censored at the date of last follow-up. The median OS with 95% CI was estimated using the Kaplan Meier method. (NCT00079001)
Timeframe: Up to 10 years

Interventionmonths (Median)
Zoledronic Acid + Androgen Deprivation Therapy37.9
Placebo + Androgen Deprivation Therapy36.0

Progression-free Survival

"Progression Free Survival (PFS) was defined as the time from registration until disease progression or death, whichever occurs first. The median PFS with 95% CI was estimated using the Kaplan-Meier method.~Progression is defined as one or more of the following: new bone metastases, biochemical progression of PSA, treatment with radiation therapy while on treatment." (NCT00079001)
Timeframe: Up to 10 years

Interventionmonths (Median)
Zoledronic Acid + Androgen Deprivation Therapy10.6
Placebo + Androgen Deprivation Therapy9.2

Time to First Skeletal Related Event

Time to first skeletal related event (SRE) was defined as the time from randomization to first skeletal event. Skeletal events are defined as radiation to bone, clinical fracture, surgery to bone and spinal cord compression and death due to prostate cancer. The median with 95% CI was estimated using the Kaplan Meier method. (NCT00079001)
Timeframe: Up to 10 years

Interventionmonths (Median)
Zoledronic Acid + Androgen Deprivation Therapy31.9
Placebo + Androgen Deprivation Therapy28.8

Duration of Maintaining uNTX (Corrected by Creatinine) < 50nmol/mmol

Time from the 1st occurrence of uNTx below 50 nmol BCE/mmol (corrected by creatinine) to the 1st occurrence of uNTx above 50 nmol BCE/mmol up to week 25. For participants who remained below 50 nmol BCE/mmol, the time is censored at the time of last evaluation of uNTx up to week 25. (NCT00104650)
Timeframe: Day 1, week 25

InterventionParticipants (Number)
Bisphosphonate IV Q4W25
Denosumab 180 mg Q12W32
Denosumab 180 mg Q4W35

Hypercalcemia

Occurrence of hypercalcemia at grade 3 or 4 according to CTCAE v3 criteria (NCT00104650)
Timeframe: Day 1, week 25

InterventionParticipants (Number)
Bisphosphonate IV Q4W0
Denosumab 180 mg Q12W0
Denosumab 180 mg Q4W0

Percent Change of Serum CTX From Baseline to Week 25

Percent change from baseline to week 25 in Type I serum C-Telopeptide (CTX), calculated using ((week 25 value - baseline value) / baseline value ) x 100. (NCT00104650)
Timeframe: Baseline, week 25

InterventionPercent change (Mean)
Bisphosphonate IV Q4W-40.68
Denosumab 180 mg Q12W-76.74
Denosumab 180 mg Q4W-68.39

Percent Change of uNTx (Corrected by Creatinne) From Baseline to Week 25

Percent change from baseline to week 25 urinary N-telopeptide (uNTX) calculated using ((week 25 value - baseline value) / baseline value ) x 100. (NCT00104650)
Timeframe: Baseline, week 25

InterventionPercent change (Mean)
Bisphosphonate IV Q4W-32.91
Denosumab 180 mg Q12W-69.09
Denosumab 180 mg Q4W-41.68

Skeletal Related Events

Skeletal Related Event (SRE), defined as >1 of the following: pathological bone fracture, spinal cord compression, surgery or radiation therapy to bone (including the use of radioisotopes). (NCT00104650)
Timeframe: Day 1, week 25

InterventionParticipants (Number)
Bisphosphonate IV Q4W6
Denosumab 180 mg Q12W4
Denosumab 180 mg Q4W2

Time to First Skeletal Related Event

Time from study day 1 to first Skeletal Related Event (SRE), defined as >1 of the following: pathological bone fracture, spinal cord compression, surgery or radiation therapy to bone (including the use of radioisotopes). (NCT00104650)
Timeframe: Day 1, week 25

InterventionParticipants (Number)
Bisphosphonate IV Q4W6
Denosumab 180 mg Q12W4
Denosumab 180 mg Q4W2

Time to Reduction of uNTX (Corrected by Creatinine) to <50nmol/mmol

Kaplan-Meier estimate of the median time from enrollment to the 1st occurrence of uNTx below 50 nmol BCE/mmol (corrected by creatinine) up to week 25. For participants whose uNTx does not go below 50 nM BCE/mM creatinine, the time is censored at time of last evaluation of uNTx by week 25. (NCT00104650)
Timeframe: Day 1, week 25

