palytoxin and Nerve-Degeneration

palytoxin has been researched along with Nerve-Degeneration* in 1 studies

Other Studies

1 other study(ies) available for palytoxin and Nerve-Degeneration

ArticleYear
The effect of palytoxin on neuromuscular junctions in the anococcygeus muscle of the rat.
    Journal of neurocytology, 1997, Volume: 26, Issue:6

    Palytoxin, a highly toxic natural product isolated from zoanthids of the genus Palythoa, is accumulated by a wide range of fishes and marine invertebrates used as food in the Indo-Pacific. It is responsible for many incidents of human morbidity and mortality. The toxin is a potent smooth muscle spasmogen. The cause of the contraction of smooth muscle is unclear, but recent work strongly suggests that it is primarily initiated by the release of neurotransmitters from the motor innervation of the smooth muscle. We show here that palytoxin caused the swelling of the muscle cells and some internal organelles of the anococcygeus muscle of the rat, but no substantial structural damage to the tissue. Axons and Schwann cells were also swollen but the most dramatic feature was the depletion of synaptic vesicles from putative release sites in the axons. Some axons were physically damaged following exposure to the toxin, but this was relatively uncommon (< 10% of all axons studied). In the majority of axons there was no damage to nerve terminal membranes, but there was damage to mitochondria. The depletion of vesicles involved all types-clear, dense-cored, large and small. Our observations and pharmacological data gathered elsewhere, provide a neuropathological basis for the spasmogenic activity of palytoxin.

    Topics: Acrylamides; Animals; Axons; Cnidarian Venoms; Male; Microscopy, Electron; Mitochondria; Motor Neurons; Muscle, Smooth; Nerve Degeneration; Neuromuscular Junction; Rats; Rats, Wistar; Schwann Cells; Synaptic Transmission

1997