palmitic acid has been researched along with Obesity in 228 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous results have shown that obesity-induced excessive palmitic acid (PA) can promote the expression of KLF7, which plays a vital role in regulation of inflammation, glucose metabolism." | 8.12 | Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs/NF-κB/KLF7 pathway. ( Chang, Y; Chu, X; Pan, C; Qiu, T; Wang, C; Wang, J; Xie, J; Xiong, J; Yang, X; Zhang, J, 2022) |
| " However, in VAT, GCs induce DNL, higher palmitic acid (PA), macrophage infiltration, and proinflammatory cytokine levels, accompanied by systemic nonesterified fatty acid (NEFA) elevation, hyperinsulinemia, and higher homeostatic model assessment for insulin resistance (HOMA-IR) levels compared with diet-induced obesity." | 7.96 | Long-term hypercortisolism induces lipogenesis promoting palmitic acid accumulation and inflammation in visceral adipose tissue compared with HFD-induced obesity. ( García-Eguren, G; Giró, O; Hanzu, FA; Sala-Vila, A; Vega-Beyhart, A, 2020) |
| " At present, researches have presented obesity is a high-risk factor for colitis, and berberine shows positive therapeutic effect on colitis." | 7.96 | Regulation of MFN2 by berberine alleviates obesity exacerbated colitis. ( Chen, Y; Liu, F; Wen, S; Zheng, Y, 2020) |
| "It was investigated whether apigenin (AP) protected against skeletal muscle atrophy induced by obesity." | 7.85 | Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice. ( Ahn, J; Choi, WH; Ha, TY; Jang, YJ; Jung, CH; Son, HJ, 2017) |
| " This study examined the effect of a novel neuroprotective curcuminoid, CNB-001 [4-((1E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-phenyl-1H-pyrazoyl-3-yl)vinyl)-2-methoxy-phenol], on glucose intolerance and insulin signaling in high-fat diet (HFD)-fed mice." | 7.80 | Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance. ( Hua, Y; Lapchak, PA; Lehmann, TE; Nair, S; Panzhinskiy, E; Ren, J; Topchiy, E, 2014) |
| "Obesity is associated with altered fatty acid profiles, reduced fertility, and assisted reproductive technology (ART) success." | 5.56 | Oleic Acid Counters Impaired Blastocyst Development Induced by Palmitic Acid During Mouse Preimplantation Development: Understanding Obesity-Related Declines in Fertility. ( Betts, DH; Calder, MD; Crocker, K; Du, JT; Rafea, BA; Ruetz, KN; Urquhart, BL; Watson, AJ; Yousif, MD, 2020) |
| "Maternal obesity is a risk factor for placental dysfunction, suggesting that factors within an obese environment may impair early placental development." | 5.56 | Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1. ( Dunk, CE; Lye, SJ; Rampersaud, AM; Renaud, SJ, 2020) |
| "Sarcopenic obesity is a new medical challenge that imposes tremendous financial burdens on healthcare authorities worldwide." | 5.51 | Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway. ( Chen, K; Hou, P; Huang, Y; Lang, H; Mi, M; Ran, L; Yi, L; Zhang, Q; Zhang, Y; Zheng, J; Zhou, M; Zhu, X, 2019) |
| "Obesity is a worldwide health problem with rising incidence and results in reproductive difficulties." | 5.51 | Palmitic acid causes insulin resistance in granulosa cells via activation of JNK. ( Chan, WY; Chen, ZJ; Ke, H; Leung, PCK; Li, W; Lu, G; Qin, Y; Wang, W; Xu, L; You, L; Zhang, X; Zhao, S, 2019) |
| "Obesity is closely associated with neuroinflammation in the hypothalamus, which is characterized by over-activated microglia and excessive production of pro-inflammatory cytokines." | 5.51 | Green Tea Polyphenol (-)-Epigallocatechin Gallate (EGCG) Attenuates Neuroinflammation in Palmitic Acid-Stimulated BV-2 Microglia and High-Fat Diet-Induced Obese Mice. ( Hochstetter, D; Mao, L; Wang, Y; Xu, P; Yao, L; Zhao, Y; Zhou, J, 2019) |
| "Obesity is the result of a positive energy balance and often leads to difficulties in maintaining normal postprandial metabolism." | 5.42 | Targeted metabolomic analysis reveals the association between the postprandial change in palmitic acid, branched-chain amino acids and insulin resistance in young obese subjects. ( Feng, R; Guo, F; Jiao, J; Li, Y; Liu, L; Sun, C, 2015) |
| "Obesity is common among reproductive age women and is associated with adverse pregnancy and fetal outcomes; however, little is known about the effects of excess FFAs on embryos and subsequent fetal development." | 5.37 | Preimplantation exposure of mouse embryos to palmitic acid results in fetal growth restriction followed by catch-up growth in the offspring. ( Chi, MM; Frolova, AI; Jungheim, ES; Louden, ED; Moley, KH; Riley, JK, 2011) |
| "Upper body obesity is associated with insulin resistance, hypertension, and endothelial dysfunction." | 5.32 | Vascular response to angiotensin II in upper body obesity. ( Halliwill, JR; Jensen, MD; Joyner, MJ; Nielsen, S, 2004) |
| "As a reflection of SCD-1 activity, we measured the ratios of palmitoleic acid (C16:1n7) to palmitic acid (C16:0) (SCD-16) and oleic acid (C18:1n9) to steric acid (C18:0) (SCD-18) in plasma samples of postmenopausal women enrolled in our clinical trial (NCT00723398) designed to test the effects of the antiestrogen, Raloxifene and/or the omega-3 preparation Lovaza, on breast density, a validated biomarker of breast cancer risk." | 5.24 | Stearoyl-CoA desaturase-1, a novel target of omega-3 fatty acids for reducing breast cancer risk in obese postmenopausal women. ( Aliaga, C; Calcagnotto, A; El-Bayoumy, K; Manni, A; Richie, JP; Schetter, SE; Trushin, N, 2017) |
| "Primary rat thoracic aortic endothelial cells treated with palmitic acid and mice fed with a high-fat diet (HFD) were used as the obesity models." | 4.31 | Asprosin aggravates vascular endothelial dysfunction via disturbing mitochondrial dynamics in obesity models. ( Chen, S; Huang, Q; Lu, Y; Wang, Z; Xiong, X; Yin, T; Yuan, W; Zeng, G; Zhang, Y, 2023) |
| "C2C12 myotubes were challenged by palmitic acid (PA) to mimic the obese microenvironment and inflammation, cell vitality, and glucose utilization were determined." | 4.31 | Lunasin ameliorates glucose utilization in C2C12 myotubes and metabolites profile in diet-induced obese mice benefiting metabolic disorders. ( Chiang, CC; Hsieh, CC; Huang, CY; Huang, PY; Kuo, CH; Kuo, HC; Lin, PY, 2023) |
| "Palmitic acid enhances the toxic effect of metabolic endotoxemia on the vascular endothelium." | 4.31 | The Role of Palmitic Acid in the Co-Toxicity of Bacterial Metabolites to Endothelial Cells. ( Bożemska, E; Chmielarz, M; Choroszy, M; Sobieszczańska, B; Środa-Pomianek, K; Wawrzyńska, M, 2023) |
| "Chronic low-grade systemic inflammation (SI), including activation of the NLRP3 inflammasome, is a feature of obesity, associated with increased circulating saturated fatty acids, such as palmitic acid (PA), and bacterial endotoxin lipopolysaccharide (LPS)." | 4.12 | Sulforaphane reduces pro-inflammatory response to palmitic acid in monocytes and adipose tissue macrophages. ( Baines, KJ; Berthon, BS; Eslick, S; Gately, M; Guilleminault, L; Karihaloo, C; Williams, EJ; Wood, LG; Wright, T, 2022) |
| "Our previous results have shown that obesity-induced excessive palmitic acid (PA) can promote the expression of KLF7, which plays a vital role in regulation of inflammation, glucose metabolism." | 4.12 | Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs/NF-κB/KLF7 pathway. ( Chang, Y; Chu, X; Pan, C; Qiu, T; Wang, C; Wang, J; Xie, J; Xiong, J; Yang, X; Zhang, J, 2022) |
| " At present, researches have presented obesity is a high-risk factor for colitis, and berberine shows positive therapeutic effect on colitis." | 3.96 | Regulation of MFN2 by berberine alleviates obesity exacerbated colitis. ( Chen, Y; Liu, F; Wen, S; Zheng, Y, 2020) |
| " However, in VAT, GCs induce DNL, higher palmitic acid (PA), macrophage infiltration, and proinflammatory cytokine levels, accompanied by systemic nonesterified fatty acid (NEFA) elevation, hyperinsulinemia, and higher homeostatic model assessment for insulin resistance (HOMA-IR) levels compared with diet-induced obesity." | 3.96 | Long-term hypercortisolism induces lipogenesis promoting palmitic acid accumulation and inflammation in visceral adipose tissue compared with HFD-induced obesity. ( García-Eguren, G; Giró, O; Hanzu, FA; Sala-Vila, A; Vega-Beyhart, A, 2020) |
| "Obesity impairs leptin-induced regulation of brain-derived neurotrophic factor (BDNF) expression and synaptogenesis, which has been considered to be associated with the incidence of neuronal degenerative diseases, cognitive decline, and depression." | 3.88 | Ginsenoside Rb1 improves leptin sensitivity in the prefrontal cortex in obese mice. ( Bell, C; Huang, XF; Wu, Y; Yu, Y, 2018) |
| " Moreover, the mRNA expression of ET-1 was significantly increased in cultured HAECs in response to acute (< 24 h) and chronic (12-16 days) treatments with palmitic acid (PA), one of the most abundant saturated fatty acids in obesity." | 3.88 | Palmitic Acid Increases Endothelin-1 Expression in Vascular Endothelial Cells through the Induction of Endoplasmic Reticulum Stress and Protein Kinase C Signaling. ( Wang, X; Xu, L; Yang, XC; Zhang, J; Zhao, WS, 2018) |
| "It was investigated whether apigenin (AP) protected against skeletal muscle atrophy induced by obesity." | 3.85 | Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice. ( Ahn, J; Choi, WH; Ha, TY; Jang, YJ; Jung, CH; Son, HJ, 2017) |
| " We observed that palmitic acid treatment in cardiac-derived H9c2 cells induced a significant increase in reactive oxygen species, inflammation, apoptosis, fibrosis and hypertrophy." | 3.83 | Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity. ( Chen, G; Chen, X; Li, X; Liang, G; Lu, K; Peng, K; Qian, Y; Xu, Z; Zhang, Y; Zhong, P, 2016) |
| "Obesity impairs cognition, and the leptin-induced increase of brain-derived neurotrophic factor (BDNF) and neurogenesis." | 3.81 | Teasaponin improves leptin sensitivity in the prefrontal cortex of obese mice. ( Huang, XF; Szabo, A; Wang, Q; Wang, S; Wu, Y; Yu, S; Yu, Y, 2015) |
| " It was previously demonstrated that, upon adequate caloric intake (12% kcal fat) and selenium deficiency, disruption of Scly in mice leads to development of metabolic syndrome." | 3.81 | Diet-induced obesity in the selenocysteine lyase knockout mouse. ( Berry, MJ; Gilman, CL; Hashimoto, AC; Ogawa-Wong, AN; Seale, LA, 2015) |
| "To investigate whether ezetimibe ameliorates hepatic steatosis and induces autophagy in a rat model of obesity and type 2 diabetes." | 3.81 | Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. ( Chang, E; Kim, L; Lee, WY; Oh, KW; Park, CY; Park, SE; Park, SW; Rhee, EJ, 2015) |
| " Utilising the 1961-2009 annual food supply data from the UN FAO, the present study investigated changes in the intake of macronutrient and specific fatty acid in the Australian population, including that of the PUFA linoleic acid (LA), due to its hypothesised role in inflammation and risk for obesity." | 3.81 | Australia's nutrition transition 1961-2009: a focus on fats. ( Hryciw, DH; Mathai, ML; McAinch, AJ; Naughton, SS, 2015) |
