palmitic acid has been researched along with Neuroblastoma in 17 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neuroblastoma (NB) is a childhood cancer, commonly treated with drugs, such as etoposide (ETO), whose efficacy is limited by the onset of resistance." | 8.31 | Imidazo-Pyrazole-Loaded Palmitic Acid and Polystyrene-Based Nanoparticles: Synthesis, Characterization and Antiproliferative Activity on Chemo-Resistant Human Neuroblastoma Cells. ( Alfei, S; Brullo, C; Domenicotti, C; Marengo, B; Milanese, M; Valenti, GE; Zuccari, G, 2023) |
| "Saturated fatty acids such as palmitic acid promote inflammation and insulin resistance in peripheral tissues, contrasting with the protective action of polyunsaturated fatty acids such docosahexaenoic acid." | 8.02 | Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma. ( Amine, H; Benomar, Y; Taouis, M, 2021) |
| "Palmitic acid (PA) is a saturated fatty acid whose high consumption has been largely associated with the development of different metabolic alterations, such as insulin resistance, metabolic syndrome, and type 2 diabetes." | 8.02 | Palmitic acid induces insulin resistance by a mechanism associated with energy metabolism and calcium entry in neuronal cells. ( Arias, C; Bastián-Eugenio, CE; Sánchez-Alegría, K; Vaca, L, 2021) |
| " We evaluated the anti-ROS effect of HO-1 and the involved pathway in palmitic acid (PA)-treated human neuroblastoma BE(2)-M17 cells." | 7.88 | Up-regulation of HO-1 by Nrf2 activation protects against palmitic acid-induced ROS increase in human neuroblastoma BE(2)-M17 cells. ( Hou, L; Jiang, L; Shi, Y; Sun, X; Sun, Y; Yao, M; Zhao, H, 2018) |
| "In the human neuroblastoma cell line SK-N-BE(2), arachidonic acid (AA), supplied in the medium at micromolar concentrations, markedly enhanced [14C]stearic acid (SA) (but not [14C]palmitic acid or [14C]oleic acid) incorporation into phosphatidylinositol (PtdIns)." | 7.69 | Arachidonic acid modulates [14C]stearic acid incorporation into phosphatidylinositol, in human neuroblastoma cells. ( De Laurenzi, V; Limatola, C; Pacini, L; Ricci, I; Spinedi, A, 1997) |
| "P-curcumin was prepared through chemical synthesis." | 5.46 | Palmitic Acid Curcumin Ester Facilitates Protection of Neuroblastoma against Oligomeric Aβ40 Insult. ( Feng, Z; Fu, Y; Huang, T; Li, C; Qi, Z; Sun, Y; Wang, T; Wu, M, 2017) |
| "Palmitic acid was the main compound responsible for this apoptotic effect by a ceramide-independent mechanism that involved endoplasmic reticulum (ER)-stress with upregulation of CCAAT/-enhancer-binding protein homologous protein (CHOP)." | 5.39 | Palmitic acid and ergosta-7,22-dien-3-ol contribute to the apoptotic effect and cell cycle arrest of an extract from Marthasterias glacialis L. in neuroblastoma cells. ( Andrade, PB; Correia-da-Silva, G; Pereira, DM; Teixeira, N; Valentão, P, 2013) |
| "Neuroblastoma (NB) is a childhood cancer, commonly treated with drugs, such as etoposide (ETO), whose efficacy is limited by the onset of resistance." | 4.31 | Imidazo-Pyrazole-Loaded Palmitic Acid and Polystyrene-Based Nanoparticles: Synthesis, Characterization and Antiproliferative Activity on Chemo-Resistant Human Neuroblastoma Cells. ( Alfei, S; Brullo, C; Domenicotti, C; Marengo, B; Milanese, M; Valenti, GE; Zuccari, G, 2023) |
| "Saturated fatty acids such as palmitic acid promote inflammation and insulin resistance in peripheral tissues, contrasting with the protective action of polyunsaturated fatty acids such docosahexaenoic acid." | 4.02 | Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma. ( Amine, H; Benomar, Y; Taouis, M, 2021) |
| "Palmitic acid (PA) is a saturated fatty acid whose high consumption has been largely associated with the development of different metabolic alterations, such as insulin resistance, metabolic syndrome, and type 2 diabetes." | 4.02 | Palmitic acid induces insulin resistance by a mechanism associated with energy metabolism and calcium entry in neuronal cells. ( Arias, C; Bastián-Eugenio, CE; Sánchez-Alegría, K; Vaca, L, 2021) |