InterventionDays (Median)
Bisphosphonate IV Q4W65
Denosumab 180 mg Q12W9
Denosumab 180 mg Q4W10

uNTx (Corrected by Creatinine) < 50 Nmol/mmol at Week 13

Urinary N-telopeptide (uNTx) corrected by creatinine (uNTx/Cr) < 50 nmol/mmol at week 13. (NCT00104650)
Timeframe: 13 weeks

InterventionParticipants (Number)
Bisphosphonate IV Q4W10
Denosumab 180 mg Q12W21
Denosumab 180 mg Q4W28

uNTx (Corrected by Creatinine) < 50 Nmol/mmol at Week 25

Urinary N-telopeptide (uNTX) corrected by creatinine < 50 nmol/mmol at week 25. (NCT00104650)
Timeframe: 25 weeks

InterventionParticipants (Number)
Bisphosphonate IV Q4W13
Denosumab 180 mg Q12W21
Denosumab 180 mg Q4W23

Time to the First On-Study SRE (Non-inferiority)

Time to the first on-study skeletal-related event (SRE) analyzed for non-inferiority. Kaplan-Meier estimates of the median and its dispersion are reported. (NCT00321620)
Timeframe: Up to 40.5 months

InterventionDays (Median)
Zoledronic Acid521.0
Denosumab629.0

Time to the First On-Study SRE (Superiority)

Time to the first on-study skeletal-related event (SRE), analyzed for superiority of denosumab. Kaplan-Meier estimates of the median and its dispersion are reported. (NCT00321620)
Timeframe: Up to 40.5 months

InterventionDays (Median)
Zoledronic Acid521.0
Denosumab629.0

Time to the First-And-Subsequent On-Study SRE

"Time to the first-and-subsequent on-study skeletal-related event (SRE), analyzed for superiority of denosumab using multiple event analysis, the event must occur at least 21 days after the previous SRE.~This outcome measure utilizes multiple event times, was analyzed based on a proportional mean model, and is therefore more appropriately summarized by the cumulative mean number of events." (NCT00321620)
Timeframe: Up to 40.5 months

InterventionEvents (Number)
Zoledronic Acid584
Denosumab494

Numbers of SRE or Death Occurred Cumulatively

Number of participants experiencing a SRE(skeletal-related event) or death occurred, cumulative from each arm ( a daily oral dose of 30 mg risedronate, or placebo) (NCT00216060)
Timeframe: 36 months

Interventionparticipants (Number)
Risedronate Arm11
Placebo Arm13

Rate of Patients Archiving a PSA (Prostate Specific Antigen) Nadir < 0.2 ng/mL

(NCT00216060)
Timeframe: 36 months

Interventionpercentage of participants (Number)
Risedronate Arm50
Placebo Arm29

Three- Year Survival Rate

(NCT00216060)
Timeframe: 36 months

Interventionpercentage of participants (Number)
Risedronate72.5
Placebo71.5

Bone Turnover Marker Changes -- Urine Total Deoxypyridinoline (DPD)

"Urine total DPD median in response to treatment on both study arms at week 24. compare median from baseline and week 24.~Deoxypyridinoline (DPD) is measured in hydrolyzed urine samples using high-performance liquid chromatography technique. After extraction of the cross-links and elimination of the urine impurities by a Bio-Rad SPE cartridge (Bio-Rad Laboratories, Hercules, CA), total DPD is eluted from reverse-phase high-performance liquid chromatography by ion pair chromatography with isocratic elution.~The compounds are detected as a result of their natural fluorescence with a fluorescence detector" (NCT00216060)
Timeframe: 24 weeks

,
Interventionnmol/mmol creatinine (Median)
week 24baseline
Placebo Arm12.6210.12
Risedronate Arm6.918.83

Bone Turnover Marker Changes-- Serum BAP

Serum BAP median changes between baseline and week 24. The Ostase assays are performed with an access immunoassay system, which is an assay of serum samples that provides a quantitative measurement of bone alkaline phosphatase (BAP). A mouse monoclonal antibody specific to BAP is added to a re-action vessel with paramagnetic particles coated with goat antimouse polyclonalantibody.Calibrators,controls,andsamplescontainingBAP are added to the coated particles and bind to the anti-BAP monoclonal antibody. After the formation of a solid phase/capture antibody/BAP complex, separation in a magnetic field and washing remove materials not bound to the solid phase. A chemiluminescent substrate, LumiPhos 530, is added to the reaction vessel, and light generated by the reaction is measured with a luminometer. The light production is directly proportional to the concentration of BAP in the sample. The amount of analyte in thesample is determined from a stored multipoint calibration curve (NCT00216060)
Timeframe: 24 week

,
Interventionng/mL (Median)
24 weekbaseline
Placebo Arm13.1619.50
Risedronate Arm9.520.95