| " This study examined the effect of a novel neuroprotective curcuminoid, CNB-001 [4-((1E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-phenyl-1H-pyrazoyl-3-yl)vinyl)-2-methoxy-phenol], on glucose intolerance and insulin signaling in high-fat diet (HFD)-fed mice." | 3.80 | Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance. ( Hua, Y; Lapchak, PA; Lehmann, TE; Nair, S; Panzhinskiy, E; Ren, J; Topchiy, E, 2014) |
| "In the present study, we investigated the effect of long-acyl chain SFA, namely palmitic acid (16:0) and stearic acid (18:0), at sn-1, 3 positions of TAG on obesity." | 3.80 | Stearic acids at sn-1, 3 positions of TAG are more efficient at limiting fat deposition than palmitic and oleic acids in C57BL/6 mice. ( Cheng, SF; Chuah, CH; Gouk, SW; Ong, AS, 2014) |
| " In addition, it was validated if IMTG palmitic acid is associated with insulin resistance as suggested earlier." | 3.76 | Desaturation of excess intramyocellular triacylglycerol in obesity: implications for glycemic control. ( Haugaard, SB; Madsbad, S; Mu, H; Vaag, A, 2010) |
| "We found strong positive relationships between adipose tissue TG content of the fatty acids myristic acid (14:0) and stearic acid (18:0) with insulin sensitivity (HOMA model) (p < 0." | 3.75 | Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans. ( Dennis, AL; Frayn, KN; Harnden, KE; Hodson, L; Humphreys, SM; Micklem, KJ; Neville, MJ; Roberts, R, 2009) |
| " In one approach, Orlistat, a drug approved for treating obesity, is used as a potent inhibitor of the thioesterase function of FAS." | 3.72 | A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2. ( Axelrod, F; Browne, CD; Knowles, LM; Smith, JW, 2004) |
| "Beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) consists of a nonmetabolizable long-chain fatty acid designed to probe the effect exerted by fatty acids on insulin sensitivity." | 3.69 | Sensitization to insulin induced by beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in obese Zucker rats in vivo. ( Bar-Tana, J; Itach, E; Kalderon, B; Mayorek, N, 1997) |
| "BRL 26830A is a thermogenic beta-adrenergic agonist drug which has an anti-obesity effect in animals and diet-restricted obese man." | 3.68 | Metabolic effects of three weeks administration of the beta-adrenoceptor agonist BRL 26830A. ( Bennet, WM; Connacher, AA; Jung, RT; Rennie, MJ, 1992) |
| "Palmitic acid is a saturated fatty acid whose blood concentration is elevated in obese patients." | 2.61 | The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms. ( Bajdak-Rusinek, K; Korbecki, J, 2019) |
| "Obesity is a major contributing factor for metabolic-associated fatty liver disease (MAFLD)." | 1.91 | FGF1 ameliorates obesity-associated hepatic steatosis by reversing IGFBP2 hypermethylation. ( Chen, C; Gao, D; Li, X; Wang, J; Yang, L; Yang, W; Yu, C; Zhang, F; Zhang, JS, 2023) |
| "Obesity is a global threat for male infertility, which can cause spermatogenic dysfunction." | 1.91 | Icariin Ameliorates Spermatogenesis Disorder in Obese Mice Induced by High-Fat Diet through Regulating the Glycolytic Pathway. ( Huang, H; Ji, L; Lei, X; Luo, M; Mo, Y; Tan, Y; Wang, J; Zhou, L; Zhuge, X, 2023) |
| "Patients with psoriasis are frequently complicated with metabolic syndrome; however, it is not fully understood how obesity and dyslipidemia contribute to the pathogenesis of psoriasis." | 1.72 | Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation. ( Akagi, T; Hiramatsu-Asano, S; Ikeda, K; Iseki, M; Ishihara, K; Kaneto, H; Morita, Y; Morizane, S; Mukai, T; Tachibana, K; Wada, J; Yahagi, A, 2022) |
| "Palmitic acid effects were dependent on TLR4 and impaired by methyltransferase inhibition and AMPK activation." | 1.72 | Weight cycling induces innate immune memory in adipose tissue macrophages. ( Boney, LY; Caslin, HL; Cottam, MA; Hasty, AH; Piñon, JM, 2022) |
| "Obesity is a known risk factor for the development of gastroesophageal reflux disease (GERD), Barrett's Esophagus (BE) and the progression to esophageal adenocarcinoma." | 1.72 | Augmented CPT1A Expression Is Associated with Proliferation and Colony Formation during Barrett's Tumorigenesis. ( Altomare, DA; Andl, CD; Andl, T; Bernard, JN; Chinnaiyan, V; Le Bras, GF; Qureshi, MN, 2022) |
| "Obesity has been associated with increased severity and mortality of COVID-19." | 1.62 | Molecular Mechanisms of Palmitic Acid Augmentation in COVID-19 Pathologies. ( Jadeja, V; Joshi, C; Zhou, H, 2021) |
| "Obesity has been recognized as a major risk factor for the development of chronic cardiomyopathy, which is associated with increased cardiac inflammation, fibrosis, and apoptosis." | 1.62 | Curcumin analogue C66 attenuates obesity-induced myocardial injury by inhibiting JNK-mediated inflammation. ( Chattipakorn, N; Chen, X; Feng, J; Guan, X; Jin, L; Liang, G; Luo, W; Pavlov, VN; Samorodov, AV; Wang, M; Wang, Y; Yang, D; Ye, L; Zhuang, Z, 2021) |
| "Obesity is a serious health issue as it is a social burden and the main risk factor for other metabolic diseases." | 1.62 | Free fatty acids induce the demethylation of the fructose 1,6-biphosphatase 2 gene promoter and potentiate its expression in hepatocytes. ( Li, X; Liu, J; Liu, M; Wang, L; Wu, Y; Yin, F; Yin, L, 2021) |
| " Consistently, a lack of MKP-5 aggravated the adverse effects of lipotoxicity." | 1.56 | MKP-5 Relieves Lipotoxicity-Induced Islet β-Cell Dysfunction and Apoptosis via Regulation of Autophagy. ( Jiao, P; Li, L; Ma, J; Ma, Y; Teng, W; Tian, Y; Wang, W; Yan, W; Zhao, T, 2020) |
| "Maternal obesity is a risk factor for placental dysfunction, suggesting that factors within an obese environment may impair early placental development." | 1.56 | Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1. ( Dunk, CE; Lye, SJ; Rampersaud, AM; Renaud, SJ, 2020) |
| "Human stem cell therapy for type 2 diabetes/obesity (T2D/O) complications is performedwith stem cell autografts, exposed to the noxious T2D/O milieu, often with suboptimal results." | 1.56 | Evaluation of the In Vitro Damage Caused by Lipid Factors on Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence. ( Cooper, C; DeCastro, WB; Gelfand, R; Gonzalez-Cadavid, NF; Kovanecz, I; Lin, G; Lue, T; Ohanian, A; Sharifzad, S, 2020) |
| "Obesity is a major health problem worldwide." | 1.56 | Lipid excess affects chaperone-mediated autophagy in hypothalamus. ( Campana, M; Hakim, MP; Ignácio-Souza, LM; Le Stunff, H; Leal, RF; Magnan, C; Milanski, M; Miyamoto, JÉ; Portovedo, M; Reginato, A; Simino, LA; Torsoni, AS; Torsoni, MA, 2020) |
| "Obesity and type 2 diabetes (T2D) are metabolic disorders influenced by lifestyle and genetic factors that are characterized by insulin resistance in skeletal muscle, a prominent site of glucose disposal." | 1.56 | Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism. ( Astrup, A; Auwerx, J; Barrès, R; Bork-Jensen, J; Grarup, N; Hansen, AN; Hansen, T; Ingerslev, LR; Pedersen, O; Ribel-Madsen, R; Small, L; Williams, K; Wohlwend, M; Workman, CT, 2020) |
| "Arachidonic acid (AA) plays a fundamental role in the function of all cells." | 1.56 | Arachidonic acid inhibits inflammatory responses by binding to myeloid differentiation factor-2 (MD2) and preventing MD2/toll-like receptor 4 signaling activation. ( Cai, Y; Chen, H; Khan, ZA; Liang, G; Liu, H; Shan, P; Wu, D; Zhang, B; Zhang, W; Zhang, Y, 2020) |
| "Obesity is a worldwide health problem with rising incidence and results in reproductive difficulties." | 1.51 | Palmitic acid causes insulin resistance in granulosa cells via activation of JNK. ( Chan, WY; Chen, ZJ; Ke, H; Leung, PCK; Li, W; Lu, G; Qin, Y; Wang, W; Xu, L; You, L; Zhang, X; Zhao, S, 2019) |
| "Obesity is underpinned by both genetic and environmental factors, including a high-saturated-fat diet." | 1.51 | Alterations to the microbiota-colon-brain axis in high-fat-diet-induced obese mice compared to diet-resistant mice. ( Huang, XF; Li, X; Qin, Y; Tang, R; Wang, H; Wang, Q; Weston-Green, K; Yu, Y; Zhang, P; Zheng, K; Zhou, Y, 2019) |
| "Obesity is closely associated with neuroinflammation in the hypothalamus, which is characterized by over-activated microglia and excessive production of pro-inflammatory cytokines." | 1.51 | Green Tea Polyphenol (-)-Epigallocatechin Gallate (EGCG) Attenuates Neuroinflammation in Palmitic Acid-Stimulated BV-2 Microglia and High-Fat Diet-Induced Obese Mice. ( Hochstetter, D; Mao, L; Wang, Y; Xu, P; Yao, L; Zhao, Y; Zhou, J, 2019) |
| "Obesity is a major cause of metabolic syndrome and type II diabetes, and it presents with metabolic disorders, such as hyperglycemia, hyperlipidemia, and insulin resistance." | 1.51 | Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice. ( Chen, CC; Lee, TY; Leu, YL; Wang, SH, 2019) |
| "Sarcopenic obesity is a new medical challenge that imposes tremendous financial burdens on healthcare authorities worldwide." | 1.51 | Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway. ( Chen, K; Hou, P; Huang, Y; Lang, H; Mi, M; Ran, L; Yi, L; Zhang, Q; Zhang, Y; Zheng, J; Zhou, M; Zhu, X, 2019) |
| "Treatment with palmitic acid (PA) or HFD significantly increased the expression of miR-33a in hepatocytes or liver tissues." | 1.48 | Hepatocyte miR-33a mediates mitochondrial dysfunction and hepatosteatosis by suppressing NDUFA5. ( Chen, Z; Dai, X; He, H; Huang, H; Li, Q; Nie, H; Ren, T; Song, C; Wang, D; Yu, X; Zhou, L; Zhou, Y, 2018) |
| "Obesity is a risk factor for infertility, but mechanisms underlying this risk are unclear." | 1.48 | Obesity-related cellular stressors regulate gonadotropin releasing hormone gene expression via c-Fos/AP-1. ( Bertsch, AD; Dao, N; Gray, NW; Grzybowski, CW; Lenkey, JA; Levi, NJ; Moseman, AW; Redweik, GAJ; Walsh, HE; Wilson, CW, 2018) |
| "Obesity is believed to negatively affect male semen quality and is accompanied by dysregulation of free fatty acid (FFA) metabolism in plasma." | 1.48 | Effects of saturated palmitic acid and omega-3 polyunsaturated fatty acids on Sertoli cell apoptosis. ( Ge, X; Hu, X; Jing, J; Liang, W; Shao, Y; Wang, C; Yao, B; Zeng, R, 2018) |
| "Obesity is associated with an increased risk of chronic kidney diseases and the conventional treatment with renin-angiotensin-aldosterone system (RAAS) inhibitors is not enough to prevent renal injury and prolong the progression of disease." | 1.46 | Silymarin protects against renal injury through normalization of lipid metabolism and mitochondrial biogenesis in high fat-fed mice. ( Bi, Y; Meng, R; Shen, S; Zhu, D, 2017) |
| "Palmitic acid treatment caused mitochondrial damage and leakage of mitochondrial DNA into the cytosol." | 1.46 | STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity. ( Abe, JI; Fujiwara, K; LeMaire, SA; Luo, W; Mao, Y; Shen, YH; Song, J; Wang, XL; Wu, W; Xu, H; Yuan, L; Zhang, L, 2017) |
| "Obesity is associated with hyperlipidemia, electrical remodeling of the heart, and increased risk of supraventricular arrhythmias in both male and female patients." | 1.43 | High-fat diet-dependent modulation of the delayed rectifier K(+) current in adult guinea pig atrial myocytes. ( Aromolaran, AS; Boutjdir, M; Colecraft, HM, 2016) |