| " We evaluated the anti-ROS effect of HO-1 and the involved pathway in palmitic acid (PA)-treated human neuroblastoma BE(2)-M17 cells." | 3.88 | Up-regulation of HO-1 by Nrf2 activation protects against palmitic acid-induced ROS increase in human neuroblastoma BE(2)-M17 cells. ( Hou, L; Jiang, L; Shi, Y; Sun, X; Sun, Y; Yao, M; Zhao, H, 2018) |
| " Furthermore, in a neuroblastoma cell GPR40 was activated by docosahexaenoic acid and selective agonists, yet not by palmitic acid." | 3.80 | GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells. ( Aymerich, MS; Etayo-Labiano, I; Franco, R; Luis Lanciego, J; Martínez-Pinilla, E; Pérez-Mediavilla, A; Ricobaraza, A; Zamarbide, M, 2014) |
| "In the human neuroblastoma cell line SK-N-BE(2), arachidonic acid (AA), supplied in the medium at micromolar concentrations, markedly enhanced [14C]stearic acid (SA) (but not [14C]palmitic acid or [14C]oleic acid) incorporation into phosphatidylinositol (PtdIns)." | 3.69 | Arachidonic acid modulates [14C]stearic acid incorporation into phosphatidylinositol, in human neuroblastoma cells. ( De Laurenzi, V; Limatola, C; Pacini, L; Ricci, I; Spinedi, A, 1997) |
| "P-curcumin was prepared through chemical synthesis." | 1.46 | Palmitic Acid Curcumin Ester Facilitates Protection of Neuroblastoma against Oligomeric Aβ40 Insult. ( Feng, Z; Fu, Y; Huang, T; Li, C; Qi, Z; Sun, Y; Wang, T; Wu, M, 2017) |
| "Palmitic acid was the main compound responsible for this apoptotic effect by a ceramide-independent mechanism that involved endoplasmic reticulum (ER)-stress with upregulation of CCAAT/-enhancer-binding protein homologous protein (CHOP)." | 1.39 | Palmitic acid and ergosta-7,22-dien-3-ol contribute to the apoptotic effect and cell cycle arrest of an extract from Marthasterias glacialis L. in neuroblastoma cells. ( Andrade, PB; Correia-da-Silva, G; Pereira, DM; Teixeira, N; Valentão, P, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Valenti, GE | 1 |
| Marengo, B | 1 |
| Milanese, M | 1 |
| Zuccari, G | 1 |
| Brullo, C | 1 |
| Domenicotti, C | 1 |
| Alfei, S | 1 |
| Amine, H | 1 |
| Benomar, Y | 1 |
| Taouis, M | 1 |
| Sánchez-Alegría, K | 2 |
| Bastián-Eugenio, CE | 1 |
| Vaca, L | 1 |
| Arias, C | 2 |
| Calvo-Ochoa, E | 1 |
| Gómez-Inclán, C | 1 |
| Ferrera, P | 1 |
| Qi, Z | 1 |
| Wu, M | 1 |
| Fu, Y | 1 |
| Huang, T | 1 |
| Wang, T | 1 |
| Sun, Y | 2 |
| Feng, Z | 1 |
| Li, C | 1 |
| Shi, Y | 1 |
| Sun, X | 1 |
| Zhao, H | 1 |
| Yao, M | 1 |
| Hou, L | 1 |
| Jiang, L | 1 |
| Bolognesi, A | 1 |
| Chatgilialoglu, A | 1 |
| Polito, L | 1 |
| Ferreri, C | 1 |
| Pereira, DM | 1 |
| Correia-da-Silva, G | 1 |
| Valentão, P | 1 |
| Teixeira, N | 1 |
| Andrade, PB | 1 |
| Zamarbide, M | 1 |
| Etayo-Labiano, I | 1 |
| Ricobaraza, A | 1 |
| Martínez-Pinilla, E | 1 |
| Aymerich, MS | 1 |
| Luis Lanciego, J | 1 |
| Pérez-Mediavilla, A | 1 |
| Franco, R | 1 |
| Chlenski, A | 1 |
| Dobratic, M | 1 |
| Salwen, HR | 1 |
| Applebaum, M | 1 |
| Guerrero, LJ | 1 |
| Miller, R | 1 |
| DeWane, G | 1 |
| Solomaha, E | 1 |
| Marks, JD | 1 |
| Cohn, SL | 1 |
| Renner, U | 1 |
| Glebov, K | 1 |
| Lang, T | 1 |
| Papusheva, E | 1 |
| Balakrishnan, S | 1 |
| Keller, B | 1 |
| Richter, DW | 1 |
| Jahn, R | 1 |
| Ponimaskin, E | 1 |
| Wiesner, DA | 1 |
| Dawson, G | 2 |
| Pacini, L | 1 |
| Limatola, C | 1 |
| De Laurenzi, V | 1 |
| Ricci, I | 1 |
| Spinedi, A | 1 |
| Boucrot, P | 1 |
| Aubry, J | 1 |
| Mezazigh, A | 1 |
| Antony, P | 1 |
| Kanfer, JN | 1 |
| Freysz, L | 1 |
| Fu, T | 1 |
| Okano, Y | 1 |
| Zhang, W | 1 |
| Ozeki, T | 1 |
| Mitsui, Y | 1 |
| Nozawa, Y | 1 |
| Farrer, RG | 1 |
17 other studies available for palmitic acid and Neuroblastoma
| Article | Year |
|---|---|
Imidazo-Pyrazole-Loaded Palmitic Acid and Polystyrene-Based Nanoparticles: Synthesis, Characterization and Antiproliferative Activity on Chemo-Resistant Human Neuroblastoma Cells.