Bone Turnover Marker Changes-- Serum Osteocalcin (OC)

Serum Osteocalcin (OC) medians between baseline and 24 weeks areperformed with the Elecsys 2010 automated analyzer, which uses an electrochemiluminescence immunoassay technique for the in vitro quantitative determination of serum total osteocalcin in humanserum. The assay uses a sandwich test principle in which afirst biotinylated monoclonal antibody recognizing N-MID osteocalcin and a second monoclonal antibody against N-MID osteocalcin labeled with ruthenium are incubated with 20mL of serum. After a first incubation, streptavidin-coated microparticles are added for a second incubation, and the complex becomes bound to the solid phase by interaction of biotin and streptavidin.These microparticles are then magnetically captured onto the surface of an electrode. Application of a voltage on this electrode induces chemiluminescent emission, which is measured by a photomultiplierand compared with a calibration curve that is generated in aninstrument-specific manner by 2-point calibration. (NCT00216060)
Timeframe: 24 week

,
Interventionug/L (Median)
at 24 weekbaseline
Placebo Arm27.3518.24
Risedronate Arm11.8820.08

Bone Turnover Marker Changes-- Urine N-telopeptide (NTX) Median

"Urine N-telopeptide (NTX) median changes between baseline and week 24. The assays are performed with the NTx Reagent Pack kit from Ortho-Clinical Diagnostics (Ortho-Clinical Diagnostics/Johnson & Johnson, Amersham, UK), which is a kit designed for the quantitative determination of N-terminal telopeptide (NTx) in human urine on the automated Vitros Immunodiagnostic System ECi (Ortho-Clinical Diagnostics/Johnson & Johnson, Amersham, UK). A competitive immunoassay technique is used. This depends on competition between NTx present in the sample and a synthetic NTx peptide coated on the wells for binding by a horseradish peroxidase (HRP)-labeled antibody conjugate (mouse monoclonal anti-NTx). The conjugate is captured by the peptide coated on the wells; unbound materials are removed by washing.~The bound HRP conjugate is measured by a luminescent reaction." (NCT00216060)
Timeframe: 24 week

,
Interventionnmol BCE/mmol creatinine (Median)
at 24 weekbaseline
Placebo Arm62.9548.08
Risedronate Arm20.6341.33

Reviews

3 reviews available for pamidronate and Bisphosphonate Osteonecrosis

ArticleYear
Adjuvant therapies in the management of medication-related osteonecrosis of the jaws: Systematic review.
    Head & neck, 2019, Volume: 41, Issue:12

    Topics: Aged; Aged, 80 and over; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservati

2019
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
    The Cochrane database of systematic reviews, 2020, 12-03, Volume: 12

    Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the

2020
The risk of bisphosphonate-related osteonecrosis of the jaw in children. A case report and literature review.
    Dental update, 2013, Volume: 40, Issue:9

    Topics: Administration, Intravenous; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conser

2013

Trials

2 trials available for pamidronate and Bisphosphonate Osteonecrosis

ArticleYear
A prospective clinical trial for assessing the efficacy of a minimally invasive protocol in patients with bisphosphonate-associated osteonecrosis of the jaws.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2011, Volume: 112, Issue:6

    Topics: Aged; Aged, 80 and over; Alendronate; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial

2011
What is the role of hyperbaric oxygen in the management of bisphosphonate-related osteonecrosis of the jaw: a randomized controlled trial of hyperbaric oxygen as an adjunct to surgery and antibiotics.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2012, Volume: 70, Issue:7

    Topics: Aged; Alendronate; Anti-Bacterial Agents; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone D

2012

Other Studies

21 other studies available for pamidronate and Bisphosphonate Osteonecrosis

ArticleYear
One changing and challenging scenario: the treatment of cancer patients with bone metastases by bisphosphonates and denosumab, the cost-benefit evaluation of different options, and the risk of medication-related osteonecrosis of the jaw (MRONJ).
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022, Volume: 30, Issue:9

    Topics: Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Bone Neoplasms

2022
Medication-Related Osteonecrosis of the Jaws in the Pediatric Population.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2022, Volume: 80, Issue:10

    Topics: Adolescent; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Ch

2022
Medication-related osteonecrosis of the jaw: An update on the memorial sloan kettering cancer center experience and the role of premedication dental evaluation in prevention.
    Oral surgery, oral medicine, oral pathology and oral radiology, 2018, Volume: 125, Issue:5

    Topics: Adult; Aged; Angiogenesis Inhibitors; Bevacizumab; Bisphosphonate-Associated Osteonecrosis of the Ja