| "Obesity is associated with abnormal lipid metabolism and impaired bone homeostasis." | 1.43 | Diet-Induced Obesity and Its Differential Impact on Periodontal Bone Loss. ( Al-Sahli, A; Celenti, R; Cremers, S; Gold, T; Jiang, H; Kiefhaber, K; Muluke, M; Schulze-Späte, U; Van Dyke, T, 2016) |
| "Obesity is the result of a positive energy balance and often leads to difficulties in maintaining normal postprandial metabolism." | 1.42 | Targeted metabolomic analysis reveals the association between the postprandial change in palmitic acid, branched-chain amino acids and insulin resistance in young obese subjects. ( Feng, R; Guo, F; Jiao, J; Li, Y; Liu, L; Sun, C, 2015) |
| "As obesity is one of the major risk factors of chronic and end-stage renal disease, we studied the role of Smad3 signaling in the pathogenesis of obesity-related renal disease." | 1.42 | Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance. ( Bertram, JF; Caruana, G; Dai, L; Fu, P; Howard, V; Jiang, X; Li, J; Nikolic-Paterson, DJ; Puelles, VG; Qu, X; Ren, Y; Sleeman, MW; Sun, YB, 2015) |
| "Obvious obese feathers associated with type 2 diabetes were observed in HFD feeding mice, with decreased circulating irisin level and FNDC5/irisin secretion in adipose tissues." | 1.42 | Decreased irisin secretion contributes to muscle insulin resistance in high-fat diet mice. ( Chen, X; Chen, Y; Yang, Z; Zhao, Q, 2015) |
| "The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in parallel with the prevalence of obesity." | 1.42 | GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance. ( Isobe, K; Nishio, N, 2015) |
| "Obesity is a state of chronic, low-grade inflammation, and increased inflammation in the adipose and kidney tissues has been shown to promote the progression of renal damage in obesity." | 1.42 | Inhibition of mitogen-activated protein kinases/nuclear factor κB-dependent inflammation by a novel chalcone protects the kidney from high fat diet-induced injuries in mice. ( Deng, L; Fang, Q; Liang, G; Pan, Y; Tong, C; Wang, J; Wang, L; Weng, Q; Yin, H; Zhang, Y, 2015) |
| "Obesity is associated with chronic low-grade inflammation and oxidative stress that blunt insulin response in its target tissues, leading to insulin resistance (IR)." | 1.40 | Defects in TLR3 expression and RNase L activation lead to decreased MnSOD expression and insulin resistance in muscle cells of obese people. ( Amouzou, C; Bisbal, C; Breuker, C; Fabre, O; Kitzmann, M; Mercier, J; Salehzada, T, 2014) |
| "Obesity is associated with insulin resistance and abnormal peripheral tissue glucose uptake." | 1.39 | Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity. ( Ang, J; Bonala, S; Chua, H; Gluckman, PD; Kambadur, R; Lee, M; Lee, YS; Leow, MK; Lim, R; Lokireddy, S; McFarlane, C; Meng, KC; Sharma, M; Shyong, TE; Sreekanth, P, 2013) |
| "Obesity is associated with an increased risk of cardiomyopathy, and mechanisms linking the underlying risk and dietary factors are not well understood." | 1.39 | Palmitate diet-induced loss of cardiac caveolin-3: a novel mechanism for lipid-induced contractile dysfunction. ( Cebova, M; Knowles, CJ; Pinz, IM, 2013) |
| "Obesity is associated with hypertriglyceridemia and elevated circulating free fatty acids (FFA), resulting in endothelial dysfunction." | 1.39 | Palmitate induces apoptosis in mouse aortic endothelial cells and endothelial dysfunction in mice fed high-calorie and high-cholesterol diets. ( Chen, B; Chen, G; Chen, L; Gui, L; Huang, D; Lu, Y; Qian, L; Zhang, Q, 2013) |
| "Obesity is associated with insulin resistance in the peripheral vasculature and is an important risk factor for coronary artery disease." | 1.37 | Preserved insulin vasorelaxation and up-regulation of the Akt/eNOS pathway in coronary arteries from insulin resistant obese Zucker rats. ( Andriantsitohaina, R; Contreras, C; García-Sacristán, A; Martínez, MC; Prieto, D; Sánchez, A, 2011) |
| "Obesity is common among reproductive age women and is associated with adverse pregnancy and fetal outcomes; however, little is known about the effects of excess FFAs on embryos and subsequent fetal development." | 1.37 | Preimplantation exposure of mouse embryos to palmitic acid results in fetal growth restriction followed by catch-up growth in the offspring. ( Chi, MM; Frolova, AI; Jungheim, ES; Louden, ED; Moley, KH; Riley, JK, 2011) |
| "Obesity is characterized by adipose tissue expansion as well as macrophage infiltration of adipose tissue." | 1.35 | Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action. ( Gurley, C; Kern, PA; McGehee, RE; Nolen, GT; Peterson, CA; Phanavanh, B; Rasouli, N; Simpson, P; Starks, T; Varma, V; Yao-Borengasser, A, 2009) |
| "Obesity is associated with lower rates of skeletal muscle fatty acid oxidation (FAO), which is linked to insulin resistance." | 1.33 | Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training. ( Basilio, JL; Berggren, JR; Cortright, RN; Dohm, GL; Hickner, RC; Houmard, JA; Hulver, MW; Sandhoff, KM, 2006) |
| "JNKs are attractive targets for treatment of obesity and type-2 diabetes." | 1.33 | Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. ( Galimi, F; Karin, M; Lee, MS; Naugler, W; Solinas, G, 2006) |
| "Upper body obesity is associated with insulin resistance, hypertension, and endothelial dysfunction." | 1.32 | Vascular response to angiotensin II in upper body obesity. ( Halliwill, JR; Jensen, MD; Joyner, MJ; Nielsen, S, 2004) |
| "The onset of NIDDM in obese Zucker diabetic fatty (fa/fa) rats is preceded by a striking increase in the plasma levels of free fatty acids (FFAs) and by a sixfold rise in triglyceride content in the pancreatic islets." | 1.30 | Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM. ( Esser, V; Hirose, H; Lee, Y; McGarry, JD; Unger, RH; Zhou, YT, 1997) |
| " It is, therefore, useful for serial examinations of adipose tissue adrenoreceptor dose-response characteristics under a variety of clinical circumstances." | 1.27 | Radioisotopic method for the measurement of lipolysis in small samples of human adipose tissue. ( Berry, EM; Gruen, RK; Hirsch, J; Leibel, RL, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (5.70) | 18.7374 |
| 1990's | 15 (6.58) | 18.2507 |
| 2000's | 41 (17.98) | 29.6817 |
| 2010's | 115 (50.44) | 24.3611 |
| 2020's | 44 (19.30) | 2.80 |
| Authors | Studies |
|---|---|
| Ye, L | 1 |
| Chen, X | 5 |
| Wang, M | 2 |
| Jin, L | 1 |
| Zhuang, Z | 1 |
| Yang, D | 1 |
| Guan, X | 1 |
| Samorodov, AV | 1 |
| Pavlov, VN | 1 |
| Chattipakorn, N | 1 |
| Feng, J | 2 |
| Wang, Y | 8 |
| Luo, W | 4 |
| Liang, G | 7 |
| Zhang, W | 2 |
| You, B | 1 |
| Qi, D | 1 |
| Qiu, L | 1 |
| Ripley-Gonzalez, JW | 1 |
| Zheng, F | 1 |
| Fu, S | 1 |
| Li, C | 3 |
| Dun, Y | 1 |
| Liu, S | 1 |
| Dai, HB | 1 |
| Wang, HY | 2 |
| Wang, FZ | 1 |
| Qian, P | 1 |
| Gao, Q | 1 |
| Zhou, H | 2 |
| Zhou, YB | 1 |
| Liu, XZ | 1 |
| Rulina, A | 1 |
| Choi, MH | 1 |
| Pedersen, L | 1 |
| Lepland, J | 1 |
| Takle, ST | 1 |
| Madeleine, N | 1 |
| Peters, SD | 1 |
| Wogsland, CE | 1 |
| Grøndal, SM | 1 |
| Lorens, JB | 1 |
| Goodarzi, H | 1 |
| Lønning, PE | 1 |
| Knappskog, S | 1 |
| Molven, A | 1 |
| Halberg, N | 1 |
| Howe, AM | 1 |
| Burke, S | 1 |
| O'Reilly, ME | 1 |
| McGillicuddy, FC | 1 |
| Costello, DA | 1 |
| Wang, S | 5 |
| Qian, Z | 1 |
| Ge, X | 2 |
| Xue, M | 1 |
| Liang, K | 1 |
| Ma, R | 1 |
| Ouyang, L | 1 |
| Zheng, L | 1 |
| Jing, J | 2 |
| Cao, S | 1 |
| Zhang, Y | 9 |
| Yang, Y | 1 |
| Chen, Y | 4 |
| Ma, J | 2 |
| Yao, B | 2 |
| Lin, K | 1 |
| Yang, N | 1 |
| Qian, JF | 1 |
| Zhu, WW | 1 |
| Ye, SJ | 1 |
| Yuan, CX | 1 |
| Xu, DY | 1 |
| Huang, WJ | 1 |
| Shan, PR | 1 |
| Williams, EJ | 1 |
| Guilleminault, L | 1 |
| Berthon, BS | 1 |
| Eslick, S | 1 |
| Wright, T | 1 |
| Karihaloo, C | 1 |
| Gately, M | 1 |
| Baines, KJ | 1 |
| Wood, LG | 1 |
| Quan, X | 1 |
| Guo, Q | 1 |
| Li, X | 6 |
| Liang, Y | 1 |
| Cui, M | 1 |
| Li, J | 4 |
| Huang, S | 1 |
| Wang, J | 10 |
| Li, B | 2 |
| Qiu, T | 2 |
| Yang, X | 2 |
| Pan, C | 1 |
| Chu, X | 2 |
| Xiong, J | 1 |
| Xie, J | 2 |
| Chang, Y | 1 |
| Wang, C | 4 |
| Zhang, J | 3 |
| Ikeda, K | 1 |
| Morizane, S | 1 |
| Akagi, T | 1 |
| Hiramatsu-Asano, S | 1 |
| Tachibana, K | 1 |
| Yahagi, A | 1 |
| Iseki, M | 1 |
| Kaneto, H | 1 |
| Wada, J | 1 |
| Ishihara, K | 1 |
| Morita, Y | 1 |
| Mukai, T | 1 |
| Chen, Z | 2 |
| Li, W | 3 |
| Liu, X | 3 |
| Ding, Y | 1 |
| Li, F | 1 |
| He, J | 1 |
| Gao, R | 1 |
| Bernard, JN | 1 |
| Chinnaiyan, V | 1 |
| Andl, T | 1 |
| Le Bras, GF | 1 |
| Qureshi, MN | 1 |
| Altomare, DA | 1 |
| Andl, CD | 1 |
| Lu, Y | 4 |
| Yuan, W | 1 |
| Xiong, X | 1 |
| Huang, Q | 2 |
| Chen, S | 1 |
| Yin, T | 1 |
| Wang, Z | 5 |
| Zeng, G | 1 |
| Caslin, HL | 1 |
| Cottam, MA | 1 |
| Piñon, JM | 1 |
| Boney, LY | 1 |
| Hasty, AH | 1 |
| Zhou, Q | 2 |
| Lu, Z | 2 |
| Wang, B | 2 |
| Li, L | 2 |
| You, M | 1 |
| Wang, L | 5 |
| Cao, T | 1 |
| Zhao, Y | 3 |
| Li, Q | 2 |
| Mou, A | 1 |
| Shu, W | 1 |
| He, H | 2 |
| Zhao, Z | 2 |
| Liu, D | 1 |
| Zhu, Z | 1 |
| Gao, P | 1 |
| Yan, Z | 1 |
| Zhang, F | 1 |
| Yang, W | 1 |
| Gao, D | 2 |
| Yang, L | 2 |
| Yu, C | 1 |
| Chen, C | 1 |
| Zhang, JS | 1 |
| Luo, M | 2 |
| Zhuge, X | 1 |
| Ji, L | 1 |
| Mo, Y | 1 |
| Tan, Y | 2 |
| Zhou, L | 2 |
| Lei, X | 1 |
| Huang, H | 2 |
| Choroszy, M | 1 |
| Środa-Pomianek, K | 1 |
| Wawrzyńska, M | 1 |
| Chmielarz, M | 1 |
| Bożemska, E | 1 |
| Sobieszczańska, B | 1 |
| Huang, PY | 1 |
| Chiang, CC | 1 |
| Huang, CY | 1 |
| Lin, PY | 1 |
| Kuo, HC | 1 |
| Kuo, CH | 1 |
| Hsieh, CC | 1 |
| Liu, J | 5 |
| Zhang, D | 1 |
| Yang, Z | 2 |
| Hao, Y | 1 |
| Zhu, X | 2 |
| Si, F | 1 |
| Hao, R | 1 |
| Zheng, J | 2 |
| Zhang, C | 1 |
| Sardon Puig, L | 1 |
| Pillon, NJ | 1 |
| Näslund, E | 1 |
| Krook, A | 1 |
| Zierath, JR | 2 |
| Mao, L | 1 |
| Hochstetter, D | 1 |
| Yao, L | 1 |
| Zhou, J | 2 |
| Xu, P | 1 |
| Marei, WFA | 1 |
| Van den Bosch, L | 1 |
| Pintelon, I | 1 |
| Mohey-Elsaeed, O | 1 |
| Bols, PEJ | 1 |
| Leroy, JLMR | 1 |
| Xie, T | 1 |
| So, WY | 1 |
| Li, XY | 1 |
| Leung, PS | 1 |
| Peleli, M | 1 |
| Ferreira, DMS | 1 |
| Tarnawski, L | 1 |
| McCann Haworth, S | 1 |
| Xuechen, L | 1 |
| Zhuge, Z | 1 |
| Newton, PT | 1 |
| Massart, J | 1 |
| Chagin, AS | 1 |
| Olofsson, PS | 1 |
| Ruas, JL | 1 |
| Weitzberg, E | 1 |
| Lundberg, JO | 1 |
| Carlström, M | 1 |
| Huang, F | 1 |
| Chen, J | 2 |
| Zhu, P | 1 |
| Lin, W | 1 |
| Park, BS | 1 |
| Tu, TH | 2 |
| Lee, H | 1 |
| Jeong, DY | 1 |
| Yang, S | 1 |
| Lee, BJ | 2 |
| Kim, JG | 1 |
| Deng, Y | 1 |
| Zhang, M | 1 |
| Wu, J | 2 |
| Zhang, X | 4 |
| Chen, K | 2 |
| Ha, X | 1 |
| Chen, H | 1 |
| Cai, Y | 1 |
| Shan, P | 2 |
| Wu, D | 1 |
| Zhang, B | 1 |
| Liu, H | 1 |
| Khan, ZA | 1 |
| Jiang, XS | 1 |
| Chen, XM | 1 |
| Hua, W | 1 |
| He, JL | 1 |
| Liu, T | 1 |
| Li, XJ | 1 |
| Wan, JM | 1 |
| Gan, H | 1 |
| Du, XG | 1 |
| García-Eguren, G | 1 |
| Sala-Vila, A | 1 |
| Giró, O | 1 |
| Vega-Beyhart, A | 1 |
| Hanzu, FA | 1 |
| Williams, K | 1 |
| Ingerslev, LR | 1 |
| Bork-Jensen, J | 1 |
| Wohlwend, M | 1 |
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| Small, L | 1 |
| Ribel-Madsen, R | 1 |
| Astrup, A | 1 |
| Pedersen, O | 1 |
