pamidronate has been researched along with Arthritis, Rheumatoid in 10 studies
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the effects of 3-amino-1-hydroxypropylidine-1,1-bisphosphonate (pamidronate) in rheumatoid arthritis (RA)." | 9.07 | Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: a double blind placebo controlled study. ( Breedveld, FC; Dijkmans, BA; Eggelmeijer, F; Papapoulos, SE; van Paassen, HC, 1994) |
| "Rate of bone resorption was assessed by the biochemical markers: serum carboxy terminal cross-linked telopeptide of type I collagen, urinary carboxy terminal cross-linked telopeptide of type I collagen normalized to creatinine and urinary amino-terminal telopeptide of type I collagen normalized to creatinine; and rate of cartilage degradation by urinary carboxy terminal telopeptide of type II collagen normalized to creatinine." | 6.71 | Short term whole body retention in relation to rate of bone resorption and cartilage degradation after intravenous bisphosphonate (pamidronate) in rheumatoid arthritis. ( Cremers, SC; Den Hartigh, J; Dijkmans, BA; Lems, WF; Lodder, MC; Papapoulos, SE; Van Pelt, P; Vermeij, P, 2004) |
| "To assess the effects of 3-amino-1-hydroxypropylidine-1,1-bisphosphonate (pamidronate) in rheumatoid arthritis (RA)." | 5.07 | Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: a double blind placebo controlled study. ( Breedveld, FC; Dijkmans, BA; Eggelmeijer, F; Papapoulos, SE; van Paassen, HC, 1994) |
| "Continuous oral pamidronate (APD), 1000 mg/day, was administered to 14 patients with rheumatoid arthritis." | 5.07 | Double blind radiological assessment of continuous oral pamidronic acid in patients with rheumatoid arthritis. ( Caballero, LE; Di Giorgio, E; Maccagno, A; Perez Lloret, A; Roldan, EJ, 1994) |
| "Rate of bone resorption was assessed by the biochemical markers: serum carboxy terminal cross-linked telopeptide of type I collagen, urinary carboxy terminal cross-linked telopeptide of type I collagen normalized to creatinine and urinary amino-terminal telopeptide of type I collagen normalized to creatinine; and rate of cartilage degradation by urinary carboxy terminal telopeptide of type II collagen normalized to creatinine." | 2.71 | Short term whole body retention in relation to rate of bone resorption and cartilage degradation after intravenous bisphosphonate (pamidronate) in rheumatoid arthritis. ( Cremers, SC; Den Hartigh, J; Dijkmans, BA; Lems, WF; Lodder, MC; Papapoulos, SE; Van Pelt, P; Vermeij, P, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lodder, MC | 2 |
| Van Pelt, PA | 1 |
| Lems, WF | 2 |
| Kostense, PJ | 1 |
| Koks, CH | 1 |
| Dijkmans, BA | 4 |
| Cremers, SC | 1 |
| Den Hartigh, J | 1 |
| Vermeij, P | 1 |
| Van Pelt, P | 1 |
| Papapoulos, SE | 3 |
| Bijvoet, OL | 1 |
| Frijlink, WB | 1 |
| Jie, K | 1 |
| van der Linden, H | 1 |
| Meijer, CJ | 1 |
| Mulder, H | 1 |
| van Paassen, HC | 3 |
| Reitsma, PH | 1 |
| te Velde, J | 1 |
| de Vries, E | 1 |
| van der Wey, JP | 1 |
| Eggelmeijer, F | 2 |
| Breedveld, FC | 2 |
| Maccagno, A | 1 |
| Di Giorgio, E | 1 |
| Roldan, EJ | 1 |
| Caballero, LE | 1 |
| Perez Lloret, A | 1 |
| Valkema, R | 1 |
| Westedt, ML | 1 |
| Landman, JO | 1 |
| Pauwels, EK | 1 |
| Lindy, O | 1 |
| Konttinen, YT | 1 |
| Sorsa, T | 1 |
| Ding, Y | 1 |
| Santavirta, S | 1 |
| Ceponis, A | 1 |
| López-Otín, C | 1 |
| El-Shafei, A | 1 |
| Sheeran, T | 1 |
| Mulherin, D | 1 |
| Ralston, SH | 1 |
| Hacking, L | 1 |
| Willocks, L | 1 |
| Bruce, F | 1 |
| Pitkeathly, DA | 1 |
| Tan, PL | 1 |
| Ames, R | 1 |
| Yeoman, S | 1 |
| Ibbertson, HK | 1 |
| Caughey, DE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Teriparatide for Joint Erosions in Rheumatoid Arthritis: The TERA Trial[NCT01400516] | Phase 4 | 26 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
BMD was measured at the lumbosacral spine antero-posterior and at the femoral neck using a densitometer. A positive change from Baseline (increased bone density) indicates improvement. (NCT01400516)