Topics: Antineoplastic Agents; Child; Drug Carriers; Etoposide; Humans; Nanoparticles; Neuroblastoma; Palmit | 2023 |
Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma.
Topics: Cell Line, Tumor; Humans; Inflammation; Insulin Resistance; Neoplasm Proteins; Neuroblastoma; Palmit | 2021 |
Palmitic acid induces insulin resistance by a mechanism associated with energy metabolism and calcium entry in neuronal cells.
Topics: Adenosine Triphosphate; Calcium; Cell Line, Tumor; Cytosol; Energy Metabolism; Fatty Acids; Humans; | 2021 |
Palmitic acid stimulates energy metabolism and inhibits insulin/PI3K/AKT signaling in differentiated human neuroblastoma cells: The role of mTOR activation and mitochondrial ROS production.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; Energy Metabolism; Humans; Insulin | 2017 |
Palmitic Acid Curcumin Ester Facilitates Protection of Neuroblastoma against Oligomeric Aβ40 Insult.
Topics: Amyloid beta-Peptides; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cell Shape; Curcumin; Hu | 2017 |
Up-regulation of HO-1 by Nrf2 activation protects against palmitic acid-induced ROS increase in human neuroblastoma BE(2)-M17 cells.
Topics: Adaptation, Physiological; Alzheimer Disease; Antioxidants; Cell Line; Dietary Fats; Extracellular S | 2018 |
Membrane lipidome reorganization correlates with the fate of neuroblastoma cells supplemented with fatty acids.
Topics: Apoptosis; Arachidonic Acid; Cell Membrane; Cell Survival; Chromatography, Gas; Dietary Supplements; | 2013 |
Palmitic acid and ergosta-7,22-dien-3-ol contribute to the apoptotic effect and cell cycle arrest of an extract from Marthasterias glacialis L. in neuroblastoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biological Products; Blotting, Western; Breast Neoplasms; | 2013 |
GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells.
Topics: Animals; Benzoates; Cell Line, Tumor; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element- | 2014 |
Secreted protein acidic and rich in cysteine (SPARC) induces lipotoxicity in neuroblastoma by regulating transport of albumin complexed with fatty acids.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Female; G | 2016 |
Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling.
Topics: Animals; Biotinylation; Calcium; Cell Line, Tumor; Enzyme Activation; Fluorescent Dyes; Green Fluore | 2007 |
Programmed cell death in neurotumour cells involves the generation of ceramide.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Apoptosis; Cell Survival; Ceramides; Diacylglycerol Kina | 1996 |
Arachidonic acid modulates [14C]stearic acid incorporation into phosphatidylinositol, in human neuroblastoma cells.
Topics: Arachidonic Acid; Carbon Radioisotopes; Cell Fractionation; Chromatography, Thin Layer; Dose-Respons | 1997 |
Severe modifications of ether- ester- or diester-linked glycerolipid and non glycerolipid synthesis in human neuroblastoma LAN-1 cells cultured with octadecylmethylglycerophosphocholine.
Topics: Antineoplastic Agents; Arachidonic Acid; Carbohydrate Metabolism; Ceramides; Esters; Ethers; Ganglio | 1995 |
Phosphatidylcholine metabolism in nuclei of phorbol ester-activated LA-N-1 neuroblastoma cells.
Topics: Carbon Radioisotopes; Cell Nucleus; Choline; Choline Kinase; Cytidine Diphosphate Choline; Humans; K | 2000 |
Receptor-linked early events induced by vasoactive intestinal contractor (VIC) on neuroblastoma and vascular smooth-muscle cells.
Topics: Animals; Calcium; Cell Line; Cells, Cultured; Choline; Diglycerides; Egtazic Acid; Fura-2; Inositol | 1990 |
Acylation of exogenous glycosylsphingosines by intact neuroblastoma (NCB-20) cells.
Topics: Acylation; Animals; Cell Line; Fatty Acids, Nonesterified; Glycosphingolipids; Kinetics; Mice; Neuro | 1990 |