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| Workman, CT | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Nicotinic Acid on Adipose Tissue Inflammation in Obese Subjects[NCT01083329] | Phase 2 | 24 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| Investigating the Effects of Aerobic and Resistance Training in Vivo on Skeletal Muscle Metabolism in Vitro in Primary Human Muscle Cells (MoTrMyo)[NCT04334343] | 400 participants (Anticipated) | Interventional | 2020-11-01 | Recruiting | |||
| Calorie Restriction and Metabolic Health[NCT01538836] | 75 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Combination of Low Dose Antiestrogens With Omega-3 Fatty Acids for Prevention of Hormone-independent Breast Cancer[NCT00723398] | 266 participants (Actual) | Interventional | 2009-03-31 | Completed | |||
| Impact of Ageing on Adipose, Muscle and Systemic Inflammation[NCT02777138] | 24 participants (Anticipated) | Observational | 2016-05-31 | Active, not recruiting | |||
| Recombinant Human Leptin Therapy Effects on Insulin Action[NCT01207934] | 18 participants (Actual) | Interventional | 1998-08-31 | Completed | |||
| Mechanisms by Which Strength Training Ameliorates the Metabolic Syndrome[NCT00727779] | 50 participants (Actual) | Interventional | 2008-01-31 | Completed | |||
| Epigenetic Regulation of Human Adipose Tissue Distribution[NCT02728635] | 27 participants (Actual) | Interventional | 2016-07-31 | Active, not recruiting | |||
| Resistance Training Modulation of Fat Metabolism in Obese Postmenopausal Women[NCT05351476] | 120 participants (Anticipated) | Interventional | 2022-05-20 | Recruiting | |||
| Body Composition and Lipid Metabolism at Rest and During Exercise: A Cross-Sectional Analysis.[NCT03029364] | 200 participants (Anticipated) | Observational | 2018-01-08 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change of absolute breast density as indicated by mammography from baseline to Year +1 and completion of study (Year +2). No other mammograms will be obtained or used for the purpose of this study. Absolute breast density volume is based on breast thickness and the x-ray attenuation at each pixel of the image. (NCT00723398)
Timeframe: 2 years
| Intervention | cm squared (Mean) | ||
|---|---|---|---|
| Absolute density at baseline | Absolute density at 1 year | Absolute density at 2 years | |
| Group 1: Control | 65.53 | 59.29 | 54.34 |
| Group 2: Raloxifene 60 mg | 64.39 | 60.48 | 60.57 |
| Group 3: Raloxifene 30 mg | 65.08 | 59.53 | 58.86 |
| Group 4: Lovaza 4 gm | 56.35 | 58.87 | 57.60 |
| Group 5: Lovaza 4 gm and Raloxifene 30 mg | 63.81 | 60.93 | 28.53 |
Changes in biomarkers for estrogen metabolism: 2-hydroxy estrone (Urinary 2-OHE1) and 16-α-hydroxy estrone (16α-OHE1) as measured by urinary analysis. Specific time points for evaluation are baseline and Year +1 (only). (NCT00723398)
Timeframe: 1 year
| Intervention | ng/mg creatinine (Mean) | |||
|---|---|---|---|---|
| Baseline: Urinary 2-OHE1 | 1 year: Urinary 2-OHE1 | Baseline: 16α-OHE1 | 1 year: 16α-OHE1 | |
| Group 1: Control | 10.57 | 7.46 | 6.22 | 5.68 |
| Group 2: Raloxifene 60 mg | 8.58 | 10.03 | 5.08 | 4.35 |
| Group 3: Raloxifene 30 mg | 8.82 | 9.10 | 6.86 | 7.46 |
| Group 4: Lovaza 4 gm | 7.15 | 7.49 | 5.24 | 4.79 |
| Group 5: Lovaza 4 gm and Raloxifene 30 mg | 15.6 | 13.2 | 6.6 | 5.68 |
Changes in biomarkers for oxidative stress. Specific time points for evaluation are baseline and Year +1 (only). Urinary 8-hydroxy-deoxyguansine as measured through urinary analysis. (NCT00723398)
Timeframe: 1 year
| Intervention | ng/mg creatinine (Mean) | |
|---|---|---|
| Baseline | 1 year | |
| Group 1: Control | 255 | 224 |
| Group 2: Raloxifene 60 mg | 285 | 309 |
| Group 3: Raloxifene 30 mg | 213 | 246 |
| Group 4: Lovaza 4 gm | 184 | 177 |
| Group 5: Lovaza 4 gm and Raloxifene 30 mg | 355 | 297 |
Changes in biomarkers for oxidative stress. Specific time points for evaluation are baseline and Year +1 (only). Urinary 8-(isoprostane) F-2α as measured through urine analysis. (NCT00723398)
Timeframe: 1 year
| Intervention | pg/mg creatinine (Mean) | |
|---|---|---|
| Baseline | 1 year | |
| Group 1: Control | 544 | 484 |
| Group 2: Raloxifene 60 mg | 366 | 360 |
| Group 3: Raloxifene 30 mg | 530 | 538 |
| Group 4: Lovaza 4 gm | 440 | 313 |
| Group 5: Lovaza 4 gm and Raloxifene 30 mg | 444 | 396 |
Changes in complete blood count levels as measured through hematocrit percentage. Specific time points for evaluation are baseline, Year +1, and Year 2. (NCT00723398)
Timeframe: 2 years
| Intervention | volume percentage (Mean) | ||
|---|---|---|---|
| Baseline: Hematocrit | 1 year: Hematocrit | 2 year: Hematocrit | |
| Group 1: Control | 39.14 | 38.83 | 39.00 |
| Group 2: Raloxifene 60 mg | 38.95 | 38.79 | 38.86 |
| Group 3: Raloxifene 30 mg | 38.79 | 38.43 | 38.31 |
| Group 4: Lovaza 4 gm | 39.09 | 39.52 | 38.59 |
| Group 5: Lovaza 4 gm and Raloxifene 30 mg | 39.20 | 39.14 | 39.14 |
Changes in complete blood count levels as measured through hemoglobin. Specific time points for evaluation are baseline, Year +1, and Year 2. (NCT00723398)
Timeframe: 2 years
| Intervention | g/dL (Mean) | ||
|---|---|---|---|
| Baseline: Hemoglobin | 1 year: Hemoglobin | 2 year: Hemoglobin | |
| Group 1: Control | 13.09 | 12.97 | 13.10 |
| Group 2: Raloxifene 60 mg | 13.11 | 12.97 | 13.07 |
| Group 3: Raloxifene 30 mg | 12.73 | 12.95 | 12.82 |
| Group 4: Lovaza 4 gm | 13.25 | 13.33 | 13.16 |
| Group 5: Lovaza 4 gm and Raloxifene 30 mg | 13.35 | 13.10 | 13.22 |
Changes in complete blood count levels as measured through red blood cells (RBC). Specific time points for evaluation are baseline, Year +1, and Year 2. (NCT00723398)
Timeframe: 2 years
| Intervention | millions of cells per microliter (Mean) | ||
|---|---|---|---|
| Baseline: RBC | 1 year: RBC | 2 year: RBC | |
| Group 1: Control | 4.31 | 4.27 | 4.32 |
| Group 2: Raloxifene 60 mg | 4.25 | 4.19 | 4.20 |
| Group 3: Raloxifene 30 mg | 4.30 | 4.25 | 4.24 |
| Group 4: Lovaza 4 gm | 4.33 | 4.36 | 4.33 |
| Group 5: Lovaza 4 gm and Raloxifene 30 mg | 4.24 | 4.20 | 4.23 |
Changes in complete blood count levels as measured through white blood cells (WBC) and platelets. Specific time points for evaluation are baseline, Year +1, and Year 2. (NCT00723398)
Timeframe: 2 years
| Intervention | thousand cells/mL (Mean) | |||||
|---|---|---|---|---|---|---|
| Baseline: WBC | 1 year: WBC | 2 year: WBC | Baseline: Platelets | 1 year: Platelets | 2 year: Platelets | |
| Group 1: Control | 5.13 | 5.15 | 5.14 | 270.70 | 237.02 | 234.02 |
| Group 2: Raloxifene 60 mg | 5.47 | 5.51 | 5.42 | 235.22 | 228.02 | 226.16 |
| Group 3: Raloxifene 30 mg | 5.00 | 4.78 | 4.90 | 240.42 | 230.61 | 232.09 |
| Group 4: Lovaza 4 gm | 5.04 | 4.95 | 4.90 | 237.33 | 231.42 | 232.47 |
| Group 5: Lovaza 4 gm and Raloxifene 30 mg | 5.27 | 4.91 | 4.91 | 235.76 | 221.49 | 223.27 |
Changes in insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-1 binding protein-3 (IGFBP-3) obtained through blood sample. Specific time points for evaluation are baseline and Year +1 (only). (NCT00723398)
Timeframe: 1 year
| Intervention | ng/mL (Mean) | |||
|---|---|---|---|---|
| Baseline: IGF-1 | 1 year: IGF-1 | Baseline: IGFBP-3 | 1 year: IGFBP-3 | |
| Group 1: Control | 4.96 | 5.05 | 7.67 | 7.75 |
| Group 2: Raloxifene 60 mg | 4.63 | 4.40 | 7.53 | 7.55 |
| Group 3: Raloxifene 30 mg | 4.80 | 4.76 | 7.69 | 7.79 |
| Group 4: Lovaza 4 gm | 4.95 | 4.96 | 7.83 | 7.83 |
| Group 5: Lovaza 4 gm and Raloxifene 30 mg | 4.89 | 4.82 | 7.57 | 7.61 |
Changes in serum biomarkers for inflammation including highly sensitive C-reactive protein and IL-6 obtained through a blood draw. Specific time points for evaluation are baseline and Year +1 (only). (NCT00723398)
Timeframe: 1 Year
| Intervention | pg/ml (Mean) | |||
|---|---|---|---|---|
| Baseline: Serum hsCRP | 1 year: Serum hsCRP | Baseline: Serum IL-6 | 1 year: Serum IL-6 | |
| Group 1: Control | 2.39 | 2.19 | 1.27 | 1.03 |
| Group 2: Raloxifene 60 mg | 0.91 | 1.04 | 1.14 | 1.13 |
| Group 3: Raloxifene 30 mg | 1.67 | 1.34 | 1.04 | 1.11 |
| Group 4: Lovaza 4 gm | 1.22 | 1.69 | 1.32 | 1.49 |
| Group 5: Lovaza 4 gm and Raloxifene 30 mg | 4.28 | 2.59 | 1.84 | 1.32 |
Changes in serum lipid levels as measured through total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides. Specific time points for evaluation are baseline, Year +1, and Year 2. (NCT00723398)
Timeframe: 2 years
| Intervention | mg/dL (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline: Total Cholesterol | 1 year: Total Cholestrol | 2 year: Total Cholesterol | Baseline: LDL Cholesterol | 1 year: LDL Cholesterol | 2 year: LDL Cholesterol | Baseline: HDL Cholesterol | 1 year: HDL Cholesterol | 2 year: HDL Cholestrol | Baseline: Triglycerides | 1 year: Triglycerides | 2 year: Triglycerides | |
| Group 1: Control | 207.3 | 208.8 | 207.5 | 114 | 115.1 | 115.3 | 68.75 | 70.71 | 70.19 | 122.7 | 114.5 | 110.1 |
| Group 2: Raloxifene 60 mg | 203.6 | 198.3 | 196.6 | 114.7 | 106.8 | 104.7 | 66.18 | 68.88 | 68.63 | 113.2 | 113.2 | 116.9 |
| Group 3: Raloxifene 30 mg | 204.3 | 199.6 | 202.3 | 111.2 | 106.2 | 106.1 | 70.92 | 70.59 | 73.17 | 110.6 | 113.7 | 115.8 |
| Group 4: Lovaza 4 gm | 197.7 | 199.6 | 200.2 | 106.6 | 109.7 | 110.4 | 68.06 | 70.59 | 70.67 | 115.1 | 96.22 | 95.41 |
| Group 5: Lovaza 4 gm and Raloxifene 30 mg | 197.6 | 189.4 | 192.6 | 108.1 | 96.58 | 99.48 | 68.9 | 76.11 | 75.77 | 103.6 | 83.71 | 86.43 |
pre-treatment glucose disposal. In general, a high glucose disposal rate is a marker of healthy metabolic function. Glucose disposal is measured by tracking the amount of tagged glucose in the bloodstream over time. It is adjusted to subject body weight. (NCT01207934)
Timeframe: baseline
| Intervention | mmol/kg body weight/minute (Mean) |
|---|---|
| Placebo | 14.3 |
| Low Dose Leptin | 18.4 |
| High Dose Leptin | 16.7 |
Leptin is an endogenous hormone. Here we measure the pre-treatment concentration of naturally-occurring leptin in the blood. (NCT01207934)
Timeframe: baseline
| Intervention | Micrograms/Liter (Mean) |
|---|---|
| Placebo | 27 |
| Low Dose Leptin | 24 |
| High Dose Leptin | 35 |
This is a measure of the body's ability to metabolize sugar after treatment with either leptin or a placebo. We compare the effect of leptin therapy on insulin-mediated stimulation of glucose disposal with that of placebo. In general, a high glucose disposal rate is a marker of healthy metabolic function. Glucose disposal is measured by tracking the amount of tagged glucose in the bloodstream over time. It is adjusted to subject body weight. (NCT01207934)
Timeframe: fourteen days
| Intervention | mmol/kg body weight/minute (Mean) |
|---|---|
| Placebo | 17.5 |
| Low Dose Leptin | 20.7 |
| High Dose Leptin | 19.1 |
plasma leptin levels after fourteen days ingestion of either leptin or placebo. (NCT01207934)
Timeframe: fourteen days
| Intervention | Micrograms/Liter (Mean) |
|---|---|
| Placebo | 25 |
| Low Dose Leptin | 76 |
| High Dose Leptin | 5024 |
3 reviews available for palmitic acid and Obesity
| Article | Year |
|---|---|
The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms.