Timeframe: Baseline and Month 12
| Intervention | grams/centimeters squared (g/cm^2) (Mean) | |||
|---|---|---|---|---|
| Spine, Baseline | Spine, Change from Baseline at Month12 | Femoral neck, Baseline | Femoral neck, Change from Baseline at Month 12 | |
| Control Arm | 0.93 | -0.002 | 0.73 | -0.03 |
| Teriparatide | 0.91 | 0.06 | 0.68 | 0.03 |
The DAS28 score is a measure of the patient's disease activity calculated using the tender joint count (TJC) [28 joints], swollen joint count (SJC) [28 joints], patient's global assessment of disease activity [visual analog scale: 0=no disease activity to 100=maximum disease activity] and C-Reactive Protein (CRP) for a total possible score of 2 to 10. Higher values indicate higher disease activity. A negative change from baseline indicates improvement. (NCT01400516)
Timeframe: Baseline and Month 12
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Baseline | Change from Baseline at Month 12 | |
| Control Arm | 2.73 | -0.50 |
| Teriparatide | 2.66 | 0.42 |
Both hands were scanned using a CT scanner. A semi-automated software tool was used to segment the erosion margins in 3D. A board certified radiologist identified the individual erosions in six sub-regions: radius, ulna, proximal carpals, distal carpals, metacarpophalangeal (MCP) joints and proximal interphalangeal (PIP) joints. The average total in a single hand/wrist was calculated. A negative change from Baseline(less joint erosions) indicates improvement. (NCT01400516)
Timeframe: Baseline and Month 12
| Intervention | cubic millimeter (mm^3) (Median) | |
|---|---|---|
| Baseline | Change from Baseline at Month 12 | |
| Control Arm | 571.4 | 9.1 |
| Teriparatide | 369.8 | -0.4 |
6 trials available for pamidronate and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Effects of high dose IV pamidronate on disease activity and bone metabolism in patients with active RA: a randomized, double-blind, placebo-controlled trial.
Topics: Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Bone and Bones; Diphosphonates; Dose-Response | 2003 |
Short term whole body retention in relation to rate of bone resorption and cartilage degradation after intravenous bisphosphonate (pamidronate) in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Biomarkers; Bone Resorption; Cartilage | 2004 |
Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: a double blind placebo controlled study.
Topics: Adult; Arthritis, Rheumatoid; Bone and Bones; Bone Resorption; Calcium; Diphosphonates; Double-Blind | 1994 |
Double blind radiological assessment of continuous oral pamidronic acid in patients with rheumatoid arthritis.
Topics: Administration, Oral; Adult; Arthritis, Rheumatoid; Cartilage, Articular; Diphosphonates; Double-Bli | 1994 |
Increased bone mass with pamidronate treatment in rheumatoid arthritis. Results of a three-year randomized, double-blind trial.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Bone and Bones; Bone De | 1996 |
Clinical, biochemical, and radiographic effects of aminohydroxypropylidene bisphosphonate treatment in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Calcium; Clinical Trials as Topic; Creatinine; Diphosphonates; Double-Blind M | 1989 |
4 other studies available for pamidronate and Arthritis, Rheumatoid
| Article | Year |
|---|---|
APD in Paget's disease of bone. Role of the mononuclear phagocyte system?
Topics: Animals; Arthritis, Rheumatoid; Calcitonin; Clodronic Acid; Diphosphonates; Drug Therapy, Combinatio | 1980 |
Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Cartilage, Articular; Clodronic Acid; Collage | 1997 |
Is pamidronate effective for acute rheumatic pain?
Topics: Adult; Analgesics; Arthritis, Rheumatoid; Diphosphonates; Female; Humans; Infusions, Parenteral; Mal | 2002 |
Effects of aminobisphosphonate infusion on biochemical indices of bone metabolism in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Bone and Bones; Calcium; Calcium-Binding Proteins; Creatinine; D | 1989 |