2018
Pamidronate enhances bacterial adhesion to bone hydroxyapatite. Another puzzle in the pathology of bisphosphonate-related osteonecrosis of the jaw?
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2013, Volume: 71, Issue:6

    Topics: Bacterial Adhesion; Biofilms; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conse

2013
The effect of bisphosphonate therapy on neutrophil function: a potential biomarker.
    International journal of oral and maxillofacial surgery, 2013, Volume: 42, Issue:5

    Topics: Aged; Aged, 80 and over; Biomarkers; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Densit

2013
Management of bisphosphonate-related osteonecrosis of the jaw with a platelet-rich fibrin membrane: technical report.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2014, Volume: 72, Issue:2

    Topics: Aged; Bisphosphonate-Associated Osteonecrosis of the Jaw; Blood Platelets; Diphosphonates; Fibrin; H

2014
A simple evaluation method for early detection of bisphosphonate-related osteonecrosis of the mandible using computed tomography.
    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2014, Volume: 42, Issue:6

    Topics: Administration, Intravenous; Administration, Oral; Alendronate; Alveolar Process; Bisphosphonate-Ass

2014
Prognostic significance of bone metastases and bisphosphonate therapy in patients with renal cell carcinoma.
    European urology, 2014, Volume: 66, Issue:3

    Topics: Aged; Antineoplastic Agents; Axitinib; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Dens

2014
In vitro effects of bisphosphonates on chemotaxis, phagocytosis, and oxidative burst of neutrophil granulocytes.
    Clinical oral investigations, 2015, Volume: 19, Issue:1

    Topics: Bisphosphonate-Associated Osteonecrosis of the Jaw; Chemotaxis; Clodronic Acid; Diphosphonates; Flow

2015
[Establishment of bisphosphonate-related osteonecrosis of the jaw model in rats and preliminary analysis of its etiological mechanism].
    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2014, Dec-18, Volume: 46, Issue:6

    Topics: Animals; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Cell

2014
High doses of bisphosphonates reduce osteoblast-like cell proliferation by arresting the cell cycle and inducing apoptosis.
    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2015, Volume: 43, Issue:3

    Topics: Alendronate; Apoptosis; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservatio

2015
Possible pathogenic engagement of soluble Semaphorin 4D produced by γδT cells in medication-related osteonecrosis of the jaw (MRONJ).
    Biochemical and biophysical research communications, 2016, Nov-04, Volume: 480, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Bisphosphonate-Associated Osteonecrosis of the Jaw; D

2016
Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphanates.
    Prilozi, 2010, Volume: 31, Issue:2

    Topics: Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Diphosphonates

2010
Bisphosphonates modulate the expression of OPG and M-CSF in hMSC-derived osteoblasts.
    Clinical oral investigations, 2012, Volume: 16, Issue:4

    Topics: Alendronate; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; C

2012
Incidence of maxillary sinusitis and oro-antral fistulae in bisphosphonate-related osteonecrosis of the jaw.
    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2012, Volume: 40, Issue:7

    Topics: Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Cone-Beam Comp

2012
Osteopathology induced by bisphosphonates and dental implants: clinical observations.
    Clinical oral investigations, 2013, Volume: 17, Issue:1

    Topics: Actinomycosis; Administration, Intravenous; Administration, Oral; Alendronate; Anti-Bacterial Agents

2013
Radical surgical treatment of bisphosphonate related osteonecrosis of the jaw.
    Australian dental journal, 2012, Volume: 57, Issue:2

    Topics: Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Collagen Type

2012
Drug-induced palate osteonecrosis following nasal surgery.
    The Israel Medical Association journal : IMAJ, 2012, Volume: 14, Issue:3

    Topics: Angiogenesis Inhibitors; Bisphosphonate-Associated Osteonecrosis of the Jaw; Diphosphonates; Drug Th

2012
Intravenous bisphosphonate-related osteonecrosis of the jaw: long-term follow-up of 109 patients.
    Oral surgery, oral medicine, oral pathology and oral radiology, 2013, Volume: 115, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Bisphosphonate-Associated Osteonecrosis of the Jaw; Chi-Square Distr

2013
Population pharmacokinetic and pharmacodynamic modeling for assessing risk of bisphosphonate-related osteonecrosis of the jaw.
    Oral surgery, oral medicine, oral pathology and oral radiology, 2013, Volume: 115, Issue:2

    Topics: Aged; Aged, 80 and over; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone and Bones; Bone De

2013
[Advances in the research of bisphosphonate-associated osteonecrosis of the jaws].
    Shanghai kou qiang yi xue = Shanghai journal of stomatology, 2006, Volume: 15, Issue:6

    Topics: Alendronate; Biomedical Research; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density C

2006