Topics: Animals; Fatty Acid-Binding Proteins; Humans; Macrophages; Obesity; Palmitic Acid; PPAR gamma; Toll- | 2019 |
A sexually dimorphic hypothalamic response to chronic high-fat diet consumption.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Estrogen Receptor alpha; Female; Hypothalamus; Infl | 2016 |
Biological and Nutritional Properties of Palm Oil and Palmitic Acid: Effects on Health.
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dietary Fats; Humans; Mice; Neoplasms; | 2015 |
13 trials available for palmitic acid and Obesity
| Article | Year |
|---|---|
Impairment of endometrial decidual reaction in early pregnant mice fed with high fat diet.
Topics: Animals; Azo Compounds; Body Weight; Bone Morphogenetic Proteins; Boron Compounds; Cholesterol; Coll | 2022 |
Subcutaneous adipose tissue free fatty acid uptake measured using positron emission tomography and adipose biopsies in humans.
Topics: Adipose Tissue; Adiposity; Adult; Biopsy; Body Fat Distribution; Body Mass Index; Carbon Isotopes; C | 2019 |
Enhanced glucose metabolism is preserved in cultured primary myotubes from obese donors in response to exercise training.
Topics: Exercise; Exercise Therapy; Glucose; Glucose Transporter Type 1; Glycogen; Humans; Male; Middle Aged | 2013 |
Enhanced glucose metabolism is preserved in cultured primary myotubes from obese donors in response to exercise training.
Topics: Exercise; Exercise Therapy; Glucose; Glucose Transporter Type 1; Glycogen; Humans; Male; Middle Aged | 2013 |
Enhanced glucose metabolism is preserved in cultured primary myotubes from obese donors in response to exercise training.
Topics: Exercise; Exercise Therapy; Glucose; Glucose Transporter Type 1; Glycogen; Humans; Male; Middle Aged | 2013 |
Enhanced glucose metabolism is preserved in cultured primary myotubes from obese donors in response to exercise training.
Topics: Exercise; Exercise Therapy; Glucose; Glucose Transporter Type 1; Glycogen; Humans; Male; Middle Aged | 2013 |
High-Protein Intake during Weight Loss Therapy Eliminates the Weight-Loss-Induced Improvement in Insulin Action in Obese Postmenopausal Women.
Topics: Biomarkers; Blood Glucose; Diet, Reducing; Dietary Proteins; Fatty Acids; Female; Gene Expression Pr | 2016 |
Stearoyl-CoA desaturase-1, a novel target of omega-3 fatty acids for reducing breast cancer risk in obese postmenopausal women.
Topics: Adult; Aged; Biomarkers; Body Mass Index; Breast Density; Breast Neoplasms; Docosahexaenoic Acids; D | 2017 |
Galactose promotes fat mobilization in obese lactating and nonlactating women.
Topics: Adult; Anti-Obesity Agents; Blood Glucose; Breast Feeding; Cross-Over Studies; Dietary Sucrose; Fema | 2011 |
Gastric bypass surgery is associated with near-normal insulin suppression of lipolysis in nondiabetic individuals.
Topics: Adult; Blood Glucose; Case-Control Studies; Cross-Sectional Studies; Down-Regulation; Fatty Acids, N | 2011 |
Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes.
Topics: Blood Glucose; Body Composition; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glycero | 2011 |
The role of leptin in human lipid and glucose metabolism: the effects of acute recombinant human leptin infusion in young healthy males.
Topics: Adipose Tissue; Adult; AMP-Activated Protein Kinases; Glucose; Humans; Leptin; Lipid Metabolism; Lip | 2011 |
Relationship between adipose tissue lipolytic activity and skeletal muscle insulin resistance in nondiabetic women.
Topics: Adipose Tissue; Adult; Aged; Diabetes Mellitus; Fatty Acids, Nonesterified; Female; Glucose Clamp Te | 2012 |
Metabolic and dietary determinants of serum lipids in obese patients with recently diagnosed non-insulin-dependent diabetes.
Topics: Adult; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diet, Reducing; Female; Follow-Up | 1994 |
Measurement of free fatty acid kinetics during non-equilibrium tracer conditions in man: implications for the estimation of the rate of appearance of free fatty acids.
Topics: Adult; Aged; Carbon Radioisotopes; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Half-Life; | 1998 |
Racial differences in lipid metabolism in women with abdominal obesity.
Topics: Abdomen; Adipose Tissue; Adult; Black People; Body Composition; Carbon Radioisotopes; Energy Metabol | 2000 |
212 other studies available for palmitic acid and Obesity
| Article | Year |
|---|---|
Curcumin analogue C66 attenuates obesity-induced myocardial injury by inhibiting JNK-mediated inflammation.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Benzylidene Compounds; Cardiomyopathies; Cell Line; Cy | 2021 |
Trimetazidine and exercise provide comparable improvements to high fat diet-induced muscle dysfunction through enhancement of mitochondrial quality control.
Topics: Animals; Cell Line; Combined Modality Therapy; Diet, High-Fat; Disease Models, Animal; Humans; Lipid | 2021 |
Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes.
Topics: Adipocytes; Adrenomedullin; Animals; Inflammation; Insulin; Insulin Resistance; Obesity; Palmitic Ac | 2022 |
C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer.
Topics: Adult; Aged; Animals; Breast Neoplasms; CCAAT-Enhancer-Binding Protein-beta; Cell Line, Tumor; Epige | 2022 |
Palmitic Acid and Oleic Acid Differently Modulate TLR2-Mediated Inflammatory Responses in Microglia and Macrophages.
Topics: Cytokines; Dietary Fats; Fatty Acids; Fatty Acids, Monounsaturated; Humans; Inflammation; Macrophage | 2022 |
LncRNA Tug1 maintains blood-testis barrier integrity by modulating Ccl2 expression in high-fat diet mice.
Topics: Animals; Blood-Testis Barrier; Cells, Cultured; Chemokine CCL2; Diet, High-Fat; Electric Impedance; | 2022 |
Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1/MAPK signaling.
Topics: Animals; Benzhydryl Compounds; Cardiomyopathies; Glucosides; Inflammation; Mice; Mice, Inbred C57BL; | 2022 |
Sulforaphane reduces pro-inflammatory response to palmitic acid in monocytes and adipose tissue macrophages.
Topics: Adipose Tissue; Humans; Inflammasomes; Inflammation; Interleukin-1beta; Isothiocyanates; Lipopolysac | 2022 |
Malus toringoides (Rehd.) Hughes improves glucose and lipid metabolism and liver injury in high fructose-induced mice.
Topics: Animals; Fructose; Glucose; Hyperlipidemias; Hypertension; Insulin Resistance; Lipid Metabolism; Liv | 2022 |
Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs/NF-κB/KLF7 pathway.
Topics: Animals; Glucose; Glucose Metabolism Disorders; Inflammation; Kruppel-Like Transcription Factors; Mi | 2022 |
Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation.
Topics: Animals; Dermatitis; Dyslipidemias; Humans; Inflammation; Interleukin-17; Keratinocytes; Leptin; Mic | 2022 |
Augmented CPT1A Expression Is Associated with Proliferation and Colony Formation during Barrett's Tumorigenesis.
Topics: Adenocarcinoma; Animals; Barrett Esophagus; Carcinogenesis; Carnitine; Carnitine O-Palmitoyltransfer | 2022 |
Asprosin aggravates vascular endothelial dysfunction via disturbing mitochondrial dynamics in obesity models.
Topics: Animals; Diet, High-Fat; Endothelial Cells; Endothelium, Vascular; Mice; Mice, Inbred C57BL; Mitocho | 2023 |
Weight cycling induces innate immune memory in adipose tissue macrophages.
Topics: Adipose Tissue; Animals; Culture Media, Conditioned; Diabetes Mellitus; Glucose; Insulin Resistance; | 2022 |
Mitochondrial dysfunction caused by SIRT3 inhibition drives proinflammatory macrophage polarization in obesity.
Topics: Animals; Body Weight; Diet, High-Fat; Inflammation; Insulin Resistance; Macrophages; Mice; Mice, Inb | 2023 |
FGF1 ameliorates obesity-associated hepatic steatosis by reversing IGFBP2 hypermethylation.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Epigenesis, Genetic; Fibroblast Growth Factor 1; In | 2023 |
Icariin Ameliorates Spermatogenesis Disorder in Obese Mice Induced by High-Fat Diet through Regulating the Glycolytic Pathway.
Topics: Animals; Diet, High-Fat; Male; Mice; Mice, Obese; Obesity; Palmitic Acid; Semen; Spermatogenesis; Te | 2023 |
The Role of Palmitic Acid in the Co-Toxicity of Bacterial Metabolites to Endothelial Cells.
Topics: E-Selectin; Endothelium, Vascular; Endotoxemia; Human Umbilical Vein Endothelial Cells; Humans; Lipo | 2023 |
Lunasin ameliorates glucose utilization in C2C12 myotubes and metabolites profile in diet-induced obese mice benefiting metabolic disorders.
Topics: Animals; Diet; Glucose; Glucose Intolerance; Inflammation; Insulin Resistance; Metabolic Diseases; M | 2023 |
Wheat Alkylresorcinols Modulate Glucose Homeostasis through Improving GLP-1 Secretion in High-Fat-Diet-Induced Obese Mice.
Topics: Animals; Diet, High-Fat; Fatty Acids, Volatile; Gastrointestinal Hormones; Glucagon-Like Peptide 1; | 2023 |
Nuciferine Protects against Obesity-Induced Nephrotoxicity through Its Hypolipidemic, Anti-Inflammatory, and Antioxidant Effects.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Antioxidants; Diet, High-Fat; Infl | 2023 |
Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression.
Topics: Adult; ARNTL Transcription Factors; Case-Control Studies; CLOCK Proteins; Cryptochromes; DNA-Binding | 2020 |
Green Tea Polyphenol (-)-Epigallocatechin Gallate (EGCG) Attenuates Neuroinflammation in Palmitic Acid-Stimulated BV-2 Microglia and High-Fat Diet-Induced Obese Mice.
Topics: Animals; Anti-Obesity Agents; Catechin; Cell Line; Diet, High-Fat; Disease Models, Animal; Hypothala | 2019 |
Mitochondria-targeted therapy rescues development and quality of embryos derived from oocytes matured under oxidative stress conditions: a bovine in vitro model.
Topics: Animals; Antioxidants; Cattle; Culture Media; Diabetes Mellitus, Type 2; Disease Models, Animal; Emb | 2019 |
Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Antibodies, Monoclonal, Humanized; A | 2019 |
Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status.
Topics: Adipocytes; Animals; Blood Glucose; Cell Respiration; Diet, High-Fat; Disease Models, Animal; Gene E | 2020 |
Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway.
Topics: Diabetes Mellitus, Type 2; Fatty Acids; Gene Expression Regulation; Glucose; Glucose Transporter Typ | 2019 |
Beta-Aminoisobutyric Acid Inhibits Hypothalamic Inflammation by Reversing Microglia Activation.
Topics: Aminoisobutyric Acids; Animals; Cell Line; Cytokines; Diet, High-Fat; Disease Models, Animal; Enceph | 2019 |
High Level of Palmitic Acid Induced Over-Expressed Methyltransferase Inhibits Anti-Inflammation Factor KLF4 Expression in Obese Status.
Topics: 3T3 Cells; Adipose Tissue; Adult; Animals; Enzyme Inhibitors; Female; Gene Expression Regulation, En | 2020 |
Arachidonic acid inhibits inflammatory responses by binding to myeloid differentiation factor-2 (MD2) and preventing MD2/toll-like receptor 4 signaling activation.
Topics: Acute Lung Injury; Animals; Arachidonic Acid; Cell Line; Diet, High-Fat; Disease Models, Animal; Fat | 2020 |
PINK1/Parkin mediated mitophagy ameliorates palmitic acid-induced apoptosis through reducing mitochondrial ROS production in podocytes.
Topics: Animals; Apoptosis; Autophagy; Diet, High-Fat; Gene Silencing; Kidney; Male; Membrane Potential, Mit | 2020 |
Long-term hypercortisolism induces lipogenesis promoting palmitic acid accumulation and inflammation in visceral adipose tissue compared with HFD-induced obesity.
Topics: Animals; Corticosterone; Cushing Syndrome; Cytokines; Diet, High-Fat; Fatty Acids; Fatty Acids, None | 2020 |
Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism.
Topics: Animals; Cell Line; Chromatin; Diabetes Mellitus, Type 2; Enhancer Elements, Genetic; Female; Gene E | 2020 |
Oleic Acid Counters Impaired Blastocyst Development Induced by Palmitic Acid During Mouse Preimplantation Development: Understanding Obesity-Related Declines in Fertility.
Topics: Animals; Blastocyst; Embryonic Development; Endoplasmic Reticulum Stress; Female; Fertility; Mice; O | 2020 |
Lipid excess affects chaperone-mediated autophagy in hypothalamus.
Topics: Animals; Cell Line; Chaperone-Mediated Autophagy; Diet, High-Fat; Hypothalamus; Mice; Neurons; Obesi | 2020 |
Evaluation of the In Vitro Damage Caused by Lipid Factors on Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence.
Topics: Animals; Apoptosis; Cells, Cultured; Cholesterol; Diabetes Mellitus, Type 2; Disease Models, Animal; | 2020 |
Regulation of MFN2 by berberine alleviates obesity exacerbated colitis.
Topics: Animals; Berberine; Colitis; Dextran Sulfate; Diet, High-Fat; Endoplasmic Reticulum Chaperone BiP; E | 2020 |
Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1.
Topics: Adult; Cell Movement; Cells, Cultured; Decidua; Female; HEK293 Cells; Humans; Inflammation; Inflamma | 2020 |
Omega-3 polyunsaturated fatty acids prevent obesity by improving tricarboxylic acid cycle homeostasis.
Topics: Animals; Cell Survival; Citric Acid Cycle; Diet, High-Fat; Docosahexaenoic Acids; Fatty Acids, Omega | 2021 |
MKP-5 Relieves Lipotoxicity-Induced Islet β-Cell Dysfunction and Apoptosis via Regulation of Autophagy.
Topics: Adenine; Adenoviridae; Animals; Apoptosis; Autophagy; Diet, High-Fat; Dual-Specificity Phosphatases; | 2020 |
Palmitic acid negatively regulates tumor suppressor PTEN through T366 phosphorylation and protein degradation.
Topics: Animals; Cell Proliferation; Colonic Neoplasms; Enzyme Inhibitors; HCT116 Cells; Humans; Male; Mice; | 2021 |
Cinnamtannin D1 Protects Pancreatic β-Cells from Glucolipotoxicity-Induced Apoptosis by Enhancement of Autophagy In Vitro and In Vivo.
Topics: Animals; Apoptosis; Autophagy; Cell Line; Glucose; Humans; Hypoglycemic Agents; Insulin-Secreting Ce | 2020 |
An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila.
Topics: 3-Hydroxybutyric Acid; Animals; Dietary Fats; Drosophila; Drosophila Proteins; Fatty Acids, Nonester | 2021 |
The role of uncoupling protein 2 in macrophages and its impact on obesity-induced adipose tissue inflammation and insulin resistance.
Topics: Adipose Tissue; Animals; Carnitine O-Palmitoyltransferase; Diabetes Mellitus, Type 2; Diet, High-Fat | 2020 |
Novel FoxO1 inhibitor, JY-2, ameliorates palmitic acid-induced lipotoxicity and gluconeogenesis in a murine model.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diet, High-Fat; Disease Models, Animal; Gene Expression R | 2021 |
Free fatty acids induce the demethylation of the fructose 1,6-biphosphatase 2 gene promoter and potentiate its expression in hepatocytes.
Topics: Animals; Betaine; Cell Line; Diet, High-Fat; DNA Demethylation; Fatty Acids, Nonesterified; Fructose | 2021 |
Impaired Ca
Topics: Alstrom Syndrome; Animals; Blood Glucose; Calcium; Calcium Signaling; Diabetes Mellitus, Type 2; Dis | 2021 |
Molecular Mechanisms of Palmitic Acid Augmentation in COVID-19 Pathologies.
Topics: Chemokines; Computational Biology; COVID-19; Cytokines; Databases, Factual; Fatty Acids, Nonesterifi | 2021 |
Does different BMI influence oocyte and embryo quality by inducing fatty acid in follicular fluid?
Topics: Adult; Body Mass Index; Embryo, Mammalian; Embryonic Development; Fatty Acids; Female; Follicular Fl | 2017 |
Fasting rapidly increases fatty acid oxidation in white adipose tissue of young broiler chickens.
Topics: Abdominal Fat; Adipocytes; Adipose Tissue, White; Animals; Chickens; Fasting; Fatty Acids; Lipid Met | 2017 |
Hypothalamic lipid-laden astrocytes induce microglia migration and activation.
Topics: Animals; Animals, Newborn; Astrocytes; Biomarkers; Cell Line; Cell Movement; Cells, Cultured; Chemot | 2017 |
Silymarin protects against renal injury through normalization of lipid metabolism and mitochondrial biogenesis in high fat-fed mice.
Topics: Animals; Antioxidants; Cell Line; Diet, High-Fat; Epithelial Cells; Humans; Kidney Tubules, Proximal | 2017 |
MD2 Blockage Protects Obesity-Induced Vascular Remodeling via Activating AMPK/Nrf2.
Topics: AMP-Activated Protein Kinases; Animals; Aorta; Diet, High-Fat; Endothelial Cells; Enzyme Activation; | 2017 |
Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival.
Topics: Adipose Tissue; Animals; CD11b Antigen; Cell Survival; Cells, Cultured; Chloroquine; Cluster Analysi | 2017 |
Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice.
Topics: AMP-Activated Protein Kinases; Animals; Apigenin; Cell Line; Diet, High-Fat; Male; Mice, Inbred C57B | 2017 |
Glucagon-like peptide-1 analog prevents obesity-related glomerulopathy by inhibiting excessive autophagy in podocytes.
Topics: Animals; Autophagy; Blood Glucose; Cell Line; Cytoprotection; Diet, High-Fat; Disease Models, Animal | 2018 |
Ginsenoside Rb1 improves leptin sensitivity in the prefrontal cortex in obese mice.
Topics: Animals; Anti-Obesity Agents; Brain-Derived Neurotrophic Factor; Cells, Cultured; Central Nervous Sy | 2018 |
CTRP3 attenuates high-fat diet-induced male reproductive dysfunction in mice.
Topics: Adipokines; Animals; Case-Control Studies; Diet, High-Fat; Drug Evaluation, Preclinical; Endoplasmic | 2018 |
Stimulating effect of palmitate and insulin on cell migration and proliferation in PNT1A and PC3 prostate cells: Counteracting role of metformin.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation | 2018 |
Effects of saturated palmitic acid and omega-3 polyunsaturated fatty acids on Sertoli cell apoptosis.
Topics: Animals; Apoptosis; Cell Survival; Diet, High-Fat; Disease Models, Animal; DNA Damage; Fas Ligand Pr | 2018 |
Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice.
Topics: Animals; Diet, Fat-Restricted; Diet, High-Fat; Glucagon-Like Peptide 1; Glucose; HEK293 Cells; Human | 2018 |
Palmitic Acid Increases Endothelin-1 Expression in Vascular Endothelial Cells through the Induction of Endoplasmic Reticulum Stress and Protein Kinase C Signaling.
Topics: Animals; Cells, Cultured; Diet, High-Fat; Endoplasmic Reticulum Stress; Endothelial Cells; Endotheli | 2018 |
Obesity-related cellular stressors regulate gonadotropin releasing hormone gene expression via c-Fos/AP-1.
Topics: Animals; Cell Line; Endoplasmic Reticulum Stress; Gene Expression Regulation; Gonadotropin-Releasing | 2018 |
Palmitate-Induced Insulin Hypersecretion and Later Secretory Decline Associated with Changes in Protein Expression Patterns in Human Pancreatic Islets.
Topics: Adolescent; Autophagy; Calcium-Binding Proteins; Child; Chromatography, Liquid; Computational Biolog | 2018 |
Palmitate aggravates proteinuria-induced cell death and inflammation via CD36-inflammasome axis in the proximal tubular cells of obese mice.
Topics: Animals; Apoptosis; CARD Signaling Adaptor Proteins; CD36 Antigens; Cell Line; Diet, High-Fat; Disea | 2018 |
Hepatocyte miR-33a mediates mitochondrial dysfunction and hepatosteatosis by suppressing NDUFA5.
Topics: Adenosine Triphosphate; Animals; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Gene Expressio | 2018 |
9-PAHSA promotes browning of white fat via activating G-protein-coupled receptor 120 and inhibiting lipopolysaccharide / NF-kappa B pathway.
Topics: 3T3-L1 Cells; Adipocytes, White; Adipose Tissue, White; Animals; Cell Line; Fatty Acids, Omega-3; In | 2018 |
Alterations to the microbiota-colon-brain axis in high-fat-diet-induced obese mice compared to diet-resistant mice.
Topics: Adiposity; Animals; Brain; Brain-Derived Neurotrophic Factor; Colitis; Colon; Diet, High-Fat; Eating | 2019 |
NDP-MSH reduces oxidative damage induced by palmitic acid in primary astrocytes.
Topics: alpha-MSH; Animals; Anti-Inflammatory Agents; Astrocytes; Diet, High-Fat; Encephalitis; Male; Neurop | 2019 |
MIP-1α Induction by Palmitate in the Human Monocytic Cells Implicates TLR4 Signaling Mechanism.
Topics: Adaptor Proteins, Signal Transducing; Diabetes Mellitus, Type 2; Humans; Macrophages; MAP Kinase Sig | 2019 |
Lipopolysaccharide and palmitic acid synergistically induced MCP-1 production via MAPK-meditated TLR4 signaling pathway in RAW264.7 cells.
Topics: Animals; Chemokine CCL2; Diabetes Mellitus; Disease Models, Animal; Drug Synergism; Gene Expression | 2019 |
Palmitic acid causes insulin resistance in granulosa cells via activation of JNK.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Fatty Acids; Female; Glucose; Granulosa Cells; | 2019 |
Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway.
Topics: Adenylate Kinase; Aging; AMP-Activated Protein Kinase Kinases; Animals; Antioxidants; Cyclic AMP-Dep | 2019 |
Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells via Hepatocyte Growth Factor/c-Met Signaling in Obesity-Associated Kidney Injury.
Topics: Animals; Apoptosis; Coculture Techniques; Culture Media, Conditioned; Diet, High-Fat; Endoplasmic Re | 2019 |
Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adipose Tissue; Animals; Cell Proliferation; Clone Cells; Di | 2019 |
Ablation of TMEM126B protects against heart injury via improving mitochondrial function in high fat diet (HFD)-induced mice.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Diet, High-Fat; DNA Damage; Dynamins; GTP Phosphohydrola | 2019 |
Protectin DX ameliorates palmitate-induced hepatic insulin resistance through AMPK/SIRT1-mediated modulation of fetuin-A and SeP expression.
Topics: Active Transport, Cell Nucleus; Adult; alpha-2-HS-Glycoprotein; AMP-Activated Protein Kinases; Docos | 2019 |
Free fatty acid flux in African-American and Caucasian adults--effect of sex and race.
Topics: Adult; Basal Metabolism; Black or African American; Calorimetry, Indirect; Fatty Acids, Nonesterifie | 2013 |
Palmitate diet-induced loss of cardiac caveolin-3: a novel mechanism for lipid-induced contractile dysfunction.
Topics: Animals; Calcium; Cardiomyopathies; Caveolin 3; Cell Membrane; Ceramides; Diet, High-Fat; Female; Ge | 2013 |
Palmitate induces apoptosis in mouse aortic endothelial cells and endothelial dysfunction in mice fed high-calorie and high-cholesterol diets.
Topics: Animals; Aorta, Thoracic; Apoptosis; Cells, Cultured; Cholesterol, Dietary; Endoplasmic Reticulum Ch | 2013 |
Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production.
Topics: Animals; Apoptosis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Fatty Acids; Humans | 2013 |
Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Diabetes Mellitus, Experimental; Down-Regulation; Dy | 2013 |
Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity.
Topics: Adult; Animals; Carrier Proteins; Down-Regulation; Gene Knockdown Techniques; Humans; Insulin; Insul | 2013 |
Stearic acids at sn-1, 3 positions of TAG are more efficient at limiting fat deposition than palmitic and oleic acids in C57BL/6 mice.
Topics: Adiposity; Animals; Diet, High-Fat; Dietary Fats; Feces; Intestinal Absorption; Intra-Abdominal Fat; | 2014 |
Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.
Topics: Adipocytes; Animals; Eye Proteins; Gene Expression Regulation; Glucose Tolerance Test; Hepatocytes; | 2014 |
Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance.
Topics: Adiposity; Animals; Catalytic Domain; Cell Line; Cell Survival; Curcumin; Dietary Fats; Endoplasmic | 2014 |
Defects in TLR3 expression and RNase L activation lead to decreased MnSOD expression and insulin resistance in muscle cells of obese people.
Topics: 2',5'-Oligoadenylate Synthetase; Animals; ATP-Binding Cassette Transporters; Case-Control Studies; D | 2014 |
Regulation of insulin degrading enzyme activity by obesity-associated factors and pioglitazone in liver of diet-induced obese mice.
Topics: Animals; Blood Glucose; Cell Line, Tumor; Diet, High-Fat; Gene Expression; Glucagon; Hepatocytes; Hy | 2014 |
Lysosomal stress in obese adipose tissue macrophages contributes to MITF-dependent Gpnmb induction.
Topics: Adipose Tissue; Adult; Animals; Cell Nucleus; Cells, Cultured; Chloroquine; Female; Humans; Interleu | 2014 |
Nuclear factor-κB is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate.
Topics: Adipocytes, Brown; Animals; Cells, Cultured; Cytokines; Growth Differentiation Factor 5; Inflammatio | 2014 |
Increased pyruvate dehydrogenase kinase expression in cultured myotubes from obese and diabetic individuals.
Topics: Adult; Blood Glucose; Body Mass Index; Body Weight; Cells, Cultured; Cholesterol; Diabetes Mellitus, | 2015 |
The expression of Ubc9 and the intensity of SERCA2a-SUMOylation were reduced in diet-induced obese rats and partially restored by trimetazidine.
Topics: Animals; Disease Models, Animal; Male; Myocytes, Cardiac; Obesity; Palmitic Acid; Rats; Rats, Spragu | 2015 |
Metabolic syndrome exacerbates inflammation and bone loss in periodontitis.
Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Animals; Chemokine CCL2; Cytokines; Diet, | 2015 |
Endoplasmic reticulum stress involved in high-fat diet and palmitic acid-induced vascular damages and fenofibrate intervention.
Topics: Animals; Aorta; Cells, Cultured; Diet, High-Fat; Endoplasmic Reticulum Stress; Endothelial Cells; En | 2015 |
Cell-based assay of MGAT2-driven diacylglycerol synthesis for profiling inhibitors: use of a stable isotope-labeled substrate and high-resolution LC/MS.
Topics: Animals; Biological Assay; Cell Line; Diabetes Mellitus, Type 2; Diglycerides; Drug Evaluation, Prec | 2015 |
Targeted metabolomic analysis reveals the association between the postprandial change in palmitic acid, branched-chain amino acids and insulin resistance in young obese subjects.
Topics: Adolescent; Adult; Amino Acids, Branched-Chain; Energy Metabolism; Fasting; Female; Gas Chromatograp | 2015 |
Plasma nutrient biomarkers are associated with waist-to-height ratio in youth with type 1 diabetes.
Topics: Adolescent; Biomarkers; Body Height; Body Mass Index; Body Weight; Child; Child, Preschool; Cross-Se | 2015 |
Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance.
Topics: Animals; Cells, Cultured; Dietary Fats; Enzyme Inhibitors; Fibrosis; Flavonoids; Gene Knockdown Tech | 2015 |
Fetuin A promotes lipotoxicity in β cells through the TLR4 signaling pathway and the role of pioglitazone in anti-lipotoxicity.
Topics: alpha-2-HS-Glycoprotein; Animals; Apoptosis; Cell Line; Diet, High-Fat; Drug Evaluation, Preclinical | 2015 |
Hepatic TLR4 signaling in obese NAFLD.
Topics: Adult; Cell Line; Cells, Cultured; Female; Hepatocytes; Humans; Interferon Regulatory Factor-3; Lipo | 2015 |
Australia's nutrition transition 1961-2009: a focus on fats.
Topics: Arachidonic Acid; Australia; Biological Availability; Culture; Diet; Diet, Western; Dietary Carbohyd | 2015 |
PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury.
Topics: Animals; Autophagy; Cells, Cultured; Diabetes Mellitus, Experimental; Endothelial Cells; Endothelium | 2015 |
Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats.
Topics: Animals; Anticholesteremic Agents; Autophagy; Biomarkers; Blood Glucose; Cells, Cultured; Diabetes M | 2015 |
Diet-induced obesity in the selenocysteine lyase knockout mouse.
Topics: Animals; Cell Line, Tumor; Diet, High-Fat; Energy Metabolism; Heat-Shock Proteins; Lyases; Metabolic | 2015 |
Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo.
Topics: Animals; Aorta; Cattle; Cell Membrane; Ceramides; Endothelial Cells; Endothelium, Vascular; Fatty Ac | 2015 |
Decreased irisin secretion contributes to muscle insulin resistance in high-fat diet mice.
Topics: Adipose Tissue; Animals; Biomarkers; Blood Glucose; Cell Line; Diabetes Mellitus, Type 2; Diet, High | 2015 |
Teasaponin improves leptin sensitivity in the prefrontal cortex of obese mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Diet, High-Fat; Hyperinsulinism; Insuli | 2015 |
GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance.
Topics: Adipogenesis; Aging; Animals; Body Weight; Carcinoma, Hepatocellular; CHO Cells; Cricetinae; Cricetu | 2015 |
Inhibition of mitogen-activated protein kinases/nuclear factor κB-dependent inflammation by a novel chalcone protects the kidney from high fat diet-induced injuries in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Chalcones; Cytokines; Diet, High- | 2015 |
Diet-Induced Obesity and Its Differential Impact on Periodontal Bone Loss.
Topics: Alveolar Bone Loss; Animals; Body Weight; Bone Remodeling; Cells, Cultured; Collagen Type I; Diet, H | 2016 |
Palmitic Acid Reduces Circulating Bone Formation Markers in Obese Animals and Impairs Osteoblast Activity via C16-Ceramide Accumulation.
Topics: Absorptiometry, Photon; Animals; Biomarkers; Ceramides; Diet, High-Fat; Disease Models, Animal; Enzy | 2016 |
Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity.
Topics: Animals; Apoptosis; Blood Glucose; Cardiomegaly; Cell Line; Diet, High-Fat; Fibrosis; Heart Injuries | 2016 |
Diet-induced obesity impairs endometrial stromal cell decidualization: a potential role for impaired autophagy.
Topics: Animals; Autophagy; Biomarkers; Decidua; Diet, High-Fat; Embryo Implantation; Female; Humans; Male; | 2016 |
High-fat diet-dependent modulation of the delayed rectifier K(+) current in adult guinea pig atrial myocytes.
Topics: Action Potentials; Animals; Diet, High-Fat; Dietary Fats; Female; Guinea Pigs; Heart Atria; Heart Co | 2016 |
Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells.
Topics: Caspase 1; Cell Line; Clustered Regularly Interspaced Short Palindromic Repeats; Female; Humans; Inf | 2016 |
A panel of free fatty acid ratios to predict the development of metabolic abnormalities in healthy obese individuals.
Topics: 8,11,14-Eicosatrienoic Acid; Adult; Arachidonic Acid; Area Under Curve; Body Mass Index; Cardiovascu | 2016 |
Zinc deficiency exacerbates while zinc supplement attenuates cardiac hypertrophy in high-fat diet-induced obese mice through modulating p38 MAPK-dependent signaling.
Topics: Animals; Cardiomegaly; Cells, Cultured; Chelating Agents; Deficiency Diseases; Diet, High-Fat; Dieta | 2016 |
Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity.
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Apoptosis; Cell Survival; Ceramides; Endopla | 2016 |
Metabolic Fate of Branched-Chain Amino Acids During Adipogenesis, in Adipocytes From Obese Mice and C2C12 Myotubes.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); 3T3-L1 Cells; Adipocytes; Adipogenesis; Amino Aci | 2017 |
Serum stearic acid/palmitic acid ratio as a potential predictor of diabetes remission after Roux-en-Y gastric bypass in obesity.
Topics: Acetyltransferases; Adult; Aged; Biomarkers; Diabetes Mellitus; Fatty Acid Elongases; Female; Gastri | 2017 |
Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2.
Topics: Animals; Cardiomyopathies; Cell Line; Diet, High-Fat; Gene Expression Regulation; Humans; Lymphocyte | 2017 |
A fatter way to metastasize.
Topics: Fatty Acids; Humans; Obesity; Palmitic Acid | 2018 |
Diet-induced obesity impairs spermatogenesis: a potential role for autophagy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cells, Cultured; Chloroquine; Diet, High-Fat; Humans; Infert | 2017 |
STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity.
Topics: Active Transport, Cell Nucleus; Adipose Tissue; Animals; Cell Line, Tumor; Coculture Techniques; Die | 2017 |
Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content.
Topics: Abdomen; Adipose Tissue; Adolescent; Body Composition; Body Mass Index; Fatty Liver; Female; Glucose | 2009 |
In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation.
Topics: Animals; Biological Transport; Carnitine O-Palmitoyltransferase; DNA, Mitochondrial; Fatty Acids; Fe | 2009 |
Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans.
Topics: Adipocytes; Adipose Tissue; Biopsy; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Angiopathies; | 2009 |
Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action.
Topics: Adult; Cell Communication; Cells, Cultured; Coculture Techniques; Cytokines; Fatty Acids, Nonesterif | 2009 |
Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure.
Topics: Animals; Blood Pressure; Cells, Cultured; Dietary Fats; Disease Models, Animal; Dose-Response Relati | 2009 |
Soraphen, an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet.
Topics: 3-Hydroxybutyric Acid; Acetyl-CoA Carboxylase; Animals; Cholesterol; Diet; Dietary Fats; Glucose Cla | 2009 |
12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Arachido | 2009 |
Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes.
Topics: Cells, Cultured; Diabetes Mellitus, Type 2; Female; Gene Expression; Glucose; Humans; Interleukin-6; | 2009 |
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity.
Topics: Animals; Central Nervous System; Diet; Dietary Fats; Eating; Energy Metabolism; Enzyme Activation; F | 2009 |
Desaturation of excess intramyocellular triacylglycerol in obesity: implications for glycemic control.
Topics: Analysis of Variance; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Diabetes Mellitus, Ty | 2010 |
Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model.
Topics: Adipose Tissue; Animals; Azo Compounds; Body Composition; Disease Models, Animal; Energy Intake; Fat | 2010 |
The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity.
Topics: Animals; Blotting, Western; Cells, Cultured; Humans; In Vitro Techniques; Insulin-Secreting Cells; I | 2010 |
Relation between degree of obesity and site-specific adipose tissue fatty acid composition in a Mediterranean population.
Topics: Adult; Aged; Body Composition; Body Mass Index; Diet; Diet, Mediterranean; Dietary Fats; Fatty Acids | 2011 |
The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways.
Topics: Animals; Gene Expression Regulation, Enzymologic; Glycogen; Hep G2 Cells; Hepatocytes; Humans; Insul | 2010 |
Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals.
Topics: Animals; Carbon Radioisotopes; Case-Control Studies; Disease Models, Animal; Fasting; Fatty Acids; H | 2010 |
In obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidation.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Biological Transport; Carnitine O-Palmitoyltransferase; C | 2011 |
Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans.
Topics: 3T3-L1 Cells; Adipose Tissue; Analysis of Variance; Animals; Blotting, Western; Cells, Cultured; Hum | 2011 |
Visfatin inhibits apoptosis of pancreatic β-cell line, MIN6, via the mitogen-activated protein kinase/phosphoinositide 3-kinase pathway.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line; Cell Proliferation; Chromones; | 2011 |
Preserved insulin vasorelaxation and up-regulation of the Akt/eNOS pathway in coronary arteries from insulin resistant obese Zucker rats.
Topics: Animals; Blotting, Western; Coronary Vessels; Disease Models, Animal; Enzyme Inhibitors; Insulin; In | 2011 |
Differential effects of natural palm oil, chemically- and enzymatically-modified palm oil on weight gain, blood lipid metabolites and fat deposition in a pediatric pig model.
Topics: Adipose Tissue; Animals; Body Weight; Cholesterol, HDL; Cholesterol, LDL; Dietary Fats; Dietary Supp | 2011 |
Preimplantation exposure of mouse embryos to palmitic acid results in fetal growth restriction followed by catch-up growth in the offspring.
Topics: Animals; Apoptosis; Blastocyst; Body Weight; Cell Count; Cell Proliferation; Cells, Cultured; Crosse | 2011 |
Involvement of visfatin in palmitate-induced upregulation of inflammatory cytokines in hepatocytes.
Topics: Adenoviridae Infections; Animals; Blood Glucose; Cholesterol; Cytokines; Enzyme-Linked Immunosorbent | 2011 |
Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle.
Topics: Animals; Cell Line; Dynamins; Fatty Acids; Glucose; Insulin Resistance; Mice; Mitochondria, Muscle; | 2012 |
Subcellular lipid droplet distribution in red and white muscles in the obese Zucker rat.
Topics: Animals; Disease Models, Animal; DNA, Mitochondrial; Fatty Acids; Female; Glucose; Insulin; Lipids; | 2012 |
The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.
Topics: Adipocytes; Adipose Tissue; Animals; Antigens, CD; Antigens, Surface; Coculture Techniques; Dietary | 2012 |
Differential impact of oleate, palmitate, and adipokines on expression of NF-κB target genes in human vascular smooth muscle cells.
Topics: Activins; Adipocytes; Adipokines; Angiopoietins; Apoptosis Regulatory Proteins; Atherosclerosis; Cel | 2012 |
ApoE and the role of very low density lipoproteins in adipose tissue inflammation.
Topics: Adipose Tissue; Adiposity; Animals; Apolipoproteins E; Blood Glucose; Cytokines; Diet, High-Fat; Dis | 2012 |
Mitochondrial dysfunction and activation of iNOS are responsible for the palmitate-induced decrease in adiponectin synthesis in 3T3L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Adipose Tissue; Animals; Endoplasmic Reticulum Stress; Insuli | 2012 |
Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice.
Topics: Animals; Blood Glucose; Eating; eIF-2 Kinase; Glucose; Glucose Intolerance; Insulin Receptor Substra | 2012 |
Cathepsin K knockout mitigates high-fat diet-induced cardiac hypertrophy and contractile dysfunction.
Topics: Animals; Apoptosis; Calcium; Cardiomegaly; Cathepsin K; Cell Line; Cytochromes c; Cytoplasm; Diet, H | 2013 |
Kinetics of saturated, monounsaturated, and polyunsaturated fatty acids in humans.
Topics: Adult; Algorithms; Body Mass Index; Carbon Radioisotopes; Fatty Acids, Nonesterified; Female; Humans | 2013 |
Metabolic response to a mixed meal in obese and lean women from two South african populations.
Topics: Adipose Tissue; Black People; Blood Glucose; Body Composition; Body Constitution; Carbon Isotopes; C | 2002 |
Energy expenditure, sex, and endogenous fuel availability in humans.
Topics: Adipose Tissue; Adult; Basal Metabolism; Body Composition; Calorimetry; Fatty Acids, Nonesterified; | 2003 |
Fasting plasma triglyceride levels and fat oxidation predict dietary obesity in rats.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Composition; Carbon Dioxide; Diet; Dietary Fats; Energy | 2003 |
Acquirement of brown fat cell features by human white adipocytes.
Topics: Adenoviridae; Adipocytes; Adipose Tissue, Brown; Animals; Blotting, Western; Carrier Proteins; Chlor | 2003 |
STUDIES OF ENERGY METABOLISM IN HUMAN SUBJECTS USING CARBON 14-LABELED COMPOUNDS. I. EFFECT OF SEX, STATE OF NUTRITION AND BODY WEIGHT.
Topics: Acetates; Body Weight; Carbohydrate Metabolism; Carbon Isotopes; Carbon Radioisotopes; Child; Energy | 1964 |
STUDIES WITH FAT EMULSIONS: METABOLISM OF INTRAVENOUSLY ADMINISTERED C14-TRIPALMITIN.
Topics: Blood Chemical Analysis; Carbon Dioxide; Carbon Isotopes; Cholesterol; Chromatography; Chylomicrons; | 1965 |
METABOLISM OF FREE FATTY ACIDS IN OBESE HUMANS.
Topics: Carbon Isotopes; Chromatography; Fatty Acids; Fatty Acids, Nonesterified; Glucose; Lipid Metabolism; | 1965 |
Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36.
Topics: Aged; Biological Transport; Body Mass Index; Carrier Proteins; CD36 Antigens; Diabetes Mellitus, Typ | 2004 |
A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.
Topics: Avidin; Biotin; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line; Cell L | 2004 |
Vascular response to angiotensin II in upper body obesity.
Topics: Acetylcholine; Adult; Angiotensin II; Blood Glucose; Body Composition; Dose-Response Relationship, D | 2004 |
Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenoviridae; Animals; Blotting, Western; Calcium; Cy | 2004 |
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Animals; Blood Glucose; Blotting, Northern; Blotting, West | 2004 |
Divergent effects of rosiglitazone on protein-mediated fatty acid uptake in adipose and in muscle tissues of Zucker rats.
Topics: Adipocytes; Adipose Tissue; Animals; CD36 Antigens; Cell Membrane; Fatty Acid Transport Proteins; Fa | 2005 |
Reduced insulin-mediated citrate synthase activity in cultured skeletal muscle cells from patients with type 2 diabetes: evidence for an intrinsic oxidative enzyme defect.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Cells, Cultured; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2005 |
Inverse relationship between PGC-1alpha protein expression and triacylglycerol accumulation in rodent skeletal muscle.
Topics: Animals; CD36 Antigens; Disease Models, Animal; Fatty Acids; Hindlimb; Lipogenesis; Male; Mice; Mice | 2006 |
Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training.
Topics: Adult; Black or African American; Citrate (si)-Synthase; Coenzyme A Ligases; Fatty Acids; Female; Hu | 2006 |
Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates.
Topics: Amino Acid Sequence; Animals; Blood Glucose; Cells, Cultured; Enzyme Activation; Fatty Acids; Gene E | 2006 |
Adipose tissue, hepatic, and skeletal muscle insulin sensitivity in extremely obese subjects with acanthosis nigricans.
Topics: Acanthosis Nigricans; Adipose Tissue; Adolescent; Adult; Fatty Acids, Nonesterified; Female; Glucose | 2006 |
Insulin dose response analysis of free fatty acid kinetics.
Topics: Adult; Body Composition; Dose-Response Relationship, Drug; Female; Glucose; Humans; Insulin; Male; O | 2007 |
Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects.
Topics: Adolescent; Adult; Body Mass Index; Calorimetry, Indirect; Ceramides; Fatty Acids, Nonesterified; Gl | 2007 |
Direct free fatty acid uptake into human adipocytes in vivo: relation to body fat distribution.
Topics: Adipocytes; Adipose Tissue; Biological Transport; Body Weight; Fatty Acid Transport Proteins; Fatty | 2007 |
Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.
Topics: Adipose Tissue; Amino Acids; Animals; Cell Line; Citric Acid Cycle; Dietary Fats; Enzyme Activation; | 2007 |
Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity.
Topics: Animals; Aorta, Thoracic; Body Composition; Body Weight; Cells, Cultured; Dietary Fats; Disease Mode | 2007 |
Metabolic challenges reveal impaired fatty acid metabolism and translocation of FAT/CD36 but not FABPpm in obese Zucker rat muscle.
Topics: Animals; CD36 Antigens; Fatty Acid-Binding Proteins; Fatty Acids; Female; Insulin; Lipid Metabolism; | 2007 |
Innate immune pathway links obesity to insulin resistance.
Topics: Animals; Aorta; Dietary Fats; Disease Models, Animal; Humans; Immunity, Innate; Inflammation; Insuli | 2007 |
Obesity increases free thyroxine proportionally to nonesterified fatty acid concentrations in adult neutered female cats.
Topics: Animals; Cats; Diabetes Mellitus, Type 2; Disease Progression; Fatty Acids, Nonesterified; Female; I | 2007 |
Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity.
Topics: Animals; CD36 Antigens; Cells, Cultured; Dyslipidemias; Energy Intake; Fatty Acids; Glucose Toleranc | 2007 |
Exercise-induced attenuation of obesity, hyperinsulinemia, and skeletal muscle lipid peroxidation in the OLETF rat.
Topics: Adipose Tissue; Aging; Aldehydes; Animals; Blood Glucose; Disease Models, Animal; Eating; Glutathion | 2008 |
Dietary fat oxidation as a function of body fat.
Topics: Adolescent; Adult; Body Mass Index; Body Weight; Deuterium; Dietary Fats; Energy Metabolism; Female; | 2008 |
Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans.
Topics: Adiponectin; Female; Glucose; Humans; Insulin; Insulin Resistance; Middle Aged; Obesity; Oxidation-R | 2008 |
Radioisotopic method for the measurement of lipolysis in small samples of human adipose tissue.
Topics: Adipose Tissue; Carbon Radioisotopes; Female; Glucose; Humans; Kinetics; Lipolysis; Obesity; Palmiti | 1984 |
In vitro study on lipogenesis and exogeneous fatty acid uptake in white adipose tissue of lean and obese Zucker rats aged 10 days.
Topics: Adipose Tissue; Animals; Biological Transport; Body Weight; Kinetics; Lipids; Obesity; Organ Size; P | 1983 |
Effect of genetic obesity on the regulation of hepatic fatty acid metabolism.
Topics: Animals; Genotype; Glucagon; In Vitro Techniques; Kinetics; Lipids; Liver; Obesity; Palmitic Acid; P | 1983 |
Sympathetic activity in thyroid-treated Zucker rats.
Topics: Animals; Body Weight; Cold Temperature; Energy Intake; Epinephrine; Insulin; Norepinephrine; Obesity | 1982 |
Palmitate metabolism and norepinephrine sensitivity in brown adipose, liver, and white adipose tissues of Zucker rats.
Topics: Adipose Tissue; Adipose Tissue, Brown; Animals; Female; Glucose; Liver; Norepinephrine; Obesity; Pal | 1982 |
A comparison of the in vitro lipogenic rates and other physiologic parameters in two strains of lean and obese chickens.
Topics: Adipose Tissue; Aging; Animals; Chickens; Esterification; Fatty Acids; Female; In Vitro Techniques; | 1982 |
Valproate and palmitate binding to serum albumin in valproate-treated patients. Relation to obesity.
Topics: Adult; Body Mass Index; Epilepsy; Fatty Acids, Nonesterified; Female; Humans; Male; Middle Aged; Mod | 1993 |
Specific decrease of mitochondrial thermogenic capacity in brown adipose tissue of obese SHR/N-cp rats.
Topics: Adipose Tissue, Brown; Animals; Body Temperature Regulation; Bucladesine; Crosses, Genetic; DNA; Ele | 1993 |
Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM.
Topics: Acyl-CoA Oxidase; Animals; Brain; Cells, Cultured; Coenzyme A Ligases; Diabetes Mellitus; Diabetes M | 1997 |
Heart disease risk-factor status and dietary changes in the Cretan population over the past 30 y: the Seven Countries Study.
Topics: Adipose Tissue; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anthropometry; Blood Pressure; | 1997 |
Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation.
Topics: Adipocytes; Animals; Cells, Cultured; Diabetes Mellitus, Type 1; DNA Primers; Enzyme Induction; Epid | 1997 |
Sensitization to insulin induced by beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in obese Zucker rats in vivo.
Topics: Adipose Tissue; Animals; Blood Glucose; Cholesterol; Fatty Acids, Nonesterified; Glucose; Glucose Cl | 1997 |
Fatty acid composition of brown adipose tissue in dietary obese rats.
Topics: Adipose Tissue, Brown; Animals; Dietary Fats; Fatty Acids; Fatty Acids, Monounsaturated; Fatty Acids | 1997 |
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.
Topics: Animals; Apoptosis; Cells, Cultured; Ceramides; Chromans; Coenzyme A Ligases; Diabetes Mellitus; Dia | 1998 |
Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/Akt stimulation and glucose uptake.
Topics: Animals; Biological Transport, Active; Cells, Cultured; Deoxyglucose; Diabetes Mellitus, Type 2; Dow | 1999 |
Tissue-specific actions of antidiabetic thiazolidinediones on the reduced fatty acid oxidation in skeletal muscle and liver of Zucker diabetic fatty rats.
Topics: Administration, Oral; Animals; Chromans; Diabetes Mellitus; Fatty Acids; Hypoglycemic Agents; Liver; | 2000 |
Lipid oxidation is reduced in obese human skeletal muscle.
Topics: Adult; Body Mass Index; Caprylates; Carbon Isotopes; Carnitine; Carnitine O-Palmitoyltransferase; Ci | 2000 |
Loss of regulation of lipogenesis in the Zucker diabetic rat. II. Changes in stearate and oleate synthesis.
Topics: Adipose Tissue; Animals; Deuterium; Diabetes Mellitus; Dietary Carbohydrates; Dietary Fats; Epididym | 2002 |
Effects of obesity on substrate utilization during exercise.
Topics: Adult; Blood Glucose; Body Mass Index; Breath Tests; Carbon Isotopes; Energy Metabolism; Exercise; F | 2002 |
Metabolic effects of three weeks administration of the beta-adrenoceptor agonist BRL 26830A.
Topics: Adrenergic beta-Agonists; Adult; Amino Acids; Blood Glucose; Energy Metabolism; Epinephrine; Ethanol | 1992 |
Effects of body fat distribution on regional lipolysis in obesity.
Topics: Adipose Tissue; Adult; Fatty Acids, Nonesterified; Female; Humans; Leg; Lipolysis; Mesentery; Obesit | 1991 |
Regulation of forearm lipolysis in different types of obesity. In vivo evidence for adipocyte heterogeneity.
Topics: Adipose Tissue; Adult; Fatty Acids, Nonesterified; Female; Forearm; Glucagon; Humans; Insulin; Lipid | 1991 |
Valproate and palmitate binding to human serum albumin: an hypothesis on obesity.
Topics: Humans; Kinetics; Mathematics; Models, Biological; Obesity; Palmitic Acid; Palmitic Acids; Protein B | 1990 |
An explanation for decreased ketogenesis in the liver of the obese Zucker rat.
Topics: Animals; Carnitine; Cytosol; DNA; Electron Transport Complex IV; Ketone Bodies; Liver; Male; Mitocho | 1989 |
Metabolic characteristics of skeletal muscle from lean and obese Zucker rats.
Topics: Animals; Glucose; Histocytochemistry; Isoleucine; Male; Muscles; Obesity; Oxidation-Reduction; Palmi | 1987 |
Effect of short-term fasting on lipolytic responsiveness in normal and obese human subjects.
Topics: Adult; Epinephrine; Fasting; Fatty Acids, Nonesterified; Glycerol; Heart Rate; Humans; Insulin; Kine | 1987 |
The fate of 14C derived from radioactively labelled dietary precursors in young rats of the Zucker strain (Fa/- and fa/fa).
Topics: Animals; Carbon Radioisotopes; Glucose; Lactates; Lactic Acid; Leucine; Obesity; Palmitic Acid; Palm | 1986 |